#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P13647	uniprotkb:P18054	intact:EBI-702187|uniprotkb:Q6PI71|uniprotkb:Q6UBJ0|uniprotkb:Q8TA91|ensembl:ENSP00000252242	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	psi-mi:k2c5_human(display_long)|uniprotkb:Cytokeratin-5(gene name synonym)|uniprotkb:58 kDa cytokeratin(gene name synonym)|uniprotkb:KRT5(gene name)|psi-mi:KRT5(display_short)|uniprotkb:Keratin-5(gene name synonym)|uniprotkb:Type-II keratin Kb5(gene name synonym)	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633236|imex:IM-18956-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000415.2|dip:DIP-39N|ensembl:ENSG00000186081(gene)|ensembl:ENST00000252242(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P13647|rcsb pdb:3TNU|rcsb pdb:6JFV|reactome:R-HSA-446107|reactome:R-HSA-6805567|reactome:R-HSA-6809371	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	-	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/05	2014/10/16	rogid:BdtVgSlWFYS/+zyXLNxvrcSWc4I9606	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	intact-crc:BED15C1BA457D907|rigid:W6ltHg8j4/q8tCem34JZ6zKpm4Y	false	sufficient binding region:260-590	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P18054	uniprotkb:P02545	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633241|imex:IM-18956-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	-	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/05	2014/10/16	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	intact-crc:56BB66C475C62908|rigid:xLSwrnDj2rxidTCtCBl8CjY4+r0	false	-	sufficient binding region:462-664	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P18054	uniprotkb:P16144	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:0018"(two hybrid)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633249|imex:IM-18956-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	comment:The range of the cytoplasmic domain of integrin beta-4 has been taken from the UniProtKB entry for the protein.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/05	2014/10/16	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	intact-crc:EB5BF9901FF5EA61|rigid:axV0tbexPgIFa2QnSk/QZPgpG2M	false	-	sufficient binding region:734-1822	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96RU8	uniprotkb:P18054	intact:EBI-492555|uniprotkb:O15180|uniprotkb:Q9H2Y8|uniprotkb:C5HU08|ensembl:ENSP00000312150|uniprotkb:B4DMM6	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	psi-mi:trib1_human(display_long)|uniprotkb:SKIP1(gene name synonym)|uniprotkb:G-protein-coupled receptor-induced gene 2 protein(gene name synonym)|uniprotkb:TRIB1(gene name)|psi-mi:TRIB1(display_short)|uniprotkb:C8FW(gene name synonym)|uniprotkb:GIG2(gene name synonym)|uniprotkb:TRB1(gene name synonym)	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633256|imex:IM-18956-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269914.1|refseq:NP_079471.1|ensembl:ENSG00000173334(gene)|ensembl:ENST00000311922(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008134"(transcription factor binding)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045645"(positive regulation of eosinophil differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0055106"(ubiquitin-protein transferase regulator activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024104|interpro:IPR024105|rcsb pdb:5CEK|rcsb pdb:5CEM|rcsb pdb:5IGO|rcsb pdb:5IGQ|rcsb pdb:6DC0|reactome:R-HSA-9031628|dip:DIP-34542N	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	-	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/05	2014/10/16	rogid:QXcwkGj6qAvJ0na1lH0tHWojias9606	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	intact-crc:B13CF25090D5D6D5|rigid:3mFbKZsaVPLOBhsJG2jgbVAa7iQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P18054	uniprotkb:P16144	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:0018"(two hybrid)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633268|imex:IM-18956-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	comment:The range of the cytoplasmic domain of integrin beta-4 has been taken from the UniProtKB entry for the protein.