#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WQG9	uniprotkb:P34609	intact:EBI-321822|uniprotkb:Q17507|uniprotkb:Q9UAH2|ensemblmetazoa:B0478.1a.1	intact:EBI-315684|uniprotkb:Q95V72|ensemblmetazoa:ZK1098.10e.1|intact:EBI-2413631|uniprotkb:A7LPE3|uniprotkb:A7LPE4|uniprotkb:C0P271|uniprotkb:C7FZT6|uniprotkb:S6EZN6|uniprotkb:S6EZP3|uniprotkb:S6F548|uniprotkb:S6F556|uniprotkb:S6FD02|uniprotkb:S6FN04|uniprotkb:S6FN08|uniprotkb:S6FWP4|uniprotkb:S6FWP6|uniprotkb:U4MKU8	psi-mi:jnk1_caeel(display_long)|uniprotkb:jnk-1(gene name)|psi-mi:jnk-1(display_short)|uniprotkb:B0478.1(orf name)	psi-mi:jip_caeel(display_long)|uniprotkb:unc-16(gene name)|psi-mi:unc-16(display_short)|uniprotkb:JNK MAP kinase scaffold protein(gene name synonym)|uniprotkb:Uncoordinated protein 16(gene name synonym)|uniprotkb:egl-39(gene name synonym)|uniprotkb:ZK1098.10(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Byrd et al. (2001)	pubmed:11738026|imex:IM-19449	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1811901|imex:IM-19449-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021270.1|refseq:NP_741434.2|wormbase:B0478.1a|wormbase:B0478.1b|ensemblmetazoa:B0478.1a.1(transcript)|ensemblmetazoa:WBGene00002178(gene)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009408"(response to heat)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030424"(axon)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-CEL-193648|reactome:R-CEL-2559580|reactome:R-CEL-2871796|reactome:R-CEL-450321|dip:DIP-26951N|reactome:R-CEL-9007892|reactome:R-CEL-450341|reactome:R-CEL-5693565|reactome:R-CEL-376172	refseq:NP_001022981.1|refseq:NP_741263.3|wormbase:ZK1098.10a|wormbase:ZK1098.10b|reactome:R-CEL-525793|ensemblmetazoa:WBGene00006755(gene)|ensemblmetazoa:ZK1098.10e.1(transcript)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0018991"(oviposition)|go:"GO:0019900"(kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030421"(defecation)|go:"GO:0030424"(axon)|go:"GO:0040011"(locomotion)|go:"GO:0043194"(axon initial segment)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019143|interpro:IPR032486|interpro:IPR034743|interpro:IPR034744|interpro:IPR039911|go:"GO:0019894"(kinesin binding)|dip:DIP-25590N|refseq:NP_001122747.1|refseq:NP_001122748.1|refseq:NP_001255008.1|refseq:NP_001255009.1|refseq:NP_001293608.1|refseq:NP_001293609.1|refseq:NP_001293610.1|refseq:NP_001293611.1|refseq:NP_001293612.1|refseq:NP_001293613.1|refseq:NP_001293614.1|refseq:NP_001293615.1|refseq:NP_001293616.1|refseq:NP_001293617.1|wormbase:ZK1098.10c|wormbase:ZK1098.10d|wormbase:ZK1098.10e|wormbase:ZK1098.10f|wormbase:ZK1098.10g|wormbase:ZK1098.10h|wormbase:ZK1098.10i|wormbase:ZK1098.10j|wormbase:ZK1098.10k|wormbase:ZK1098.10l|wormbase:ZK1098.10m|wormbase:ZK1098.10n|wormbase:ZK1098.10o|wormbase:ZK1098.10p	-	-	-	figure legend:Fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/09/15	2019/11/14	rogid:qEMqBNLEYxdnt/w+TUTpI3JV4qU6239	rogid:Z6LvQ+tQH1l39F8E0oCiUdlJeuo6239	intact-crc:26E7063E62576A68|rigid:4hqCUPXh5PA48ki0Lhj7uP4e3Po	false	ha tag:n-n	t7 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P34609	uniprotkb:G5EDT6	