#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13507	uniprotkb:Q14573	intact:EBI-520807|uniprotkb:O00593|uniprotkb:Q15660|uniprotkb:Q52M35|uniprotkb:A7VJS1|uniprotkb:E9PCJ9|uniprotkb:Q5G1L5	intact:EBI-351055|uniprotkb:Q14649|uniprotkb:Q5TAQ2|intact:EBI-28978202|ensembl:ENSP00000363435|ensembl:ENSP00000475177	psi-mi:trpc3_human(display_long)|uniprotkb:Transient receptor protein 3(gene name synonym)|uniprotkb:TRPC3(gene name)|psi-mi:TRPC3(display_short)|uniprotkb:TRP3(gene name synonym)	psi-mi:itpr3_human(display_long)|uniprotkb:ITPR3(gene name)|psi-mi:ITPR3(display_short)|uniprotkb:Type 3 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Boulay et al. (1999)	pubmed:10611319|imex:IM-19580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2105622|imex:IM-19580-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001124170.1|refseq:NP_003296.1|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-3295583|reactome:R-HSA-418890|dip:DIP-34311N|reactome:R-HSA-9022699|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007338"(single fertilization)|go:"GO:0007602"(phototransduction)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0033198"(response to ATP)|go:"GO:0034703"(cation channel complex)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005459(Transient receptor potential channel 3)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:5ZBG|rcsb pdb:6CUD|rcsb pdb:6D7L|rcsb pdb:6DJS	refseq:NP_002215.2|ensembl:ENSP00000363435|ensembl:ENSP00000475177|ensembl:ENSG00000096433(gene)|ensembl:ENST00000374316(transcript)|ensembl:ENST00000605930(transcript)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050913"(sensory perception of bitter taste)|go:"GO:0050916"(sensory perception of sweet taste)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:Q14573|rcsb pdb:6DQJ|rcsb pdb:6DQN|rcsb pdb:6DQS|rcsb pdb:6DQV|rcsb pdb:6DQZ|rcsb pdb:6DR0|rcsb pdb:6DR2|rcsb pdb:6DRA|rcsb pdb:6DRC|rcsb pdb:6UQK|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|go:"GO:0007613"(memory)|reactome:R-HSA-983695	-	-	-	figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/11/10	2014/10/16	rogid:+cpkw8G+u8CX1vRaeVynSg3owOk9606	rogid:O+1OC4E0IrAOt+D672eXnhWHy3I9606	intact-crc:5805A2FFC09DAC2D|rigid:xolbgQuouTy4vO6+OJtg/XvLRQ0	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y210	uniprotkb:Q14573	intact:EBI-929362|uniprotkb:Q52M59|uniprotkb:Q9HCW3|uniprotkb:Q9NQA8|uniprotkb:Q9NQA9|ensembl:ENSP00000340913	intact:EBI-351055|uniprotkb:Q14649|uniprotkb:Q5TAQ2|intact:EBI-28978202|ensembl:ENSP00000363435|ensembl:ENSP00000475177	psi-mi:trpc6_human(display_long)|uniprotkb:TRPC6(gene name)|psi-mi:TRPC6(display_short)|uniprotkb:TRP6(gene name synonym)|uniprotkb:Transient receptor protein 6(gene name synonym)	psi-mi:itpr3_human(display_long)|uniprotkb:ITPR3(gene name)|psi-mi:ITPR3(display_short)|uniprotkb:Type 3 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Boulay et al. (1999)	pubmed:10611319|imex:IM-19580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2105629|imex:IM-19580-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004612.2|refseq:XP_016873710.1|ensembl:ENSG00000137672(gene)|ensembl:ENST00000344327(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007338"(single fertilization)|go:"GO:0007568"(aging)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005462(Transient receptor potential channel 6)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:5YX9|rcsb pdb:6UZ8|rcsb pdb:6UZA|rcsb pdb:7A6U|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-3295583|reactome:R-HSA-418890	