#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WYA1	uniprotkb:Q99814	intact:EBI-1793513|uniprotkb:Q8WYA2|uniprotkb:Q8WYA3|uniprotkb:Q8WYA4|uniprotkb:Q96J63|uniprotkb:Q9H2M4|uniprotkb:Q9NS70|uniprotkb:Q9NYQ4|uniprotkb:Q9NYQ5|uniprotkb:B7Z429|uniprotkb:F5H402|ensembl:ENSP00000266503	intact:EBI-447470|uniprotkb:Q86VA2|uniprotkb:Q99630|ensembl:ENSP00000263734	psi-mi:bmal2_human(display_long)|uniprotkb:ARNTL2(gene name)|psi-mi:ARNTL2(display_short)|uniprotkb:BMAL2(gene name synonym)|uniprotkb:CLIF(gene name synonym)|uniprotkb:MOP9(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 2(gene name synonym)|uniprotkb:Member of PAS protein 9(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP9(gene name synonym)|uniprotkb:CYCLE-like factor(gene name synonym)|uniprotkb:BHLHE6(gene name synonym)|uniprotkb:PASD9(gene name synonym)|uniprotkb:PAS domain-containing protein 9(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 6(gene name synonym)	psi-mi:epas1_human(display_long)|uniprotkb:EPAS1(gene name)|psi-mi:EPAS1(display_short)|uniprotkb:HIF2A(gene name synonym)|uniprotkb:MOP2(gene name synonym)|uniprotkb:Member of PAS protein 2(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP2(gene name synonym)|uniprotkb:BHLHE73(gene name synonym)|uniprotkb:PASD2(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:PAS domain-containing protein 2(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 73(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Maemura et al. (2000)	pubmed:11018023|imex:IM-20044	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1794150|imex:IM-20044-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064568.3|refseq:NP_001234934.1|refseq:NP_001234931.1|refseq:NP_001234932.1|refseq:NP_001234933.1|ensembl:ENST00000261178|ensembl:ENSP00000261178|ensembl:ENSP00000266503|ensembl:ENST00000311001|ensembl:ENSP00000312247|ensembl:ENST00000395901|ensembl:ENSP00000379238|ensembl:ENST00000542388|ensembl:ENSP00000445836|ensembl:ENST00000544915|ensembl:ENSP00000442438|ensembl:ENST00000546179|ensembl:ENSP00000438545|ensembl:ENSG00000029153(gene)|ensembl:ENST00000266503(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:2KDK|reactome:R-HSA-1368108	refseq:NP_001421.2|dip:DIP-32857N|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q99814|rcsb pdb:1P97|rcsb pdb:2A24|rcsb pdb:3F1N|rcsb pdb:3F1O|rcsb pdb:3F1P|rcsb pdb:3H7W|rcsb pdb:3H82|rcsb pdb:4GHI|rcsb pdb:4GS9|rcsb pdb:4PKY|rcsb pdb:4XT2|rcsb pdb:5KIZ|rcsb pdb:5TBM|rcsb pdb:5UFP|rcsb pdb:6BVB|rcsb pdb:6CZW|rcsb pdb:6D09|rcsb pdb:6D0B|rcsb pdb:6D0C|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6X21|rcsb pdb:6X28|rcsb pdb:6X2H|rcsb pdb:6X37|rcsb pdb:6X3D|reactome:R-HSA-1234158|reactome:R-HSA-1234174|go:"GO:0048469"(cell maturation)|reactome:R-HSA-1234176|reactome:R-HSA-452723|reactome:R-HSA-8849473|reactome:R-HSA-8951664|reactome:R-HSA-9664873|ensembl:ENSG00000116016(gene)|ensembl:ENST00000263734(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/07/16	2014/10/16	rogid:2e2Uf+uNQ9UtIw1FdFzd3QvtPOM9606	rogid:rBmVytqL/OrXjDJxbgvsa8r98DI9606	intact-crc:98A9A66D0095BC2E|rigid:ffGKJy19UWn34ydOYh6Ns2YZETs	false	-	sufficient binding region:30-380	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99814	uniprotkb:P27540	intact:EBI-447470|uniprotkb:Q86VA2|uniprotkb:Q99630|ensembl:ENSP00000263734	intact:EBI-80809|uniprotkb:C4AMA1|ensembl:ENSP00000351407|uniprotkb:B2R9H1|uniprotkb:F8WAP6|uniprotkb:Q59ED4|uniprotkb:Q5QP39|uniprotkb:Q8NDC7	