intact:EBI-315684|uniprotkb:Q95V72|ensemblmetazoa:ZK1098.10e.1|intact:EBI-2413631|uniprotkb:A7LPE3|uniprotkb:A7LPE4|uniprotkb:C0P271|uniprotkb:C7FZT6|uniprotkb:S6EZN6|uniprotkb:S6EZP3|uniprotkb:S6F548|uniprotkb:S6F556|uniprotkb:S6FD02|uniprotkb:S6FN04|uniprotkb:S6FN08|uniprotkb:S6FWP4|uniprotkb:S6FWP6|uniprotkb:U4MKU8	intact:EBI-321088|ensemblmetazoa:F35C8.3.1	psi-mi:jip_caeel(display_long)|uniprotkb:unc-16(gene name)|psi-mi:unc-16(display_short)|uniprotkb:JNK MAP kinase scaffold protein(gene name synonym)|uniprotkb:Uncoordinated protein 16(gene name synonym)|uniprotkb:egl-39(gene name synonym)|uniprotkb:ZK1098.10(orf name)	psi-mi:jkk1_caeel(display_long)|uniprotkb:jkk-1(gene name)|psi-mi:jkk-1(display_short)|uniprotkb:JNK-1 activator kinase(gene name synonym)|uniprotkb:F35C8.3(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Byrd et al. (2001)	pubmed:11738026|imex:IM-19449	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1811913|imex:IM-19449-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001022981.1|refseq:NP_741263.3|wormbase:ZK1098.10a|wormbase:ZK1098.10b|reactome:R-CEL-525793|ensemblmetazoa:WBGene00006755(gene)|ensemblmetazoa:ZK1098.10e.1(transcript)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0018991"(oviposition)|go:"GO:0019900"(kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030421"(defecation)|go:"GO:0030424"(axon)|go:"GO:0040011"(locomotion)|go:"GO:0043194"(axon initial segment)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019143|interpro:IPR032486|interpro:IPR034743|interpro:IPR034744|interpro:IPR039911|go:"GO:0019894"(kinesin binding)|dip:DIP-25590N|refseq:NP_001122747.1|refseq:NP_001122748.1|refseq:NP_001255008.1|refseq:NP_001255009.1|refseq:NP_001293608.1|refseq:NP_001293609.1|refseq:NP_001293610.1|refseq:NP_001293611.1|refseq:NP_001293612.1|refseq:NP_001293613.1|refseq:NP_001293614.1|refseq:NP_001293615.1|refseq:NP_001293616.1|refseq:NP_001293617.1|wormbase:ZK1098.10c|wormbase:ZK1098.10d|wormbase:ZK1098.10e|wormbase:ZK1098.10f|wormbase:ZK1098.10g|wormbase:ZK1098.10h|wormbase:ZK1098.10i|wormbase:ZK1098.10j|wormbase:ZK1098.10k|wormbase:ZK1098.10l|wormbase:ZK1098.10m|wormbase:ZK1098.10n|wormbase:ZK1098.10o|wormbase:ZK1098.10p	uniprotkb:Q9UAH1(uniprot-removed-ac)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|refseq:NP_508913.1|ensemblmetazoa:F35C8.3.1(transcript)|ensemblmetazoa:WBGene00002177(gene)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0030424"(axon)|go:"GO:0040011"(locomotion)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|wormbase:F35C8.3	-	-	-	figure legend:Fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/09/15	2019/11/14	rogid:Z6LvQ+tQH1l39F8E0oCiUdlJeuo6239	rogid:NrEUEDXOn75SFPdM/QofXTZhoUI6239	intact-crc:5A49B8BF523960C8|rigid:67niyBw3COsFYQAU7RGyMvCsA0E	false	t7 tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-1811923	uniprotkb:P34609	-	intact:EBI-315684|uniprotkb:Q95V72|ensemblmetazoa:ZK1098.10e.1|intact:EBI-2413631|uniprotkb:A7LPE3|uniprotkb:A7LPE4|uniprotkb:C0P271|uniprotkb:C7FZT6|uniprotkb:S6EZN6|uniprotkb:S6EZP3|uniprotkb:S6F548|uniprotkb:S6F556|uniprotkb:S6FD02|uniprotkb:S6FN04|uniprotkb:S6FN08|uniprotkb:S6FWP4|uniprotkb:S6FWP6|uniprotkb:U4MKU8	psi-mi:q95y19_caeel(display_short)|psi-mi:EBI-1811923(display_long)|uniprotkb:Y41D4B.18(orf