#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P92973	uniprotkb:Q08467	intact:EBI-1644880|uniprotkb:Q8S8N5|ensemblplants:AT2G46830.1	intact:EBI-1644972|uniprotkb:Q9FN14|uniprotkb:B9DH00|uniprotkb:F4K3Q1|uniprotkb:B9DHA8|uniprotkb:Q94F17|ensemblplants:AT5G67380.1	psi-mi:cca1_arath(display_long)|uniprotkb:CCA1(gene name)|psi-mi:CCA1(display_short)|uniprotkb:At2g46830(locus name)|uniprotkb:Protein CIRCADIAN CLOCK ASSOCIATED 1(gene name synonym)|uniprotkb:MYB-related transcription factor CCA1(gene name synonym)|uniprotkb:F19D11(orf name)	psi-mi:csk21_arath(display_long)|uniprotkb:CKA1(gene name)|psi-mi:CKA1(display_short)|uniprotkb:Casein kinase alpha 1(gene name synonym)|uniprotkb:K8K14.10(orf name)|uniprotkb:At5g67380(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Daniel et al. (2004)	pubmed:14978263|imex:IM-19458	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645249|imex:IM-19458-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_850460.1|refseq:NP_850461.1|interpro:IPR009057(Homeodomain-like)|interpro:IPR006447(Myb-like DNA-binding region, SHAQKYF class)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR017930|interpro:IPR017884|refseq:NP_001318437.1|ensemblplants:AT2G46830(gene)|ensemblplants:AT2G46830.1(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009409"(response to cold)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048574"(long-day photoperiodism, flowering)	interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:6Z1C|refseq:NP_201539.2|refseq:NP_001032165.1|rcsb pdb:6XX6|rcsb pdb:6XX7|rcsb pdb:6XX8|rcsb pdb:6XX9|ensemblplants:AT5G67380(gene)|ensemblplants:AT5G67380.1(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	-	-	-	figure legend:Figure 1|resulting-ptm:Phosphorylation of P92973|comment:"The authors note that \"Using mass spectroscopy, we confirmed Ser-5 and -6, as well as one or more of four additional serine residues (Ser-431, -432, -433, and -484) as being phosphorylated by CK2 in vitro (data not shown). We substituted nucleotides in CCA1 so that these six serine residues were changed into alanine residues to make a new protein, mCCA1. We performed in vitro CK2 phosphorylation assays with increasing amounts of GST-CCA1 or GST-mCCA1 proteins as substrates. The results shown in Fig. 1C demonstrate that these substitutions virtually eliminated mCCA1 phosphorylation by CK2 in vitro\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/04	2014/10/16	rogid:gCmXG7mgYmDgRQEJkPo73O9pZEA3702	rogid:LM6VLcabFYFMS6/icN+LAr3IDuA3702	intact-crc:58EA66F88875AC2D|rigid:IOe1HLd1fgtX6wA0YjnqR2VLX44	false	glutathione s tranferase tag:?-?|sufficient binding region:1-12|sufficient binding region:437-525|mutation decreasing interaction:5-5|mutation decreasing interaction:6-6|mutation decreasing interaction:431-431|mutation decreasing interaction:432-432|mutation decreasing interaction:433-433|mutation decreasing interaction:484-484	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O81275	uniprotkb:P92973	intact:EBI-1644873|uniprotkb:Q24JI1|ensemblplants:AT3G60250.1	intact:EBI-1644880|uniprotkb:Q8S8N5|ensemblplants:AT2G46830.1	psi-mi:csk2d_arath(display_long)|uniprotkb:CKB3(gene name)|psi-mi:CKB3(display_short)|uniprotkb:F27H5_40(orf name)|uniprotkb:At3g60250(locus name)	psi-mi:cca1_arath(display_long)|uniprotkb:CCA1(gene name)|psi-mi:CCA1(display_short)|uniprotkb:At2g46830(locus name)|uniprotkb:Protein CIRCADIAN CLOCK ASSOCIATED 1(gene name synonym)|uniprotkb:MYB-related transcription factor CCA1(gene name synonym)|uniprotkb:F19D11(orf name)	psi-mi:"MI:0018"(two hybrid)	Daniel et al. (2004)	pubmed:14978263|imex:IM-19458	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645282|imex:IM-19458-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_191584.1|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR035991|ensemblplants:AT3G60250(gene)|ensemblplants:AT3G60250.