#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P00221	uniprotkb:P00455	intact:EBI-864933	intact:EBI-865079	psi-mi:fer1_spiol(display_long)|uniprotkb:Ferredoxin I(gene name synonym)|uniprotkb:PETF(gene name)|psi-mi:PETF(display_short)	psi-mi:fenr_spiol(display_long)|uniprotkb:PETH(gene name)|psi-mi:PETH(display_short)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Aliverti et al. (1994)	pubmed:8174709|imex:IM-19101	taxid:3562(spiol)|taxid:3562("Spinacia oleracea (Spinach)")	taxid:3562(spiol)|taxid:3562("Spinacia oleracea (Spinach)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-865134|imex:IM-19101-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR010241(Ferredoxin [2Fe-2S], plant)|interpro:IPR001041(Ferredoxin)|rcsb pdb:1A70|interpro:IPR036010|go:"GO:0009055"(electron transfer activity)|go:"GO:0009507"(chloroplast)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)	rcsb pdb:1FRQ|interpro:IPR017927|interpro:IPR015701(Ferredoxin Reductase)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR017938|rcsb pdb:1BX0|rcsb pdb:1BX1|rcsb pdb:1FNB|rcsb pdb:1FNC|rcsb pdb:1FND|rcsb pdb:1FRN|interpro:IPR039261|interpro:IPR035442|go:"GO:0004324"(ferredoxin-NADP+ reductase activity)|go:"GO:0009535"(chloroplast thylakoid membrane)|go:"GO:0009570"(chloroplast stroma)|go:"GO:0015979"(photosynthesis)	go:"GO:0008937"("ferredoxin-NAD(P) reductase activity")	-	-	inhibition:High ionic strength.|kinetics:The mutant K88Q of FNR have a lower affinity for ferredoxin. The Km for the wild type protein is 0.4 10-6 M, and the Km is 3.5 10-6 M for the K88Q mutant.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cyanobacteria - Interaction dataset based on Cyanobacteria proteins and related species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/22	2014/10/16	rogid:5tN7aaunrmdgDmZFGFRRIJxtmCU3562	rogid:LL/hLdApdJ6mqqGVIe0TcCpr95g3562	intact-crc:A013B4014500EF37|rigid:1rjqVvg4HkrC/gN6DofBp5ANWeU	false	-	mutation decreasing interaction:88-88	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00221	uniprotkb:P00455	intact:EBI-864933	intact:EBI-865079	psi-mi:fer1_spiol(display_long)|uniprotkb:Ferredoxin I(gene name synonym)|uniprotkb:PETF(gene name)|psi-mi:PETF(display_short)	psi-mi:fenr_spiol(display_long)|uniprotkb:PETH(gene name)|psi-mi:PETH(display_short)	psi-mi:"MI:0030"(cross-linking study)	Aliverti et al. (1994)	pubmed:8174709|imex:IM-19101	taxid:3562(spiol)|taxid:3562("Spinacia oleracea (Spinach)")	taxid:3562(spiol)|taxid:3562("Spinacia oleracea (Spinach)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-865202|imex:IM-19101-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR010241(Ferredoxin [2Fe-2S], plant)|interpro:IPR001041(Ferredoxin)|rcsb pdb:1A70|interpro:IPR036010|go:"GO:0009055"(electron transfer activity)|go:"GO:0009507"(chloroplast)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)	rcsb pdb:1FRQ|interpro:IPR017927|interpro:IPR015701(Ferredoxin Reductase)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR017938|rcsb pdb:1BX0|rcsb pdb:1BX1|rcsb pdb:1FNB|rcsb pdb:1FNC|rcsb pdb:1FND|rcsb pdb:1FRN|interpro:IPR039261|interpro:IPR035442|go:"GO:0004324"(ferredoxin-NADP+ reductase activity)|go:"GO:0009535"(chloroplast thylakoid membrane)|go:"GO:0009570"(chloroplast stroma)|go:"GO:0015979"(photosynthesis)	-	-	-	inhibition:High ionic strength.|kinetics:The mutant K88Q of FNR have a lower affinity for ferredoxin. The Km for the wild type protein is 0.4 10-6 M, and the Km is 3.5 10-6 M for the K88Q mutant.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cyanobacteria - Interaction dataset based on Cyanobacteria proteins and related species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/22	2014/10/16	rogid:5tN7aaunrmdgDmZFGFRRIJxtmCU3562	rogid:LL/hLdApdJ6mqqGVIe0TcCpr95g3562	intact-crc:192755347AF79635|rigid:1rjqVvg4HkrC/gN6DofBp5ANWeU	false	-	mutation decreasing interaction:88-88	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00004	uniprotkb:P00455	intact:EBI-865260	intact:EBI-865079	psi-mi:cyc_horse(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:fenr_spiol(display_long)|uniprotkb:PETH(gene name)|psi-mi:PETH(display_short)	psi-mi:"MI:0415"(enzymatic