#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15078	uniprotkb:Q6ZMQ8-2	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	intact:EBI-2008441	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:q6zmq8-2(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)|uniprotkb:hAATYKs-p35BP(isoform synonym)	psi-mi:"MI:0018"(two hybrid)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008413|imex:IM-20115-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	intact:EBI-2008380(isoform-parent)	-	-	-	figure legend:Fig. 1A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/10/03	2014/10/16	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	rogid:vStnmL0srQ7K8F5Uuwrv8a0nf+g9606	intact-crc:80F363C91CDF8791|rigid:PovbAvppumDTqgXQB1Vpv/yBHaU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15078	uniprotkb:Q6ZMQ8-2	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	intact:EBI-2008441	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:q6zmq8-2(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)|uniprotkb:hAATYKs-p35BP(isoform synonym)	psi-mi:"MI:0018"(two hybrid)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008458|imex:IM-20115-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	intact:EBI-2008380(isoform-parent)	-	-	-	figure legend:Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/10/03	2014/10/16	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	rogid:vStnmL0srQ7K8F5Uuwrv8a0nf+g9606	intact-crc:F0EFE943FB149B6C|rigid:PovbAvppumDTqgXQB1Vpv/yBHaU	false	-	necessary binding region:40-56	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15078	uniprotkb:Q6ZMQ8-2	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	intact:EBI-2008441	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:q6zmq8-2(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)|uniprotkb:hAATYKs-p35BP(isoform synonym)	psi-mi:"MI:0018"(two hybrid)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008467|imex:IM-20115-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	intact:EBI-2008380(isoform-parent)	-	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/10/03	2014/10/16	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	rogid:vStnmL0srQ7K8F5Uuwrv8a0nf+g9606	intact-crc:DF6D55E6578DF9DE|rigid:PovbAvppumDTqgXQB1Vpv/yBHaU	false	necessary binding region:291-307|necessary binding region:1-97	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZMQ8-2	uniprotkb:Q03114	intact:EBI-2008441	intact:EBI-2008531|ensembl:ENSRNOP00000011052	psi-mi:q6zmq8-2(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)|uniprotkb:hAATYKs-p35BP(isoform synonym)	psi-mi:cdk5_rat(display_long)|uniprotkb:Cdk5(gene name)|psi-mi:Cdk5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:Cdkn5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008524|imex:IM-20115-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2008380(isoform-parent)	rgd:70514|refseq:NP_543161.1|dip:DIP-29351N|ensembl:ENSRNOG00000008017(gene)|ensembl:ENSRNOT00000011052(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042220"(response to cocaine)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099533"(positive regulation of presynaptic cytosolic calcium concentration)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q03114|reactome:R-RNO-180024|reactome:R-RNO-399956|reactome:R-RNO-6804756	-	-	-	figure legend:Fig. 3A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/10/03	2014/10/16	rogid:vStnmL0srQ7K8F5Uuwrv8a0nf+g9606	rogid:I/vFYZi6Vs4Y+Itk5sPLBj+QJxk10116	intact-crc:1BFF14B89B359A32|rigid:wNhukYuxQizM3571i24kKgWefrQ	false	sufficient binding region:1-169	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZMQ8-2	uniprotkb:P61810	intact:EBI-2008441	intact:EBI-2008489|uniprotkb:Q62938|ensembl:ENSRNOP00000062473	psi-mi:q6zmq8-2(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)|uniprotkb:hAATYKs-p35BP(isoform synonym)	psi-mi:cd5r1_rat(display_long)|uniprotkb:Cdk5r1(gene name)|psi-mi:Cdk5r1(display_short)|uniprotkb:Cdk5r(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008524|imex:IM-20115-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2008380(isoform-parent)	rgd:629472|refseq:NP_446343.1|dip:DIP-29352N|ensembl:ENSRNOG00000021685(gene)|ensembl:ENSRNOT00000031746(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|mint:P61810|reactome:R-RNO-399956|reactome:R-RNO-6804756	-	-	-	figure legend:Fig. 3A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/10/03	2014/10/16	rogid:vStnmL0srQ7K8F5Uuwrv8a0nf+g9606	rogid:VkEjZ4nsw2rhfNWK5hlbCUlmNw810116	intact-crc:1BFF14B89B359A32|rigid:wNhukYuxQizM3571i24kKgWefrQ	false	sufficient binding region:1-169	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15078	uniprotkb:Q00535	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	intact:EBI-1041567|uniprotkb:A1XKG3|ensembl:ENSP00000419782	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:cdk5_human(display_long)|uniprotkb:CDK5(gene