#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WQG9	uniprotkb:P05412	intact:EBI-321822|uniprotkb:Q17507|uniprotkb:Q9UAH2|ensemblmetazoa:B0478.1a.1	intact:EBI-852823|uniprotkb:Q96G93|uniprotkb:Q6FHM7|ensembl:ENSP00000360266|ensembl:ENSP00000503132	psi-mi:jnk1_caeel(display_long)|uniprotkb:jnk-1(gene name)|psi-mi:jnk-1(display_short)|uniprotkb:B0478.1(orf name)	psi-mi:jun_human(display_long)|uniprotkb:JUN(gene name)|psi-mi:JUN(display_short)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:p39(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Kawasaki et al. (1999)	pubmed:10393177|imex:IM-19830	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1812101|imex:IM-19830-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021270.1|refseq:NP_741434.2|wormbase:B0478.1a|wormbase:B0478.1b|ensemblmetazoa:B0478.1a.1(transcript)|ensemblmetazoa:WBGene00002178(gene)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009408"(response to heat)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030424"(axon)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-CEL-193648|reactome:R-CEL-2559580|reactome:R-CEL-2871796|reactome:R-CEL-450321|dip:DIP-26951N|reactome:R-CEL-9007892|reactome:R-CEL-450341|reactome:R-CEL-5693565|reactome:R-CEL-376172	refseq:NP_002219.1|ensembl:ENSP00000360266|ensembl:ENSP00000503132|dip:DIP-5961N|ensembl:ENSG00000177606(gene)|ensembl:ENST00000371222(transcript)|ensembl:ENST00000678696(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P05412|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1JNM|rcsb pdb:1JUN|rcsb pdb:1S9K|rcsb pdb:1T2K|rcsb pdb:5FV8|rcsb pdb:5T01|rcsb pdb:6Y3V|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-5617472|reactome:R-HSA-5687128|reactome:R-HSA-6796648|reactome:R-HSA-8862803|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9673324	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 4A|stimulant:Phosphorylation of JUN by jnk-1 requires prior activation of jnk-1 by jkk-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/15	2014/10/16	rogid:qEMqBNLEYxdnt/w+TUTpI3JV4qU6239	rogid:zAVYwedHKKdvPPGttBP4XZkbCXA9606	intact-crc:E5645E3C86379D0E|rigid:+yfHDrva2YjfXH5dGMb5e4dAwTM	false	ha tag:n-n|mutation disrupting interaction:148-148	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15336	uniprotkb:Q17446	intact:EBI-1170906|uniprotkb:Q13000|uniprotkb:Q4ZFU9|uniprotkb:Q53RY2|uniprotkb:A1L3Z2|uniprotkb:D3DPE9|uniprotkb:Q8TAR1|uniprotkb:A4D7U4|uniprotkb:G8JLM5|uniprotkb:Q3B7B7|uniprotkb:A4D7U5|uniprotkb:A4D7V1|uniprotkb:Q96JT8|intact:EBI-28988937|ensembl:ENSP00000264110|ensembl:ENSP00000376327	intact:EBI-312987|ensemblmetazoa:B0218.3.1	psi-mi:atf2_human(display_long)|uniprotkb:ATF2(gene name)|psi-mi:ATF2(display_short)|uniprotkb:CREB2(gene name synonym)|uniprotkb:CREBP1(gene name synonym)|uniprotkb:Activating transcription factor 2(gene name synonym)|uniprotkb:cAMP response element-binding protein CRE-BP1(gene name synonym)|uniprotkb:HB16(gene name synonym)|uniprotkb:Cyclic AMP-responsive element-binding protein 2(gene name synonym)	psi-mi:pmk1_caeel(display_long)|uniprotkb:pmk-1(gene name)|psi-mi:pmk-1(display_short)|uniprotkb:B0218.3(orf name)|uniprotkb:p38 MAP kinase 1(gene name synonym)|uniprotkb:Stress-activated protein kinase pmk-1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Kawasaki et al. (1999)	pubmed:10393177|imex:IM-19830	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1812134|imex:IM-19830-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243019.1|refseq:NP_001243020.1|refseq:NP_001871.2|refseq:NP_001243023.1|ensembl:ENST00000345739|ensembl:ENSP00000340576|ensembl:ENSP00000376327|ensembl:ENST00000409499|ensembl:ENSP00000386282|ensembl:ENST00000409635|ensembl:ENSP00000387093|ensembl:ENST00000409833|ensembl:ENSP00000386526|ensembl:ENST00000426833|ensembl:ENSP00000407911|ensembl:ENSP00000264110|refseq:NP_001243021.1|refseq:NP_001243022.1|ensembl:ENSG00000115966(gene)|ensembl:ENST00000264110(transcript)|ensembl:ENST00000392544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0009414"(response