#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16649	uniprotkb:P48743	intact:EBI-19654|uniprotkb:P17995|uniprotkb:P18323|uniprotkb:D6VR85|ensemblfungi:YCR084C	intact:EBI-15036|uniprotkb:D6VYI0|ensemblfungi:YLR176C	psi-mi:tup1_yeast(display_long)|uniprotkb:TUP1(gene name)|psi-mi:TUP1(display_short)|uniprotkb:AAR1(gene name synonym)|uniprotkb:AER2(gene name synonym)|uniprotkb:AMM1(gene name synonym)|uniprotkb:CYC9(gene name synonym)|uniprotkb:FLK1(gene name synonym)|uniprotkb:SFL2(gene name synonym)|uniprotkb:UMR7(gene name synonym)|uniprotkb:YCR084C(locus name)|uniprotkb:YCR84C(orf name)|uniprotkb:Glucose repression regulatory protein TUP1(gene name synonym)|uniprotkb:Flocculation suppressor protein(gene name synonym)|uniprotkb:Repressor AER2(gene name synonym)	psi-mi:rfx1_yeast(display_long)|uniprotkb:RFX1(gene name)|psi-mi:RFX1(display_short)|uniprotkb:CRT1(gene name synonym)|uniprotkb:YLR176C(locus name)|uniprotkb:L9470.18(orf name)	psi-mi:"MI:0096"(pull down)	Huang et al. (1998)	pubmed:9741624|imex:IM-19610	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1167215|imex:IM-19610-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010007.1|sgd:S000000680|ensemblfungi:YCR084C(gene)|ensemblfungi:YCR084C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0001198"(negative regulation of mating-type specific transcription from RNA polymerase II promoter)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060256"(regulation of flocculation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:1900192"(positive regulation of single-species biofilm formation)|go:"GO:2000217"(regulation of invasive growth in response to glucose limitation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013890(Transcriptional repressor Tup1,  N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1ERJ|rcsb pdb:3VP8|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|rcsb pdb:3VP9|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043486"(histone exchange)|dip:DIP-512N|mint:P16649	refseq:NP_013277.1|sgd:S000004166|ensemblfungi:YLR176C(gene)|ensemblfungi:YLR176C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|dip:DIP-6790N|mint:P48743	-	crc64:444104AAD63CB944	-	figure legend:1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/17	2014/10/16	rogid:luwCf4aC9uWc9C8Vt2etbCoLcU8559292	rogid:dgFrkSUKAX1vfcjlSax39k6V7ss559292	intact-crc:1EE8CA9BFE2ABA09|rigid:/+o2nm1sCraF/K5dwH0mX+eUsBc	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14922	uniprotkb:P48743	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-15036|uniprotkb:D6VYI0|ensemblfungi:YLR176C	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:rfx1_yeast(display_long)|uniprotkb:RFX1(gene name)|psi-mi:RFX1(display_short)|uniprotkb:CRT1(gene name synonym)|uniprotkb:YLR176C(locus name)|uniprotkb:L9470.18(orf name)	psi-mi:"MI:0096"(pull down)	Huang et al. (1998)	pubmed:9741624|imex:IM-19610	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1167229|imex:IM-19610-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	refseq:NP_013277.1|sgd:S000004166|ensemblfungi:YLR176C(gene)|ensemblfungi:YLR176C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|dip:DIP-6790N|mint:P48743	-	crc64:FC2D0D0C1B181207	-	figure legend:1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/17	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:dgFrkSUKAX1vfcjlSax39k6V7ss559292	intact-crc:A6BE31D44AD1F7BC|rigid:nt/aPqrWq2eiFHhoO8kF3vCuov0	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48743	uniprotkb:P16649	intact:EBI-15036|uniprotkb:D6VYI0|ensemblfungi:YLR176C	intact:EBI-19654|uniprotkb:P17995|uniprotkb:P18323|uniprotkb:D6VR85|ensemblfungi:YCR084C	psi-mi:rfx1_yeast(display_long)|uniprotkb:RFX1(gene name)|psi-mi:RFX1(display_short)|uniprotkb:CRT1(gene name synonym)|uniprotkb:YLR176C(locus name)|uniprotkb:L9470.18(orf name)	psi-mi:tup1_yeast(display_long)|uniprotkb:TUP1(gene name)|psi-mi:TUP1(display_short)|uniprotkb:AAR1(gene name synonym)|uniprotkb:AER2(gene name synonym)|uniprotkb:AMM1(gene name synonym)|uniprotkb:CYC9(gene name synonym)|uniprotkb:FLK1(gene name synonym)|uniprotkb:SFL2(gene name synonym)|uniprotkb:UMR7(gene name synonym)|uniprotkb:YCR084C(locus