name)|psi-mi:CDK5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:CDKN5(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008570|imex:IM-20115-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	refseq:NP_001157882.1|refseq:NP_004926.1|ensembl:ENSG00000164885(gene)|ensembl:ENST00000485972(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q00535|rcsb pdb:1H4L|rcsb pdb:1LFR|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:4AU8|reactome:R-HSA-180024|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|reactome:R-HSA-983231|dip:DIP-24221N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 4C|resulting-ptm:Phosphorlaytion of Q6ZMQ8-2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/10/03	2014/10/16	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	rogid:NddS77Gpf0Gt5O3MPylAUfJ7QOE9606	intact-crc:F622B7C973388042|rigid:0m7yUg80g1q4GrJy0i7Om2BBahY	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q15078	uniprotkb:Q6ZMQ8-2	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	intact:EBI-2008441	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:q6zmq8-2(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)|uniprotkb:hAATYKs-p35BP(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008570|imex:IM-20115-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	intact:EBI-2008380(isoform-parent)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 4C|resulting-ptm:Phosphorlaytion of Q6ZMQ8-2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/10/03	2014/10/16	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	rogid:vStnmL0srQ7K8F5Uuwrv8a0nf+g9606	intact-crc:F622B7C973388042|rigid:0m7yUg80g1q4GrJy0i7Om2BBahY	false	-	sufficient binding region:1-169	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q15078	uniprotkb:Q00535	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	intact:EBI-1041567|uniprotkb:A1XKG3|ensembl:ENSP00000419782	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:cdk5_human(display_long)|uniprotkb:CDK5(gene name)|psi-mi:CDK5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:CDKN5(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008581|imex:IM-20115-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	refseq:NP_001157882.1|refseq:NP_004926.1|ensembl:ENSG00000164885(gene)|ensembl:ENST00000485972(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q00535|rcsb pdb:1H4L|rcsb pdb:1LFR|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:4AU8|reactome:R-HSA-180024|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|reactome:R-HSA-983231|dip:DIP-24221N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 4C|resulting-ptm:Phosphorylation of Q6ZMQ8|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/10/03	2014/10/16	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	rogid:NddS77Gpf0Gt5O3MPylAUfJ7QOE9606	intact-crc:5D5AB6B5BE005A26|rigid:VuCPOZe/uD/+xaQRhVV4DnVeP2k	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q15078	uniprotkb:Q6ZMQ8	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	intact:EBI-2008380|uniprotkb:O75136|uniprotkb:Q6ZN31|uniprotkb:Q86X28|intact:EBI-28968821|ensembl:ENSP00000324196	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:lmtk1_human(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008581|imex:IM-20115-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	ensembl:ENSP00000324196|ensembl:ENST00000374792|ensembl:ENSP00000363924|refseq:NP_001073864.2|refseq:NP_004911.2|ensembl:ENSG00000181409(gene)|ensembl:ENST00000326724(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042817|mint:Q6ZMQ8	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 4C|resulting-ptm:Phosphorylation of Q6ZMQ8|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/10/03	2014/10/16	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	rogid:vbD+xWCUBxokHFuu8/eqv6y4KN49606	intact-crc:5D5AB6B5BE005A26|rigid:VuCPOZe/uD/+xaQRhVV4DnVeP2k	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q15078	uniprotkb:Q6ZMQ8-2	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	intact:EBI-2008441	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:q6zmq8-2(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)|uniprotkb:hAATYKs-p35BP(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008595|imex:IM-20115-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	intact:EBI-2008380(isoform-parent)	-	-	-	figure legend:Fig. 5A|stimulant:"CDK5 (Q00535)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/10/03	2014/10/16	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	rogid:vStnmL0srQ7K8F5Uuwrv8a0nf+g9606	intact-crc:0E7FC0B4F60CF222|rigid:PovbAvppumDTqgXQB1Vpv/yBHaU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15078	uniprotkb:Q6ZMQ8-1	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	intact:EBI-2008436|ensembl:ENSP00000324196	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:q6zmq8-1(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008600|imex:IM-20115-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	