#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53041	uniprotkb:Q92731	intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443	intact:EBI-78505|uniprotkb:A8K8K5|uniprotkb:O60608|uniprotkb:O60685|uniprotkb:O60702|uniprotkb:O60703|uniprotkb:O75583|uniprotkb:O75584|uniprotkb:Q86Z31|uniprotkb:Q9UEV6|uniprotkb:Q9UHD3|uniprotkb:Q9UQK9|uniprotkb:Q0MWT5|uniprotkb:Q0MWT6|uniprotkb:G3V5M5|ensembl:ENSP00000343925	psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym)	psi-mi:esr2_human(display_long)|uniprotkb:ESR2(gene name)|psi-mi:ESR2(display_short)|uniprotkb:ESTRB(gene name synonym)|uniprotkb:NR3A2(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ikeda et al. (2004)	pubmed:14764652|imex:IM-19817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780835|imex:IM-19817-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N	refseq:NP_001035365.1|refseq:NP_001201831.1|refseq:NP_001428.1|refseq:NP_001258805.1|refseq:NP_001258806.1|refseq:NP_001278641.1|refseq:NP_001278652.1|refseq:XP_016876568.1|refseq:XP_016876569.1|refseq:XP_016876570.1|refseq:XP_016876571.1|refseq:XP_016876572.1|refseq:XP_016876573.1|dip:DIP-5966N|ensembl:ENSG00000140009(gene)|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2FSZ|rcsb pdb:2GIU|rcsb pdb:2I0G|rcsb pdb:2JJ3|rcsb pdb:2NV7|rcsb pdb:2QTU|rcsb pdb:2YJD|rcsb pdb:2YLY|rcsb pdb:2Z4B|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:4J24|rcsb pdb:4J26|rcsb pdb:4ZI1|rcsb pdb:5TOA|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-6811558|reactome:R-HSA-8939211|reactome:R-HSA-9009391|ensembl:ENST00000341099(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021064|interpro:IPR024178|interpro:IPR028355|interpro:IPR035500|rcsb pdb:1L2J|rcsb pdb:1NDE|rcsb pdb:1QKM|rcsb pdb:1U3Q|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1U9E|rcsb pdb:1X76	-	-	-	comment:"The Estrogen receptor (ER) beta construct aa 1-481 is a dominant negative form, that has the potential to repress both ERalpha- and ERbeta-mediated transactivation."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/06/10	2014/10/16	rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606	rogid:uRLA3ysTgqKQuay0GPRQzdZXnuQ9606	intact-crc:4EF087C6364C831B|rigid:Bcb9PLh2h9o90ZEUiEq+vl/T+Ig	false	-	sufficient binding region:1-481	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53041	uniprotkb:Q92731	intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443	intact:EBI-78505|uniprotkb:A8K8K5|uniprotkb:O60608|uniprotkb:O60685|uniprotkb:O60702|uniprotkb:O60703|uniprotkb:O75583|uniprotkb:O75584|uniprotkb:Q86Z31|uniprotkb:Q9UEV6|uniprotkb:Q9UHD3|uniprotkb:Q9UQK9|uniprotkb:Q0MWT5|uniprotkb:Q0MWT6|uniprotkb:G3V5M5|ensembl:ENSP00000343925	psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym)	psi-mi:esr2_human(display_long)|uniprotkb:ESR2(gene name)|psi-mi:ESR2(display_short)|uniprotkb:ESTRB(gene name synonym)|uniprotkb:NR3A2(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ikeda et al. (2004)	pubmed:14764652|imex:IM-19817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780913|imex:IM-19817-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N	refseq:NP_001035365.1|refseq:NP_001201831.1|refseq:NP_001428.1|refseq:NP_001258805.1|refseq:NP_001258806.1|refseq:NP_001278641.1|refseq:NP_001278652.1|refseq:XP_016876568.1|refseq:XP_016876569.1|refseq:XP_016876570.1|refseq:XP_016876571.1|refseq:XP_016876572.1|refseq:XP_016876573.1|dip:DIP-5966N|ensembl:ENSG00000140009(gene)|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2FSZ|rcsb pdb:2GIU|rcsb