#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P09119 uniprotkb:P07834 intact:EBI-4447|uniprotkb:D6VVZ7|ensemblfungi:YJL194W intact:EBI-4434|ensemblfungi:YFL009W|uniprotkb:D6VTM1 psi-mi:cdc6_yeast(display_long)|uniprotkb:CDC6(gene name)|psi-mi:CDC6(display_short)|uniprotkb:J0347(orf name)|uniprotkb:YJL194W(locus name) psi-mi:cdc4_yeast(display_long)|uniprotkb:CDC4(gene name)|psi-mi:CDC4(display_short)|uniprotkb:YFL009W(locus name)|uniprotkb:F-box protein CDC4(gene name synonym)|uniprotkb:E3 ubiquitin ligase complex SCF subunit CDC4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Drury et al. (1997) pubmed:9312054|imex:IM-19862 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-906403|imex:IM-19862-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012341.1|sgd:S000003730|mint:P09119|dip:DIP-2267N|ensemblfungi:YJL194W(gene)|ensemblfungi:YJL194W_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0051301"(cell division)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5V8F|rcsb pdb:6WGC|rcsb pdb:6WGG|rcsb pdb:6WGI|rcsb pdb:7MCA|reactome:R-SCE-68689|reactome:R-SCE-68949|reactome:R-SCE-68962|reactome:R-SCE-69017 reactome:R-SCE-174113|reactome:R-SCE-8951664|reactome:R-SCE-983168|ensemblfungi:YFL009W(gene)|ensemblfungi:YFL009W_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030686"(90S preribosome)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0043130"(ubiquitin binding)|refseq:NP_116585.1|sgd:S000001885|dip:DIP-1625N|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR031740|interpro:IPR036047|interpro:IPR036322|rcsb pdb:1NEX|rcsb pdb:2P63|rcsb pdb:3MKS|rcsb pdb:3V7D - crc64:13645F65BEAB5EE8 crc64:0348F2F8FA78F3BC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/03/17 2014/10/16 rogid:JR9a6JdKg9hu4gkYo3Df0KrSkis559292 rogid:KUKB7HDw6k4t7Gb1pDGW8P5J1kw559292 intact-crc:309F04469636E308|rigid:RLrgN843xTCKNNFN5Z8ZOOLop7c false necessary binding region:17-33|binding-associated region:1-47|sufficient binding region:1-18 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)