#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P05943 uniprotkb:Q62968 intact:EBI-1800351|uniprotkb:Q5BJ98|ensembl:ENSRNOP00000037097 intact:EBI-1800320|uniprotkb:Q63554|uniprotkb:Q6EWG6|ensembl:ENSRNOP00000047944 psi-mi:s10aa_rat(display_long)|uniprotkb:S100a10(gene name)|psi-mi:S100a10(display_short)|uniprotkb:S100 calcium-binding protein A10(gene name synonym)|uniprotkb:Calpactin-1 light chain(gene name synonym)|uniprotkb:Calpactin I light chain(gene name synonym)|uniprotkb:p10 protein(gene name synonym)|uniprotkb:p11(gene name synonym)|uniprotkb:Cellular ligand of annexin II(gene name synonym)|uniprotkb:Nerve growth factor-induced protein 42C(gene name synonym) psi-mi:scnaa_rat(display_long)|uniprotkb:Scn10a(gene name)|psi-mi:Scn10a(display_short)|uniprotkb:Sns(gene name synonym)|uniprotkb:Sodium channel protein type X subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.8(gene name synonym)|uniprotkb:Peripheral nerve sodium channel 3(gene name synonym)|uniprotkb:Sensory neuron sodium channel(gene name synonym) psi-mi:"MI:0018"(two hybrid) Okuse et al. (2002) pubmed:12050667 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1800935 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:628655|refseq:NP_112376.1|ensembl:ENSRNOG00000023226(gene)|ensembl:ENSRNOT00000035240(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990665"(AnxA2-p11 complex)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR028476|reactome:R-RNO-75205 rgd:3629|refseq:NP_058943.1|ensembl:ENSRNOG00000032473(gene)|ensembl:ENSRNOT00000046864(transcript)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0044299"(C-fiber)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0061337"(cardiac conduction)|go:"GO:0071439"(clathrin complex)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086016"(AV node cell action potential)|go:"GO:0086043"(bundle of His cell action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR010526(Sodium ion transport-associated)|interpro:IPR027359|interpro:IPR028809|interpro:IPR043203|interpro:IPR044564|reactome:R-RNO-5576892 - - - figure legend:no figure taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/08/08 2014/10/16 rogid:/MGaZckvZx44usKBC50esHsGgy810116 rogid:pOcv5fn4mMg5YmWNsvdrWdN18I410116 intact-crc:6E4BC543BC1A97E1|rigid:v5G8DBsJuf5yjfOxu+zAZcQkOfI false - sufficient binding region:1-127 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q62968 uniprotkb:P05943 intact:EBI-1800320|uniprotkb:Q63554|uniprotkb:Q6EWG6|ensembl:ENSRNOP00000047944 intact:EBI-1800351|uniprotkb:Q5BJ98|ensembl:ENSRNOP00000037097 psi-mi:scnaa_rat(display_long)|uniprotkb:Scn10a(gene name)|psi-mi:Scn10a(display_short)|uniprotkb:Sns(gene name synonym)|uniprotkb:Sodium channel protein type X subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.8(gene name synonym)|uniprotkb:Peripheral nerve sodium channel 3(gene name synonym)|uniprotkb:Sensory neuron sodium channel(gene name synonym) psi-mi:s10aa_rat(display_long)|uniprotkb:S100a10(gene name)|psi-mi:S100a10(display_short)|uniprotkb:S100 calcium-binding protein A10(gene name synonym)|uniprotkb:Calpactin-1 light chain(gene name synonym)|uniprotkb:Calpactin I light chain(gene name synonym)|uniprotkb:p10 protein(gene name synonym)|uniprotkb:p11(gene name synonym)|uniprotkb:Cellular ligand of annexin II(gene name synonym)|uniprotkb:Nerve growth factor-induced protein 42C(gene name synonym) psi-mi:"MI:0096"(pull down) Okuse et al. (2002) pubmed:12050667 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1800942 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3629|refseq:NP_058943.1|ensembl:ENSRNOG00000032473(gene)|ensembl:ENSRNOT00000046864(transcript)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0044299"(C-fiber)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0061337"(cardiac conduction)|go:"GO:0071439"(clathrin complex)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086016"(AV node cell action potential)|go:"GO:0086043"(bundle of His cell action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR010526(Sodium ion transport-associated)|interpro:IPR027359|interpro:IPR028809|interpro:IPR043203|interpro:IPR044564|reactome:R-RNO-5576892 rgd:628655|refseq:NP_112376.1|ensembl:ENSRNOG00000023226(gene)|ensembl:ENSRNOT00000035240(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990665"(AnxA2-p11 complex)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR028476|reactome:R-RNO-75205 - - - figure legend:supplement fig A taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/08/08 2014/10/16 rogid:pOcv5fn4mMg5YmWNsvdrWdN18I410116 rogid:/MGaZckvZx44usKBC50esHsGgy810116 intact-crc:8B987CFDEEA0BB5D|rigid:v5G8DBsJuf5yjfOxu+zAZcQkOfI false sufficient binding region:1-127|glutathione s tranferase tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q62968 uniprotkb:P05943 intact:EBI-1800320|uniprotkb:Q63554|uniprotkb:Q6EWG6|ensembl:ENSRNOP00000047944 intact:EBI-1800351|uniprotkb:Q5BJ98|ensembl:ENSRNOP00000037097 psi-mi:scnaa_rat(display_long)|uniprotkb:Scn10a(gene name)|psi-mi:Scn10a(display_short)|uniprotkb:Sns(gene name synonym)|uniprotkb:Sodium channel protein type X subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.8(gene name synonym)|uniprotkb:Peripheral nerve sodium channel 3(gene name synonym)|uniprotkb:Sensory neuron sodium channel(gene name synonym) psi-mi:s10aa_rat(display_long)|uniprotkb:S100a10(gene name)|psi-mi:S100a10(display_short)|uniprotkb:S100 calcium-binding protein A10(gene name synonym)|uniprotkb:Calpactin-1 light chain(gene name synonym)|uniprotkb:Calpactin I light chain(gene name synonym)|uniprotkb:p10 protein(gene name synonym)|uniprotkb:p11(gene name synonym)|uniprotkb:Cellular ligand of annexin II(gene name synonym)|uniprotkb:Nerve growth factor-induced protein 42C(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Okuse et al. (2002) pubmed:12050667 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-1807408 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3629|refseq:NP_058943.1|ensembl:ENSRNOG00000032473(gene)|ensembl:ENSRNOT00000046864(transcript)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0044299"(C-fiber)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0061337"(cardiac conduction)|go:"GO:0071439"(clathrin complex)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086016"(AV node cell action potential)|go:"GO:0086043"(bundle of His cell action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR010526(Sodium ion transport-associated)|interpro:IPR027359|interpro:IPR028809|interpro:IPR043203|interpro:IPR044564|reactome:R-RNO-5576892 rgd:628655|refseq:NP_112376.1|ensembl:ENSRNOG00000023226(gene)|ensembl:ENSRNOT00000035240(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990665"(AnxA2-p11 complex)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR028476|reactome:R-RNO-75205 go:"GO:0005886"(plasma membrane) - - figure legend:2c|delivery method:P05943; Q62968 transfection taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2008/08/08 2014/10/16 rogid:pOcv5fn4mMg5YmWNsvdrWdN18I410116 rogid:/MGaZckvZx44usKBC50esHsGgy810116 intact-crc:29C3349686ECDF1E|rigid:v5G8DBsJuf5yjfOxu+zAZcQkOfI false - green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)