pdb:2I0G|rcsb pdb:2JJ3|rcsb pdb:2NV7|rcsb pdb:2QTU|rcsb pdb:2YJD|rcsb pdb:2YLY|rcsb pdb:2Z4B|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:4J24|rcsb pdb:4J26|rcsb pdb:4ZI1|rcsb pdb:5TOA|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-6811558|reactome:R-HSA-8939211|reactome:R-HSA-9009391|ensembl:ENST00000341099(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021064|interpro:IPR024178|interpro:IPR028355|interpro:IPR035500|rcsb pdb:1L2J|rcsb pdb:1NDE|rcsb pdb:1QKM|rcsb pdb:1U3Q|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1U9E|rcsb pdb:1X76	-	-	-	comment:"The Estrogen receptor (ER) beta construct aa 1-481 is a dominant negative form, that has the potential to repress both ERalpha- and ERbeta-mediated transactivation."|figure legend:1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/06/10	2014/10/16	rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606	rogid:uRLA3ysTgqKQuay0GPRQzdZXnuQ9606	intact-crc:8591F8A40657E85E|rigid:Bcb9PLh2h9o90ZEUiEq+vl/T+Ig	false	-	sufficient binding region:1-481	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53041	uniprotkb:Q92731	intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443	intact:EBI-78505|uniprotkb:A8K8K5|uniprotkb:O60608|uniprotkb:O60685|uniprotkb:O60702|uniprotkb:O60703|uniprotkb:O75583|uniprotkb:O75584|uniprotkb:Q86Z31|uniprotkb:Q9UEV6|uniprotkb:Q9UHD3|uniprotkb:Q9UQK9|uniprotkb:Q0MWT5|uniprotkb:Q0MWT6|uniprotkb:G3V5M5|ensembl:ENSP00000343925	psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym)	psi-mi:esr2_human(display_long)|uniprotkb:ESR2(gene name)|psi-mi:ESR2(display_short)|uniprotkb:ESTRB(gene name synonym)|uniprotkb:NR3A2(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ikeda et al. (2004)	pubmed:14764652|imex:IM-19817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780941|imex:IM-19817-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N	refseq:NP_001035365.1|refseq:NP_001201831.1|refseq:NP_001428.1|refseq:NP_001258805.1|refseq:NP_001258806.1|refseq:NP_001278641.1|refseq:NP_001278652.1|refseq:XP_016876568.1|refseq:XP_016876569.1|refseq:XP_016876570.1|refseq:XP_016876571.1|refseq:XP_016876572.1|refseq:XP_016876573.1|dip:DIP-5966N|ensembl:ENSG00000140009(gene)|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2FSZ|rcsb pdb:2GIU|rcsb pdb:2I0G|rcsb pdb:2JJ3|rcsb pdb:2NV7|rcsb pdb:2QTU|rcsb pdb:2YJD|rcsb pdb:2YLY|rcsb pdb:2Z4B|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:4J24|rcsb pdb:4J26|rcsb pdb:4ZI1|rcsb pdb:5TOA|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-6811558|reactome:R-HSA-8939211|reactome:R-HSA-9009391|ensembl:ENST00000341099(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021064|interpro:IPR024178|interpro:IPR028355|interpro:IPR035500|rcsb pdb:1L2J|rcsb pdb:1NDE|rcsb pdb:1QKM|rcsb pdb:1U3Q|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1U9E|rcsb pdb:1X76	-	-	-	figure legend:2|comment:This interaction is not ligand-dependent. The level of interaction was not affected by the presence or absence of E2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/10	2014/10/16	rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606	rogid:uRLA3ysTgqKQuay0GPRQzdZXnuQ9606	intact-crc:EE353C40B9FC9047|rigid:Bcb9PLh2h9o90ZEUiEq+vl/T+Ig	false	glutathione s tranferase tag:?-?