#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07834	uniprotkb:P52286	intact:EBI-4434|ensemblfungi:YFL009W|uniprotkb:D6VTM1	intact:EBI-4090|uniprotkb:Q07186|uniprotkb:D6VSW0|ensemblfungi:YDR328C	psi-mi:cdc4_yeast(display_long)|uniprotkb:CDC4(gene name)|psi-mi:CDC4(display_short)|uniprotkb:YFL009W(locus name)|uniprotkb:F-box protein CDC4(gene name synonym)|uniprotkb:E3 ubiquitin ligase complex SCF subunit CDC4(gene name synonym)	psi-mi:skp1_yeast(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:CBF3D(gene name synonym)|uniprotkb:YDR328C(locus name)|uniprotkb:D9798.14(orf name)|uniprotkb:Centromere DNA-binding protein complex CBF3 subunit D(gene name synonym)|uniprotkb:E3 ubiquitin ligase complex SCF subunit SKP1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Bai et al. (1996)	pubmed:8706131|imex:IM-19863	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-906500|imex:IM-19863-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-SCE-174113|reactome:R-SCE-8951664|reactome:R-SCE-983168|ensemblfungi:YFL009W(gene)|ensemblfungi:YFL009W_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030686"(90S preribosome)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0043130"(ubiquitin binding)|refseq:NP_116585.1|sgd:S000001885|dip:DIP-1625N|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR031740|interpro:IPR036047|interpro:IPR036322|rcsb pdb:1NEX|rcsb pdb:2P63|rcsb pdb:3MKS|rcsb pdb:3V7D	sgd:S000002736|refseq:NP_010615.3|dip:DIP-1236N|mint:P52286|ensemblfungi:YDR328C(gene)|ensemblfungi:YDR328C_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000921"(septin ring assembly)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010458"(exit from mitosis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031518"(CBF3 complex)|go:"GO:0034622"|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043291"(RAVE complex)|go:"GO:0045116"(protein neddylation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|rcsb pdb:1NEX|rcsb pdb:3MKS|rcsb pdb:3V7D|rcsb pdb:5AN3|rcsb pdb:6F07|rcsb pdb:6FE8|rcsb pdb:6GSA|rcsb pdb:6GYP|rcsb pdb:6GYS|rcsb pdb:6GYU|rcsb pdb:7K79|reactome:R-SCE-174113|reactome:R-SCE-68949|reactome:R-SCE-8854050|reactome:R-SCE-8951664|reactome:R-SCE-983168	-	crc64:0348F2F8FA78F3BC	crc64:746DDE6470A69432	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/17	2014/10/16	rogid:KUKB7HDw6k4t7Gb1pDGW8P5J1kw559292	rogid:HO5Uz+KzzWNBubxoXRDNTVi8eIA559292	intact-crc:C04D36F56B26C257|rigid:UqB03WVcGngprAjLKNB09ZbwMAE	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P52286	uniprotkb:P07834	intact:EBI-4090|uniprotkb:Q07186|uniprotkb:D6VSW0|ensemblfungi:YDR328C	intact:EBI-4434|ensemblfungi:YFL009W|uniprotkb:D6VTM1	psi-mi:skp1_yeast(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:CBF3D(gene name synonym)|uniprotkb:YDR328C(locus name)|uniprotkb:D9798.14(orf name)|uniprotkb:Centromere DNA-binding protein complex CBF3 subunit D(gene name synonym)|uniprotkb:E3 ubiquitin ligase complex SCF subunit SKP1(gene name synonym)	psi-mi:cdc4_yeast(display_long)|uniprotkb:CDC4(gene name)|psi-mi:CDC4(display_short)|uniprotkb:YFL009W(locus name)|uniprotkb:F-box protein CDC4(gene name synonym)|uniprotkb:E3 ubiquitin ligase complex SCF subunit CDC4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bai et al. (1996)	pubmed:8706131|imex:IM-19863	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-906577|imex:IM-19863-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002736|refseq:NP_010615.3|dip:DIP-1236N|mint:P52286|ensemblfungi:YDR328C(gene)|ensemblfungi:YDR328C_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000921"(septin ring assembly)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010458"(exit from mitosis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031518"(CBF3 complex)|go:"GO:0034622"|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043291"(RAVE