#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O08769	uniprotkb:P03255	intact:EBI-7796656|ensembl:ENSRNOP00000050173|intact:MINT-1785011	intact:EBI-2603114|uniprotkb:P06438|uniprotkb:Q64825|uniprotkb:Q64826	psi-mi:o08769_rat(display_long)|uniprotkb:Cdkn1b(gene name)|psi-mi:Cdkn1b(display_short)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:rCG_29991(orf name)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)	psi-mi:e1a_ade05(display_long)|uniprotkb:Early E1A 32 kDa protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nomura et al. (1998)	mint:MINT-6548026|pubmed:9675118	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8677531|mint:MINT-1785028	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000007249(gene)|ensembl:ENSRNOT00000049848(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|reactome:R-RNO-187577|reactome:R-RNO-198323|go:"GO:0051087"(chaperone binding)|reactome:R-RNO-2559582|reactome:R-RNO-2559586|reactome:R-RNO-6804116|reactome:R-RNO-69202|reactome:R-RNO-69231|reactome:R-RNO-69563|reactome:R-RNO-69656|reactome:R-RNO-8849470|reactome:R-RNO-9607240|reactome:R-RNO-9634638|refseq:NP_113950.2|rgd:69062|refseq:XP_006237601.1|dip:DIP-44911N|mint:MINT-1785030(identity)	refseq:AP_000197.1|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0046719"(regulation by virus of viral protein levels in host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR014410(Adenovirus early E1A)|rcsb pdb:2KJE|rcsb pdb:2R7G|rcsb pdb:6H6D|rcsb pdb:6H6H|go:"GO:0042025"(host cell nucleus)|dip:DIP-40736N|mint:P03255|mint:MINT-1785029(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/14	2014/10/16	rogid:POU4KWBUcNKjv5Ie2IS5UYVa7Qk10116	rogid:Yj7851FOR0yCEZBF540O97/Oo/M28285	intact-crc:BB2E1B0E2CCE73B6|rigid:8GBSWz+Kc71NN30Kyo8cSteYQFA	false	binding-associated region:1-102(MINT-1785079)|his tag:?-?(MINT-1785073)	glutathione s tranferase tag:?-?(MINT-1785065)	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08769	uniprotkb:P03259	intact:EBI-7796656|ensembl:ENSRNOP00000050173|intact:MINT-1785011	intact:EBI-6947456|intact:MINT-1785129|intact:EBI-11735753	psi-mi:o08769_rat(display_long)|uniprotkb:Cdkn1b(gene name)|psi-mi:Cdkn1b(display_short)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:rCG_29991(orf name)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)	psi-mi:e1a_ade12(display_long)|uniprotkb:Early E1A 29.5 kDa protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nomura et al. (1998)	mint:MINT-6548026|pubmed:9675118	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:28282(ade12)|taxid:28282("Human adenovirus A serotype 12 (HAdV-12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8677579|mint:MINT-1785108	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000007249(gene)|ensembl:ENSRNOT00000049848(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|reactome:R-RNO-187577|reactome:R-RNO-198323|go:"GO:0051087"(chaperone binding)|reactome:R-RNO-2559582|reactome:R-RNO-2559586|reactome:R-RNO-6804116|reactome:R-RNO-69202|reactome:R-RNO-69231|reactome:R-RNO-69563|reactome:R-RNO-69656|reactome:R-RNO-8849470|reactome:R-RNO-9607240|reactome:R-RNO-9634638|refseq:NP_113950.2|rgd:69062|refseq:XP_006237601.1|dip:DIP-44911N|mint:MINT-1785120(identity)	go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR014410(Adenovirus early E1A)|refseq:NP_040910.2|mint:P03259|mint:MINT-1785109(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	function:E1A protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2B|figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/14	2014/10/16	rogid:POU4KWBUcNKjv5Ie2IS5UYVa7Qk10116	rogid:RmgY0yP1YcnAzd30yic8mb38rTU28282	intact-crc:89A5023562E78C3C|rigid:hTA6I2zqHXv10pBfVcS/jZg8PWs	false	binding-associated region:1-88(MINT-1785127)|his tag:?-?(MINT-1785121)	glutathione s tranferase tag:?-?