#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P12497	uniprotkb:P62937	intact:EBI-1026248	intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220	psi-mi:pol_hv1n5(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym)	psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Gamble et al. (1996)	pubmed:8980234|mint:MINT-6641493	taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1026278|rcsb pdb:1AK4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1A43|rcsb pdb:1A8O|rcsb pdb:1AFV|rcsb pdb:1AK4|rcsb pdb:1AUM|rcsb pdb:1B92|rcsb pdb:1B9D|rcsb pdb:1B9F|rcsb pdb:1BAJ|rcsb pdb:1BHL|rcsb pdb:1BI4|rcsb pdb:1BIS|rcsb pdb:1BIU|rcsb pdb:1BIZ|rcsb pdb:1BL3|rcsb pdb:1GWP|rcsb pdb:1HIW|rcsb pdb:1HYV|rcsb pdb:1HYZ|rcsb pdb:1ITG|rcsb pdb:1K6Y|rcsb pdb:1M9D|rcsb pdb:1QS4|rcsb pdb:1UPH|rcsb pdb:1WJB|rcsb pdb:1WJD|rcsb pdb:1WKN|rcsb pdb:1ZA9|rcsb pdb:2B4J|rcsb pdb:2GOL|rcsb pdb:2GON|rcsb pdb:2H3F|rcsb pdb:2H3I|rcsb pdb:2H3Q|rcsb pdb:2H3V|rcsb pdb:2H3Z|rcsb pdb:2HMX|rcsb pdb:2HVP|rcsb pdb:2ITG|rcsb pdb:2JPR|rcsb pdb:2JYG|rcsb pdb:2JYL|rcsb pdb:2ONT|rcsb pdb:2PWM|rcsb pdb:2PWO|rcsb pdb:2PXR|rcsb pdb:2X2D|rcsb pdb:3DIK|rcsb pdb:3DPH|rcsb pdb:3DS0|rcsb pdb:3DS1|rcsb pdb:3DS2|rcsb pdb:3DS3|rcsb pdb:3DS4|rcsb pdb:3DS5|rcsb pdb:3DTJ|rcsb pdb:3GV2|rcsb pdb:3H47|rcsb pdb:3H4E|rcsb pdb:3L3U|rcsb pdb:3L3V|rcsb pdb:3LPT|rcsb pdb:2M8L|rcsb pdb:2M8N|rcsb pdb:2M8P|rcsb pdb:4IPY|rcsb pdb:4JMU|rcsb pdb:3AV9|rcsb pdb:3AVA|rcsb pdb:3AVB|rcsb pdb:3AVC|rcsb pdb:3AVF|rcsb pdb:3AVG|rcsb pdb:3AVH|rcsb pdb:3AVJ|rcsb pdb:3AVK|rcsb pdb:3AVL|rcsb pdb:3AVM|rcsb pdb:3AVN|rcsb pdb:3WNE|rcsb pdb:3WNF|rcsb pdb:3WNG|rcsb pdb:3WNH|rcsb pdb:3LPU|rcsb pdb:3LRY|rcsb pdb:3MGE|rcsb pdb:3NF6|rcsb pdb:3NF7|rcsb pdb:3NF8|rcsb pdb:3NF9|rcsb pdb:3NFA|rcsb pdb:3P05|rcsb pdb:3P0A|rcsb pdb:4PHV|rcsb pdb:5HVP|rcsb pdb:9HVP|interpro:IPR043502|rcsb pdb:6OOU|rcsb pdb:6OPW|rcsb pdb:6OXO|rcsb pdb:6OXP|rcsb pdb:6OXQ|rcsb pdb:6OXR|rcsb pdb:6OXS|rcsb pdb:6OXT|rcsb pdb:6OXU|rcsb pdb:6OXV|rcsb pdb:6OXW|rcsb pdb:6OXX|rcsb pdb:6OXY|rcsb pdb:6OXZ|rcsb pdb:6OY0|rcsb pdb:6OY1|rcsb pdb:6OY2|rcsb pdb:2M3Z|rcsb pdb:2LF4|rcsb pdb:7D83|rcsb pdb:6ES8|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:4QNB|rcsb pdb:4WYM|rcsb pdb:2XV6|rcsb pdb:2XXM|rcsb pdb:4DMN|rcsb pdb:4DGA|rcsb pdb:4DGE|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:3S85|rcsb pdb:4E1M|rcsb pdb:4E1N|rcsb pdb:4E91|rcsb pdb:4E92|rcsb pdb:4NX4|rcsb pdb:2XDE|rcsb pdb:4AH9|rcsb pdb:4AHR|rcsb pdb:4AHS|rcsb pdb:4AHT|rcsb pdb:4AHU|rcsb pdb:4AHV|rcsb pdb:2LYA|rcsb pdb:2LYB|interpro:IPR034170|rcsb pdb:4ZHR|rcsb