|figure legend:Fig. 1, Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/05	2014/10/16	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	intact-crc:14AF51E8E90B1A6A|rigid:axV0tbexPgIFa2QnSk/QZPgpG2M	false	-	sufficient binding region:734-1822	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18054	uniprotkb:P13647	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	intact:EBI-702187|uniprotkb:Q6PI71|uniprotkb:Q6UBJ0|uniprotkb:Q8TA91|ensembl:ENSP00000252242	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:k2c5_human(display_long)|uniprotkb:Cytokeratin-5(gene name synonym)|uniprotkb:58 kDa cytokeratin(gene name synonym)|uniprotkb:KRT5(gene name)|psi-mi:KRT5(display_short)|uniprotkb:Keratin-5(gene name synonym)|uniprotkb:Type-II keratin Kb5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633275|imex:IM-18956-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	refseq:NP_000415.2|dip:DIP-39N|ensembl:ENSG00000186081(gene)|ensembl:ENST00000252242(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P13647|rcsb pdb:3TNU|rcsb pdb:6JFV|reactome:R-HSA-446107|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:Fig. 1, Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/05	2014/10/16	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	rogid:BdtVgSlWFYS/+zyXLNxvrcSWc4I9606	intact-crc:BC95E89DE42D9E24|rigid:W6ltHg8j4/q8tCem34JZ6zKpm4Y	false	-	sufficient binding region:260-590	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96RU8	uniprotkb:P18054	intact:EBI-492555|uniprotkb:O15180|uniprotkb:Q9H2Y8|uniprotkb:C5HU08|ensembl:ENSP00000312150|uniprotkb:B4DMM6	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	psi-mi:trib1_human(display_long)|uniprotkb:SKIP1(gene name synonym)|uniprotkb:G-protein-coupled receptor-induced gene 2 protein(gene name synonym)|uniprotkb:TRIB1(gene name)|psi-mi:TRIB1(display_short)|uniprotkb:C8FW(gene name synonym)|uniprotkb:GIG2(gene name synonym)|uniprotkb:TRB1(gene name synonym)	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633281|imex:IM-18956-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269914.1|refseq:NP_079471.1|ensembl:ENSG00000173334(gene)|ensembl:ENST00000311922(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008134"(transcription factor binding)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045645"(positive regulation of eosinophil differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0055106"(ubiquitin-protein transferase regulator activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024104|interpro:IPR024105|rcsb pdb:5CEK|rcsb pdb:5CEM|rcsb pdb:5IGO|rcsb pdb:5IGQ|rcsb pdb:6DC0|reactome:R-HSA-9031628|dip:DIP-34542N	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	-	-	-	figure legend:Fig. 1, Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/05	2014/10/16	rogid:QXcwkGj6qAvJ0na1lH0tHWojias9606	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	intact-crc:C3D9EF8DA5DE24E8|rigid:3mFbKZsaVPLOBhsJG2jgbVAa7iQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02545	uniprotkb:P18054	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633285|imex:IM-18956-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	-	-	-	figure legend:Fig. 1, Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/02/05	2014/10/16	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	intact-crc:1AD26DA664752220|rigid:xLSwrnDj2rxidTCtCBl8CjY4+r0	false	sufficient binding region:462-664	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13647	uniprotkb:P18054	intact:EBI-702187|uniprotkb:Q6PI71|uniprotkb:Q6UBJ0|uniprotkb:Q8TA91|ensembl:ENSP00000252242	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	psi-mi:k2c5_human(display_long)|uniprotkb:Cytokeratin-5(gene name synonym)|uniprotkb:58 kDa cytokeratin(gene name synonym)|uniprotkb:KRT5(gene name)|psi-mi:KRT5(display_short)|uniprotkb:Keratin-5(gene name synonym)|uniprotkb:Type-II keratin Kb5(gene name synonym)	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633328|imex:IM-18956-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000415.2|dip:DIP-39N|ensembl:ENSG00000186081(gene)|ensembl:ENST00000252242(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P13647|rcsb