psi-mi:epas1_human(display_long)|uniprotkb:EPAS1(gene name)|psi-mi:EPAS1(display_short)|uniprotkb:HIF2A(gene name synonym)|uniprotkb:MOP2(gene name synonym)|uniprotkb:Member of PAS protein 2(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP2(gene name synonym)|uniprotkb:BHLHE73(gene name synonym)|uniprotkb:PASD2(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:PAS domain-containing protein 2(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 73(gene name synonym)	psi-mi:arnt_human(display_long)|uniprotkb:ARNT(gene name)|psi-mi:ARNT(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)|uniprotkb:BHLHE2(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Maemura et al. (2000)	pubmed:11018023|imex:IM-20044	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1793580|imex:IM-20044-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001421.2|dip:DIP-32857N|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q99814|rcsb pdb:1P97|rcsb pdb:2A24|rcsb pdb:3F1N|rcsb pdb:3F1O|rcsb pdb:3F1P|rcsb pdb:3H7W|rcsb pdb:3H82|rcsb pdb:4GHI|rcsb pdb:4GS9|rcsb pdb:4PKY|rcsb pdb:4XT2|rcsb pdb:5KIZ|rcsb pdb:5TBM|rcsb pdb:5UFP|rcsb pdb:6BVB|rcsb pdb:6CZW|rcsb pdb:6D09|rcsb pdb:6D0B|rcsb pdb:6D0C|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6X21|rcsb pdb:6X28|rcsb pdb:6X2H|rcsb pdb:6X37|rcsb pdb:6X3D|reactome:R-HSA-1234158|reactome:R-HSA-1234174|go:"GO:0048469"(cell maturation)|reactome:R-HSA-1234176|reactome:R-HSA-452723|reactome:R-HSA-8849473|reactome:R-HSA-8951664|reactome:R-HSA-9664873|ensembl:ENSG00000116016(gene)|ensembl:ENST00000263734(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)	ensembl:ENSG00000143437(gene)|ensembl:ENST00000358595(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|refseq:NP_001184254.1|refseq:NP_001659.1|refseq:NP_848514.1|refseq:NP_001272964.1|refseq:NP_001272965.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:P27540|rcsb pdb:1D7G|rcsb pdb:1X0O|rcsb pdb:2A24|rcsb pdb:2ARN|rcsb pdb:2B02|rcsb pdb:2HV1|rcsb pdb:2K7S|rcsb pdb:3F1N|rcsb pdb:3F1O|rcsb pdb:3F1P|rcsb pdb:3H7W|rcsb pdb:6D09|rcsb pdb:6D0B|rcsb pdb:6D0C|rcsb pdb:6X21|rcsb pdb:3H82|rcsb pdb:6X28|rcsb pdb:6X2H|rcsb pdb:6X37|rcsb pdb:6X3D|rcsb pdb:4EQ1|rcsb pdb:4GHI|rcsb pdb:4GS9|rcsb pdb:4H6J|rcsb pdb:4LPZ|rcsb pdb:4PKY|rcsb pdb:4XT2|reactome:R-HSA-1234158|rcsb pdb:5TBM|reactome:R-HSA-1989781|reactome:R-HSA-211945|rcsb pdb:5UFP|reactome:R-HSA-211976|reactome:R-HSA-211981|rcsb pdb:5V0L|rcsb pdb:6CZW|reactome:R-HSA-8937144|ensembl:ENST00000354396|ensembl:ENSP00000346372|ensembl:ENSP00000351407|ensembl:ENST00000505755|ensembl:ENSP00000427571|ensembl:ENST00000515192|ensembl:ENSP00000423851|refseq:XP_016856778.1|dip:DIP-30886N	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/07/16	2014/10/16	rogid:rBmVytqL/OrXjDJxbgvsa8r98DI9606	rogid:MAYVa32fLDGxgEr0VL9ZVg/EcIA9606	intact-crc:D8FBA4BAEAF24A41|rigid:Docz16xIVYxJhJAyjees9ScQ5Js	false	-	sufficient binding region:70-508	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00327	uniprotkb:Q99814	intact:EBI-1794206|uniprotkb:O00313|uniprotkb:O00314|uniprotkb:O00315|uniprotkb:O00316|uniprotkb:O00317|uniprotkb:Q99631|uniprotkb:Q99649|uniprotkb:Q8IUT4|uniprotkb:D3DQW6|uniprotkb:A8K645|uniprotkb:B7WPG7|uniprotkb:B5ME11|uniprotkb:Q4G136|uniprotkb:A2I2N6|intact:EBI-28970920|ensembl:ENSP00000384517|ensembl:ENSP00000385581|ensembl:ENSP00000433571	intact:EBI-447470|uniprotkb:Q86VA2|uniprotkb:Q99630|ensembl:ENSP00000263734	psi-mi:bmal1_human(display_long)|uniprotkb:ARNTL(gene