intact:EBI-2008380(isoform-parent)|ensembl:ENSG00000181409(gene)|ensembl:ENST00000326724(transcript)	-	-	-	figure legend:Fig. 5A|stimulant:"CDK5 (Q00535)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/10/03	2014/10/16	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	rogid:vbD+xWCUBxokHFuu8/eqv6y4KN49606	intact-crc:0405FE5E716B3314|rigid:pW/tJjBoC4RzKGTxzsJRa6Lt2IQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00535	uniprotkb:Q6ZMQ8-1	intact:EBI-1041567|uniprotkb:A1XKG3|ensembl:ENSP00000419782	intact:EBI-2008436|ensembl:ENSP00000324196	psi-mi:cdk5_human(display_long)|uniprotkb:CDK5(gene name)|psi-mi:CDK5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:CDKN5(gene name synonym)	psi-mi:q6zmq8-1(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008624|imex:IM-20115-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157882.1|refseq:NP_004926.1|ensembl:ENSG00000164885(gene)|ensembl:ENST00000485972(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q00535|rcsb pdb:1H4L|rcsb pdb:1LFR|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:4AU8|reactome:R-HSA-180024|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|reactome:R-HSA-983231|dip:DIP-24221N	intact:EBI-2008380(isoform-parent)|ensembl:ENSG00000181409(gene)|ensembl:ENST00000326724(transcript)	-	-	-	figure legend:Fig. 5B|stimulant:CDK5R1 was also transfected into the cells|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/10/03	2014/10/16	rogid:NddS77Gpf0Gt5O3MPylAUfJ7QOE9606	rogid:vbD+xWCUBxokHFuu8/eqv6y4KN49606	intact-crc:3D5E73488C378369|rigid:w8T8Pb8azH3x3O/rhfhIaiJgSus	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZMQ8-2	uniprotkb:Q00535	intact:EBI-2008441	intact:EBI-1041567|uniprotkb:A1XKG3|ensembl:ENSP00000419782	psi-mi:q6zmq8-2(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)|uniprotkb:hAATYKs-p35BP(isoform synonym)	psi-mi:cdk5_human(display_long)|uniprotkb:CDK5(gene name)|psi-mi:CDK5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:CDKN5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008637|imex:IM-20115-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2008380(isoform-parent)	refseq:NP_001157882.1|refseq:NP_004926.1|ensembl:ENSG00000164885(gene)|ensembl:ENST00000485972(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q00535|rcsb pdb:1H4L|rcsb pdb:1LFR|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:4AU8|reactome:R-HSA-180024|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|reactome:R-HSA-983231|dip:DIP-24221N	-	-	-	figure legend:Fig. 5A|comment:CDK5R1 was also transfected into the cells|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/10/03	2014/10/16	rogid:vStnmL0srQ7K8F5Uuwrv8a0nf+g9606	rogid:NddS77Gpf0Gt5O3MPylAUfJ7QOE9606	intact-crc:C8E4C2D0A6F2A2C4|rigid:18taV/JpbCmhgAaJhZroUtzGeXM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZMQ8-2	uniprotkb:Q15078	intact:EBI-2008441	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	psi-mi:q6zmq8-2(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)|uniprotkb:hAATYKs-p35BP(isoform synonym)	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008662|imex:IM-20115-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2008380(isoform-parent)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	-	-	-	figure legend:Fig. 5C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/10/03	2014/10/16	rogid:vStnmL0srQ7K8F5Uuwrv8a0nf+g9606	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	intact-crc:876AA4F3F715BE46|rigid:PovbAvppumDTqgXQB1Vpv/yBHaU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZMQ8-1	uniprotkb:Q15078	intact:EBI-2008436|ensembl:ENSP00000324196	intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486	psi-mi:q6zmq8-1(display_long)|uniprotkb:AATK(gene name)|psi-mi:AATK(display_short)|uniprotkb:AATYK(gene name synonym)|uniprotkb:KIAA0641(gene name synonym)|uniprotkb:LMR1(gene name synonym)|uniprotkb:LMTK1(gene name synonym)|uniprotkb:Apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:Brain apoptosis-associated tyrosine kinase(gene name synonym)|uniprotkb:CDK5-binding protein(gene name synonym)|uniprotkb:Lemur tyrosine kinase 1(gene name synonym)|uniprotkb:p35-binding protein(gene name synonym)	psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Honma et al. (2003)	pubmed:14521924|imex:IM-20115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2008676|imex:IM-20115-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2008380(isoform-parent)|ensembl:ENSG00000181409(gene)|ensembl:ENST00000326724(transcript)	refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N	-	-	-	figure legend:Fig. 5C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/10/03	2014/10/16	rogid:vbD+xWCUBxokHFuu8/eqv6y4KN49606	rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606	intact-crc:712416C1D6587398|rigid:pW/tJjBoC4RzKGTxzsJRa6Lt2IQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)