to water deprivation)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0110024"(positive regulation of cardiac muscle myoblast proliferation)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902562"(H4 histone acetyltransferase complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR016378(Transcription factor, cyclic AMP-dependent)|interpro:IPR029836|interpro:IPR036236|mint:P15336|rcsb pdb:1BHI|rcsb pdb:1T2K|rcsb pdb:4H36|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|rcsb pdb:6ZQS|rcsb pdb:6ZR5|reactome:R-HSA-2151201|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-450341|reactome:R-HSA-6796648|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9633012|reactome:R-HSA-9707616|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043969"(histone H2B acetylation)|go:"GO:0044013"(H2B histone acetyltransferase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060612"(adipose tissue development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097186"(amelogenesis)|dip:DIP-632N	refseq:NP_501365.1|wormbase:B0218.3|ensemblmetazoa:B0218.3.1(transcript)|ensemblmetazoa:WBGene00004055(gene)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000303"(response to superoxide)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012501"(programmed cell death)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:0093002"(response to nematicide)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902097"(positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-CEL-432142|dip:DIP-26892N|reactome:R-CEL-168638|reactome:R-CEL-171007|reactome:R-CEL-2559580|reactome:R-CEL-418592|reactome:R-CEL-4420097|reactome:R-CEL-450302|reactome:R-CEL-6798695|reactome:R-CEL-525793|reactome:R-CEL-198753|reactome:R-CEL-376172|reactome:R-CEL-450341|reactome:R-CEL-5675221	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/15	2014/10/16	rogid:9krWq+A9Y3xvkInqyJnJs1g9tfc9606	rogid:jxwufzDXxogpS+/Y2TN23iQefqw6239	intact-crc:A02E1EBE5913FFF3|rigid:eZo45K4iRgVZBQyf8bnTowjj+TE	false	glutathione s tranferase tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45983	uniprotkb:P05412	intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304	intact:EBI-852823|uniprotkb:Q96G93|uniprotkb:Q6FHM7|ensembl:ENSP00000360266|ensembl:ENSP00000503132	psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym)	psi-mi:jun_human(display_long)|uniprotkb:JUN(gene name)|psi-mi:JUN(display_short)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:p39(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Kawasaki et al. (1999)	pubmed:10393177|imex:IM-19830	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1812150|imex:IM-19830-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324	refseq:NP_002219.1|ensembl:ENSP00000360266|ensembl:ENSP00000503132|dip:DIP-5961N|ensembl:ENSG00000177606(gene)|ensembl:ENST00000371222(transcript)|ensembl:ENST00000678696(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P05412|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1JNM|rcsb pdb:1JUN|rcsb pdb:1S9K|rcsb pdb:1T2K|rcsb pdb:5FV8|rcsb pdb:5T01|rcsb pdb:6Y3V|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-5617472|reactome:R-HSA-5687128|reactome:R-HSA-6796648|reactome:R-HSA-8862803|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9673324	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 4B|stimulant:Phosphorylation of JUN by MAPK8 requires prior activation of MAPK8 by jkk-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/15	2014/10/16	rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606	rogid:zAVYwedHKKdvPPGttBP4XZkbCXA9606	intact-crc:12B1C0D5EED82F33|rigid:rBkGqYt34+wpZHfgVCgJkPnh7gw	false	ha tag:n-n	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)