pdb:3TNU|rcsb pdb:6JFV|reactome:R-HSA-446107|reactome:R-HSA-6805567|reactome:R-HSA-6809371	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	-	-	-	figure legend:2 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_431)|taxid:9606(Homo sapiens epidermoid carcinoma)	-	2008/02/05	2014/10/16	rogid:BdtVgSlWFYS/+zyXLNxvrcSWc4I9606	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	intact-crc:44B5BC84C8F329D3|rigid:W6ltHg8j4/q8tCem34JZ6zKpm4Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P18054	uniprotkb:P13647	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	intact:EBI-702187|uniprotkb:Q6PI71|uniprotkb:Q6UBJ0|uniprotkb:Q8TA91|ensembl:ENSP00000252242	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:k2c5_human(display_long)|uniprotkb:Cytokeratin-5(gene name synonym)|uniprotkb:58 kDa cytokeratin(gene name synonym)|uniprotkb:KRT5(gene name)|psi-mi:KRT5(display_short)|uniprotkb:Keratin-5(gene name synonym)|uniprotkb:Type-II keratin Kb5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633335|imex:IM-18956-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	refseq:NP_000415.2|dip:DIP-39N|ensembl:ENSG00000186081(gene)|ensembl:ENST00000252242(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P13647|rcsb pdb:3TNU|rcsb pdb:6JFV|reactome:R-HSA-446107|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:2 B|delivery method:P18054 tansfection|expression level:P18054 over-expression|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_431)|taxid:9606(Homo sapiens epidermoid carcinoma)	-	2008/02/05	2014/10/16	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	rogid:BdtVgSlWFYS/+zyXLNxvrcSWc4I9606	intact-crc:0E22326E617B1CD1|rigid:W6ltHg8j4/q8tCem34JZ6zKpm4Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13647	uniprotkb:P18054	intact:EBI-702187|uniprotkb:Q6PI71|uniprotkb:Q6UBJ0|uniprotkb:Q8TA91|ensembl:ENSP00000252242	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	psi-mi:k2c5_human(display_long)|uniprotkb:Cytokeratin-5(gene name synonym)|uniprotkb:58 kDa cytokeratin(gene name synonym)|uniprotkb:KRT5(gene name)|psi-mi:KRT5(display_short)|uniprotkb:Keratin-5(gene name synonym)|uniprotkb:Type-II keratin Kb5(gene name synonym)	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633342|imex:IM-18956-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000415.2|dip:DIP-39N|ensembl:ENSG00000186081(gene)|ensembl:ENST00000252242(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P13647|rcsb pdb:3TNU|rcsb pdb:6JFV|reactome:R-HSA-446107|reactome:R-HSA-6805567|reactome:R-HSA-6809371	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	-	-	-	figure legend:2 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_431)|taxid:9606(Homo sapiens epidermoid carcinoma)	-	2008/02/05	2014/10/16	rogid:BdtVgSlWFYS/+zyXLNxvrcSWc4I9606	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	intact-crc:152854BD04A5D021|rigid:W6ltHg8j4/q8tCem34JZ6zKpm4Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13647	uniprotkb:P18054	intact:EBI-702187|uniprotkb:Q6PI71|uniprotkb:Q6UBJ0|uniprotkb:Q8TA91|ensembl:ENSP00000252242	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	psi-mi:k2c5_human(display_long)|uniprotkb:Cytokeratin-5(gene name synonym)|uniprotkb:58 kDa cytokeratin(gene name synonym)|uniprotkb:KRT5(gene name)|psi-mi:KRT5(display_short)|uniprotkb:Keratin-5(gene name synonym)|uniprotkb:Type-II keratin Kb5(gene name synonym)	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633349|imex:IM-18956-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000415.2|dip:DIP-39N|ensembl:ENSG00000186081(gene)|ensembl:ENST00000252242(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P13647|rcsb pdb:3TNU|rcsb pdb:6JFV|reactome:R-HSA-446107|reactome:R-HSA-6805567|reactome:R-HSA-6809371	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	-	-	-	figure legend:2 B|delivery method:P18054 tansfection|expression level:P18054 over-expression|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_431)|taxid:9606(Homo sapiens epidermoid carcinoma)	-	2008/02/05	2014/10/16	rogid:BdtVgSlWFYS/+zyXLNxvrcSWc4I9606	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	intact-crc:B5C800028CDB827E|rigid:W6ltHg8j4/q8tCem34JZ6zKpm4Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02545	uniprotkb:P18054	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633356|imex:IM-18956-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	go:"GO:0005634"(nucleus)	-	-	figure legend:4|comment:This interaction was observed in nuclear extracts and not cytoplasmic extracts.