#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04014	uniprotkb:P07305	intact:EBI-7014446|intact:MINT-95113	intact:EBI-725224|uniprotkb:Q6FG88|uniprotkb:Q8N6R3|uniprotkb:B4DRD6|uniprotkb:B2R6I0|ensembl:ENSP00000344504	psi-mi:ve1_hpv11(display_long)|uniprotkb:E1(gene name)|psi-mi:E1(display_short)|uniprotkb:ATP-dependent helicase E1(gene name synonym)	psi-mi:h10_human(display_long)|uniprotkb:H1-0(gene name)|psi-mi:H1-0(display_short)|uniprotkb:H1F0(gene name synonym)|uniprotkb:H1FV(gene name synonym)|uniprotkb:Histone H1'(gene name synonym)|uniprotkb:"Histone H1(0)"(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Swindle et al. (1998)	pubmed:9499053|mint:MINT-6547671	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8679663|mint:MINT-73423	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P04014|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0034214"(protein hexamerization)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001177(DNA helicase E1 protein, C-terminal, Papillomavirus)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR016393(Replication protein E1, papillomavirus)|interpro:IPR027417|interpro:IPR014000(DNA helicase E1 protein, N-terminal, Papillomavirus)|mint:MINT-1533006(identity)	refseq:NP_005309.1|ensembl:ENSG00000189060(gene)|ensembl:ENST00000340857(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016604"(nuclear body)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0005634"(nucleus)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P07305|rcsb pdb:6HQ1|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6N88|rcsb pdb:6N89|rcsb pdb:7DBP|rcsb pdb:7K5X|reactome:R-HSA-140342|reactome:R-HSA-2559584|dip:DIP-41775N|mint:MINT-1533011(identity)	-	comment:mint|function:ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/01/06	2014/10/16	rogid:Xg3fdEVHcqOpmqe7MPf9EXciD3s10580	rogid:7ir9Jz/gNZypmWkTopCusDQFEhs9606	intact-crc:5D1C7F21A53BEB89|rigid:esGj2dRRn3WrYF8GvWkMo/3D7ts	false	-	-	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P04014	uniprotkb:P07305	intact:EBI-7014446|intact:MINT-95113	intact:EBI-725224|uniprotkb:Q6FG88|uniprotkb:Q8N6R3|uniprotkb:B4DRD6|uniprotkb:B2R6I0|ensembl:ENSP00000344504	psi-mi:ve1_hpv11(display_long)|uniprotkb:E1(gene name)|psi-mi:E1(display_short)|uniprotkb:ATP-dependent helicase E1(gene name synonym)	psi-mi:h10_human(display_long)|uniprotkb:H1-0(gene name)|psi-mi:H1-0(display_short)|uniprotkb:H1F0(gene name synonym)|uniprotkb:H1FV(gene name synonym)|uniprotkb:Histone H1'(gene name synonym)|uniprotkb:"Histone H1(0)"(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Swindle et al. (1998)	pubmed:9499053|mint:MINT-6547671	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8679683|mint:MINT-73422	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P04014|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0034214"(protein hexamerization)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001177(DNA helicase E1 protein, C-terminal, Papillomavirus)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR016393(Replication protein E1, papillomavirus)|interpro:IPR027417|interpro:IPR014000(DNA helicase E1 protein, N-terminal, Papillomavirus)|mint:MINT-1533021(identity)	refseq:NP_005309.1|ensembl:ENSG00000189060(gene)|ensembl:ENST00000340857(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016604"(nuclear body)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0005634"(nucleus)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P07305|rcsb pdb:6HQ1|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6N88|rcsb pdb:6N89|rcsb pdb:7DBP|rcsb pdb:7K5X|reactome:R-HSA-140342|reactome:R-HSA-2559584|dip:DIP-41775N|mint:MINT-1533030(identity)	-	comment:mint|function:ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/01/06	2014/10/16	rogid:Xg3fdEVHcqOpmqe7MPf9EXciD3s10580	rogid:7ir9Jz/gNZypmWkTopCusDQFEhs9606	intact-crc:E315842A0898648B|rigid:esGj2dRRn3WrYF8GvWkMo/3D7ts	false	his tag:?-?(MINT-1533024)|binding-associated region:1-185(MINT-1533022)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)