#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35569	uniprotkb:P06213	intact:EBI-400825	intact:EBI-475899|uniprotkb:Q17RW0|uniprotkb:Q59H98|uniprotkb:Q9UCB7|uniprotkb:Q9UCB8|uniprotkb:Q9UCB9|ensembl:ENSP00000303830	psi-mi:irs1_mouse(display_long)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:insr_human(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:"MI:0434"(phosphatase assay)	Shimizu et al. (2002)	mint:MINT-6741604|pubmed:12446583	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8561837|mint:MINT-6794075	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034700.2|mint:P35569|dip:DIP-32456N|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0090275"(negative regulation of somatostatin secretion)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:1AYB|rcsb pdb:5AXI|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|mint:MINT-6794076(identity)|uniprotkb:P35569(P35569)	refseq:NP_000199.2|refseq:NP_001073285.1|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P06213|rcsb pdb:1GAG|rcsb pdb:1I44|rcsb pdb:1IR3|rcsb pdb:1IRK|rcsb pdb:1P14|rcsb pdb:1RQQ|rcsb pdb:2AUH|rcsb pdb:2B4S|rcsb pdb:2HR7|rcsb pdb:2MFR|go:"GO:0032809"(neuronal cell body membrane)|rcsb pdb:2Z8C|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|rcsb pdb:3EKK|rcsb pdb:3EKN|dip:DIP-480N|rcsb pdb:7BW8|rcsb pdb:7BWA|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:4IBM|rcsb pdb:4OGA|rcsb pdb:4XLV|rcsb pdb:4XSS|rcsb pdb:4XST|rcsb pdb:4ZXB|rcsb pdb:5E1S|rcsb pdb:5HHW|rcsb pdb:5J3H|rcsb pdb:5KQV|rcsb pdb:5U1M|rcsb pdb:6HN4|rcsb pdb:6HN5|rcsb pdb:6PXV|rcsb pdb:3ETA|rcsb pdb:6PXW|rcsb pdb:6SOF|rcsb pdb:6VEP|rcsb pdb:6VEQ|rcsb pdb:7BW7|mint:MINT-6794079(identity)|uniprotkb:P06213(P06213)	-	-	-	figure legend:F2A|comment:The phosphatase overexpression cause the dephosphorylation of predicted substrate.|comment:No evidence for a direct de-phosphorylation is reported in this experiments. Anyway the curator was self confident to indicate this interaction as an evidence of a direct phosphatase effect on the indicated protein.|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-3t3_l1)|taxid:10090(Mus musculus embryonic cells  Fibroblast-like. Adipose like when confluent)	-	2008/10/23	2014/10/16	rogid:S9ooRqBQ2LriTIe+f2hSyxU8oP010090	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	intact-crc:74A7621064B07565|rigid:WuSqLXEwJ27vzvwCm+4xpRnaXM4	false	-	mutation disrupting interaction:215-215(MINT-6794084)|tag:?-?(MINT-6794086)|binding-associated region:?-?(MINT-6794082)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15208	uniprotkb:P06213	intact:EBI-6999015|ensembl:ENSMUSP00000088837|uniprotkb:F8VPU4|intact:MINT-1516207	intact:EBI-475899|uniprotkb:Q17RW0|uniprotkb:Q59H98|uniprotkb:Q9UCB7|uniprotkb:Q9UCB8|uniprotkb:Q9UCB9|ensembl:ENSP00000303830	psi-mi:insr_mouse(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:insr_human(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:"MI:0434"(phosphatase assay)	Shimizu et al. (2002)	mint:MINT-6741604|pubmed:12446583	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8561894|mint:MINT-6794090	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000005534(gene)|ensembl:ENSMUST00000091291(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031405"(lipoic acid binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0060417"(yolk)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:2000194"(regulation of female gonad development)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR000494(EGF receptor, L domain)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P15208|rcsb pdb:1LK2|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-74752|reactome:R-MMU-77387|refseq:NP_034698.2|dip:DIP-41452N|mint:MINT-6794091(identity)|uniprotkb:P15208(P15208)	