#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04015	uniprotkb:P04014	intact:EBI-7010556|intact:MINT-95651	intact:EBI-7014446|intact:MINT-95113	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ve1_hpv11(display_long)|uniprotkb:E1(gene name)|psi-mi:E1(display_short)|uniprotkb:ATP-dependent helicase E1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Titolo et al. (1999)	pubmed:10364274|mint:MINT-6623984	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7014465|mint:MINT-6628348	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-6628351(identity)|uniprotkb:P04015(P04015)	mint:P04014|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0034214"(protein hexamerization)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001177(DNA helicase E1 protein, C-terminal, Papillomavirus)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR016393(Replication protein E1, papillomavirus)|interpro:IPR027417|interpro:IPR014000(DNA helicase E1 protein, N-terminal, Papillomavirus)|mint:MINT-6628349(identity)|uniprotkb:P04014(P04014)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	comment:mint|function:ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins	figure legend:F5 F7|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2014/10/16	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:Xg3fdEVHcqOpmqe7MPf9EXciD3s10580	intact-crc:95D6CCD283B01F76|rigid:IILAk5yRi6yqzv5kVcDSyEVOkso	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:P04014	intact:EBI-7010556|intact:MINT-95651	intact:EBI-7014446|intact:MINT-95113	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ve1_hpv11(display_long)|uniprotkb:E1(gene name)|psi-mi:E1(display_short)|uniprotkb:ATP-dependent helicase E1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Titolo et al. (1999)	pubmed:10364274|mint:MINT-6623984	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7014478|mint:MINT-8195117	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-8195121(identity)|uniprotkb:P04015(P04015)	mint:P04014|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0034214"(protein hexamerization)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001177(DNA helicase E1 protein, C-terminal, Papillomavirus)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR016393(Replication protein E1, papillomavirus)|interpro:IPR027417|interpro:IPR014000(DNA helicase E1 protein, N-terminal, Papillomavirus)|mint:MINT-8195119(identity)|uniprotkb:P04014(P04014)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	comment:mint|function:ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2014/10/16	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:Xg3fdEVHcqOpmqe7MPf9EXciD3s10580	intact-crc:582FD40651351E6A|rigid:IILAk5yRi6yqzv5kVcDSyEVOkso	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)