#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P32561 uniprotkb:P14832 intact:EBI-15864|uniprotkb:D6W0L7|ensemblfungi:YNL330C intact:EBI-5463|uniprotkb:D6VSD6|ensemblfungi:YDR155C psi-mi:rpd3_yeast(display_long)|uniprotkb:RPD3(gene name)|psi-mi:RPD3(display_short)|uniprotkb:SDI2(gene name synonym)|uniprotkb:YNL330C(locus name)|uniprotkb:N0305(orf name)|uniprotkb:MOF6(gene name synonym)|uniprotkb:REC3(gene name synonym)|uniprotkb:SDS6(gene name synonym)|uniprotkb:Transcriptional regulatory protein RPD3(gene name synonym) psi-mi:cyph_yeast(display_long)|uniprotkb:CPR1(gene name)|psi-mi:CPR1(display_short)|uniprotkb:CPH1(gene name synonym)|uniprotkb:SCC1(gene name synonym)|uniprotkb:YDR155C(locus name)|uniprotkb:YD8358.10C(orf name)|uniprotkb:CYP1(gene name synonym)|uniprotkb:Cyclophilin(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPI-II(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:"MI:0096"(pull down) Arevalo-Rodriguez et al. (2000) pubmed:10899127|imex:IM-19825 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1782909|imex:IM-19825-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YNL330C(gene)|ensemblfungi:YNL330C_mRNA(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000117"(regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032221"(Rpd3S/Clr6-CII complex)|go:"GO:0033698"(Rpd3L complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045128"(negative regulation of reciprocal meiotic recombination)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051038"(negative regulation of transcription involved in meiotic cell cycle)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:0070211"(Snt2C complex)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0070550"(rDNA condensation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-SCE-3214815|reactome:R-SCE-4551638|reactome:R-SCE-9018519|go:"GO:0070822"(Sin3-type complex)|go:"GO:0070932"(histone H3 deacetylation)|refseq:NP_014069.1|sgd:S000005274|dip:DIP-681N|mint:P32561 refseq:NP_010439.1|sgd:S000002562|dip:DIP-5203N|mint:P14832|ensemblfungi:YDR155C(gene)|ensemblfungi:YDR155C_mRNA(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003729"(mRNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006457"(protein folding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016575"(histone deacetylation)|go:"GO:0030437"(ascospore formation)|go:"GO:0034967"(Set3 complex)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|rcsb pdb:1IST|rcsb pdb:1VDN - crc64:34FFD72A7E7425DB crc64:012D8E8E4D85B4B7 figure legend:Fig. 5|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/17 2014/10/16 rogid:GQ1xB56fpHiVV03yhoPADv04fl0559292 rogid:ytAesNyLcntrLis8Ts7FuX0lNkw559292 intact-crc:2B25406AA9954C8C|rigid:ssHCJYDpbOgde9/2UbdXaYpN6UI false - his tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22696 uniprotkb:P32561 intact:EBI-6679|uniprotkb:D6VWJ3|ensemblfungi:YJR017C intact:EBI-15864|uniprotkb:D6W0L7|ensemblfungi:YNL330C psi-mi:ess1_yeast(display_long)|uniprotkb:Processing/termination factor 1(gene name synonym)|uniprotkb:ESS1(gene name)|psi-mi:ESS1(display_short)|uniprotkb:PIN1(gene name synonym)|uniprotkb:PTF1(gene name synonym)|uniprotkb:J1452(orf name)|uniprotkb:YJR017C(locus name)|uniprotkb:Parvulin ESS1(gene name synonym) psi-mi:rpd3_yeast(display_long)|uniprotkb:RPD3(gene name)|psi-mi:RPD3(display_short)|uniprotkb:SDI2(gene name synonym)|uniprotkb:YNL330C(locus name)|uniprotkb:N0305(orf name)|uniprotkb:MOF6(gene name synonym)|uniprotkb:REC3(gene name synonym)|uniprotkb:SDS6(gene name synonym)|uniprotkb:Transcriptional regulatory protein RPD3(gene name synonym) psi-mi:"MI:0096"(pull down) Arevalo-Rodriguez et al. (2000) pubmed:10899127|imex:IM-19825 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1782915|imex:IM-19825-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012551.2|sgd:S000003778|dip:DIP-3856N|mint:P22696|ensemblfungi:YJR017C(gene)|ensemblfungi:YJR017C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000749"(positive regulation of rDNA heterochromatin assembly)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|reactome:R-SCE-5668599|reactome:R-SCE-6811555 ensemblfungi:YNL330C(gene)|ensemblfungi:YNL330C_mRNA(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000117"(regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032221"(Rpd3S/Clr6-CII complex)|go:"GO:0033698"(Rpd3L complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045128"(negative regulation of reciprocal meiotic recombination)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051038"(negative regulation of transcription involved in meiotic cell cycle)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:0070211"(Snt2C complex)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0070550"(rDNA condensation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-SCE-3214815|reactome:R-SCE-4551638|reactome:R-SCE-9018519|go:"GO:0070822"(Sin3-type complex)|go:"GO:0070932"(histone H3 deacetylation)|refseq:NP_014069.1|sgd:S000005274|dip:DIP-681N|mint:P32561 - crc64:18D3EC02E8395175 crc64:34FFD72A7E7425DB figure legend:Fig. 5|comment:This interaction requires the presence of SIN3.