name)	psi-mi:jip_caeel(display_long)|uniprotkb:unc-16(gene name)|psi-mi:unc-16(display_short)|uniprotkb:JNK MAP kinase scaffold protein(gene name synonym)|uniprotkb:Uncoordinated protein 16(gene name synonym)|uniprotkb:egl-39(gene name synonym)|uniprotkb:ZK1098.10(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Byrd et al. (2001)	pubmed:11738026|imex:IM-19449	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1811929|imex:IM-19449-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q95Y19(uniprot-removed-ac)	refseq:NP_001022981.1|refseq:NP_741263.3|wormbase:ZK1098.10a|wormbase:ZK1098.10b|reactome:R-CEL-525793|ensemblmetazoa:WBGene00006755(gene)|ensemblmetazoa:ZK1098.10e.1(transcript)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0018991"(oviposition)|go:"GO:0019900"(kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030421"(defecation)|go:"GO:0030424"(axon)|go:"GO:0040011"(locomotion)|go:"GO:0043194"(axon initial segment)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019143|interpro:IPR032486|interpro:IPR034743|interpro:IPR034744|interpro:IPR039911|go:"GO:0019894"(kinesin binding)|dip:DIP-25590N|refseq:NP_001122747.1|refseq:NP_001122748.1|refseq:NP_001255008.1|refseq:NP_001255009.1|refseq:NP_001293608.1|refseq:NP_001293609.1|refseq:NP_001293610.1|refseq:NP_001293611.1|refseq:NP_001293612.1|refseq:NP_001293613.1|refseq:NP_001293614.1|refseq:NP_001293615.1|refseq:NP_001293616.1|refseq:NP_001293617.1|wormbase:ZK1098.10c|wormbase:ZK1098.10d|wormbase:ZK1098.10e|wormbase:ZK1098.10f|wormbase:ZK1098.10g|wormbase:ZK1098.10h|wormbase:ZK1098.10i|wormbase:ZK1098.10j|wormbase:ZK1098.10k|wormbase:ZK1098.10l|wormbase:ZK1098.10m|wormbase:ZK1098.10n|wormbase:ZK1098.10o|wormbase:ZK1098.10p	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/09/15	2019/11/14	rogid:eN3QsAn3ANYPA3B5635/9mPoQVo6239	rogid:Z6LvQ+tQH1l39F8E0oCiUdlJeuo6239	intact-crc:FD6C6026C9FA7F8C|rigid:6Cqj0y6fiyZNo/tPnu4jL7/JYbg	false	flag tag:n-n	t7 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P05412	uniprotkb:Q8WQG9	intact:EBI-852823|uniprotkb:Q96G93|uniprotkb:Q6FHM7|ensembl:ENSP00000360266|ensembl:ENSP00000503132	intact:EBI-321822|uniprotkb:Q17507|uniprotkb:Q9UAH2|ensemblmetazoa:B0478.1a.1	psi-mi:jun_human(display_long)|uniprotkb:JUN(gene name)|psi-mi:JUN(display_short)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:p39(gene name synonym)	psi-mi:jnk1_caeel(display_long)|uniprotkb:jnk-1(gene name)|psi-mi:jnk-1(display_short)|uniprotkb:B0478.1(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Byrd et al. (2001)	pubmed:11738026|imex:IM-19449	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1812046|imex:IM-19449-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002219.1|ensembl:ENSP00000360266|ensembl:ENSP00000503132|dip:DIP-5961N|ensembl:ENSG00000177606(gene)|ensembl:ENST00000371222(transcript)|ensembl:ENST00000678696(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P05412|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1JNM|rcsb pdb:1JUN|rcsb pdb:1S9K|rcsb pdb:1T2K|rcsb pdb:5FV8|rcsb pdb:5T01|rcsb