refseq:NP_000199.2|refseq:NP_001073285.1|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P06213|rcsb pdb:1GAG|rcsb pdb:1I44|rcsb pdb:1IR3|rcsb pdb:1IRK|rcsb pdb:1P14|rcsb pdb:1RQQ|rcsb pdb:2AUH|rcsb pdb:2B4S|rcsb pdb:2HR7|rcsb pdb:2MFR|go:"GO:0032809"(neuronal cell body membrane)|rcsb pdb:2Z8C|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|rcsb pdb:3EKK|rcsb pdb:3EKN|dip:DIP-480N|rcsb pdb:7BW8|rcsb pdb:7BWA|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:4IBM|rcsb pdb:4OGA|rcsb pdb:4XLV|rcsb pdb:4XSS|rcsb pdb:4XST|rcsb pdb:4ZXB|rcsb pdb:5E1S|rcsb pdb:5HHW|rcsb pdb:5J3H|rcsb pdb:5KQV|rcsb pdb:5U1M|rcsb pdb:6HN4|rcsb pdb:6HN5|rcsb pdb:6PXV|rcsb pdb:3ETA|rcsb pdb:6PXW|rcsb pdb:6SOF|rcsb pdb:6VEP|rcsb pdb:6VEQ|rcsb pdb:7BW7|mint:MINT-6794094(identity)|uniprotkb:P06213(P06213)	-	comment:mint|function:This receptor binds insulin and has a tyrosine-protein kinase activity	-	figure legend:F2B|comment:The phosphatase overexpression cause the dephosphorylation of predicted substrate.|comment:No evidence for a direct de-phosphorylation is reported in this experiments. Anyway the curator was self confident to indicate this interaction as an evidence of a direct phosphatase effect on the indicated protein.|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-3t3_l1)|taxid:10090(Mus musculus embryonic cells  Fibroblast-like. Adipose like when confluent)	-	2008/10/23	2014/10/16	rogid:DduFddui4LY0r8EIHI5S5EN485Y10090	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	intact-crc:D074E1186687088F|rigid:LXalNYsMuEWonA2CqCEXFrBnMFU	false	-	binding-associated region:?-?(MINT-6794097)|mutation disrupting interaction:215-215(MINT-6794099)|tag:?-?(MINT-6794101)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5M824	uniprotkb:P62994	intact:EBI-7152521|intact:UNK-5443077	intact:EBI-401775|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q5BKA7|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSRNOP00000005347	psi-mi:shc1_rat(display_long)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)	psi-mi:grb2_rat(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Ash(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Shimizu et al. (2002)	mint:MINT-6741604|pubmed:12446583	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8561960|mint:MINT-6794115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q5M824|interpro:IPR029586|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035094"(response to nicotine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-RNO-1250347|reactome:R-RNO-167044|reactome:R-RNO-180336|reactome:R-RNO-210993|reactome:R-RNO-2424491|reactome:R-RNO-2428933|reactome:R-RNO-2730905|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-354192|reactome:R-RNO-512988|reactome:R-RNO-5654688|reactome:R-RNO-5654699|reactome:R-RNO-5654704|reactome:R-RNO-5654719|reactome:R-RNO-5673001|reactome:R-RNO-74749|reactome:R-RNO-1250196|reactome:R-RNO-74751|reactome:R-RNO-8851805|reactome:R-RNO-8853659|reactome:R-RNO-8983432|reactome:R-RNO-9009391|reactome:R-RNO-9020558|reactome:R-RNO-9027284|reactome:R-RNO-912526|reactome:R-RNO-9674555|interpro:IPR011993(Pleckstrin homology-type)|rgd:620446|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|refseq:NP_445969.2|interpro:IPR000980(SH2 motif)|interpro:IPR035676|interpro:IPR036860|mint:MINT-6794119(identity)|uniprotkb:Q5M824(Q5M824)	