#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-1521221	uniprotkb:Q06187	-	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	psi-mi:ebi-1521221(display_short)|psi-mi:EBI-1521221(display_long)	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2001)	pubmed:11577348|imex:IM-20016|mint:MINT-5214610	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646805|imex:IM-20016-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.|comment:sequence is significantly different from parent.	-	caution:The coordinates given for the BTK construct used, do not match with the length of the protein nor the coordinates of the specified domains as given by the UniProtKB entry. The range given is taken from the ranges of these domains in the UniProtKB entry.|figure legend:1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/03/10	2014/10/16	rogid:Yen8HK2fsjJJYSp5LJ2iOXrtHBA9606	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	intact-crc:DAED709B48FB8EB1|rigid:l/UrFRPac+UepLJqi13YNfIp+VM	false	-	sufficient binding region:3..3-377..377	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06187	intact:EBI-1521221	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	-	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:ebi-1521221(display_short)|psi-mi:EBI-1521221(display_long)	psi-mi:"MI:0096"(pull down)	Liu et al. (2001)	pubmed:11577348|imex:IM-20016|mint:MINT-5214610	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646827|imex:IM-20016-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	-	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.|comment:sequence is significantly different from parent.	caution:The coordinates given for the BTK construct used, do not match with the coordinates of the specified domains as given by the UniProtKB entry. The ranges given are taken from the ranges of these domains in the UniProtKB entry.|figure legend:3 A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/10	2014/10/16	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:Yen8HK2fsjJJYSp5LJ2iOXrtHBA9606	intact-crc:71B5EFCC72F508CC|rigid:l/UrFRPac+UepLJqi13YNfIp+VM	false	sufficient binding region:3..3-171..171(IPR001562)|sufficient binding region:281..281-377..377(IPR000980)|glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q06187	intact:EBI-1521221	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	-	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:ebi-1521221(display_short)|psi-mi:EBI-1521221(display_long)	psi-mi:"MI:0096"(pull down)	Liu et al. (2001)	pubmed:11577348|imex:IM-20016|mint:MINT-5214610	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646842|imex:IM-20016-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	-	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.|comment:sequence is significantly different from parent.	figure legend:3 C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-b-cell)|taxid:9606(Homo sapiens B cell)	-	2008/03/10	2014/10/16	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:Yen8HK2fsjJJYSp5LJ2iOXrtHBA9606	intact-crc:DD6C443B5B1317FE|rigid:l/UrFRPac+UepLJqi13YNfIp+VM	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06187	intact:EBI-1521221	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	-	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:ebi-1521221(display_short)|psi-mi:EBI-1521221(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2001)	pubmed:11577348|imex:IM-20016|mint:MINT-5214610	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646866|imex:IM-20016-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	-	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.|comment:sequence is significantly different from parent.	figure legend:3 D|delivery method:Q9P2D0-4; Q06187 transfection|inhibition:IBTK peptide - An IBTK peptide displaced the immunoprecipitation activity of the anti-IBTK serum.