pdb:6Y3V|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-5617472|reactome:R-HSA-5687128|reactome:R-HSA-6796648|reactome:R-HSA-8862803|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9673324	refseq:NP_001021270.1|refseq:NP_741434.2|wormbase:B0478.1a|wormbase:B0478.1b|ensemblmetazoa:B0478.1a.1(transcript)|ensemblmetazoa:WBGene00002178(gene)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009408"(response to heat)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030424"(axon)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-CEL-193648|reactome:R-CEL-2559580|reactome:R-CEL-2871796|reactome:R-CEL-450321|dip:DIP-26951N|reactome:R-CEL-9007892|reactome:R-CEL-450341|reactome:R-CEL-5693565|reactome:R-CEL-376172	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	resulting-ptm:Phosphorylation of c-JUN.|figure legend:Fig 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/15	2014/10/16	rogid:zAVYwedHKKdvPPGttBP4XZkbCXA9606	rogid:qEMqBNLEYxdnt/w+TUTpI3JV4qU6239	intact-crc:BF04A2549A2AD99D|rigid:+yfHDrva2YjfXH5dGMb5e4dAwTM	false	glutathione s tranferase tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WQG9	uniprotkb:P05412	intact:EBI-321822|uniprotkb:Q17507|uniprotkb:Q9UAH2|ensemblmetazoa:B0478.1a.1	intact:EBI-852823|uniprotkb:Q96G93|uniprotkb:Q6FHM7|ensembl:ENSP00000360266|ensembl:ENSP00000503132	psi-mi:jnk1_caeel(display_long)|uniprotkb:jnk-1(gene name)|psi-mi:jnk-1(display_short)|uniprotkb:B0478.1(orf name)	psi-mi:jun_human(display_long)|uniprotkb:JUN(gene name)|psi-mi:JUN(display_short)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:p39(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Byrd et al. (2001)	pubmed:11738026|imex:IM-19449	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1812071|imex:IM-19449-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021270.1|refseq:NP_741434.2|wormbase:B0478.1a|wormbase:B0478.1b|ensemblmetazoa:B0478.1a.1(transcript)|ensemblmetazoa:WBGene00002178(gene)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009408"(response to heat)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030424"(axon)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-CEL-193648|reactome:R-CEL-2559580|reactome:R-CEL-2871796|reactome:R-CEL-450321|dip:DIP-26951N|reactome:R-CEL-9007892|reactome:R-CEL-450341|reactome:R-CEL-5693565|reactome:R-CEL-376172	refseq:NP_002219.1|ensembl:ENSP00000360266|ensembl:ENSP00000503132|dip:DIP-5961N|ensembl:ENSG00000177606(gene)|ensembl:ENST00000371222(transcript)|ensembl:ENST00000678696(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P05412|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1JNM|rcsb pdb:1JUN|rcsb pdb:1S9K|rcsb pdb:1T2K|rcsb pdb:5FV8|rcsb pdb:5T01|rcsb pdb:6Y3V|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-5617472|reactome:R-HSA-5687128|reactome:R-HSA-6796648|reactome:R-HSA-8862803|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9673324	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	resulting-ptm:Phosphorylation of c-JUN.|figure legend:Fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/15	2014/10/16	rogid:qEMqBNLEYxdnt/w+TUTpI3JV4qU6239	rogid:zAVYwedHKKdvPPGttBP4XZkbCXA9606	intact-crc:86762B50CFA07018|rigid:+yfHDrva2YjfXH5dGMb5e4dAwTM	false	ha tag:n-n	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)