rgd:619758|refseq:NP_110473.2|ensembl:ENSRNOG00000003990(gene)|ensembl:ENSRNOT00000005347(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62994|reactome:R-RNO-109704|reactome:R-RNO-112412|reactome:R-RNO-1250347|reactome:R-RNO-1257604|reactome:R-RNO-1295596|reactome:R-RNO-1433557|reactome:R-RNO-1433559|reactome:R-RNO-167044|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-186763|reactome:R-RNO-1963640|reactome:R-RNO-1963642|reactome:R-RNO-2029482|reactome:R-RNO-210993|reactome:R-RNO-2179392|reactome:R-RNO-2424491|reactome:R-RNO-2428933|reactome:R-RNO-2730905|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-354194|reactome:R-RNO-375165|reactome:R-RNO-388841|reactome:R-RNO-389359|reactome:R-RNO-391160|reactome:R-RNO-5654688|reactome:R-RNO-5654689|reactome:R-RNO-5654693|reactome:R-RNO-5654695|reactome:R-RNO-5654699|reactome:R-RNO-5654700|reactome:R-RNO-5654704|reactome:R-RNO-5654706|reactome:R-RNO-5654710|reactome:R-RNO-5654712|reactome:R-RNO-5654719|reactome:R-RNO-5654720|reactome:R-RNO-5654726|reactome:R-RNO-5654727|reactome:R-RNO-5654732|reactome:R-RNO-5654733|reactome:R-RNO-5663213|reactome:R-RNO-5673001|reactome:R-RNO-6807004|reactome:R-RNO-6811558|reactome:R-RNO-74749|reactome:R-RNO-74751|reactome:R-RNO-8851805|reactome:R-RNO-8851907|reactome:R-RNO-8853659|reactome:R-RNO-8856828|reactome:R-RNO-8865999|reactome:R-RNO-8875555|reactome:R-RNO-8875656|reactome:R-RNO-8983432|reactome:R-RNO-9027284|reactome:R-RNO-9028731|reactome:R-RNO-912526|reactome:R-RNO-912631|reactome:R-RNO-9607240|reactome:R-RNO-9674555|reactome:R-RNO-983695|reactome:R-RNO-8856825|mint:MINT-6794116(identity)|uniprotkb:P62994(P62994)	-	comment:mint	-	figure legend:F3D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2008/10/23	2014/10/16	rogid:MjscQEdZttIGMDyqfEUijAfBmaA10116	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA410116	intact-crc:51FC360807E7C67C|rigid:IBeebB1k++vKscXHyZJf9j2FZuY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63787	uniprotkb:P35570	intact:EBI-518443|uniprotkb:O55085|uniprotkb:P70544|uniprotkb:Q63790	intact:EBI-520230	psi-mi:p85a_rat(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:irs1_rat(display_long)|uniprotkb:pp185(gene name synonym)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Shimizu et al. (2002)	mint:MINT-6741604|pubmed:12446583	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8561932|mint:MINT-6794107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3329|refseq:NP_037137.1|mint:Q63787|dip:DIP-33696N|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009750"(response to fructose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0033574"(response to testosterone)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070848"(response to growth factor)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|rcsb pdb:1FU5|rcsb pdb:1FU6|reactome:R-RNO-109704|reactome:R-RNO-112399|reactome:R-RNO-114604|reactome:R-RNO-1250342|reactome:R-RNO-1257604|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-1660499|reactome:R-RNO-180292|reactome:R-RNO-186763|reactome:R-RNO-1963642|reactome:R-RNO-198203|reactome:R-RNO-202424|reactome:R-RNO-2029485|reactome:R-RNO-210993|reactome:R-RNO-2424491|reactome:R-RNO-2730905|reactome:R-RNO-388841|reactome:R-RNO-389357|reactome:R-RNO-416476|reactome:R-RNO-430116|reactome:R-RNO-4420097|reactome:R-RNO-512988|reactome:R-RNO-5654689|reactome:R-RNO-5654695|reactome:R-RNO-5654710|reactome:R-RNO-5654720|reactome:R-RNO-5673001|reactome:R-RNO-6811558|reactome:R-RNO-8851907|reactome:R-RNO-8853659|reactome:R-RNO-8980692|reactome:R-RNO-9009391|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013420|reactome:R-RNO-9013423|reactome:R-RNO-9013424|reactome:R-RNO-9027276|reactome:R-RNO-9035034|reactome:R-RNO-912526|reactome:R-RNO-912631|reactome:R-RNO-9607240|reactome:R-RNO-9696264|reactome:R-RNO-9696270|reactome:R-RNO-9696273|reactome:R-RNO-983695|mint:MINT-6794112(identity)|uniprotkb:P62994(P62994)	go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:5WRK|rcsb pdb:5WRL|rcsb pdb:5WRM|reactome:R-RNO-109704|reactome:R-RNO-112399|reactome:R-RNO-112412|reactome:R-RNO-1257604|reactome:R-RNO-1266695|reactome:R-RNO-198203|reactome:R-RNO-2428928|reactome:R-RNO-5673001|reactome:R-RNO-6811558|reactome:R-RNO-74713|reactome:R-RNO-74749|rgd:2922|refseq:NP_037101.1|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0090275"(negative