name)|psi-mi:ARNTL(display_short)|uniprotkb:BMAL1(gene name synonym)|uniprotkb:MOP3(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Member of PAS protein 3(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP3(gene name synonym)|uniprotkb:bHLH-PAS protein JAP3(gene name synonym)|uniprotkb:BHLHE5(gene name synonym)|uniprotkb:PASD3(gene name synonym)|uniprotkb:PAS domain-containing protein 3(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 5(gene name synonym)	psi-mi:epas1_human(display_long)|uniprotkb:EPAS1(gene name)|psi-mi:EPAS1(display_short)|uniprotkb:HIF2A(gene name synonym)|uniprotkb:MOP2(gene name synonym)|uniprotkb:Member of PAS protein 2(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP2(gene name synonym)|uniprotkb:BHLHE73(gene name synonym)|uniprotkb:PASD2(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:PAS domain-containing protein 2(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 73(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Maemura et al. (2000)	pubmed:11018023|imex:IM-20044	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1794261|imex:IM-20044-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000389707|ensembl:ENSP00000374357|ensembl:ENST00000401424|ensembl:ENSP00000385915|ensembl:ENSP00000384517|ensembl:ENST00000403482|ensembl:ENSP00000385897|ensembl:ENSP00000385581|ensembl:ENSP00000433571|refseq:XP_011518414.1|refseq:XP_011518415.1|refseq:NP_001025443.1|refseq:NP_001025444.1|refseq:NP_001169.3|refseq:XP_016873232.1|refseq:NP_001284648.1|refseq:NP_001284651.1|refseq:NP_001284653.1|refseq:XP_016873231.1|refseq:XP_016873235.1|refseq:XP_016873236.1|refseq:XP_016873237.1|dip:DIP-46008N|ensembl:ENSG00000133794(gene)|ensembl:ENST00000403290(transcript)|ensembl:ENST00000403510(transcript)|ensembl:ENST00000529388(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4H10|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-400253|reactome:R-HSA-9707616	refseq:NP_001421.2|dip:DIP-32857N|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q99814|rcsb pdb:1P97|rcsb pdb:2A24|rcsb pdb:3F1N|rcsb pdb:3F1O|rcsb pdb:3F1P|rcsb pdb:3H7W|rcsb pdb:3H82|rcsb pdb:4GHI|rcsb pdb:4GS9|rcsb pdb:4PKY|rcsb pdb:4XT2|rcsb pdb:5KIZ|rcsb pdb:5TBM|rcsb pdb:5UFP|rcsb pdb:6BVB|rcsb pdb:6CZW|rcsb pdb:6D09|rcsb pdb:6D0B|rcsb pdb:6D0C|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6X21|rcsb pdb:6X28|rcsb pdb:6X2H|rcsb pdb:6X37|rcsb pdb:6X3D|reactome:R-HSA-1234158|reactome:R-HSA-1234174|go:"GO:0048469"(cell maturation)|reactome:R-HSA-1234176|reactome:R-HSA-452723|reactome:R-HSA-8849473|reactome:R-HSA-8951664|reactome:R-HSA-9664873|ensembl:ENSG00000116016(gene)|ensembl:ENST00000263734(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/07/16	2014/10/16	rogid:UJwUJQAcLUT6aEBNSUZOF6YyvMA9606	rogid:rBmVytqL/OrXjDJxbgvsa8r98DI9606	intact-crc:8CC6029D5F9B7528|rigid:XcElu/BXNfRAkq8jfjCN9heB4uU	false	sufficient binding region:64-445	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00327	uniprotkb:O15516	intact:EBI-1794206|uniprotkb:O00313|uniprotkb:O00314|uniprotkb:O00315|uniprotkb:O00316|uniprotkb:O00317|uniprotkb:Q99631|uniprotkb:Q99649|uniprotkb:Q8IUT4|uniprotkb:D3DQW6|uniprotkb:A8K645|uniprotkb:B7WPG7|uniprotkb:B5ME11|uniprotkb:Q4G136|uniprotkb:A2I2N6|intact:EBI-28970920|ensembl:ENSP00000384517|ensembl:ENSP00000385581|ensembl:ENSP00000433571	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	psi-mi:bmal1_human(display_long)|uniprotkb:ARNTL(gene