#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P11972	uniprotkb:P08539	intact:EBI-18232|uniprotkb:Q06207|uniprotkb:D6VZ86|ensemblfungi:YLR452C	intact:EBI-7376|uniprotkb:D3DKU8|ensemblfungi:YHR005C	psi-mi:sst2_yeast(display_long)|uniprotkb:SST2(gene name)|psi-mi:SST2(display_short)|uniprotkb:L9324.9(orf name)|uniprotkb:YLR452C(locus name)	psi-mi:gpa1_yeast(display_long)|uniprotkb:YHR005C(locus name)|uniprotkb:GPA1(gene name)|psi-mi:GPA1(display_short)|uniprotkb:CDC70(gene name synonym)|uniprotkb:DAC1(gene name synonym)|uniprotkb:SCG1(gene name synonym)|uniprotkb:GP1-alpha(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Dohlman et al. (1996)	pubmed:8756677|imex:IM-19854	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-904406|imex:IM-19854-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013557.1|sgd:S000004444|ensemblfungi:YLR452C(gene)|ensemblfungi:YLR452C_mRNA(transcript)|go:"GO:0000754"(adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|interpro:IPR016137(Regulator of G protein signalling superfamily)|dip:DIP-2354N|mint:P11972	refseq:NP_011868.1|sgd:S000001047|reactome:R-SCE-112043|reactome:R-SCE-202040|reactome:R-SCE-416482|dip:DIP-15N|reactome:R-SCE-399997|reactome:R-SCE-416476|reactome:R-SCE-418592|reactome:R-SCE-434316|reactome:R-SCE-9013148|ensemblfungi:YHR005C(gene)|ensemblfungi:YHR005C_mRNA(transcript)|go:"GO:0000742"(karyogamy involved in conjugation with cellular fusion)|go:"GO:0000743"(nuclear migration involved in conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0000754"(adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR002975(Fungal G-protein, alpha subunit)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:1SCG|rcsb pdb:7AD3	go:"GO:0005886"(plasma membrane)	-	crc64:2E87C546E133D6E5	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/14	2014/10/16	rogid:a452jzptv3MtejNfc+LDrwSFSks559292	rogid:SxuqaRpicb7ZBsQju2vD6C8h3X4559292	intact-crc:19714F457C215DC0|rigid:9mpgu9fe/hp+Losod2PPnN0RP0g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0CI39	uniprotkb:P18851	intact:EBI-18360|uniprotkb:Q70D63|uniprotkb:Q70D65|uniprotkb:Q70D69|uniprotkb:Q70D73|uniprotkb:Q70D74|uniprotkb:P06842	intact:EBI-7390|uniprotkb:D6W2R8|ensemblfungi:YOR212W	psi-mi:ste2_yeasx(display_long)|uniprotkb:STE2(gene name)|psi-mi:STE2(display_short)	psi-mi:gbb_yeast(display_long)|uniprotkb:YOR50-2(orf name)|uniprotkb:YOR212W(locus name)|uniprotkb:STE4(gene name)|psi-mi:STE4(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Dohlman et al. (1996)	pubmed:8756677|imex:IM-19854	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-904429|imex:IM-19854-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000366(Fungal pheromone mating factor STE2 GPCR)|go:"GO:0004932"(mating-type factor pheromone receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019236"(response to pheromone)|interpro:IPR027458|mint:P0CI39	sgd:S000005738|refseq:NP_014855.3|mint:P18851|dip:DIP-954N|ensemblfungi:YOR212W(gene)|ensemblfungi:YOR212W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005937"(mating projection)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043577"(chemotropism)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|go:"GO:1903260"(protein localization to mating projection tip)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1SCG|reactome:R-SCE-6814122	go:"GO:0005886"(plasma membrane)	-	crc64:4B0E26040AAA83E5	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/14	2014/10/16	rogid:Xw+4tatIKPl42hhE5XQUighaCP44932	rogid:nDgadSWQPcmSvQlIEjpNHPl3Hjc559292	intact-crc:20320240FBE61D68|rigid:pvadM6NZm2TY9y4irbCNKI9VHhQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11972	uniprotkb:P08539	intact:EBI-18232|uniprotkb:Q06207|uniprotkb:D6VZ86|ensemblfungi:YLR452C	intact:EBI-7376|uniprotkb:D3DKU8|ensemblfungi:YHR005C	psi-mi:sst2_yeast(display_long)|uniprotkb:SST2(gene name)|psi-mi:SST2(display_short)|uniprotkb:L9324.9(orf name)|uniprotkb:YLR452C(locus name)	psi-mi:gpa1_yeast(display_long)|uniprotkb:YHR005C(locus name)|uniprotkb:GPA1(gene name)|psi-mi:GPA1(display_short)|uniprotkb:CDC70(gene name synonym)|uniprotkb:DAC1(gene name synonym)|uniprotkb:SCG1(gene name synonym)|uniprotkb:GP1-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Dohlman et al. (1996)	pubmed:8756677|imex:IM-19854	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-904457|imex:IM-19854-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013557.1|sgd:S000004444|ensemblfungi:YLR452C(gene)|ensemblfungi:YLR452C_mRNA(transcript)|go:"GO:0000754"(adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|interpro:IPR016137(Regulator of G protein signalling superfamily)|dip:DIP-2354N|mint:P11972	refseq:NP_011868.1|sgd:S000001047|reactome:R-SCE-112043|reactome:R-SCE-202040|reactome:R-SCE-416482|dip:DIP-15N|reactome:R-SCE-399997|reactome:R-SCE-416476|reactome:R-SCE-418592|reactome:R-SCE-434316|reactome:R-SCE-9013148|ensemblfungi:YHR005C(gene)|ensemblfungi:YHR005C_mRNA(transcript)|go:"GO:0000742"(karyogamy involved in conjugation with cellular fusion)|go:"GO:0000743"(nuclear migration involved in conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0000754"(adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR002975(Fungal G-protein, alpha subunit)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:1SCG|rcsb pdb:7AD3	-	-	crc64:2E87C546E133D6E5	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/14	2014/10/16	rogid:a452jzptv3MtejNfc+LDrwSFSks559292	rogid:SxuqaRpicb7ZBsQju2vD6C8h3X4559292	intact-crc:6A626CA7B069853B|rigid:9mpgu9fe/hp+Losod2PPnN0RP0g	false	-	glutathione s tranferase tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)