#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19838-1	uniprotkb:Q8NFZ5	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627268	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	-	-	-	figure legend:Fig. 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/01/28	2014/10/16	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	intact-crc:678585705E14F545|rigid:jTRFQKwRLyiEXQnzp4ktanCgSkM	false	mutation:927-927|ha tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P19838-1	uniprotkb:Q00653-1	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	intact:EBI-307341|ensembl:ENSP00000358983|ensembl:ENSP00000499294	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:q00653-1(display_long)|uniprotkb:p100(isoform synonym)|uniprotkb:NFKB2(gene name)|psi-mi:NFKB2(display_short)|uniprotkb:LYT10(gene name synonym)|uniprotkb:DNA-binding factor KBF2(gene name synonym)|uniprotkb:H2TF1(gene name synonym)|uniprotkb:Lymphocyte translocation chromosome 10 protein(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2(gene name synonym)|uniprotkb:Oncogene Lyt-10(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627268	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	intact:EBI-307326(nfkb2_human)|ensembl:ENSG00000077150(gene)|ensembl:ENST00000369966(transcript)|ensembl:ENST00000661543(transcript)	-	-	-	figure legend:Fig. 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/01/28	2014/10/16	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	rogid:bGZ4DuEhX8eCNtkuMCJnh8PCcEI9606	intact-crc:678585705E14F545|rigid:jTRFQKwRLyiEXQnzp4ktanCgSkM	false	mutation:927-927|ha tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P19838-1	uniprotkb:P19838-PRO_0000030311	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	intact:EBI-697771	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:p19838-pro_0000030311(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627268	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	intact:EBI-300010(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:433	figure legend:Fig. 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/01/28	2014/10/16	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	rogid:ZgJEP6sTCusv6e6HxIkMJ5Yuv1E9606	intact-crc:678585705E14F545|rigid:jTRFQKwRLyiEXQnzp4ktanCgSkM	false	mutation:927-927|ha tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P19838-1	uniprotkb:P41279	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627290	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	-	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/01/28	2014/10/16	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	intact-crc:5A9ED46118D85462|rigid:XdacxahldhF+d0rPEZc+ligtcVE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19838-1	uniprotkb:Q00653-1	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	intact:EBI-307341|ensembl:ENSP00000358983|ensembl:ENSP00000499294	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:q00653-1(display_long)|uniprotkb:p100(isoform synonym)|uniprotkb:NFKB2(gene name)|psi-mi:NFKB2(display_short)|uniprotkb:LYT10(gene name synonym)|uniprotkb:DNA-binding factor KBF2(gene name synonym)|uniprotkb:H2TF1(gene name synonym)|uniprotkb:Lymphocyte translocation chromosome 10 protein(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2(gene name synonym)|uniprotkb:Oncogene Lyt-10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627290	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	intact:EBI-307326(nfkb2_human)|ensembl:ENSG00000077150(gene)|ensembl:ENST00000369966(transcript)|ensembl:ENST00000661543(transcript)	-	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/01/28	2014/10/16	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	rogid:bGZ4DuEhX8eCNtkuMCJnh8PCcEI9606	intact-crc:5A9ED46118D85462|rigid:XdacxahldhF+d0rPEZc+ligtcVE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19838-1	uniprotkb:Q8NFZ5	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627290	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	-	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/01/28	2014/10/16	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	intact-crc:5A9ED46118D85462|rigid:XdacxahldhF+d0rPEZc+ligtcVE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41279	uniprotkb:Q8NFZ5	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	-	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/01/28	2014/10/16	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	intact-crc:A617E3C170E50F06|rigid:4CnZOV+9okNPDKSSQIEAfAk0rXI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41279	uniprotkb:P19838-1	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	-	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/01/28	2014/10/16	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:A617E3C170E50F06|rigid:4CnZOV+9okNPDKSSQIEAfAk0rXI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NFZ5	uniprotkb:P41279	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627310	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	-	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/01/28	2014/10/16	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	intact-crc:50570B6F72438845|rigid:4CnZOV+9okNPDKSSQIEAfAk0rXI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NFZ5	uniprotkb:P19838-1	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627310	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	-	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2008/01/28	2014/10/16	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:50570B6F72438845|rigid:4CnZOV+9okNPDKSSQIEAfAk0rXI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NFZ5	uniprotkb:P19838-1	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627316	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	-	-	-	figure legend:Fig. 2A and 2C|comment:Removal of endogenous MAP3K8 from 293 cell lysates did not reduce the level of TNIP2 which coimmunoprecipitated with NFKB1/p105|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/01/28	2014/10/16	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:725B07401CEAAD95|rigid:KnT9TGDrXQSIOc9AgfF6VLzhePw	false	flag tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41279	uniprotkb:Q8NFZ5	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627329	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	-	-	-	figure legend:Fig. 2B and 2D|comment:Immunodepletion of endogenous p105 with anti-p105C antibody did not alter binding of TNIP2 to MAP3K8|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/01/28	2014/10/16	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	intact-crc:80BED5FF45B720C4|rigid:rcn5MHlGuVwEHE9u/AOqKWslo5Y	false	myc tag:?