(MINT-1785118)	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08769	uniprotkb:P03255	intact:EBI-7796656|ensembl:ENSRNOP00000050173|intact:MINT-1785011	intact:EBI-2603114|uniprotkb:P06438|uniprotkb:Q64825|uniprotkb:Q64826	psi-mi:o08769_rat(display_long)|uniprotkb:Cdkn1b(gene name)|psi-mi:Cdkn1b(display_short)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:rCG_29991(orf name)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)	psi-mi:e1a_ade05(display_long)|uniprotkb:Early E1A 32 kDa protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nomura et al. (1998)	mint:MINT-6548026|pubmed:9675118	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8677553|mint:MINT-1785086	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000007249(gene)|ensembl:ENSRNOT00000049848(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|reactome:R-RNO-187577|reactome:R-RNO-198323|go:"GO:0051087"(chaperone binding)|reactome:R-RNO-2559582|reactome:R-RNO-2559586|reactome:R-RNO-6804116|reactome:R-RNO-69202|reactome:R-RNO-69231|reactome:R-RNO-69563|reactome:R-RNO-69656|reactome:R-RNO-8849470|reactome:R-RNO-9607240|reactome:R-RNO-9634638|refseq:NP_113950.2|rgd:69062|refseq:XP_006237601.1|dip:DIP-44911N|mint:MINT-1785087(identity)	refseq:AP_000197.1|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0046719"(regulation by virus of viral protein levels in host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR014410(Adenovirus early E1A)|rcsb pdb:2KJE|rcsb pdb:2R7G|rcsb pdb:6H6D|rcsb pdb:6H6H|go:"GO:0042025"(host cell nucleus)|dip:DIP-40736N|mint:P03255|mint:MINT-1785096(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/14	2014/10/16	rogid:POU4KWBUcNKjv5Ie2IS5UYVa7Qk10116	rogid:Yj7851FOR0yCEZBF540O97/Oo/M28285	intact-crc:1A2B8DB7E218D4E6|rigid:8GBSWz+Kc71NN30Kyo8cSteYQFA	false	binding-associated region:88-197(MINT-1785088)|his tag:?-?(MINT-1785094)	glutathione s tranferase tag:?-?(MINT-1785102)|binding-associated region:1-235(MINT-1785104)	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08769	uniprotkb:P03259	intact:EBI-7796656|ensembl:ENSRNOP00000050173|intact:MINT-1785011	intact:EBI-6947456|intact:MINT-1785129|intact:EBI-11735753	psi-mi:o08769_rat(display_long)|uniprotkb:Cdkn1b(gene name)|psi-mi:Cdkn1b(display_short)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:rCG_29991(orf name)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)	psi-mi:e1a_ade12(display_long)|uniprotkb:Early E1A 29.5 kDa protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nomura et al. (1998)	mint:MINT-6548026|pubmed:9675118	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:28282(ade12)|taxid:28282("Human adenovirus A serotype 12 (HAdV-12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8677602|mint:MINT-1785157	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000007249(gene)|ensembl:ENSRNOT00000049848(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|reactome:R-RNO-187577|reactome:R-RNO-198323|go:"GO:0051087"(chaperone binding)|reactome:R-RNO-2559582|reactome:R-RNO-2559586|reactome:R-RNO-6804116|reactome:R-RNO-69202|reactome:R-RNO-69231|reactome:R-RNO-69563|reactome:R-RNO-69656|reactome:R-RNO-8849470|reactome:R-RNO-9607240|reactome:R-RNO-9634638|refseq:NP_113950.2|rgd:69062|refseq:XP_006237601.1|dip:DIP-44911N|mint:MINT-1785169(identity)	go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR014410(Adenovirus early E1A)|refseq:NP_040910.2|mint:P03259|mint:MINT-1785158(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	function:E1A protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2B|figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/14	2014/10/16	rogid:POU4KWBUcNKjv5Ie2IS5UYVa7Qk10116	rogid:RmgY0yP1YcnAzd30yic8mb38rTU28282	intact-crc:BDD88EC6888E9FC0|rigid:hTA6I2zqHXv10pBfVcS/jZg8PWs	false	binding-associated region:88-143(MINT-1785170)|his tag:?-?(MINT-1785176)	binding-associated region:1-235(MINT-1785159)|glutathione s tranferase tag:?-?(MINT-1785167)	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)