refseq:NP_002215.2|ensembl:ENSP00000363435|ensembl:ENSP00000475177|ensembl:ENSG00000096433(gene)|ensembl:ENST00000374316(transcript)|ensembl:ENST00000605930(transcript)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050913"(sensory perception of bitter taste)|go:"GO:0050916"(sensory perception of sweet taste)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:Q14573|rcsb pdb:6DQJ|rcsb pdb:6DQN|rcsb pdb:6DQS|rcsb pdb:6DQV|rcsb pdb:6DQZ|rcsb pdb:6DR0|rcsb pdb:6DR2|rcsb pdb:6DRA|rcsb pdb:6DRC|rcsb pdb:6UQK|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|go:"GO:0007613"(memory)|reactome:R-HSA-983695	-	-	-	figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/11/10	2014/10/16	rogid:RZFIj3atDkAg0EqcBqAHSOo7Cns9606	rogid:O+1OC4E0IrAOt+D672eXnhWHy3I9606	intact-crc:56ACB5BE461B67FF|rigid:v1j9FH5DLjXwTKHTwz8dw5Ia1Gk	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14573	uniprotkb:Q13507	intact:EBI-351055|uniprotkb:Q14649|uniprotkb:Q5TAQ2|intact:EBI-28978202|ensembl:ENSP00000363435|ensembl:ENSP00000475177	intact:EBI-520807|uniprotkb:O00593|uniprotkb:Q15660|uniprotkb:Q52M35|uniprotkb:A7VJS1|uniprotkb:E9PCJ9|uniprotkb:Q5G1L5	psi-mi:itpr3_human(display_long)|uniprotkb:ITPR3(gene name)|psi-mi:ITPR3(display_short)|uniprotkb:Type 3 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 3(gene name synonym)	psi-mi:trpc3_human(display_long)|uniprotkb:Transient receptor protein 3(gene name synonym)|uniprotkb:TRPC3(gene name)|psi-mi:TRPC3(display_short)|uniprotkb:TRP3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boulay et al. (1999)	pubmed:10611319|imex:IM-19580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2105638|imex:IM-19580-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002215.2|ensembl:ENSP00000363435|ensembl:ENSP00000475177|ensembl:ENSG00000096433(gene)|ensembl:ENST00000374316(transcript)|ensembl:ENST00000605930(transcript)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050913"(sensory perception of bitter taste)|go:"GO:0050916"(sensory perception of sweet taste)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:Q14573|rcsb pdb:6DQJ|rcsb pdb:6DQN|rcsb pdb:6DQS|rcsb pdb:6DQV|rcsb pdb:6DQZ|rcsb pdb:6DR0|rcsb pdb:6DR2|rcsb pdb:6DRA|rcsb pdb:6DRC|rcsb pdb:6UQK|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|go:"GO:0007613"(memory)|reactome:R-HSA-983695	refseq:NP_001124170.1|refseq:NP_003296.1|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-3295583|reactome:R-HSA-418890|dip:DIP-34311N|reactome:R-HSA-9022699|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007338"(single fertilization)|go:"GO:0007602"(phototransduction)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0033198"(response to ATP)|go:"GO:0034703"(cation channel complex)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005459(Transient receptor potential channel 3)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:5ZBG|rcsb pdb:6CUD|rcsb pdb:6D7L|rcsb pdb:6DJS	-	-	-	figure legend:1|stimulant:Deglycosylation with PNGase increased the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/11/10	2014/10/16	rogid:O+1OC4E0IrAOt+D672eXnhWHy3I9606	rogid:+cpkw8G+u8CX1vRaeVynSg3owOk9606	intact-crc:3F135CE793398755|rigid:xolbgQuouTy4vO6+OJtg/XvLRQ0	false	-	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13507	uniprotkb:Q14573	intact:EBI-520807|uniprotkb:O00593|uniprotkb:Q15660|uniprotkb:Q52M35|uniprotkb:A7VJS1|uniprotkb:E9PCJ9|uniprotkb:Q5G1L5	intact:EBI-351055|uniprotkb:Q14649|uniprotkb:Q5TAQ2|intact:EBI-28978202|ensembl:ENSP00000363435|ensembl:ENSP00000475177	