|sufficient binding region:28-165	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P03372	uniprotkb:P53041	intact:EBI-78473|uniprotkb:Q6MZQ9|ensembl:ENSP00000387500|ensembl:ENSP00000342630|ensembl:ENSP00000206249|ensembl:ENSP00000405330|uniprotkb:Q13511|uniprotkb:Q14276|uniprotkb:Q9NU51|uniprotkb:Q9UDZ7|uniprotkb:Q9UIS7|intact:EBI-28988800|uniprotkb:Q5T5H7	intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443	psi-mi:esr1_human(display_long)|uniprotkb:ESR1(gene name)|psi-mi:ESR1(display_short)|uniprotkb:ESR(gene name synonym)|uniprotkb:NR3A1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ikeda et al. (2004)	pubmed:14764652|imex:IM-19817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1781027|imex:IM-19817-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000091831(gene)|ensembl:ENST00000206249(transcript)|ensembl:ENST00000338799(transcript)|ensembl:ENST00000440973(transcript)|ensembl:ENST00000443427(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_000116.2|refseq:NP_001116212.1|refseq:NP_001116213.1|refseq:NP_001116214.1|refseq:XP_011533845.1|refseq:XP_011533846.1|refseq:XP_011533847.1|refseq:XP_006715438.1|ensembl:ENSP00000206249|ensembl:ENSP00000342630|ensembl:ENSP00000405330|ensembl:ENSP00000387500|refseq:NP_001278159.1|refseq:NP_001278170.1|refseq:NP_001315029.1|refseq:XP_016865865.1|refseq:XP_016865866.1|refseq:XP_016865867.1|refseq:XP_016865868.1|refseq:XP_016865869.1|refseq:XP_016865870.1|dip:DIP-5965N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035327"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P03372|rcsb pdb:1A52|rcsb pdb:1AKF|rcsb pdb:1ERE|rcsb pdb:1ERR|rcsb pdb:1G50|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1HCP|rcsb pdb:1HCQ|rcsb pdb:1L2I|rcsb pdb:1PCG|rcsb pdb:1QKT|rcsb pdb:1QKU|rcsb pdb:1R5K|rcsb pdb:1SJ0|rcsb pdb:1UOM|rcsb pdb:1X7E|rcsb pdb:1X7R|rcsb pdb:1XP1|rcsb pdb:1XP6|rcsb pdb:1XP9|rcsb pdb:1XPC|rcsb pdb:1XQC|rcsb pdb:1YIM|rcsb pdb:1YIN|rcsb pdb:1ZKY|rcsb pdb:2AYR|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2BJ4|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2I0J|rcsb pdb:2IOG|rcsb pdb:2IOK|rcsb pdb:2JF9|rcsb pdb:2JFA|rcsb pdb:2LLO|rcsb pdb:2LLQ|rcsb pdb:2OCF|rcsb pdb:2OUZ|rcsb pdb:2P15|rcsb pdb:2POG|rcsb pdb:2Q6J|rcsb pdb:2Q70|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QE4|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QXS|rcsb pdb:2QZO|rcsb pdb:2R6W|rcsb pdb:2R6Y|rcsb pdb:2YAT|rcsb pdb:2YJA|rcsb pdb:3DT3|rcsb pdb:3ERD|rcsb pdb:3ERT|rcsb pdb:3HLV|rcsb pdb:3HM1|rcsb pdb:3L03|rcsb pdb:3OS8|rcsb pdb:3OS9|rcsb pdb:3OSA|rcsb pdb:3Q95|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUC|rcsb pdb:3UUD|rcsb pdb:4AA6|rcsb pdb:4DMA|rcsb pdb:4IU7|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4JC3|rcsb pdb:4JDD|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4O6F|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:4PXM|rcsb pdb:4Q13|rcsb pdb:4Q50|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4XI3|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:5AAU|rcsb pdb:5AAV|rcsb pdb:5ACC|rcsb pdb:5AK2|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5FQP|rcsb pdb:5FQR|rcsb pdb:5FQS|rcsb pdb:5FQT|rcsb pdb:5FQV|rcsb pdb:5GS4|rcsb pdb:5GTR|rcsb pdb:5HYR|rcsb pdb:5JMM|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5N10|rcsb pdb:5T0X|rcsb pdb:5T1Z|rcsb pdb:5T92|rcsb pdb:5T97|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5TN9|rcsb pdb:5TNB|rcsb pdb:5U2B|rcsb pdb:5U2D|rcsb pdb:5UFW|rcsb pdb:5DXP|rcsb pdb:5UFX|rcsb pdb:5W9C|rcsb pdb:5W9D|rcsb pdb:5WGD|rcsb pdb:5WGQ|rcsb pdb:6B0F|rcsb pdb:6C42|rcsb pdb:6CBZ|rcsb pdb:6CHW|rcsb pdb:6CHZ|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:6DF6|rcsb pdb:6DFN|rcsb pdb:6HHP|rcsb pdb:6HKF|rcsb pdb:6HMU|rcsb pdb:6IAR|rcsb pdb:6OWC|rcsb