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/03/10	2014/10/16	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:Yen8HK2fsjJJYSp5LJ2iOXrtHBA9606	intact-crc:CB446939CBD4EB89|rigid:l/UrFRPac+UepLJqi13YNfIp+VM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06187	uniprotkb:Q9P2D0	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-1052017|uniprotkb:Q2QKU2|uniprotkb:Q2QKU3|uniprotkb:Q2QKU4|uniprotkb:Q5TFD7|uniprotkb:Q5TFD9|uniprotkb:Q8IUQ9|uniprotkb:Q8IUY7|uniprotkb:Q8TAI4|uniprotkb:Q9HBI8|uniprotkb:Q9Y3T8|ensembl:ENSP00000305721|ensembl:ENSP00000489389	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:ibtk_human(display_long)|uniprotkb:IBTK(gene name)|psi-mi:IBTK(display_short)|uniprotkb:BTKI(gene name synonym)|uniprotkb:KIAA1417(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2001)	pubmed:11577348|imex:IM-20016|mint:MINT-5214610	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646880|imex:IM-20016-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	refseq:NP_056340.2|refseq:NP_001287835.1|ensembl:ENSG00000005700(gene)|ensembl:ENSG00000283068(gene)|ensembl:ENST00000306270(transcript)|ensembl:ENST00000635454(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR002110(Ankyrin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR020683|interpro:IPR036770	-	-	-	figure legend:3 E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-b-cell)|taxid:9606(Homo sapiens B cell)	-	2008/03/10	2014/10/16	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:cP+4mOtwZi3q2AjApgwpcJRpJ6M9606	intact-crc:BE5167FB1F18C55F|rigid:UWI7Cd+cvw7gcxXakgwjlm0ZzbY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9P2D0	uniprotkb:Q06187	intact:EBI-1052017|uniprotkb:Q2QKU2|uniprotkb:Q2QKU3|uniprotkb:Q2QKU4|uniprotkb:Q5TFD7|uniprotkb:Q5TFD9|uniprotkb:Q8IUQ9|uniprotkb:Q8IUY7|uniprotkb:Q8TAI4|uniprotkb:Q9HBI8|uniprotkb:Q9Y3T8|ensembl:ENSP00000305721|ensembl:ENSP00000489389	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	psi-mi:ibtk_human(display_long)|uniprotkb:IBTK(gene name)|psi-mi:IBTK(display_short)|uniprotkb:BTKI(gene name synonym)|uniprotkb:KIAA1417(gene name synonym)	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Liu et al. (2001)	pubmed:11577348|imex:IM-20016|mint:MINT-5214610	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646896|imex:IM-20016-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056340.2|refseq:NP_001287835.1|ensembl:ENSG00000005700(gene)|ensembl:ENSG00000283068(gene)|ensembl:ENST00000306270(transcript)|ensembl:ENST00000635454(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR002110(Ankyrin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR020683|interpro:IPR036770	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:3 F, G|comment:In unstimulated cells, colocalization of IBtk and Btk took place in the cytoplasm. Upon BCR cross-linking, colocalization took place in the sub-membrane region.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-b-cell)|taxid:9606(Homo sapiens B cell)	-	2008/03/10	2014/10/16	rogid:cP+4mOtwZi3q2AjApgwpcJRpJ6M9606	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	intact-crc:3556F30EE8A959E6|rigid:UWI7Cd+cvw7gcxXakgwjlm0ZzbY	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q06187	uniprotkb:Q06187	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Liu et al. (2001)	pubmed:11577348|imex:IM-20016|mint:MINT-5214610	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646923|imex:IM-20016-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:4 A|inhibition:IBTK - GST-IBTK inhibition of BTK kinase activity increases with increasing concentration of GST-IBTK.|resulting-ptm:"The BTK substrate peptide (BTK 217-229) is autophosphorylated on Tyr-223."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/10	2014/10/16	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	intact-crc:8E3212673A77AE31|rigid:7za25OavEOm11akBmB01tTIlmdg	false	sufficient binding region:217-229	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06187	uniprotkb:Q06187	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Liu et al. (2001)	pubmed:11577348|imex:IM-20016|mint:MINT-5214610	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646936|imex:IM-20016-8	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:4 C, E, F|inhibition:IBTK - GST-IBTK inhibition of BTK kinase activity increases with increasing concentration of GST-IBTK. Deletion analysis revealed that the C-terminal construct of IBTK retained inhibitory activty but the N-terminal construct did not.|resulting-ptm:"The BTK substrate peptide (BTK 217-229) is autophosphorylated on Tyr-223."|comment:IBTK causes nearly complete inhibition of BTK from unstimulated cells and only a substantial decrease in BCR-stimulated cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/10	2014/10/16	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	intact-crc:BF364DD7CA3D02FC|rigid:7za25OavEOm11akBmB01tTIlmdg	false	-	sufficient binding region:217-229	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)