#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14778	uniprotkb:P18510	intact:EBI-525905|uniprotkb:Q587I7|ensembl:ENSP00000386380	intact:EBI-1026330|uniprotkb:Q14628|uniprotkb:Q7RTZ4|uniprotkb:Q96GD6|uniprotkb:Q9UPC0|uniprotkb:A8K4G1|uniprotkb:Q53SC2|ensembl:ENSP00000387173	psi-mi:il1r1_human(display_long)|uniprotkb:Interleukin-1 receptor type I(gene name synonym)|uniprotkb:Interleukin-1 receptor alpha(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:CD121 antigen-like family member A(gene name synonym)|uniprotkb:IL1RT1(gene name synonym)|uniprotkb:IL1R1(gene name)|psi-mi:IL1R1(display_short)|uniprotkb:IL1R(gene name synonym)|uniprotkb:IL1RA(gene name synonym)	psi-mi:il1ra_human(display_long)|uniprotkb:IL1RN(gene name)|psi-mi:IL1RN(display_short)|uniprotkb:IL1F3(gene name synonym)|uniprotkb:IL1RA(gene name synonym)|uniprotkb:IL1 inhibitor(gene name synonym)|uniprotkb:ICIL-1RA(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schreuder et al. (1997)	pubmed:9062194|mint:MINT-5221369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1026371|rcsb pdb:1IRA	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000868.1|refseq:XP_005263987.1|refseq:XP_005263991.1|refseq:NP_001275635.1|refseq:XP_011509417.1|refseq:XP_011509418.1|refseq:XP_011509419.1|refseq:XP_011509420.1|ensembl:ENSG00000115594(gene)|ensembl:ENST00000410023(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004909"(interleukin-1, type I, activating receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000661"(positive regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004076(Interleukin-1 receptor IL1R)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:1G0Y|rcsb pdb:1IRA|rcsb pdb:1ITB|rcsb pdb:4DEP|rcsb pdb:4GAF|reactome:R-HSA-6783783|reactome:R-HSA-9020702|reactome:R-HSA-9679191|dip:DIP-93N|refseq:NP_001307907.1|refseq:NP_001307909.1|refseq:NP_001307910.1|refseq:NP_001307911.1|refseq:NP_001307912.1|refseq:NP_001307913.1|refseq:NP_001307914.1|refseq:XP_016859478.1	refseq:XP_011509423.1|refseq:NP_000568.1|refseq:NP_776213.1|refseq:NP_776214.1|refseq:NP_776215.1|refseq:NP_001305843.1|refseq:XP_005263718.1|ensembl:ENSG00000136689(gene)|ensembl:ENST00000409930(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0005125"(cytokine activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005150"(interleukin-1, type I receptor binding)|go:"GO:0005151"(interleukin-1, type II receptor binding)|go:"GO:0005152"(interleukin-1 receptor antagonist activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0030073"(insulin secretion)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0045352"(interleukin-1 type I receptor antagonist activity)|go:"GO:0045353"(interleukin-1 type II receptor antagonist activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000975(Interleukin-1)|interpro:IPR003297(Interleukin-1 receptor antagonist IL1RA)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR020877|interpro:IPR039348|rcsb pdb:1ILR|rcsb pdb:1ILT|rcsb pdb:1IRA|rcsb pdb:1IRP|rcsb pdb:1ITN|rcsb pdb:2IRT|reactome:R-HSA-6783783|reactome:R-HSA-9020702	-	-	-	assembly:dimeric, multimeric|3d-r-factors:working 78.700%, free 68.600%|3d-resolution:2.7A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:2qxcax5pAtmXBQudsAOyK1V2/Oo9606	rogid:OaL5ISV3Q9oS6sFZyjnbrlbdsbI9606	intact-crc:966EEC062F9415D8|rigid:7T50Nl0iAwVFYWZCsnxdlkmGk18	false	sufficient binding region:18-336	sufficient binding region:26-177	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)