pdb:6PET|rcsb pdb:6PFM|rcsb pdb:6PIT|rcsb pdb:6PSJ|rcsb pdb:6SBO|rcsb pdb:6SQ0|rcsb pdb:6SUO|rcsb pdb:6TJM|rcsb pdb:6TL3|rcsb pdb:6V87|rcsb pdb:6V8T|rcsb pdb:6VGH|rcsb pdb:6VIG|rcsb pdb:6VJ1|rcsb pdb:6VJD|rcsb pdb:6VMU|rcsb pdb:6VPF|rcsb pdb:6VPK|rcsb pdb:6VVP|rcsb pdb:6WOK|rcsb pdb:6ZOQ|rcsb pdb:6ZOR|rcsb pdb:6ZOS|rcsb pdb:7JHD|rcsb pdb:7KBS|rcsb pdb:7KCA|rcsb pdb:7KCD|rcsb pdb:7MSA|rcsb pdb:7NFW|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-8931987|reactome:R-HSA-8939211|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-9009391|reactome:R-HSA-9018519|rcsb pdb:6HKB	refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N	-	-	-	figure legend:2|comment:This interaction is not ligand-dependent. The level of interaction was not affected by the presence or absence of E2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/10	2014/10/16	rogid:T8sQVUNhd5AfJXfL0mjq9TA/C/o9606	rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606	intact-crc:9B54FFCF80B0A05F|rigid:DxqoAWLBhFCKaTbu9KJR7OHYy7w	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:28-165	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q92731	uniprotkb:P53041	intact:EBI-78505|uniprotkb:A8K8K5|uniprotkb:O60608|uniprotkb:O60685|uniprotkb:O60702|uniprotkb:O60703|uniprotkb:O75583|uniprotkb:O75584|uniprotkb:Q86Z31|uniprotkb:Q9UEV6|uniprotkb:Q9UHD3|uniprotkb:Q9UQK9|uniprotkb:Q0MWT5|uniprotkb:Q0MWT6|uniprotkb:G3V5M5|ensembl:ENSP00000343925	intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443	psi-mi:esr2_human(display_long)|uniprotkb:ESR2(gene name)|psi-mi:ESR2(display_short)|uniprotkb:ESTRB(gene name synonym)|uniprotkb:NR3A2(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 2(gene name synonym)	psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ikeda et al. (2004)	pubmed:14764652|imex:IM-19817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1781078|imex:IM-19817-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035365.1|refseq:NP_001201831.1|refseq:NP_001428.1|refseq:NP_001258805.1|refseq:NP_001258806.1|refseq:NP_001278641.1|refseq:NP_001278652.1|refseq:XP_016876568.1|refseq:XP_016876569.1|refseq:XP_016876570.1|refseq:XP_016876571.1|refseq:XP_016876572.1|refseq:XP_016876573.1|dip:DIP-5966N|ensembl:ENSG00000140009(gene)|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2FSZ|rcsb pdb:2GIU|rcsb pdb:2I0G|rcsb pdb:2JJ3|rcsb pdb:2NV7|rcsb pdb:2QTU|rcsb pdb:2YJD|rcsb pdb:2YLY|rcsb pdb:2Z4B|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:4J24|rcsb pdb:4J26|rcsb pdb:4ZI1|rcsb pdb:5TOA|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-6811558|reactome:R-HSA-8939211|reactome:R-HSA-9009391|ensembl:ENST00000341099(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021064|interpro:IPR024178|interpro:IPR028355|interpro:IPR035500|rcsb pdb:1L2J|rcsb pdb:1NDE|rcsb pdb:1QKM|rcsb pdb:1U3Q|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1U9E|rcsb pdb:1X76	refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N	-	-	-	figure legend:3|comment:"The highest level of interaction was observed when the ERbeta construct containing only the E domain (aa 248-481) was used."