#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q80W92	uniprotkb:P29476	intact:EBI-7164017|ensembl:ENSRNOP00000023383|intact:MINT-4571292|intact:MINT-3982533	intact:EBI-349460|uniprotkb:P70594	psi-mi:vac14_rat(display_long)|uniprotkb:Vac14(gene name)|psi-mi:Vac14(display_short)	psi-mi:nos1_rat(display_long)|uniprotkb:Nos1(gene name)|psi-mi:Nos1(display_short)|uniprotkb:Bnos(gene name synonym)|uniprotkb:BNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemaire et al. (2006)	pubmed:17161399|imex:IM-11097|mint:MINT-5219443	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7164035|mint:MINT-3982865|imex:IM-11097-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000017219(gene)|ensembl:ENSRNOT00000023383(transcript)|go:"GO:0000306"(extrinsic component of vacuolar membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0070772"(PAS complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021841|interpro:IPR026825|mint:Q80W92|reactome:R-RNO-1660514|reactome:R-RNO-1660517|reactome:R-RNO-1660516|refseq:NP_808791.1|rgd:631410|mint:MINT-3982866(identity)	refseq:NP_434686.1|rgd:3184|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010288"(response to lead ion)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030141"(secretory granule)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035094"(response to nicotine)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042582"(azurophil granule)|go:"GO:0042738"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044305"(calyx of Held)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0061875"(negative regulation of hepatic stellate cell contraction)|go:"GO:0070402"(NADPH binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071731"(response to nitric oxide)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099163"(synaptic signaling by nitric oxide)|go:"GO:0140196"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1B8Q|rcsb pdb:1CMI|rcsb pdb:1F20|rcsb pdb:1K2R|rcsb pdb:1K2S|rcsb pdb:1K2T|rcsb pdb:1K2U|rcsb pdb:1LZX|rcsb pdb:1LZZ|rcsb pdb:1M00|rcsb pdb:1MMV|interpro:IPR023173|rcsb pdb:1MMW|rcsb pdb:1OM4|rcsb pdb:1OM5|rcsb pdb:1P6H|rcsb pdb:1P6I|rcsb pdb:1P6J|rcsb pdb:1P6K|rcsb pdb:1QAU|rcsb pdb:1QAV|rcsb pdb:1QW6|rcsb pdb:1QWC|rcsb pdb:1RS6|rcsb pdb:1RS7|rcsb pdb:1VAG|rcsb pdb:1ZVI|rcsb pdb:1ZVL|rcsb pdb:1ZZQ|rcsb pdb:1ZZR|rcsb pdb:1ZZU|rcsb pdb:2G6H|rcsb pdb:2G6I|rcsb pdb:2G6J|rcsb pdb:1TLL|rcsb pdb:2G6K|rcsb pdb:2G6L|rcsb pdb:2G6M|rcsb pdb:2G6N|rcsb pdb:2HX3|rcsb pdb:2HX4|rcsb pdb:3B3M|rcsb pdb:3B3N|rcsb pdb:3B3O|rcsb pdb:3B3P|rcsb pdb:3DQR|rcsb pdb:3FC5|rcsb pdb:3HSN|rcsb pdb:3HSO|rcsb pdb:3HSP|rcsb pdb:3JT3|rcsb pdb:3JT4|rcsb pdb:3JT5|rcsb pdb:3JT6|rcsb pdb:3JT7|rcsb pdb:3JT8|rcsb pdb:3N5Y|rcsb pdb:3JT9|rcsb pdb:3JTA|rcsb pdb:3N5Z|rcsb pdb:3N60|rcsb pdb:3N61|rcsb pdb:3N62|rcsb pdb:3N63|rcsb pdb:3N64|rcsb pdb:3N65|rcsb pdb:3N66|rcsb pdb:3JWS|rcsb pdb:3N67|rcsb