#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9H0H5 uniprotkb:Q96RN1 intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374 intact:EBI-1792052|uniprotkb:Q5JVR5|uniprotkb:Q812C7|uniprotkb:Q8TC65|uniprotkb:Q96MA0|uniprotkb:Q96PK8|ensembl:ENSP00000347778|ensembl:ENSP00000417638 psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym) psi-mi:s26a8_human(display_long)|uniprotkb:SLC26A8(gene name)|psi-mi:SLC26A8(display_short)|uniprotkb:TAT1(gene name synonym)|uniprotkb:Anion exchange transporter(gene name synonym)|uniprotkb:Solute carrier family 26 member 8(gene name synonym) psi-mi:"MI:0018"(two hybrid) Toure et al. (2001) pubmed:11278976 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1792034 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N refseq:NP_001180405.1|refseq:NP_443193.1|refseq:NP_619732.2|refseq:XP_016865724.1|ensembl:ENSG00000112053(gene)|ensembl:ENST00000355574(transcript)|ensembl:ENST00000490799(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008271"(secondary active sulfate transmembrane transporter activity)|go:"GO:0008272"(sulfate transport)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0019531"(oxalate transmembrane transporter activity)|go:"GO:0019532"(oxalate transport)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0048240"(sperm capacitation)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR001902(Sulphate anion transporter)|interpro:IPR002645(Sulphate transporter/antisigma-factor antagonist STAS)|interpro:IPR011547(Sulphate transporter)|interpro:IPR030303|interpro:IPR036513 pubmed:9497316(see-also) - - figure legend:Fig. 8A|caution:The authors state the positions used in the protein sequence for MgcRacGAP that they had published in 1998 PMID 9497316. However the sequence in UniProtKB has an N-terminus extension by 105 AA and so the positions have been updated accordingly. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/07/14 2014/10/16 rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606 rogid:mRmhAYhpI6zif02DlwdR80K8jIk9606 intact-crc:BAA7F9ECB58124CA|rigid:hvxkiE0LU6jwFPHD/DcjMLJSl6g false necessary binding region:106-285 binding-associated region:664-970 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96RN1 uniprotkb:Q9H0H5 intact:EBI-1792052|uniprotkb:Q5JVR5|uniprotkb:Q812C7|uniprotkb:Q8TC65|uniprotkb:Q96MA0|uniprotkb:Q96PK8|ensembl:ENSP00000347778|ensembl:ENSP00000417638 intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374 psi-mi:s26a8_human(display_long)|uniprotkb:SLC26A8(gene name)|psi-mi:SLC26A8(display_short)|uniprotkb:TAT1(gene name synonym)|uniprotkb:Anion exchange transporter(gene name synonym)|uniprotkb:Solute carrier family 26 member 8(gene name synonym) psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Toure et al. (2001) pubmed:11278976 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1792134 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180405.1|refseq:NP_443193.1|refseq:NP_619732.2|refseq:XP_016865724.1|ensembl:ENSG00000112053(gene)|ensembl:ENST00000355574(transcript)|ensembl:ENST00000490799(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008271"(secondary active sulfate transmembrane transporter activity)|go:"GO:0008272"(sulfate transport)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0019531"(oxalate transmembrane transporter activity)|go:"GO:0019532"(oxalate transport)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0048240"(sperm capacitation)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR001902(Sulphate anion transporter)|interpro:IPR002645(Sulphate transporter/antisigma-factor antagonist STAS)|interpro:IPR011547(Sulphate transporter)|interpro:IPR030303|interpro:IPR036513 refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N pubmed:9497316(primary-reference) - - figure legend:Fig. 8B|comment:These results demonstrate that MgcRacGAP interacts through its NH2-terminal region with the cytoplasmic COOH-terminal domain of Slc26a8/Tat1.|caution:The authors state the positions used in the protein sequence for MgcRacGAP that they had published in 1998 PMID 9497316. However the sequence in UniProtKB has an N-terminus extension by 105 AA and so the positions have been updated accordingly. taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/07/14 2014/10/16 rogid:mRmhAYhpI6zif02DlwdR80K8jIk9606 rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606 intact-crc:649CBE8D3080D609|rigid:hvxkiE0LU6jwFPHD/DcjMLJSl6g false binding-associated region:664-970 necessary binding region:106-285|glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)