#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02340	uniprotkb:Q99986	intact:EBI-474016|uniprotkb:Q9QUP3|ensembl:ENSMUSP00000104298	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	psi-mi:p53_mouse(display_long)|uniprotkb:Tp53(gene name)|psi-mi:Tp53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Trp53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Lopez-Borges et al. (2000)	pubmed:10951572|imex:IM-20058	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1796528|imex:IM-20058-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000059552(gene)|ensembl:ENSMUST00000108658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|mint:P02340|rcsb pdb:1HU8|rcsb pdb:2GEQ|rcsb pdb:2IOI|rcsb pdb:2IOM|rcsb pdb:2IOO|rcsb pdb:2P52|rcsb pdb:3EXJ|rcsb pdb:3EXL|reactome:R-MMU-2559580|reactome:R-MMU-2559584|reactome:R-MMU-2559585|reactome:R-MMU-2559586|reactome:R-MMU-349425|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-5693565|reactome:R-MMU-6804754|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-6804760|reactome:R-MMU-6811555|reactome:R-MMU-69473|reactome:R-MMU-69481|reactome:R-MMU-69541|reactome:R-MMU-69895|reactome:R-MMU-8852276|reactome:R-MMU-8941855|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007569"(cell aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009411"(response to UV)|go:"GO:0009651"(response to salt stress)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010038"(response to metal ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033552"(response to vitamin B3)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043200"(response to amino acid)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045471"(response to ethanol)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051276"(chromosome organization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0034644"(cellular response to UV)|refseq:NP_001120705.1|refseq:NP_035770.2|refseq:XP_006533220.1|dip:DIP-369N	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/07/24	2018/10/11	rogid:ZU1071LBVm95uqzi6RBNluw8wFo10090	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	intact-crc:8171B345A572E616|rigid:YjOyRJo1kCOWA4sL0bJ9ZE8xeI0	false	glutathione s tranferase tag:?-?|sufficient binding region:14-67|mutation:21-21	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99986	-	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	-	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	-	psi-mi:"MI:0424"(protein kinase assay)	Lopez-Borges et al. (2000)	pubmed:10951572|imex:IM-20058	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1796539|imex:IM-20058-2	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:2A|resulting-ptm:VRk autophosphorylated|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/07/24	2014/10/16	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	-	intact-crc:66B0188D6BBDC252	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-
uniprotkb:Q99986	-	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	-	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	-	psi-mi:"MI:0424"(protein kinase assay)	Lopez-Borges et al. (2000)	pubmed:10951572|imex:IM-20058	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1796556|imex:IM-20058-3	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:2A|resulting-ptm:VRk autophosphorylated|comment:GST tag was removed by digestion with thrombin.|resulting-ptm:Serine and Threonines were found to be phsophorylated, while tyrosines were not.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/07/24	2014/10/16	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	-	intact-crc:D3C0282631721484	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-