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/06/10	2014/10/16	rogid:uRLA3ysTgqKQuay0GPRQzdZXnuQ9606	rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606	intact-crc:1CEF2E6105F9598B|rigid:Bcb9PLh2h9o90ZEUiEq+vl/T+Ig	false	sufficient binding region:248-481	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53041	uniprotkb:P03372	intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443	intact:EBI-78473|uniprotkb:Q6MZQ9|ensembl:ENSP00000387500|ensembl:ENSP00000342630|ensembl:ENSP00000206249|ensembl:ENSP00000405330|uniprotkb:Q13511|uniprotkb:Q14276|uniprotkb:Q9NU51|uniprotkb:Q9UDZ7|uniprotkb:Q9UIS7|intact:EBI-28988800|uniprotkb:Q5T5H7	psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym)	psi-mi:esr1_human(display_long)|uniprotkb:ESR1(gene name)|psi-mi:ESR1(display_short)|uniprotkb:ESR(gene name synonym)|uniprotkb:NR3A1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ikeda et al. (2004)	pubmed:14764652|imex:IM-19817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1781141|imex:IM-19817-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N	ensembl:ENSG00000091831(gene)|ensembl:ENST00000206249(transcript)|ensembl:ENST00000338799(transcript)|ensembl:ENST00000440973(transcript)|ensembl:ENST00000443427(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_000116.2|refseq:NP_001116212.1|refseq:NP_001116213.1|refseq:NP_001116214.1|refseq:XP_011533845.1|refseq:XP_011533846.1|refseq:XP_011533847.1|refseq:XP_006715438.1|ensembl:ENSP00000206249|ensembl:ENSP00000342630|ensembl:ENSP00000405330|ensembl:ENSP00000387500|refseq:NP_001278159.1|refseq:NP_001278170.1|refseq:NP_001315029.1|refseq:XP_016865865.1|refseq:XP_016865866.1|refseq:XP_016865867.1|refseq:XP_016865868.1|refseq:XP_016865869.1|refseq:XP_016865870.1|dip:DIP-5965N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035327"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P03372|rcsb pdb:1A52|rcsb pdb:1AKF|rcsb pdb:1ERE|rcsb pdb:1ERR|rcsb pdb:1G50|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1HCP|rcsb pdb:1HCQ|rcsb pdb:1L2I|rcsb pdb:1PCG|rcsb pdb:1QKT|rcsb pdb:1QKU|rcsb pdb:1R5K|rcsb pdb:1SJ0|rcsb pdb:1UOM|rcsb pdb:1X7E|rcsb pdb:1X7R|rcsb pdb:1XP1|rcsb pdb:1XP6|rcsb pdb:1XP9|rcsb pdb:1XPC|rcsb pdb:1XQC|rcsb pdb:1YIM|rcsb pdb:1YIN|rcsb pdb:1ZKY|rcsb pdb:2AYR|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2BJ4|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2I0J|rcsb pdb:2IOG|rcsb pdb:2IOK|rcsb pdb:2JF9|rcsb pdb:2JFA|rcsb pdb:2LLO|rcsb pdb:2LLQ|rcsb pdb:2OCF|rcsb pdb:2OUZ|rcsb pdb:2P15|rcsb pdb:2POG|rcsb pdb:2Q6J|rcsb pdb:2Q70|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QE4|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QXS|rcsb pdb:2QZO|rcsb pdb:2R6W|rcsb pdb:2R6Y|rcsb pdb:2YAT|rcsb pdb:2YJA|rcsb pdb:3DT3|rcsb pdb:3ERD|rcsb pdb:3ERT|rcsb pdb:3HLV|rcsb pdb:3HM1|rcsb pdb:3L03|rcsb pdb:3OS8|rcsb pdb:3OS9|rcsb pdb:3OSA|rcsb pdb:3Q95|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUC|rcsb pdb:3UUD|rcsb pdb:4AA6|rcsb pdb:4DMA|rcsb pdb:4IU7|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4JC3|rcsb pdb:4JDD|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4O6F|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:4PXM|rcsb pdb:4Q13|rcsb pdb:4Q50|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4XI3|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:5AAU|rcsb pdb:5AAV|rcsb pdb:5ACC|rcsb pdb:5AK2|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5FQP|rcsb pdb:5FQR|rcsb pdb:5FQS|rcsb pdb:5FQT|rcsb pdb:5FQV|rcsb pdb:5GS4|rcsb pdb:5GTR|rcsb pdb:5HYR|rcsb pdb:5JMM|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5N10|rcsb pdb:5T0X|rcsb pdb:5T1Z|rcsb pdb:5T92|rcsb pdb:5T97|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5TN9|rcsb pdb:5TNB|rcsb pdb:5U2B|rcsb pdb:5U2D|rcsb pdb:5UFW|rcsb pdb:5DXP|rcsb pdb:5UFX|rcsb pdb:5W9C|rcsb pdb:5W9D|rcsb pdb:5WGD|rcsb pdb:5WGQ|rcsb pdb:6B0F|rcsb pdb:6C42|rcsb pdb:6CBZ|rcsb pdb:6CHW|rcsb