#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UBW5 uniprotkb:O00499 intact:EBI-2042570|uniprotkb:Q86VV0|uniprotkb:Q9NWK4|uniprotkb:Q9UKN4|uniprotkb:B7Z6F3|uniprotkb:F5H0W4|ensembl:ENSP00000483983 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 psi-mi:bin2_human(display_long)|uniprotkb:BIN2(gene name)|psi-mi:BIN2(display_short)|uniprotkb:BRAP1(gene name synonym)|uniprotkb:Breast cancer-associated protein 1(gene name synonym) psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ge et al. (2000) pubmed:10903846|imex:IM-20165 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-2042589|imex:IM-20165-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276936.1|refseq:NP_001276937.1|refseq:NP_001276938.1|refseq:NP_057377.3|ensembl:ENSG00000110934(gene)|ensembl:ENST00000615107(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0030054"(cell junction)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042995"(cell projection)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071800"(podosome assembly)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003005(Amphiphysin)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028827|rcsb pdb:4AVM|rcsb pdb:4I1Q|reactome:R-HSA-6798695|reactome:R-HSA-9673768 ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N - - - figure legend:4A and C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/11/06 2014/10/16 rogid:wD8yD0/ulLv6pt3ICEGRI+G0W0Y9606 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 intact-crc:7EBB5D821BCC9BF9|rigid:HTwz1FvuQY8WWFE/8izSi186wnk false 35s radiolabel:?-? binding-associated region:1-122|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9UBW5 uniprotkb:O00499 intact:EBI-2042570|uniprotkb:Q86VV0|uniprotkb:Q9NWK4|uniprotkb:Q9UKN4|uniprotkb:B7Z6F3|uniprotkb:F5H0W4|ensembl:ENSP00000483983 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 psi-mi:bin2_human(display_long)|uniprotkb:BIN2(gene name)|psi-mi:BIN2(display_short)|uniprotkb:BRAP1(gene name synonym)|uniprotkb:Breast cancer-associated protein 1(gene name synonym) psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ge et al. (2000) pubmed:10903846|imex:IM-20165 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-2042602|imex:IM-20165-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276936.1|refseq:NP_001276937.1|refseq:NP_001276938.1|refseq:NP_057377.3|ensembl:ENSG00000110934(gene)|ensembl:ENST00000615107(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0030054"(cell junction)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042995"(cell projection)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071800"(podosome assembly)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003005(Amphiphysin)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028827|rcsb pdb:4AVM|rcsb pdb:4I1Q|reactome:R-HSA-6798695|reactome:R-HSA-9673768 ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N - - - figure legend:4D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2008/11/06 2014/10/16 rogid:wD8yD0/ulLv6pt3ICEGRI+G0W0Y9606 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 intact-crc:7795BAEDB5B34143|rigid:HTwz1FvuQY8WWFE/8izSi186wnk false ha tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)