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_431)|taxid:9606(Homo sapiens epidermoid carcinoma)	-	2008/02/05	2014/10/16	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	intact-crc:9143A00B4EA8DCE0|rigid:xLSwrnDj2rxidTCtCBl8CjY4+r0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P18054	uniprotkb:P02545	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633361|imex:IM-18956-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	go:"GO:0005634"(nucleus)	-	-	figure legend:4|comment:This interaction was observed in nuclear extracts and not cytoplasmic extracts.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_431)|taxid:9606(Homo sapiens epidermoid carcinoma)	-	2008/02/05	2014/10/16	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	intact-crc:39B575D24A5ED180|rigid:xLSwrnDj2rxidTCtCBl8CjY4+r0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P18054	uniprotkb:P13647	intact:EBI-1633210|uniprotkb:O95569|uniprotkb:Q6ISF8|uniprotkb:Q9UQM4|ensembl:ENSP00000251535	intact:EBI-702187|uniprotkb:Q6PI71|uniprotkb:Q6UBJ0|uniprotkb:Q8TA91|ensembl:ENSP00000252242	psi-mi:lox12_human(display_long)|uniprotkb:"Arachidonate (12S)-lipoxygenase"(gene name synonym)|uniprotkb:"Arachidonate (15S)-lipoxygenase"(gene name synonym)|uniprotkb:"Linoleate (13S)-lipoxygenase"(gene name synonym)|uniprotkb:ALOX12(gene name)|psi-mi:ALOX12(display_short)|uniprotkb:LOG12(gene name synonym)|uniprotkb:Platelet-type lipoxygenase 12(gene name synonym)|uniprotkb:12LO(gene name synonym)|uniprotkb:Lipoxin synthase 12-LO(gene name synonym)	psi-mi:k2c5_human(display_long)|uniprotkb:Cytokeratin-5(gene name synonym)|uniprotkb:58 kDa cytokeratin(gene name synonym)|uniprotkb:KRT5(gene name)|psi-mi:KRT5(display_short)|uniprotkb:Keratin-5(gene name synonym)|uniprotkb:Type-II keratin Kb5(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Tang et al. (2000)	pubmed:10727209|imex:IM-18956	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633378|imex:IM-18956-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000688.2|ensembl:ENSG00000108839(gene)|ensembl:ENST00000251535(transcript)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016165"(linoleate 13S-lipoxygenase activity)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033559"(unsaturated fatty acid metabolic process)|go:"GO:0034440"(lipid oxidation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0047977"(hepoxilin-epoxide hydrolase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050473"(arachidonate 15-lipoxygenase activity)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901751"(leukotriene A4 metabolic process)|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|go:"GO:2001303"(lipoxin A4 biosynthetic process)|go:"GO:2001306"(lipoxin B4 biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABU|rcsb pdb:3D3L|reactome:R-HSA-2142696|reactome:R-HSA-2142700|reactome:R-HSA-2142712|reactome:R-HSA-9018677|reactome:R-HSA-9025106|reactome:R-HSA-9026290	refseq:NP_000415.2|dip:DIP-39N|ensembl:ENSG00000186081(gene)|ensembl:ENST00000252242(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P13647|rcsb pdb:3TNU|rcsb pdb:6JFV|reactome:R-HSA-446107|reactome:R-HSA-6805567|reactome:R-HSA-6809371	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:3|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_431)|taxid:9606(Homo sapiens epidermoid carcinoma)	-	2008/02/05	2014/10/16	rogid:8rflal3gFNTu9CHevTRRmen+r2Y9606	rogid:BdtVgSlWFYS/+zyXLNxvrcSWc4I9606	intact-crc:4D916403B659DFCD|rigid:W6ltHg8j4/q8tCem34JZ6zKpm4Y	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)