pdb:6CHZ|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:6DF6|rcsb pdb:6DFN|rcsb pdb:6HHP|rcsb pdb:6HKF|rcsb pdb:6HMU|rcsb pdb:6IAR|rcsb pdb:6OWC|rcsb pdb:6PET|rcsb pdb:6PFM|rcsb pdb:6PIT|rcsb pdb:6PSJ|rcsb pdb:6SBO|rcsb pdb:6SQ0|rcsb pdb:6SUO|rcsb pdb:6TJM|rcsb pdb:6TL3|rcsb pdb:6V87|rcsb pdb:6V8T|rcsb pdb:6VGH|rcsb pdb:6VIG|rcsb pdb:6VJ1|rcsb pdb:6VJD|rcsb pdb:6VMU|rcsb pdb:6VPF|rcsb pdb:6VPK|rcsb pdb:6VVP|rcsb pdb:6WOK|rcsb pdb:6ZOQ|rcsb pdb:6ZOR|rcsb pdb:6ZOS|rcsb pdb:7JHD|rcsb pdb:7KBS|rcsb pdb:7KCA|rcsb pdb:7KCD|rcsb pdb:7MSA|rcsb pdb:7NFW|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-8931987|reactome:R-HSA-8939211|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-9009391|reactome:R-HSA-9018519|rcsb pdb:6HKB	-	-	-	figure legend:3|comment:"The highest levels of this interaction were observed when the ERalpha construct containing only the E domain (aa 302-530) was used."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/06/10	2014/10/16	rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606	rogid:T8sQVUNhd5AfJXfL0mjq9TA/C/o9606	intact-crc:7D406FD7D350210A|rigid:DxqoAWLBhFCKaTbu9KJR7OHYy7w	false	-	sufficient binding region:302-530	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53041	uniprotkb:P03372	intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443	intact:EBI-78473|uniprotkb:Q6MZQ9|ensembl:ENSP00000387500|ensembl:ENSP00000342630|ensembl:ENSP00000206249|ensembl:ENSP00000405330|uniprotkb:Q13511|uniprotkb:Q14276|uniprotkb:Q9NU51|uniprotkb:Q9UDZ7|uniprotkb:Q9UIS7|intact:EBI-28988800|uniprotkb:Q5T5H7	psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym)	psi-mi:esr1_human(display_long)|uniprotkb:ESR1(gene name)|psi-mi:ESR1(display_short)|uniprotkb:ESR(gene name synonym)|uniprotkb:NR3A1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ikeda et al. (2004)	pubmed:14764652|imex:IM-19817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1781183|imex:IM-19817-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N	ensembl:ENSG00000091831(gene)|ensembl:ENST00000206249(transcript)|ensembl:ENST00000338799(transcript)|ensembl:ENST00000440973(transcript)|ensembl:ENST00000443427(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_000116.2|refseq:NP_001116212.1|refseq:NP_001116213.1|refseq:NP_001116214.1|refseq:XP_011533845.1|refseq:XP_011533846.1|refseq:XP_011533847.1|refseq:XP_006715438.1|ensembl:ENSP00000206249|ensembl:ENSP00000342630|ensembl:ENSP00000405330|ensembl:ENSP00000387500|refseq:NP_001278159.1|refseq:NP_001278170.1|refseq:NP_001315029.1|refseq:XP_016865865.1|refseq:XP_016865866.1|refseq:XP_016865867.1|refseq:XP_016865868.1|refseq:XP_016865869.1|refseq:XP_016865870.1|dip:DIP-5965N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035327"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P03372|rcsb pdb:1A52|rcsb pdb:1AKF|rcsb pdb:1ERE|rcsb pdb:1ERR|rcsb pdb:1G50|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1HCP|rcsb pdb:1HCQ|rcsb pdb:1L2I|rcsb pdb:1PCG|rcsb pdb:1QKT|rcsb pdb:1QKU|rcsb pdb:1R5K|rcsb pdb:1SJ0|rcsb pdb:1UOM|rcsb pdb:1X7E|rcsb pdb:1X7R|rcsb pdb:1XP1|rcsb pdb:1XP6|rcsb pdb:1XP9|rcsb pdb:1XPC|rcsb pdb:1XQC|rcsb pdb:1YIM|rcsb pdb:1YIN|rcsb pdb:1ZKY|rcsb pdb:2AYR|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2BJ4|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2I0J|rcsb pdb:2IOG|rcsb pdb:2IOK|rcsb pdb:2JF9|rcsb pdb:2JFA|rcsb pdb:2LLO|rcsb pdb:2LLQ|rcsb pdb:2OCF|rcsb pdb:2OUZ|rcsb pdb:2P15|rcsb pdb:2POG|rcsb pdb:2Q6J|rcsb