name)|psi-mi:ARNTL(display_short)|uniprotkb:BMAL1(gene name synonym)|uniprotkb:MOP3(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Member of PAS protein 3(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP3(gene name synonym)|uniprotkb:bHLH-PAS protein JAP3(gene name synonym)|uniprotkb:BHLHE5(gene name synonym)|uniprotkb:PASD3(gene name synonym)|uniprotkb:PAS domain-containing protein 3(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 5(gene name synonym)	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Maemura et al. (2000)	pubmed:11018023|imex:IM-20044	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1794288|imex:IM-20044-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000389707|ensembl:ENSP00000374357|ensembl:ENST00000401424|ensembl:ENSP00000385915|ensembl:ENSP00000384517|ensembl:ENST00000403482|ensembl:ENSP00000385897|ensembl:ENSP00000385581|ensembl:ENSP00000433571|refseq:XP_011518414.1|refseq:XP_011518415.1|refseq:NP_001025443.1|refseq:NP_001025444.1|refseq:NP_001169.3|refseq:XP_016873232.1|refseq:NP_001284648.1|refseq:NP_001284651.1|refseq:NP_001284653.1|refseq:XP_016873231.1|refseq:XP_016873235.1|refseq:XP_016873236.1|refseq:XP_016873237.1|dip:DIP-46008N|ensembl:ENSG00000133794(gene)|ensembl:ENST00000403290(transcript)|ensembl:ENST00000403510(transcript)|ensembl:ENST00000529388(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4H10|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-400253|reactome:R-HSA-9707616	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/07/16	2014/10/16	rogid:UJwUJQAcLUT6aEBNSUZOF6YyvMA9606	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	intact-crc:D224DFC371F29FED|rigid:B3002o6Cfu9oEDxPcWy9CZ6rop8	false	sufficient binding region:64-445	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99814	uniprotkb:Q8WYA1	intact:EBI-447470|uniprotkb:Q86VA2|uniprotkb:Q99630|ensembl:ENSP00000263734	intact:EBI-1793513|uniprotkb:Q8WYA2|uniprotkb:Q8WYA3|uniprotkb:Q8WYA4|uniprotkb:Q96J63|uniprotkb:Q9H2M4|uniprotkb:Q9NS70|uniprotkb:Q9NYQ4|uniprotkb:Q9NYQ5|uniprotkb:B7Z429|uniprotkb:F5H402|ensembl:ENSP00000266503	psi-mi:epas1_human(display_long)|uniprotkb:EPAS1(gene name)|psi-mi:EPAS1(display_short)|uniprotkb:HIF2A(gene name synonym)|uniprotkb:MOP2(gene name synonym)|uniprotkb:Member of PAS protein 2(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP2(gene name synonym)|uniprotkb:BHLHE73(gene name synonym)|uniprotkb:PASD2(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:PAS domain-containing protein 2(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 73(gene name synonym)	psi-mi:bmal2_human(display_long)|uniprotkb:ARNTL2(gene name)|psi-mi:ARNTL2(display_short)|uniprotkb:BMAL2(gene name synonym)|uniprotkb:CLIF(gene name synonym)|uniprotkb:MOP9(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 2(gene name synonym)|uniprotkb:Member of PAS protein 9(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP9(gene name synonym)|uniprotkb:CYCLE-like factor(gene name synonym)|uniprotkb:BHLHE6(gene name synonym)|uniprotkb:PASD9(gene name synonym)|uniprotkb:PAS domain-containing protein 9(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Maemura et al. (2000)	pubmed:11018023|imex:IM-20044	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1794292|imex:IM-20044-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001421.2|dip:DIP-32857N|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q99814|rcsb pdb:1P97|rcsb pdb:2A24|rcsb