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/17 2014/10/16 rogid:B4I62u/hH9W+CPLsb0xvkSVaP/Y559292 rogid:GQ1xB56fpHiVV03yhoPADv04fl0559292 intact-crc:D7B9D73071F8F5D6|rigid:NwRR/p/m+CETupk2f+3fhiJoikw false his tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38429 uniprotkb:P14832 intact:EBI-27570|uniprotkb:Q03501|uniprotkb:D6W089|ensemblfungi:YMR263W intact:EBI-5463|uniprotkb:D6VSD6|ensemblfungi:YDR155C psi-mi:sap30_yeast(display_long)|uniprotkb:YM8156.05(orf name)|uniprotkb:YMR263W(locus name)|uniprotkb:SAP30(gene name)|psi-mi:SAP30(display_short) psi-mi:cyph_yeast(display_long)|uniprotkb:CPR1(gene name)|psi-mi:CPR1(display_short)|uniprotkb:CPH1(gene name synonym)|uniprotkb:SCC1(gene name synonym)|uniprotkb:YDR155C(locus name)|uniprotkb:YD8358.10C(orf name)|uniprotkb:CYP1(gene name synonym)|uniprotkb:Cyclophilin(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPI-II(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:"MI:0096"(pull down) Arevalo-Rodriguez et al. (2000) pubmed:10899127|imex:IM-19825 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1782928|imex:IM-19825-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013990.1|sgd:S000004876|dip:DIP-3846N|mint:P38429|ensemblfungi:YMR263W(gene)|ensemblfungi:YMR263W_mRNA(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0033698"(Rpd3L complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:2000219"(positive regulation of invasive growth in response to glucose limitation)|interpro:IPR024145|interpro:IPR025718|interpro:IPR038291|reactome:R-SCE-3214815 refseq:NP_010439.1|sgd:S000002562|dip:DIP-5203N|mint:P14832|ensemblfungi:YDR155C(gene)|ensemblfungi:YDR155C_mRNA(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003729"(mRNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006457"(protein folding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016575"(histone deacetylation)|go:"GO:0030437"(ascospore formation)|go:"GO:0034967"(Set3 complex)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|rcsb pdb:1IST|rcsb pdb:1VDN - - crc64:012D8E8E4D85B4B7 figure legend:Fig. 5|comment:This interaction requires the presence of RPD3.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/17 2014/10/16 rogid:37Rq1e4YnQ0iYtV3Ax1RjddetpM559292 rogid:ytAesNyLcntrLis8Ts7FuX0lNkw559292 intact-crc:F90BBD7C5E946166|rigid:b/GwHp0g+FVqyaSEGO3acst6pHA false v5 tag:?-? his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P38429 uniprotkb:P22696 intact:EBI-27570|uniprotkb:Q03501|uniprotkb:D6W089|ensemblfungi:YMR263W intact:EBI-6679|uniprotkb:D6VWJ3|ensemblfungi:YJR017C psi-mi:sap30_yeast(display_long)|uniprotkb:YM8156.05(orf name)|uniprotkb:YMR263W(locus name)|uniprotkb:SAP30(gene name)|psi-mi:SAP30(display_short) psi-mi:ess1_yeast(display_long)|uniprotkb:Processing/termination factor 1(gene name synonym)|uniprotkb:ESS1(gene name)|psi-mi:ESS1(display_short)|uniprotkb:PIN1(gene name synonym)|uniprotkb:PTF1(gene name synonym)|uniprotkb:J1452(orf name)|uniprotkb:YJR017C(locus name)|uniprotkb:Parvulin ESS1(gene name synonym) psi-mi:"MI:0096"(pull down) Arevalo-Rodriguez et al. (2000) pubmed:10899127|imex:IM-19825 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1782937|imex:IM-19825-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013990.1|sgd:S000004876|dip:DIP-3846N|mint:P38429|ensemblfungi:YMR263W(gene)|ensemblfungi:YMR263W_mRNA(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0033698"(Rpd3L complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:2000219"(positive regulation of invasive growth in response to glucose limitation)|interpro:IPR024145|interpro:IPR025718|interpro:IPR038291|reactome:R-SCE-3214815 refseq:NP_012551.2|sgd:S000003778|dip:DIP-3856N|mint:P22696|ensemblfungi:YJR017C(gene)|ensemblfungi:YJR017C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000749"(positive regulation of rDNA heterochromatin assembly)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|reactome:R-SCE-5668599|reactome:R-SCE-6811555 - - crc64:18D3EC02E8395175 figure legend:Fig. 5|comment:This interaction requires the presence of SIN3 and RPD3.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/17 2014/10/16 rogid:37Rq1e4YnQ0iYtV3Ax1RjddetpM559292 rogid:B4I62u/hH9W+CPLsb0xvkSVaP/Y559292 intact-crc:ED09157B98CBDA49|rigid:aLnuScQRl989BuNZ9/5E5NVfBbc false v5 tag:?-? his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)