pdb:4GVM|rcsb pdb:4GW6|rcsb pdb:4ID1|rcsb pdb:4JLH|rcsb pdb:4COC|rcsb pdb:4COP|rcsb pdb:4LQW|rcsb pdb:4O0J|rcsb pdb:4O55|rcsb pdb:4O5B|rcsb pdb:6IK9|rcsb pdb:6VX2|rcsb pdb:6W0U|rcsb pdb:6VRG|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5JL4|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TEO|rcsb pdb:5XN0|rcsb pdb:5XN1|rcsb pdb:5XN2|rcsb pdb:5VCK|rcsb pdb:5VEA|rcsb pdb:5VJ3|rcsb pdb:6IKA|rcsb pdb:6PJB|rcsb pdb:6PJC|rcsb pdb:6PJD|rcsb pdb:6PJE|rcsb pdb:6PJF|rcsb pdb:6PJG|rcsb pdb:6PJH|rcsb pdb:6PJI|rcsb pdb:6PJK|rcsb pdb:6PJL|rcsb pdb:6PJM|rcsb pdb:6PJN|rcsb pdb:6PJO|rcsb pdb:6U8Q|rcsb pdb:6UM8|rcsb pdb:6VDK|rcsb pdb:6MCR|rcsb pdb:6MCS|rcsb pdb:5U1C|rcsb pdb:3ZCM|rcsb pdb:3ZSO|rcsb pdb:3ZSQ|rcsb pdb:3ZSR|rcsb pdb:3ZSV|rcsb pdb:3ZSW|rcsb pdb:3ZSX|rcsb pdb:3ZSY|rcsb pdb:3ZSZ|rcsb pdb:3ZT0|rcsb pdb:3ZT1|rcsb pdb:3ZT2|rcsb pdb:3ZT3|rcsb pdb:3ZT4|rcsb pdb:4CE9|rcsb pdb:4CEA|rcsb pdb:4CEB|rcsb pdb:4CEC|rcsb pdb:4CED|rcsb pdb:4CEE|rcsb pdb:4CEF|rcsb pdb:4CEO|rcsb pdb:4CEQ|rcsb pdb:4CER|rcsb pdb:4CES|rcsb pdb:4CEZ|rcsb pdb:4CF0|rcsb pdb:4CF1|rcsb pdb:4CF2|rcsb pdb:4CF8|rcsb pdb:4CF9|rcsb pdb:4CFA|rcsb pdb:4CFB|rcsb pdb:4CFC|rcsb pdb:4CFD|rcsb pdb:4CGD|rcsb pdb:4CGF|rcsb pdb:4CGG|rcsb pdb:4CGH|rcsb pdb:4CGI|rcsb pdb:4CGJ|rcsb pdb:4CHN|rcsb pdb:4CHO|rcsb pdb:4CHP|rcsb pdb:4CHQ|rcsb pdb:4CHY|rcsb pdb:4CHZ|rcsb pdb:4CIE|rcsb pdb:4CIF|rcsb pdb:4CIG|rcsb pdb:4CJ3|rcsb pdb:4CJ4|rcsb pdb:4CJ5|rcsb pdb:4CJE|rcsb pdb:4CJF|rcsb pdb:4CJK|rcsb pdb:4CJL|rcsb pdb:4CJP|rcsb pdb:4CJQ|rcsb pdb:4CJR|rcsb pdb:4CJS|rcsb pdb:4CJT|rcsb pdb:4CJU|rcsb pdb:4CJV|rcsb pdb:4CJW|rcsb pdb:4CK1|rcsb pdb:4CK2|rcsb pdb:4CK3|rcsb pdb:4LH4|rcsb pdb:4LH5|rcsb pdb:4OVL|rcsb pdb:4Y1C|rcsb pdb:4Y1D|rcsb pdb:5KGW|rcsb pdb:5KGX|rcsb pdb:5KRS|rcsb pdb:5KRT|rcsb pdb:6JCF|rcsb pdb:6JCG|rcsb pdb:6LMI|interpro:IPR043128|rcsb pdb:6KDJ|rcsb pdb:6KDK|rcsb pdb:6KDM|rcsb pdb:6KDN|rcsb pdb:6KDO|rcsb pdb:6OOS|rcsb pdb:6OOT|rcsb pdb:6OPY|rcsb pdb:6OPZ|rcsb pdb:6OYD|rcsb pdb:6OYR|rcsb pdb:6PUT|rcsb pdb:6PUW|rcsb pdb:6PUY|rcsb pdb:6PUZ|rcsb pdb:6V3K|rcsb pdb:6LMQ|rcsb pdb:6T6E	refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N	-	-	-	assembly:dimeric, multimeric|3d-r-factors:working 76.200%, free 69.400%|3d-resolution:2.36A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:mHx9XLy+8upnoRm4iO+bsTepkog11698	rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606	intact-crc:617AB67F923068DA|rigid:r1iexov2Bo686PFfMpcSeF0bjyg	false	sufficient binding region:133-277	sufficient binding region:2-165	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)