#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O35973	uniprotkb:Q9R1X4	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	intact:EBI-1793117|uniprotkb:Q63ZX9|uniprotkb:Q6P204|uniprotkb:Q6PDL4|uniprotkb:Q7TPV8|uniprotkb:Q8R0Q2|uniprotkb:Q9R268|uniprotkb:Q9Z0E7|ensembl:ENSMUSP00000058021|ensembl:ENSMUSP00000100879	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:tim_mouse(display_long)|uniprotkb:Timeless(gene name)|psi-mi:Timeless(display_short)|uniprotkb:Tim1(gene name synonym)|uniprotkb:Timeless1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Takumi et al. (1999)	pubmed:10231394|imex:IM-19198	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1793174|imex:IM-19198-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	refseq:NP_035719.1|refseq:NP_001129554.1|refseq:NP_001157552.1|refseq:NP_001157553.1|ensembl:ENSMUSG00000039994|refseq:XP_006513646.1|ensembl:ENSMUSG00000039994(gene)|ensembl:ENSMUST00000055539(transcript)|ensembl:ENSMUST00000105245(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0030324"(lung development)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048478"(replication fork protection)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072719"(cellular response to cisplatin)|go:"GO:1904976"(cellular response to bleomycin)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR006906(Timeless protein)|interpro:IPR007725(Timeless C-terminal)|reactome:R-MMU-5693607	-	-	-	figure legend:4A|caution:"Note the Figure indicates that the mTIM protein is 1196 amino acids in length whereas the sequence provided for this protein (and UniProt record) indicate it is 1197 amino acids in length."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/07/16	2014/10/16	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rogid:rNPQ3ekXr3/qwyvIxvN1HEKnwa410090	intact-crc:CDF73C545349787A|rigid:Qm4sraIFNp/cNo3v8P8K9zxRCJw	false	glutathione s tranferase tag:?-?|sufficient binding region:135-638	35s radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9R1X4	uniprotkb:O35973	intact:EBI-1793117|uniprotkb:Q63ZX9|uniprotkb:Q6P204|uniprotkb:Q6PDL4|uniprotkb:Q7TPV8|uniprotkb:Q8R0Q2|uniprotkb:Q9R268|uniprotkb:Q9Z0E7|ensembl:ENSMUSP00000058021|ensembl:ENSMUSP00000100879	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	psi-mi:tim_mouse(display_long)|uniprotkb:Timeless(gene name)|psi-mi:Timeless(display_short)|uniprotkb:Tim1(gene name synonym)|uniprotkb:Timeless1(gene name synonym)	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takumi et al. (1999)	pubmed:10231394|imex:IM-19198	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1793211|imex:IM-19198-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035719.1|refseq:NP_001129554.1|refseq:NP_001157552.1|refseq:NP_001157553.1|ensembl:ENSMUSG00000039994|refseq:XP_006513646.1|ensembl:ENSMUSG00000039994(gene)|ensembl:ENSMUST00000055539(transcript)|ensembl:ENSMUST00000105245(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0030324"(lung development)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048478"(replication fork protection)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072719"(cellular response to cisplatin)|go:"GO:1904976"(cellular response to bleomycin)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR006906(Timeless protein)|interpro:IPR007725(Timeless C-terminal)|reactome:R-MMU-5693607	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	-	-	-	figure legend:4B|sample process:FLAG-TIM and HA-PER1 tansfected|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/07/16	2014/10/16	rogid:rNPQ3ekXr3/qwyvIxvN1HEKnwa410090	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	intact-crc:04DF2432FD95D84C|rigid:Qm4sraIFNp/cNo3v8P8K9zxRCJw	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35973	uniprotkb:Q9R1X4	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	intact:EBI-1793117|uniprotkb:Q63ZX9|uniprotkb:Q6P204|uniprotkb:Q6PDL4|uniprotkb:Q7TPV8|uniprotkb:Q8R0Q2|uniprotkb:Q9R268|uniprotkb:Q9Z0E7|ensembl:ENSMUSP00000058021|ensembl:ENSMUSP00000100879	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:tim_mouse(display_long)|uniprotkb:Timeless(gene name)|psi-mi:Timeless(display_short)|uniprotkb:Tim1(gene name synonym)|uniprotkb:Timeless1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takumi et al. (1999)	pubmed:10231394|imex:IM-19198	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1793222|imex:IM-19198-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	refseq:NP_035719.1|refseq:NP_001129554.1|refseq:NP_001157552.1|refseq:NP_001157553.1|ensembl:ENSMUSG00000039994|refseq:XP_006513646.1|ensembl:ENSMUSG00000039994(gene)|ensembl:ENSMUST00000055539(transcript)|ensembl:ENSMUST00000105245(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0030324"(lung development)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048478"(replication fork protection)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072719"(cellular response to cisplatin)|go:"GO:1904976"(cellular response to bleomycin)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR006906(Timeless protein)|interpro:IPR007725(Timeless C-terminal)|reactome:R-MMU-5693607	-	-	-	figure legend:4B|sample process:FLAG-TIM and HA-PER1 tansfected|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/07/16	2014/10/16	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rogid:rNPQ3ekXr3/qwyvIxvN1HEKnwa410090	intact-crc:F1B7ABADDC259FBB|rigid:Qm4sraIFNp/cNo3v8P8K9zxRCJw	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)