#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q12923 uniprotkb:P25445 intact:EBI-355227|uniprotkb:Q9UDA8|uniprotkb:Q15159|uniprotkb:Q15263|uniprotkb:Q15264|uniprotkb:Q15265|uniprotkb:Q15674|uniprotkb:Q16826|uniprotkb:Q8IWH7|uniprotkb:Q9NYN9|uniprotkb:B2RTR0|ensembl:ENSP00000407249 intact:EBI-494743|uniprotkb:Q14292|uniprotkb:Q14293|uniprotkb:Q14294|uniprotkb:Q14295|uniprotkb:Q16652|uniprotkb:Q6SSE9|uniprotkb:Q5T9P1|uniprotkb:Q5T9P2|uniprotkb:A9UJX4|uniprotkb:B6VNV4|uniprotkb:Q5T9P3|ensembl:ENSP00000498466 psi-mi:ptn13_human(display_long)|uniprotkb:PTPN13(gene name)|psi-mi:PTPN13(display_short)|uniprotkb:PNP1(gene name synonym)|uniprotkb:PTP1E(gene name synonym)|uniprotkb:PTPL1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1E(gene name synonym)|uniprotkb:PTP-BAS(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase PTPL1(gene name synonym)|uniprotkb:Fas-associated protein-tyrosine phosphatase 1(gene name synonym) psi-mi:tnr6_human(display_long)|uniprotkb:FASLG receptor(gene name synonym)|uniprotkb:Apoptosis-mediating surface antigen FAS(gene name synonym)|uniprotkb:Apo-1 antigen(gene name synonym)|uniprotkb:FAS(gene name)|psi-mi:FAS(display_short)|uniprotkb:APT1(gene name synonym)|uniprotkb:TNFRSF6(gene name synonym)|uniprotkb:FAS1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Li et al. (2000) pubmed:10918185|imex:IM-20023 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1748194|imex:IM-20023-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006255.1|refseq:NP_542414.1|refseq:NP_542415.1|refseq:NP_542416.1|ensembl:ENST00000316707|ensembl:ENSP00000322675|ensembl:ENSP00000407249|ensembl:ENST00000427191|ensembl:ENSP00000408368|ensembl:ENST00000436978|ensembl:ENSP00000394794|ensembl:ENST00000511467|ensembl:ENSP00000426626|dip:DIP-40449N|ensembl:ENSG00000163629(gene)|ensembl:ENST00000411767(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011019(KIND)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012153(Protein-tyrosine phosphatase, non-receptor type-13)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|mint:Q12923|rcsb pdb:1D5G|rcsb pdb:1Q7X|go:"GO:0001933"(negative regulation of protein phosphorylation)|rcsb pdb:1WCH|rcsb pdb:2M0Z|rcsb pdb:2M10|rcsb pdb:3LNX|rcsb pdb:3LNY|rcsb pdb:3PDZ|rcsb pdb:5GLJ|reactome:R-HSA-1660499|reactome:R-HSA-9008059|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273 refseq:NP_000034.1|refseq:NP_690610.1|refseq:NP_690611.1|refseq:NP_001307548.1|dip:DIP-924N|ensembl:ENSG00000026103(gene)|ensembl:ENST00000652046(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019900"(kinase binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036337"(Fas signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR008063(Fas receptor)|interpro:IPR011029(DEATH-like)|interpro:IPR033998|interpro:IPR033999|mint:P25445|rcsb pdb:1BZI|rcsb pdb:1DDF|rcsb pdb:2NA7|rcsb pdb:3EWT|rcsb pdb:3THM|rcsb pdb:3TJE|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75157|rcsb pdb:3EZQ - - - figure legend:1|delivery method:Q12923; P25445 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2008/03/25 2014/10/16 rogid:PU9d6x+mLnjomT1yfPSVBg0i2Bk9606 rogid:Yz5oIuvCmfV62Fpd/XjXGmSDZms9606 intact-crc:A2431E1574DA5452|rigid:TDqIp5I0+fDGodfbk8GnUL1XkhQ false - mutation decreasing interaction:333-333 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)