study)	Aliverti et al. (1994)	pubmed:8174709|imex:IM-19101	taxid:9796(horse)|taxid:9796("Equus caballus (Horse)")	taxid:3562(spiol)|taxid:3562("Spinacia oleracea (Spinach)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-865304|imex:IM-19101-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-36774N|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070069"(cytochrome complex)|go:"GO:0070469"(respirasome)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:1AKK|rcsb pdb:1CRC|rcsb pdb:1FI7|rcsb pdb:1FI9|rcsb pdb:1GIW|rcsb pdb:1HRC|rcsb pdb:1I5T|rcsb pdb:1LC1|rcsb pdb:1LC2|rcsb pdb:1M60|rcsb pdb:1OCD|rcsb pdb:1U75|rcsb pdb:1WEJ|rcsb pdb:2FRC|rcsb pdb:2GIW|rcsb pdb:2N3B|rcsb pdb:2PCB|rcsb pdb:3JBT|rcsb pdb:3NBS|rcsb pdb:3NBT|rcsb pdb:3O1Y|rcsb pdb:3O20|rcsb pdb:3WC8|rcsb pdb:3WUI|rcsb pdb:4NFG|rcsb pdb:4RSZ|rcsb pdb:5IY5|rcsb pdb:5WVE|rcsb pdb:5ZKV|rcsb pdb:6K9I|rcsb pdb:6K9J|rcsb pdb:6SUV	rcsb pdb:1FRQ|interpro:IPR017927|interpro:IPR015701(Ferredoxin Reductase)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR017938|rcsb pdb:1BX0|rcsb pdb:1BX1|rcsb pdb:1FNB|rcsb pdb:1FNC|rcsb pdb:1FND|rcsb pdb:1FRN|interpro:IPR039261|interpro:IPR035442|go:"GO:0004324"(ferredoxin-NADP+ reductase activity)|go:"GO:0009535"(chloroplast thylakoid membrane)|go:"GO:0009570"(chloroplast stroma)|go:"GO:0015979"(photosynthesis)	-	-	-	kinetics:The kcat is deduced by varing both NADPH and Ferredoxin consnetration and fitting the data to a 'ping-pong mechanism'.The kcat for the wild type protein is 3800 U/FAD, and the kcat is 2200 for the K88Q mutant.|stimulant:ferredoxin is necessary|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cyanobacteria - Interaction dataset based on Cyanobacteria proteins and related species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/22	2014/10/16	rogid:rr0R4M6Q4s825u6AM3R9C6CEHos9796	rogid:LL/hLdApdJ6mqqGVIe0TcCpr95g3562	intact-crc:9409AB8C7BFAB820|rigid:YxpXTvJazKvrT6u0u6UTDTq4OzA	false	-	mutation decreasing interaction:88-88	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00004	uniprotkb:P00221	intact:EBI-865260	intact:EBI-864933	psi-mi:cyc_horse(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:fer1_spiol(display_long)|uniprotkb:Ferredoxin I(gene name synonym)|uniprotkb:PETF(gene name)|psi-mi:PETF(display_short)	psi-mi:"MI:0415"(enzymatic study)	Aliverti et al. (1994)	pubmed:8174709|imex:IM-19101	taxid:9796(horse)|taxid:9796("Equus caballus (Horse)")	taxid:3562(spiol)|taxid:3562("Spinacia oleracea (Spinach)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-865304|imex:IM-19101-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-36774N|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070069"(cytochrome complex)|go:"GO:0070469"(respirasome)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:1AKK|rcsb pdb:1CRC|rcsb pdb:1FI7|rcsb pdb:1FI9|rcsb pdb:1GIW|rcsb pdb:1HRC|rcsb pdb:1I5T|rcsb pdb:1LC1|rcsb pdb:1LC2|rcsb pdb:1M60|rcsb pdb:1OCD|rcsb pdb:1U75|rcsb pdb:1WEJ|rcsb pdb:2FRC|rcsb pdb:2GIW|rcsb pdb:2N3B|rcsb pdb:2PCB|rcsb pdb:3JBT|rcsb pdb:3NBS|rcsb pdb:3NBT|rcsb pdb:3O1Y|rcsb pdb:3O20|rcsb pdb:3WC8|rcsb pdb:3WUI|rcsb pdb:4NFG|rcsb pdb:4RSZ|rcsb pdb:5IY5|rcsb pdb:5WVE|rcsb pdb:5ZKV|rcsb pdb:6K9I|rcsb pdb:6K9J|rcsb pdb:6SUV	interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR010241(Ferredoxin [2Fe-2S], plant)|interpro:IPR001041(Ferredoxin)|rcsb pdb:1A70|interpro:IPR036010|go:"GO:0009055"(electron transfer activity)|go:"GO:0009507"(chloroplast)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)	-	-	-	kinetics:The kcat is deduced by varing both NADPH and Ferredoxin consnetration and fitting the data to a 'ping-pong mechanism'.The kcat for the wild type protein is 3800 U/FAD, and the kcat is 2200 for the K88Q mutant.|stimulant:ferredoxin is necessary|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cyanobacteria - Interaction dataset based on Cyanobacteria proteins and related species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/22	2014/10/16	rogid:rr0R4M6Q4s825u6AM3R9C6CEHos9796	rogid:5tN7aaunrmdgDmZFGFRRIJxtmCU3562	intact-crc:9409AB8C7BFAB820|rigid:YxpXTvJazKvrT6u0u6UTDTq4OzA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)