pdb:3F1N|rcsb pdb:3F1O|rcsb pdb:3F1P|rcsb pdb:3H7W|rcsb pdb:3H82|rcsb pdb:4GHI|rcsb pdb:4GS9|rcsb pdb:4PKY|rcsb pdb:4XT2|rcsb pdb:5KIZ|rcsb pdb:5TBM|rcsb pdb:5UFP|rcsb pdb:6BVB|rcsb pdb:6CZW|rcsb pdb:6D09|rcsb pdb:6D0B|rcsb pdb:6D0C|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6X21|rcsb pdb:6X28|rcsb pdb:6X2H|rcsb pdb:6X37|rcsb pdb:6X3D|reactome:R-HSA-1234158|reactome:R-HSA-1234174|go:"GO:0048469"(cell maturation)|reactome:R-HSA-1234176|reactome:R-HSA-452723|reactome:R-HSA-8849473|reactome:R-HSA-8951664|reactome:R-HSA-9664873|ensembl:ENSG00000116016(gene)|ensembl:ENST00000263734(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_064568.3|refseq:NP_001234934.1|refseq:NP_001234931.1|refseq:NP_001234932.1|refseq:NP_001234933.1|ensembl:ENST00000261178|ensembl:ENSP00000261178|ensembl:ENSP00000266503|ensembl:ENST00000311001|ensembl:ENSP00000312247|ensembl:ENST00000395901|ensembl:ENSP00000379238|ensembl:ENST00000542388|ensembl:ENSP00000445836|ensembl:ENST00000544915|ensembl:ENSP00000442438|ensembl:ENST00000546179|ensembl:ENSP00000438545|ensembl:ENSG00000029153(gene)|ensembl:ENST00000266503(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:2KDK|reactome:R-HSA-1368108	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/07/16	2014/10/16	rogid:rBmVytqL/OrXjDJxbgvsa8r98DI9606	rogid:2e2Uf+uNQ9UtIw1FdFzd3QvtPOM9606	intact-crc:7C4A3880F423F620|rigid:ffGKJy19UWn34ydOYh6Ns2YZETs	false	-	sufficient binding region:74-445	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15516	uniprotkb:Q8WYA1	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	intact:EBI-1793513|uniprotkb:Q8WYA2|uniprotkb:Q8WYA3|uniprotkb:Q8WYA4|uniprotkb:Q96J63|uniprotkb:Q9H2M4|uniprotkb:Q9NS70|uniprotkb:Q9NYQ4|uniprotkb:Q9NYQ5|uniprotkb:B7Z429|uniprotkb:F5H402|ensembl:ENSP00000266503	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:bmal2_human(display_long)|uniprotkb:ARNTL2(gene name)|psi-mi:ARNTL2(display_short)|uniprotkb:BMAL2(gene name synonym)|uniprotkb:CLIF(gene name synonym)|uniprotkb:MOP9(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 2(gene name synonym)|uniprotkb:Member of PAS protein 9(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP9(gene name synonym)|uniprotkb:CYCLE-like factor(gene name synonym)|uniprotkb:BHLHE6(gene name synonym)|uniprotkb:PASD9(gene name synonym)|uniprotkb:PAS domain-containing protein 9(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Maemura et al. (2000)	pubmed:11018023|imex:IM-20044	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1794297|imex:IM-20044-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	refseq:NP_064568.3|refseq:NP_001234934.1|refseq:NP_001234931.1|refseq:NP_001234932.1|refseq:NP_001234933.1|ensembl:ENST00000261178|ensembl:ENSP00000261178|ensembl:ENSP00000266503|ensembl:ENST00000311001|ensembl:ENSP00000312247|ensembl:ENST00000395901|ensembl:ENSP00000379238|ensembl:ENST00000542388|ensembl:ENSP00000445836|ensembl:ENST00000544915|ensembl:ENSP00000442438|ensembl:ENST00000546179|ensembl:ENSP00000438545|ensembl:ENSG00000029153(gene)|ensembl:ENST00000266503(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:2KDK|reactome:R-HSA-1368108	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/07/16	2014/10/16	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rogid:2e2Uf+uNQ9UtIw1FdFzd3QvtPOM9606	intact-crc:EE4A3FE554C4F6C7|rigid:JGE3uwm9ZJW5baNYGmlgs/QY1BQ	false	-	sufficient binding region:74-445	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)