psi-mi:trpc3_human(display_long)|uniprotkb:Transient receptor protein 3(gene name synonym)|uniprotkb:TRPC3(gene name)|psi-mi:TRPC3(display_short)|uniprotkb:TRP3(gene name synonym)	psi-mi:itpr3_human(display_long)|uniprotkb:ITPR3(gene name)|psi-mi:ITPR3(display_short)|uniprotkb:Type 3 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boulay et al. (1999)	pubmed:10611319|imex:IM-19580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2105665|imex:IM-19580-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001124170.1|refseq:NP_003296.1|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-3295583|reactome:R-HSA-418890|dip:DIP-34311N|reactome:R-HSA-9022699|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007338"(single fertilization)|go:"GO:0007602"(phototransduction)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0033198"(response to ATP)|go:"GO:0034703"(cation channel complex)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005459(Transient receptor potential channel 3)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:5ZBG|rcsb pdb:6CUD|rcsb pdb:6D7L|rcsb pdb:6DJS	refseq:NP_002215.2|ensembl:ENSP00000363435|ensembl:ENSP00000475177|ensembl:ENSG00000096433(gene)|ensembl:ENST00000374316(transcript)|ensembl:ENST00000605930(transcript)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050913"(sensory perception of bitter taste)|go:"GO:0050916"(sensory perception of sweet taste)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:Q14573|rcsb pdb:6DQJ|rcsb pdb:6DQN|rcsb pdb:6DQS|rcsb pdb:6DQV|rcsb pdb:6DQZ|rcsb pdb:6DR0|rcsb pdb:6DR2|rcsb pdb:6DRA|rcsb pdb:6DRC|rcsb pdb:6UQK|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|go:"GO:0007613"(memory)|reactome:R-HSA-983695	-	-	-	figure legend:2, 5|comment:"Mutant C7 fragment of TRP3 showed decreased activity when interacting with the c terminal of ITPR3 (638-1133)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/10	2014/10/16	rogid:+cpkw8G+u8CX1vRaeVynSg3owOk9606	rogid:O+1OC4E0IrAOt+D672eXnhWHy3I9606	intact-crc:0E5D94734DCF9A7C|rigid:xolbgQuouTy4vO6+OJtg/XvLRQ0	false	glutathione s tranferase tag:c-c|sufficient binding region:730-783	35s radiolabel:?-?|sufficient binding region:638-927	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q13507	uniprotkb:Q14573	intact:EBI-520807|uniprotkb:O00593|uniprotkb:Q15660|uniprotkb:Q52M35|uniprotkb:A7VJS1|uniprotkb:E9PCJ9|uniprotkb:Q5G1L5	intact:EBI-351055|uniprotkb:Q14649|uniprotkb:Q5TAQ2|intact:EBI-28978202|ensembl:ENSP00000363435|ensembl:ENSP00000475177	psi-mi:trpc3_human(display_long)|uniprotkb:Transient receptor protein 3(gene name synonym)|uniprotkb:TRPC3(gene name)|psi-mi:TRPC3(display_short)|uniprotkb:TRP3(gene name synonym)	psi-mi:itpr3_human(display_long)|uniprotkb:ITPR3(gene name)|psi-mi:ITPR3(display_short)|uniprotkb:Type 3 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boulay et al. (1999)	pubmed:10611319|imex:IM-19580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2266199|imex:IM-19580-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001124170.1|refseq:NP_003296.1|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-3295583|reactome:R-HSA-418890|dip:DIP-34311N|reactome:R-HSA-9022699|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007338"(single fertilization)|go:"GO:0007602"(phototransduction)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0033198"(response to ATP)|go:"GO:0034703"(cation channel complex)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005459(Transient receptor potential channel 3)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:5ZBG|rcsb