pdb:2Q70|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QE4|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QXS|rcsb pdb:2QZO|rcsb pdb:2R6W|rcsb pdb:2R6Y|rcsb pdb:2YAT|rcsb pdb:2YJA|rcsb pdb:3DT3|rcsb pdb:3ERD|rcsb pdb:3ERT|rcsb pdb:3HLV|rcsb pdb:3HM1|rcsb pdb:3L03|rcsb pdb:3OS8|rcsb pdb:3OS9|rcsb pdb:3OSA|rcsb pdb:3Q95|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUC|rcsb pdb:3UUD|rcsb pdb:4AA6|rcsb pdb:4DMA|rcsb pdb:4IU7|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4JC3|rcsb pdb:4JDD|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4O6F|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:4PXM|rcsb pdb:4Q13|rcsb pdb:4Q50|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4XI3|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:5AAU|rcsb pdb:5AAV|rcsb pdb:5ACC|rcsb pdb:5AK2|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5FQP|rcsb pdb:5FQR|rcsb pdb:5FQS|rcsb pdb:5FQT|rcsb pdb:5FQV|rcsb pdb:5GS4|rcsb pdb:5GTR|rcsb pdb:5HYR|rcsb pdb:5JMM|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5N10|rcsb pdb:5T0X|rcsb pdb:5T1Z|rcsb pdb:5T92|rcsb pdb:5T97|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5TN9|rcsb pdb:5TNB|rcsb pdb:5U2B|rcsb pdb:5U2D|rcsb pdb:5UFW|rcsb pdb:5DXP|rcsb pdb:5UFX|rcsb pdb:5W9C|rcsb pdb:5W9D|rcsb pdb:5WGD|rcsb pdb:5WGQ|rcsb pdb:6B0F|rcsb pdb:6C42|rcsb pdb:6CBZ|rcsb pdb:6CHW|rcsb pdb:6CHZ|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:6DF6|rcsb pdb:6DFN|rcsb pdb:6HHP|rcsb pdb:6HKF|rcsb pdb:6HMU|rcsb pdb:6IAR|rcsb pdb:6OWC|rcsb pdb:6PET|rcsb pdb:6PFM|rcsb pdb:6PIT|rcsb pdb:6PSJ|rcsb pdb:6SBO|rcsb pdb:6SQ0|rcsb pdb:6SUO|rcsb pdb:6TJM|rcsb pdb:6TL3|rcsb pdb:6V87|rcsb pdb:6V8T|rcsb pdb:6VGH|rcsb pdb:6VIG|rcsb pdb:6VJ1|rcsb pdb:6VJD|rcsb pdb:6VMU|rcsb pdb:6VPF|rcsb pdb:6VPK|rcsb pdb:6VVP|rcsb pdb:6WOK|rcsb pdb:6ZOQ|rcsb pdb:6ZOR|rcsb pdb:6ZOS|rcsb pdb:7JHD|rcsb pdb:7KBS|rcsb pdb:7KCA|rcsb pdb:7KCD|rcsb pdb:7MSA|rcsb pdb:7NFW|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-8931987|reactome:R-HSA-8939211|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-9009391|reactome:R-HSA-9018519|rcsb pdb:6HKB	-	-	-	figure legend:4 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/06/10	2014/10/16	rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606	rogid:T8sQVUNhd5AfJXfL0mjq9TA/C/o9606	intact-crc:419510726857F1D6|rigid:DxqoAWLBhFCKaTbu9KJR7OHYy7w	false	flag tag:?-?|sufficient binding region:28-165	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P03372	uniprotkb:P53041	intact:EBI-78473|uniprotkb:Q6MZQ9|ensembl:ENSP00000387500|ensembl:ENSP00000342630|ensembl:ENSP00000206249|ensembl:ENSP00000405330|uniprotkb:Q13511|uniprotkb:Q14276|uniprotkb:Q9NU51|uniprotkb:Q9UDZ7|uniprotkb:Q9UIS7|intact:EBI-28988800|uniprotkb:Q5T5H7	intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443	psi-mi:esr1_human(display_long)|uniprotkb:ESR1(gene name)|psi-mi:ESR1(display_short)|uniprotkb:ESR(gene name synonym)|uniprotkb:NR3A1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ikeda et al. (2004)	pubmed:14764652|imex:IM-19817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1781211|imex:IM-19817-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000091831(gene)|ensembl:ENST00000206249(transcript)|ensembl:ENST00000338799(transcript)|ensembl:ENST00000440973(transcript)|ensembl:ENST00000443427(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_000116.2|refseq:NP_001116212.1|refseq:NP_001116213.1|refseq:NP_001116214.1|refseq:XP_011533845.1|refseq:XP_011533846.1|refseq:XP_011533847.1|refseq:XP_006715438.1|ensembl:ENSP00000206249|ensembl:ENSP00000342630|ensembl:ENSP00000405330|ensembl:ENSP00000387500|refseq:NP_001278159.1|refseq:NP_001278170.1|refseq:NP_001315029.1|refseq:XP_016865865.1|refseq:XP_016865866.1|refseq:XP_016865867.1|refseq:XP_016865868.1|refseq:XP_016865869.1|refseq:XP_016865870.1|dip:DIP-5965N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035327"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P03372|rcsb