#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01588	uniprotkb:P19235	intact:EBI-1027362|uniprotkb:Q2M2L6|uniprotkb:Q549U2|uniprotkb:Q9UDZ0|uniprotkb:Q9UEZ5|uniprotkb:Q9UHA0|ensembl:ENSP00000252723	intact:EBI-617321|uniprotkb:Q15443|uniprotkb:Q2M205|uniprotkb:B2RCG4|ensembl:ENSP00000222139	psi-mi:epo_human(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:epor_human(display_long)|uniprotkb:EPOR(gene name)|psi-mi:EPOR(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Syed et al. (1998)	pubmed:9774108|imex:IM-24309	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-1027385|wwpdb:1CN4|dip:DIP-9856E|imex:IM-24309-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130427(gene)|ensembl:ENST00000252723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005125"(cytokine activity)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033574"(response to testosterone)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048678"(response to axon injury)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071548"(response to dexamethasone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1902251"(negative regulation of erythrocyte apoptotic process)|go:"GO:2001258"(negative regulation of cation channel activity)|interpro:IPR001323(Erythropoietin/thrombopoeitin)|interpro:IPR003013(Erythropoietin)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019767|rcsb pdb:1BUY|rcsb pdb:1CN4|rcsb pdb:1EER|reactome:R-HSA-1234158|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|refseq:NP_000790.2|dip:DIP-5731N	refseq:NP_000112.1|dip:DIP-5732N|rcsb pdb:1ERN|rcsb pdb:2JIX|rcsb pdb:2MV6|rcsb pdb:4Y5V|rcsb pdb:4Y5X|rcsb pdb:4Y5Y|rcsb pdb:6E2Q|rcsb pdb:6MOE|rcsb pdb:6MOF|rcsb pdb:6MOH|rcsb pdb:6MOI|rcsb pdb:6MOJ|rcsb pdb:6MOK|rcsb pdb:6MOL|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|ensembl:ENSG00000187266(gene)|ensembl:ENST00000222139(transcript)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046697"(decidualization)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P19235|rcsb pdb:1CN4|rcsb pdb:1EBA|rcsb pdb:1EBP|rcsb pdb:1EER	psi-mi:"MI:0465"(dip)	-	-	assembly:trimeric, multimeric|3d-r-factors:working 72.00%, free 66.400%|3d-resolution:2.8A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2017/06/30	rogid:60h2LdtVdr9clHmpscOO35dSVOM9606	rogid:tQiA0I1YOgo0qGcgBDNJKvzkvMg9606	intact-crc:8E86F3A1010DD3DF|rigid:xecLg5yL93V6CIHv5I0v8yyCRxw	false	sufficient binding region:28-193	sufficient binding region:25-249	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01588	uniprotkb:P19235	intact:EBI-1027362|uniprotkb:Q2M2L6|uniprotkb:Q549U2|uniprotkb:Q9UDZ0|uniprotkb:Q9UEZ5|uniprotkb:Q9UHA0|ensembl:ENSP00000252723	intact:EBI-617321|uniprotkb:Q15443|uniprotkb:Q2M205|uniprotkb:B2RCG4|ensembl:ENSP00000222139	psi-mi:epo_human(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:epor_human(display_long)|uniprotkb:EPOR(gene name)|psi-mi:EPOR(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Syed et al. (1998)	pubmed:9774108|imex:IM-24309	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-1027396|wwpdb:1EER|imex:IM-24309-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130427(gene)|ensembl:ENST00000252723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005125"(cytokine activity)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033574"(response to testosterone)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048678"(response to axon injury)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071548"(response to dexamethasone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1902251"(negative regulation of erythrocyte apoptotic process)|go:"GO:2001258"(negative regulation of cation channel activity)|interpro:IPR001323(Erythropoietin/thrombopoeitin)|interpro:IPR003013(Erythropoietin)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019767|rcsb pdb:1BUY|rcsb pdb:1CN4|rcsb pdb:1EER|reactome:R-HSA-1234158|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|refseq:NP_000790.2|dip:DIP-5731N	refseq:NP_000112.1|dip:DIP-5732N|rcsb pdb:1ERN|rcsb pdb:2JIX|rcsb pdb:2MV6|rcsb pdb:4Y5V|rcsb pdb:4Y5X|rcsb pdb:4Y5Y|rcsb pdb:6E2Q|rcsb pdb:6MOE|rcsb pdb:6MOF|rcsb pdb:6MOH|rcsb pdb:6MOI|rcsb pdb:6MOJ|rcsb pdb:6MOK|rcsb pdb:6MOL|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|ensembl:ENSG00000187266(gene)|ensembl:ENST00000222139(transcript)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046697"(decidualization)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P19235|rcsb pdb:1CN4|rcsb pdb:1EBA|rcsb pdb:1EBP|rcsb pdb:1EER	-	-	-	assembly:trimeric, multimeric|3d-r-factors:working 75.800%, free 68.200%|3d-resolution:1.9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2017/06/30	rogid:60h2LdtVdr9clHmpscOO35dSVOM9606	rogid:tQiA0I1YOgo0qGcgBDNJKvzkvMg9606	intact-crc:38A69063485A9EF9|rigid:xecLg5yL93V6CIHv5I0v8yyCRxw	false	sufficient binding region:28-193	sufficient binding region:31-250	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)