-?	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NFZ5	uniprotkb:P41279	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627351	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	-	-	-	figure legend:Fig. 3C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	intact-crc:E56478E81D05EA69|rigid:4CnZOV+9okNPDKSSQIEAfAk0rXI	false	glutathione s tranferase tag:?-?|sufficient binding region:1-429	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NFZ5	uniprotkb:P19838-1	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627351	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	-	-	-	figure legend:Fig. 3C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:E56478E81D05EA69|rigid:4CnZOV+9okNPDKSSQIEAfAk0rXI	false	glutathione s tranferase tag:?-?|sufficient binding region:1-429	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NFZ5	uniprotkb:P41279	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627363	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	-	-	-	figure legend:Fig. 3C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	intact-crc:8ADC4335579D6DBA|rigid:rcn5MHlGuVwEHE9u/AOqKWslo5Y	false	glutathione s tranferase tag:?-?|sufficient binding region:1-429	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19838-1	uniprotkb:Q8NFZ5	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1629995	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	-	-	-	figure legend:Fig. 5A, 5B|comment:Cell lysates were prepared using 1% Brij 58 buffer A - interaction not observed when milder conditions were used.|comment:"Optimal association also requires the PEST region (893-968) and, to a lesser extent, NFKB1/p105 residues 497 to 538"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	intact-crc:0024293E8D8143F4|rigid:KnT9TGDrXQSIOc9AgfF6VLzhePw	false	ha tag:?-?|mutation disrupting interaction:841-841|necessary binding region:805..805-892..892(IPR000488)	glutathione s tranferase tag:?-?|sufficient binding region:1-429	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NFZ5	uniprotkb:P41279	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1630616	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	-	-	-	figure legend:Fig. 5E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	intact-crc:D548FE0BFE93B130|rigid:rcn5MHlGuVwEHE9u/AOqKWslo5Y	false	flag tag:?-?	biotin tag:?-?|necessary binding region:398-467	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99JG7	uniprotkb:Q07174	intact:EBI-1627383|uniprotkb:Q3TVF3|ensembl:ENSMUSP00000085030	intact:EBI-309771|ensembl:ENSMUSP00000025078	psi-mi:tnip2_mouse(display_long)|uniprotkb:Tnip2(gene name)|psi-mi:Tnip2(display_short)|uniprotkb:Abin2(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:m3k8_mouse(display_long)|uniprotkb:Map3k8(gene name)|psi-mi:Map3k8(display_short)|uniprotkb:Cot(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)|uniprotkb:Tpl2(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627400	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620703.1|ensembl:ENSMUSG00000059866(gene)|ensembl:ENSMUST00000087737(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR032419|interpro:IPR034735|reactome:R-MMU-5684264|reactome:R-MMU-5689896	refseq:NP_031772.1|ensembl:ENSMUSG00000024235(gene)|go:"GO:0007049"(cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENSMUST00000025078(transcript)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|reactome:R-MMU-389357|reactome:R-MMU-5684264|go:"GO:0002376"(immune system process)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:Fig. 4A|comment:TNIP2 immunodepletion removed the majority of MAP3K8 detected directly in cell lysates or after reimmunoprecipitation with anti-TNIP2 or anti-NFKB1/p105 antibodies. Immunodepletion of p105 using anti-NFKB1/p105C antibody also removed a substantial fraction of TNIP2 and cleared MAP3K8 from lysates.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2008/01/28	2014/10/16	rogid:CSqX/Am+1wVccTMn2rMpQrg8fNg10090	rogid:iIYjcxEFNTRfKgArCfTKH9Frf+410090	intact-crc:64DD8547E8E316A7|rigid:OQaAbMDWl7e3tEUSPtjXxK9TJYQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99JG7	uniprotkb:P25799-1	intact:EBI-1627383|uniprotkb:Q3TVF3|ensembl:ENSMUSP00000085030	intact:EBI-643974|ensembl:ENSMUSP00000029812|ensembl:ENSMUSP00000128345	psi-mi:tnip2_mouse(display_long)|uniprotkb:Tnip2(gene name)|psi-mi:Tnip2(display_short)|uniprotkb:Abin2(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:p25799-1(display_long)|uniprotkb:p105(isoform synonym)|uniprotkb:Nfkb1(gene name)|psi-mi:Nfkb1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:NF-kappa-B1 p84/NF-kappa-B1 p98(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lang et al. (2004)	pubmed:15169888	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1627400	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620703.1|ensembl:ENSMUSG00000059866(gene)|ensembl:ENSMUST00000087737(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR032419|interpro:IPR034735|reactome:R-MMU-5684264|reactome:R-MMU-5689896	intact:EBI-643958(nfkb1_mouse)|ensembl:ENSMUSG00000028163(gene)|ensembl:ENSMUST00000029812(transcript)|ensembl:ENSMUST00000164430(transcript)	-	-	-	figure legend:Fig. 4A|comment:TNIP2 immunodepletion removed the majority of MAP3K8 detected directly in cell lysates or after reimmunoprecipitation with anti-TNIP2 or anti-NFKB1/p105 antibodies. Immunodepletion of p105 using anti-NFKB1/p105C antibody also removed a substantial fraction of TNIP2 and cleared MAP3K8 from lysates.