complex)|go:"GO:0045116"(protein neddylation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|rcsb pdb:1NEX|rcsb pdb:3MKS|rcsb pdb:3V7D|rcsb pdb:5AN3|rcsb pdb:6F07|rcsb pdb:6FE8|rcsb pdb:6GSA|rcsb pdb:6GYP|rcsb pdb:6GYS|rcsb pdb:6GYU|rcsb pdb:7K79|reactome:R-SCE-174113|reactome:R-SCE-68949|reactome:R-SCE-8854050|reactome:R-SCE-8951664|reactome:R-SCE-983168	reactome:R-SCE-174113|reactome:R-SCE-8951664|reactome:R-SCE-983168|ensemblfungi:YFL009W(gene)|ensemblfungi:YFL009W_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030686"(90S preribosome)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0043130"(ubiquitin binding)|refseq:NP_116585.1|sgd:S000001885|dip:DIP-1625N|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR031740|interpro:IPR036047|interpro:IPR036322|rcsb pdb:1NEX|rcsb pdb:2P63|rcsb pdb:3MKS|rcsb pdb:3V7D	-	crc64:746DDE6470A69432	crc64:0348F2F8FA78F3BC	comment:Shows that conserved residues within the Cdc4 F-box are required for binding to Cbf3d and mutations of these residues significantly reduced or abolished the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/17	2014/10/16	rogid:HO5Uz+KzzWNBubxoXRDNTVi8eIA559292	rogid:KUKB7HDw6k4t7Gb1pDGW8P5J1kw559292	intact-crc:CDA8F8807656CF3B|rigid:UqB03WVcGngprAjLKNB09ZbwMAE	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?|necessary binding region:279-279,290-290,286-286,316-316,278-279	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41002	uniprotkb:P52286	intact:EBI-1207574|uniprotkb:Q96EG9|uniprotkb:B2R8H3|ensembl:ENSP00000380256	intact:EBI-4090|uniprotkb:Q07186|uniprotkb:D6VSW0|ensemblfungi:YDR328C	psi-mi:ccnf_human(display_long)|uniprotkb:CCNF(gene name)|psi-mi:CCNF(display_short)|uniprotkb:FBX1(gene name synonym)|uniprotkb:FBXO1(gene name synonym)|uniprotkb:F-box only protein 1(gene name synonym)	psi-mi:skp1_yeast(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:CBF3D(gene name synonym)|uniprotkb:YDR328C(locus name)|uniprotkb:D9798.14(orf name)|uniprotkb:Centromere DNA-binding protein complex CBF3 subunit D(gene name synonym)|uniprotkb:E3 ubiquitin ligase complex SCF subunit SKP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bai et al. (1996)	pubmed:8706131|imex:IM-19863	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-907638|imex:IM-19863-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001752.2|ensembl:ENSG00000162063(gene)|ensembl:ENST00000397066(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030054"(cell junction)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036047|interpro:IPR036915|interpro:IPR039361|reactome:R-HSA-8951664|reactome:R-HSA-983168|dip:DIP-44939N	sgd:S000002736|refseq:NP_010615.3|dip:DIP-1236N|mint:P52286|ensemblfungi:YDR328C(gene)|ensemblfungi:YDR328C_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000921"(septin ring assembly)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010458"(exit from mitosis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031518"(CBF3 complex)|go:"GO:0034622"|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043291"(RAVE complex)|go:"GO:0045116"(protein neddylation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|rcsb pdb:1NEX|rcsb pdb:3MKS|rcsb pdb:3V7D|rcsb pdb:5AN3|rcsb pdb:6F07|rcsb pdb:6FE8|rcsb pdb:6GSA|rcsb pdb:6GYP|rcsb pdb:6GYS|rcsb pdb:6GYU|rcsb pdb:7K79|reactome:R-SCE-174113|reactome:R-SCE-68949|reactome:R-SCE-8854050|reactome:R-SCE-8951664|reactome:R-SCE-983168	-	-	crc64:746DDE6470A69432	comment:Shows that Cbf3d is able to bind to Cyclin F in the absence of Skp2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/17	2014/10/16	rogid:sH7lANHfBlcWBuE582VMlSjojLI9606	rogid:HO5Uz+KzzWNBubxoXRDNTVi8eIA559292	intact-crc:27C83E14334E6C34|rigid:2KcflJV7kJ2hHrd494kjCYIViWg	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)