#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q31099 uniprotkb:P28078 intact:EBI-1027288|uniprotkb:Q31609|uniprotkb:Q60975|ensembl:ENSMUSP00000043526 intact:EBI-1027262 psi-mi:q31099_mouse(display_long)|uniprotkb:H2-DMb2(gene name)|psi-mi:H2-DMb2(display_short)|uniprotkb:H2-Mb2(gene name synonym)|uniprotkb:H2-M beta2(gene name synonym) psi-mi:dma_mouse(display_long)|uniprotkb:H2-DMa(gene name)|psi-mi:H2-DMa(display_short)|uniprotkb:H2-Ma(gene name synonym)|uniprotkb:Ma(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Fremont et al. (1998) pubmed:9768758 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1027316|rcsb pdb:1K8I - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|ensembl:ENSMUSG00000037548(gene)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1K8I|ensembl:ENSMUST00000041982(transcript)|go:"GO:0002250"(adaptive immune response)|refseq:NP_034518.1 interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|rcsb pdb:1K8I|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002636"(positive regulation of germinal center formation)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR036179|reactome:R-MMU-2132295 - - - assembly:dimeric, multimeric|3d-r-factors:working 79.500%, free 74.400%|3d-resolution:3.1A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:ggwtaBEbnai/onm17dGjgNUWIKc10090 rogid:JnRJG+bi7D7tyWg7luwKTclTJ2g10090 intact-crc:F868966CF6028082|rigid:GNh4Nr5FRVLjyVfP20WlTBbyDmI false sufficient binding region:20-210 sufficient binding region:30-220 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)