name)|uniprotkb:YCR84C(orf name)|uniprotkb:Glucose repression regulatory protein TUP1(gene name synonym)|uniprotkb:Flocculation suppressor protein(gene name synonym)|uniprotkb:Repressor AER2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huang et al. (1998)	pubmed:9741624|imex:IM-19610	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1167257|imex:IM-19610-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013277.1|sgd:S000004166|ensemblfungi:YLR176C(gene)|ensemblfungi:YLR176C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|dip:DIP-6790N|mint:P48743	refseq:NP_010007.1|sgd:S000000680|ensemblfungi:YCR084C(gene)|ensemblfungi:YCR084C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0001198"(negative regulation of mating-type specific transcription from RNA polymerase II promoter)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060256"(regulation of flocculation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:1900192"(positive regulation of single-species biofilm formation)|go:"GO:2000217"(regulation of invasive growth in response to glucose limitation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013890(Transcriptional repressor Tup1,  N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1ERJ|rcsb pdb:3VP8|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|rcsb pdb:3VP9|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043486"(histone exchange)|dip:DIP-512N|mint:P16649	-	-	crc64:444104AAD63CB944	figure legend:1E|comment:When TUP1 and CYC8/SSN6 are cotranslated, significantly more Tup1 is bound by GST-RFX1/CRT1, probably due to TUP1 interaction with CYC8.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/17	2014/10/16	rogid:dgFrkSUKAX1vfcjlSax39k6V7ss559292	rogid:luwCf4aC9uWc9C8Vt2etbCoLcU8559292	intact-crc:FEA9C853DA1A8E5E|rigid:WDOLQQnYgw8jbvyYs6e53xeD+KE	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48743	uniprotkb:P14922	intact:EBI-15036|uniprotkb:D6VYI0|ensemblfungi:YLR176C	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	psi-mi:rfx1_yeast(display_long)|uniprotkb:RFX1(gene name)|psi-mi:RFX1(display_short)|uniprotkb:CRT1(gene name synonym)|uniprotkb:YLR176C(locus name)|uniprotkb:L9470.18(orf name)	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huang et al. (1998)	pubmed:9741624|imex:IM-19610	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1167257|imex:IM-19610-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013277.1|sgd:S000004166|ensemblfungi:YLR176C(gene)|ensemblfungi:YLR176C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|dip:DIP-6790N|mint:P48743	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	-	-	crc64:FC2D0D0C1B181207	figure legend:1E|comment:When TUP1 and CYC8/SSN6 are cotranslated, significantly more Tup1 is bound by GST-RFX1/CRT1, probably due to TUP1 interaction with CYC8.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/17	2014/10/16	rogid:dgFrkSUKAX1vfcjlSax39k6V7ss559292	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	intact-crc:FEA9C853DA1A8E5E|rigid:WDOLQQnYgw8jbvyYs6e53xeD+KE	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-1168230	uniprotkb:P48743	-	intact:EBI-15036|uniprotkb:D6VYI0|ensemblfungi:YLR176C	psi-mi:rnr2-yeast-dna(display_short)|psi-mi:EBI-1168230(display_long)	psi-mi:rfx1_yeast(display_long)|uniprotkb:RFX1(gene name)|psi-mi:RFX1(display_short)|uniprotkb:CRT1(gene name synonym)|uniprotkb:YLR176C(locus name)|uniprotkb:L9470.18(orf name)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Huang et al. (1998)	pubmed:9741624|imex:IM-19610	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1168232|imex:IM-19610-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_013277.1|sgd:S000004166|ensemblfungi:YLR176C(gene)|ensemblfungi:YLR176C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|dip:DIP-6790N|mint:P48743	-	-	-	figure legend:3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/17	2014/10/16	crc64:C9600517777C61AD	rogid:dgFrkSUKAX1vfcjlSax39k6V7ss559292	intact-crc:9BCE3D6E30698BD0	false	mutation decreasing interaction:7-7|mutation disrupting interaction:9-9|mutation decreasing interaction:10-10|mutation disrupting interaction:13-13|32p radiolabel:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)