pdb:1A52|rcsb pdb:1AKF|rcsb pdb:1ERE|rcsb pdb:1ERR|rcsb pdb:1G50|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1HCP|rcsb pdb:1HCQ|rcsb pdb:1L2I|rcsb pdb:1PCG|rcsb pdb:1QKT|rcsb pdb:1QKU|rcsb pdb:1R5K|rcsb pdb:1SJ0|rcsb pdb:1UOM|rcsb pdb:1X7E|rcsb pdb:1X7R|rcsb pdb:1XP1|rcsb pdb:1XP6|rcsb pdb:1XP9|rcsb pdb:1XPC|rcsb pdb:1XQC|rcsb pdb:1YIM|rcsb pdb:1YIN|rcsb pdb:1ZKY|rcsb pdb:2AYR|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2BJ4|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2I0J|rcsb pdb:2IOG|rcsb pdb:2IOK|rcsb pdb:2JF9|rcsb pdb:2JFA|rcsb pdb:2LLO|rcsb pdb:2LLQ|rcsb pdb:2OCF|rcsb pdb:2OUZ|rcsb pdb:2P15|rcsb pdb:2POG|rcsb pdb:2Q6J|rcsb pdb:2Q70|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QE4|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QXS|rcsb pdb:2QZO|rcsb pdb:2R6W|rcsb pdb:2R6Y|rcsb pdb:2YAT|rcsb pdb:2YJA|rcsb pdb:3DT3|rcsb pdb:3ERD|rcsb pdb:3ERT|rcsb pdb:3HLV|rcsb pdb:3HM1|rcsb pdb:3L03|rcsb pdb:3OS8|rcsb pdb:3OS9|rcsb pdb:3OSA|rcsb pdb:3Q95|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUC|rcsb pdb:3UUD|rcsb pdb:4AA6|rcsb pdb:4DMA|rcsb pdb:4IU7|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4JC3|rcsb pdb:4JDD|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4O6F|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:4PXM|rcsb pdb:4Q13|rcsb pdb:4Q50|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4XI3|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:5AAU|rcsb pdb:5AAV|rcsb pdb:5ACC|rcsb pdb:5AK2|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5FQP|rcsb pdb:5FQR|rcsb pdb:5FQS|rcsb pdb:5FQT|rcsb pdb:5FQV|rcsb pdb:5GS4|rcsb pdb:5GTR|rcsb pdb:5HYR|rcsb pdb:5JMM|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5N10|rcsb pdb:5T0X|rcsb pdb:5T1Z|rcsb pdb:5T92|rcsb pdb:5T97|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5TN9|rcsb pdb:5TNB|rcsb pdb:5U2B|rcsb pdb:5U2D|rcsb pdb:5UFW|rcsb pdb:5DXP|rcsb pdb:5UFX|rcsb pdb:5W9C|rcsb pdb:5W9D|rcsb pdb:5WGD|rcsb pdb:5WGQ|rcsb pdb:6B0F|rcsb pdb:6C42|rcsb pdb:6CBZ|rcsb pdb:6CHW|rcsb pdb:6CHZ|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:6DF6|rcsb pdb:6DFN|rcsb pdb:6HHP|rcsb pdb:6HKF|rcsb pdb:6HMU|rcsb pdb:6IAR|rcsb pdb:6OWC|rcsb pdb:6PET|rcsb pdb:6PFM|rcsb pdb:6PIT|rcsb pdb:6PSJ|rcsb pdb:6SBO|rcsb pdb:6SQ0|rcsb pdb:6SUO|rcsb pdb:6TJM|rcsb pdb:6TL3|rcsb pdb:6V87|rcsb pdb:6V8T|rcsb pdb:6VGH|rcsb pdb:6VIG|rcsb pdb:6VJ1|rcsb pdb:6VJD|rcsb pdb:6VMU|rcsb pdb:6VPF|rcsb pdb:6VPK|rcsb pdb:6VVP|rcsb pdb:6WOK|rcsb pdb:6ZOQ|rcsb pdb:6ZOR|rcsb pdb:6ZOS|rcsb pdb:7JHD|rcsb pdb:7KBS|rcsb pdb:7KCA|rcsb pdb:7KCD|rcsb pdb:7MSA|rcsb pdb:7NFW|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-8931987|reactome:R-HSA-8939211|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-9009391|reactome:R-HSA-9018519|rcsb pdb:6HKB	refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N	-	-	-	figure legend:4 C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/06/10	2014/10/16	rogid:T8sQVUNhd5AfJXfL0mjq9TA/C/o9606	rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606	intact-crc:08DD9C850624E882|rigid:DxqoAWLBhFCKaTbu9KJR7OHYy7w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)