regulation of somatostatin secretion)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071478"(cellular response to radiation)|mint:P35570|dip:DIP-664N|mint:MINT-6794108(identity)|uniprotkb:P35570(P35570)	-	-	-	figure legend:F2B|comment:The PTP1B overexpression disrupts the interaction|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2008/10/23	2014/10/16	rogid:jr9Hr1Rmtwi0SRC6OSkceJ+hSFU10116	rogid:SJ1RT9ubHcFhkPSArSJ6TsPIp0E10116	intact-crc:AD9372B6B40338BF|rigid:HyXxqzDd/G5jJU66U+L++quQwO8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35570	uniprotkb:P62994	intact:EBI-520230	intact:EBI-401775|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q5BKA7|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSRNOP00000005347	psi-mi:irs1_rat(display_long)|uniprotkb:pp185(gene name synonym)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:grb2_rat(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Ash(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Shimizu et al. (2002)	mint:MINT-6741604|pubmed:12446583	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8561988|mint:MINT-6798215	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:5WRK|rcsb pdb:5WRL|rcsb pdb:5WRM|reactome:R-RNO-109704|reactome:R-RNO-112399|reactome:R-RNO-112412|reactome:R-RNO-1257604|reactome:R-RNO-1266695|reactome:R-RNO-198203|reactome:R-RNO-2428928|reactome:R-RNO-5673001|reactome:R-RNO-6811558|reactome:R-RNO-74713|reactome:R-RNO-74749|rgd:2922|refseq:NP_037101.1|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0090275"(negative regulation of somatostatin secretion)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071478"(cellular response to radiation)|mint:P35570|dip:DIP-664N|mint:MINT-6798220(identity)|uniprotkb:P35570(P35570)	rgd:619758|refseq:NP_110473.2|ensembl:ENSRNOG00000003990(gene)|ensembl:ENSRNOT00000005347(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62994|reactome:R-RNO-109704|reactome:R-RNO-112412|reactome:R-RNO-1250347|reactome:R-RNO-1257604|reactome:R-RNO-1295596|reactome:R-RNO-1433557|reactome:R-RNO-1433559|reactome:R-RNO-167044|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-186763|reactome:R-RNO-1963640|reactome:R-RNO-1963642|reactome:R-RNO-2029482|reactome:R-RNO-210993|reactome:R-RNO-2179392|reactome:R-RNO-2424491|reactome:R-RNO-2428933|reactome:R-RNO-2730905|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-354194|reactome:R-RNO-375165|reactome:R-RNO-388841|reactome:R-RNO-389359|reactome:R-RNO-391160|reactome:R-RNO-5654688|reactome:R-RNO-5654689|reactome:R-RNO-5654693|reactome:R-RNO-5654695|reactome:R-RNO-5654699|reactome:R-RNO-5654700|reactome:R-RNO-5654704|reactome:R-RNO-5654706|reactome:R-RNO-5654710|reactome:R-RNO-5654712|reactome:R-RNO-5654719|reactome:R-RNO-5654720|reactome:R-RNO-5654726|reactome:R-RNO-5654727|reactome:R-RNO-5654732|reactome:R-RNO-5654733|reactome:R-RNO-5663213|reactome:R-RNO-5673001|reactome:R-RNO-6807004|reactome:R-RNO-6811558|reactome:R-RNO-74749|reactome:R-RNO-74751|reactome:R-RNO-8851805|reactome:R-RNO-8851907|reactome:R-RNO-8853659|reactome:R-RNO-8856828|reactome:R-RNO-8865999|reactome:R-RNO-8875555|reactome:R-RNO-8875656|reactome:R-RNO-8983432|reactome:R-RNO-9027284|reactome:R-RNO-9028731|reactome:R-RNO-912526|reactome:R-RNO-912631|reactome:R-RNO-9607240|reactome:R-RNO-9674555|reactome:R-RNO-983695|reactome:R-RNO-8856825|mint:MINT-6798217(identity)|uniprotkb:P62994(P62994)	-	-	-	figure legend:F3c|comment:The PTP1B overexpression disrupts the interaction|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2008/10/23	2014/10/16	rogid:SJ1RT9ubHcFhkPSArSJ6TsPIp0E10116	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA410116	intact-crc:CBFB7C3C09838AA6|rigid:NEgPPOXnn/DdEME8YD5/qfXjYZA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)