pdb:6CUD|rcsb pdb:6D7L|rcsb pdb:6DJS	refseq:NP_002215.2|ensembl:ENSP00000363435|ensembl:ENSP00000475177|ensembl:ENSG00000096433(gene)|ensembl:ENST00000374316(transcript)|ensembl:ENST00000605930(transcript)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050913"(sensory perception of bitter taste)|go:"GO:0050916"(sensory perception of sweet taste)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:Q14573|rcsb pdb:6DQJ|rcsb pdb:6DQN|rcsb pdb:6DQS|rcsb pdb:6DQV|rcsb pdb:6DQZ|rcsb pdb:6DR0|rcsb pdb:6DR2|rcsb pdb:6DRA|rcsb pdb:6DRC|rcsb pdb:6UQK|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|go:"GO:0007613"(memory)|reactome:R-HSA-983695	-	-	-	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/10	2014/10/16	rogid:+cpkw8G+u8CX1vRaeVynSg3owOk9606	rogid:O+1OC4E0IrAOt+D672eXnhWHy3I9606	intact-crc:1EBC1D48811273E6|rigid:xolbgQuouTy4vO6+OJtg/XvLRQ0	false	sufficient binding region:664-836|35s radiolabel:?-?|sufficient binding region:730-785|sufficient binding region:664-836	glutathione s tranferase tag:?-?|sufficient binding region:638-710|necessary binding region:687-710|sufficient binding region:669-698	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q13507	uniprotkb:Q14573	intact:EBI-520807|uniprotkb:O00593|uniprotkb:Q15660|uniprotkb:Q52M35|uniprotkb:A7VJS1|uniprotkb:E9PCJ9|uniprotkb:Q5G1L5	intact:EBI-351055|uniprotkb:Q14649|uniprotkb:Q5TAQ2|intact:EBI-28978202|ensembl:ENSP00000363435|ensembl:ENSP00000475177	psi-mi:trpc3_human(display_long)|uniprotkb:Transient receptor protein 3(gene name synonym)|uniprotkb:TRPC3(gene name)|psi-mi:TRPC3(display_short)|uniprotkb:TRP3(gene name synonym)	psi-mi:itpr3_human(display_long)|uniprotkb:ITPR3(gene name)|psi-mi:ITPR3(display_short)|uniprotkb:Type 3 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boulay et al. (1999)	pubmed:10611319|imex:IM-19580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2266291|imex:IM-19580-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001124170.1|refseq:NP_003296.1|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-3295583|reactome:R-HSA-418890|dip:DIP-34311N|reactome:R-HSA-9022699|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007338"(single fertilization)|go:"GO:0007602"(phototransduction)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0033198"(response to ATP)|go:"GO:0034703"(cation channel complex)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005459(Transient receptor potential channel 3)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:5ZBG|rcsb pdb:6CUD|rcsb pdb:6D7L|rcsb pdb:6DJS	refseq:NP_002215.2|ensembl:ENSP00000363435|ensembl:ENSP00000475177|ensembl:ENSG00000096433(gene)|ensembl:ENST00000374316(transcript)|ensembl:ENST00000605930(transcript)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050913"(sensory perception of bitter taste)|go:"GO:0050916"(sensory perception of sweet taste)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:Q14573|rcsb pdb:6DQJ|rcsb pdb:6DQN|rcsb pdb:6DQS|rcsb pdb:6DQV|rcsb pdb:6DQZ|rcsb pdb:6DR0|rcsb pdb:6DR2|rcsb pdb:6DRA|rcsb pdb:6DRC|rcsb pdb:6UQK|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|go:"GO:0007613"(memory)|reactome:R-HSA-983695	-	-	-	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/10	2014/10/16	rogid:+cpkw8G+u8CX1vRaeVynSg3owOk9606	rogid:O+1OC4E0IrAOt+D672eXnhWHy3I9606	intact-crc:04AFF8F43070ABA7|rigid:xolbgQuouTy4vO6+OJtg/XvLRQ0	false	35s radiolabel:?-?|sufficient binding region:739-809	sufficient binding region:742-797|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)