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2008/01/28	2014/10/16	rogid:CSqX/Am+1wVccTMn2rMpQrg8fNg10090	rogid:OiCZGnyznh4scSRI6QeIuv4pHbA10090	intact-crc:64DD8547E8E316A7|rigid:OQaAbMDWl7e3tEUSPtjXxK9TJYQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NFZ5	uniprotkb:P19838-1	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1630564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	-	-	-	figure legend:Fig. 5C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:7B11622E64CB30A1|rigid:KnT9TGDrXQSIOc9AgfF6VLzhePw	false	flag tag:?-?|35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:497-968	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P41279	uniprotkb:Q8NFZ5	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1630595	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	-	-	-	figure legend:Fig. 5D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	intact-crc:4BFCDD260C26C8CD|rigid:rcn5MHlGuVwEHE9u/AOqKWslo5Y	false	myc tag:?-?|necessary binding region:398-467	glutathione s tranferase tag:?-?|sufficient binding region:1-429	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NFZ5	uniprotkb:P19838-1	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	intact:EBI-1452239|ensembl:ENSP00000378297|ensembl:ENSP00000424790	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:p19838-1(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1631921	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|intact:EBI-300010(isoform-parent)	-	-	-	figure legend:Fig. 6A, 6B, 6C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:60E7EE1AD9601542|rigid:KnT9TGDrXQSIOc9AgfF6VLzhePw	false	glutathione s tranferase tag:?-?|sufficient binding region:1-250	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NFZ5	uniprotkb:P41279	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1631938	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	-	-	-	figure legend:Fig. 6A, 6B, 6C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	intact-crc:33C00282E27AE888|rigid:rcn5MHlGuVwEHE9u/AOqKWslo5Y	false	glutathione s tranferase tag:?-?|sufficient binding region:194-250	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P21580	uniprotkb:Q8NFZ5	intact:EBI-527670|uniprotkb:Q9NSR6|uniprotkb:Q2HIX9|uniprotkb:Q5VXQ7|uniprotkb:B2R767|uniprotkb:E1P588|ensembl:ENSP00000237289|ensembl:ENSP00000481570	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:tnap3_human(display_long)|uniprotkb:Putative DNA-binding protein A20(gene name synonym)|uniprotkb:Zinc finger protein A20(gene name synonym)|uniprotkb:TNFAIP3(gene name)|psi-mi:TNFAIP3(display_short)|uniprotkb:OTUD7C(gene name synonym)|uniprotkb:OTU domain-containing protein 7C(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1631952	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-33804N|refseq:NP_006281.1|ensembl:ENSG00000118503(gene)|ensembl:ENST00000237289(transcript)|ensembl:ENST00000612899(transcript)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019900"(kinase binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034148"(negative regulation of toll-like receptor 5 signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0061043"(regulation of vascular wound healing)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070429"(negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0072573"(tolerance induction to lipopolysaccharide)|go:"GO:0072666"(establishment of protein localization to vacuole)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR033478|mint:P21580|rcsb pdb:2EQE|rcsb pdb:2EQF|rcsb pdb:2EQG|rcsb pdb:2VFJ|rcsb pdb:3DKB|rcsb pdb:3OJ3|rcsb pdb:3OJ4|rcsb pdb:3VUW|rcsb pdb:3VUX|rcsb pdb:3VUY|rcsb pdb:3ZJD|rcsb pdb:3ZJE|rcsb pdb:3ZJF|rcsb pdb:3ZJG|rcsb pdb:5LRX|rcsb pdb:5V3B|rcsb pdb:5V3P|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:XP_011534397.1|refseq:NP_001257436.1|refseq:NP_001257437.1|refseq:XP_005267176.1	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	-	-	-	figure legend:Fig. 6A, 6B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:+D5JkFvXGge36r13YBqkpk99DLo9606	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	intact-crc:9A8DD7E52A3E703B|rigid:INAZHlLcqsZsG5EZCyXqpVvc75s	false	myc tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:251-429	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41279	uniprotkb:P29678	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-1631983	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:mp2k1_rabit(display_long)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Lang et al. (2004)	pubmed:15169888	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1631992	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	refseq:NP_001076098.1|dip:DIP-40535N|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|rcsb pdb:7JUW|rcsb pdb:7JUX|rcsb pdb:7JUY|rcsb pdb:7JUZ|rcsb pdb:7JV0|rcsb pdb:7JV1	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	resulting-ptm:Phosphorylation of MAP2K1|figure legend:Fig. 9E|caution:Mutated lysine in MAP2K1 is at position 205 in the rabbit sequence, not 207 as given in the paper.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/01/28	2014/10/16	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:iWhuovLEQN1LC0GdvJhs5VbZ8Dw9986	intact-crc:AB0845BFBFA90F47|rigid:2d5fOEUOH3pbAERCIhaN8/ZIYXU	false	myc tag:?-?	glutathione s tranferase tag:?-?|mutation:205-205	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)