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)	refseq:NP_850460.1|refseq:NP_850461.1|interpro:IPR009057(Homeodomain-like)|interpro:IPR006447(Myb-like DNA-binding region, SHAQKYF class)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR017930|interpro:IPR017884|refseq:NP_001318437.1|ensemblplants:AT2G46830(gene)|ensemblplants:AT2G46830.1(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009409"(response to cold)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048574"(long-day photoperiodism, flowering)	-	-	-	figure legend:Figure 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/03/04	2014/10/16	rogid:sDlTm7H521kEumvmo0/V32ImPg43702	rogid:gCmXG7mgYmDgRQEJkPo73O9pZEA3702	intact-crc:6B2DD8C16954B7D9|rigid:/WZbmmE3lRPqTjRzrR+UKcqElw4	false	-	sufficient binding region:317-608	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P92973	uniprotkb:P92973	intact:EBI-1644880|uniprotkb:Q8S8N5|ensemblplants:AT2G46830.1	intact:EBI-1644880|uniprotkb:Q8S8N5|ensemblplants:AT2G46830.1	psi-mi:cca1_arath(display_long)|uniprotkb:CCA1(gene name)|psi-mi:CCA1(display_short)|uniprotkb:At2g46830(locus name)|uniprotkb:Protein CIRCADIAN CLOCK ASSOCIATED 1(gene name synonym)|uniprotkb:MYB-related transcription factor CCA1(gene name synonym)|uniprotkb:F19D11(orf name)	psi-mi:cca1_arath(display_long)|uniprotkb:CCA1(gene name)|psi-mi:CCA1(display_short)|uniprotkb:At2g46830(locus name)|uniprotkb:Protein CIRCADIAN CLOCK ASSOCIATED 1(gene name synonym)|uniprotkb:MYB-related transcription factor CCA1(gene name synonym)|uniprotkb:F19D11(orf name)	psi-mi:"MI:0018"(two hybrid)	Daniel et al. (2004)	pubmed:14978263|imex:IM-19458	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1645291|imex:IM-19458-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_850460.1|refseq:NP_850461.1|interpro:IPR009057(Homeodomain-like)|interpro:IPR006447(Myb-like DNA-binding region, SHAQKYF class)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR017930|interpro:IPR017884|refseq:NP_001318437.1|ensemblplants:AT2G46830(gene)|ensemblplants:AT2G46830.1(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009409"(response to cold)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048574"(long-day photoperiodism, flowering)	refseq:NP_850460.1|refseq:NP_850461.1|interpro:IPR009057(Homeodomain-like)|interpro:IPR006447(Myb-like DNA-binding region, SHAQKYF class)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR017930|interpro:IPR017884|refseq:NP_001318437.1|ensemblplants:AT2G46830(gene)|ensemblplants:AT2G46830.1(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009409"(response to cold)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048574"(long-day photoperiodism, flowering)	-	-	-	figure legend:Figure 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/03/04	2014/10/16	rogid:gCmXG7mgYmDgRQEJkPo73O9pZEA3702	rogid:gCmXG7mgYmDgRQEJkPo73O9pZEA3702	intact-crc:07949F19BB0A81BC|rigid:QUGrgUfMMxrMWL1RifhIjSWFOHw	false	-	sufficient binding region:100-317|mutation decreasing interaction:5-5|mutation decreasing interaction:6-6|mutation decreasing interaction:431-431|mutation decreasing interaction:432-432|mutation decreasing interaction:433-433|mutation decreasing interaction:484-484	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)