pdb:3N68|rcsb pdb:3JWT|rcsb pdb:3N69|rcsb pdb:3JWU|rcsb pdb:3JWV|rcsb pdb:3JX0|rcsb pdb:3N6A|rcsb pdb:3N6B|rcsb pdb:3N6C|rcsb pdb:3N6D|rcsb pdb:3N6E|rcsb pdb:3N6F|rcsb pdb:3N6G|rcsb pdb:3NLJ|rcsb pdb:3NLK|rcsb pdb:3NLM|rcsb pdb:3NLN|rcsb pdb:3NLO|rcsb pdb:3NLP|rcsb pdb:3NLQ|rcsb pdb:3NLR|rcsb pdb:3NLV|rcsb pdb:3NLW|rcsb pdb:3NLX|rcsb pdb:3JX1|rcsb pdb:3NLY|rcsb pdb:3NLZ|rcsb pdb:3JX2|rcsb pdb:3JX3|rcsb pdb:3JX4|rcsb pdb:3JX5|rcsb pdb:3JX6|rcsb pdb:3N2R|rcsb pdb:3NM0|rcsb pdb:3NNY|rcsb pdb:3N5V|rcsb pdb:3N5W|rcsb pdb:3N5X|rcsb pdb:3NNZ|rcsb pdb:3PNE|rcsb pdb:3PNF|rcsb pdb:3PNG|rcsb pdb:3Q99|rcsb pdb:3Q9A|rcsb pdb:3RQJ|rcsb pdb:3RQK|rcsb pdb:3RQL|rcsb pdb:3RQM|rcsb pdb:3RQN|rcsb pdb:3SVQ|rcsb pdb:3TYL|rcsb pdb:3TYM|rcsb pdb:3TYN|rcsb pdb:3TYO|rcsb pdb:3UFO|rcsb pdb:3UFP|rcsb pdb:3UFQ|rcsb pdb:3UFR|rcsb pdb:3UFS|rcsb pdb:3UFT|rcsb pdb:3UFU|rcsb pdb:3SVP|rcsb pdb:3UFV|rcsb pdb:3UFW|rcsb pdb:4C39|rcsb pdb:4CAM|rcsb pdb:4CAN|rcsb pdb:4CAO|rcsb pdb:4CAP|rcsb pdb:4CAQ|rcsb pdb:4CDT|rcsb pdb:4CTP|rcsb pdb:4CTQ|rcsb pdb:4CTR|rcsb pdb:4CTT|rcsb pdb:4CTV|rcsb pdb:4CTW|rcsb pdb:4CTX|rcsb pdb:4CX3|rcsb pdb:4CX4|rcsb pdb:4CX5|rcsb pdb:4CX6|rcsb pdb:4D2Y|rcsb pdb:4D2Z|rcsb pdb:4D30|rcsb pdb:4D31|rcsb pdb:4D32|rcsb pdb:4D3B|rcsb pdb:4D7O|rcsb pdb:4EUX|rcsb pdb:4FVW|rcsb pdb:4FVX|rcsb pdb:4FVY|rcsb pdb:4FVZ|rcsb pdb:4FW0|rcsb pdb:4CTU|rcsb pdb:4GQE|rcsb pdb:4HOP|rcsb pdb:4IMS|rcsb pdb:4IMT|rcsb pdb:4IMU|rcsb pdb:4IMW|rcsb pdb:4JSE|rcsb pdb:4JSF|rcsb pdb:4JSG|rcsb pdb:4JSH|rcsb pdb:4JSI|rcsb pdb:4JSJ|rcsb pdb:4K5D|rcsb pdb:4K5E|rcsb pdb:4K5F|rcsb pdb:4K5G|rcsb pdb:4KCH|rcsb pdb:4KCI|rcsb pdb:4KCJ|rcsb pdb:4KCK|rcsb pdb:4KCL|rcsb pdb:4KCM|rcsb pdb:4KCN|rcsb pdb:4KCO|rcsb pdb:4LUX|rcsb pdb:4UGZ|rcsb pdb:4UH0|rcsb pdb:4UH1|rcsb pdb:4UH2|rcsb pdb:4UH3|rcsb pdb:4UH4|rcsb pdb:4UPM|rcsb pdb:4UPN|rcsb pdb:4UPO|rcsb pdb:4UPP|rcsb pdb:4V3V|rcsb pdb:4V3W|rcsb pdb:4V3X|rcsb pdb:4V3Y|rcsb pdb:4V3Z|rcsb pdb:5AD4|rcsb pdb:5AD5|rcsb pdb:5AD6|rcsb pdb:5AD7|rcsb pdb:5AD8|rcsb pdb:5AD9|rcsb pdb:5ADA|rcsb pdb:5ADB|rcsb pdb:5ADC|rcsb pdb:5ADD|rcsb pdb:5ADE|rcsb pdb:5AGK|rcsb pdb:5AGL|rcsb pdb:5AGM|rcsb pdb:5AGN|rcsb pdb:5AGO|rcsb pdb:5AGP|rcsb pdb:5FVO|rcsb pdb:5FVQ|rcsb pdb:5FVP|rcsb pdb:5FVR|rcsb pdb:5FVS|rcsb pdb:5FVT|rcsb pdb:5FW0|rcsb pdb:5G0N|rcsb pdb:5G0O|rcsb pdb:5G0P|rcsb pdb:5UNR|rcsb pdb:5UNS|rcsb pdb:5UNT|rcsb pdb:5UNU|rcsb pdb:5UNV|rcsb pdb:5UNW|rcsb pdb:5UNX|rcsb pdb:5UNY|rcsb pdb:5UNZ|rcsb pdb:5UO0|rcsb pdb:5VUI|rcsb pdb:5VUJ|rcsb pdb:5VUK|rcsb pdb:5VUQ|rcsb pdb:5VUR|rcsb pdb:5VUS|rcsb pdb:5VUT|rcsb pdb:5VUU|rcsb pdb:6AUQ|rcsb pdb:6AUR|rcsb pdb:6AUS|rcsb pdb:6AUT|rcsb pdb:6AUU|rcsb pdb:6AUV|rcsb pdb:6AUW|rcsb pdb:6AUX|rcsb pdb:6NGJ|rcsb pdb:6NGK|rcsb pdb:6NGL|rcsb pdb:6NGM|rcsb pdb:6NGN|rcsb pdb:6NGP|rcsb pdb:5VUL|rcsb pdb:6NGQ|rcsb pdb:6NGR|rcsb pdb:6NGS|rcsb pdb:6NGT|rcsb pdb:6NGU|rcsb pdb:6NGV|rcsb pdb:6NGW|rcsb pdb:6NGX|rcsb pdb:6NGY|rcsb pdb:6NGZ|rcsb pdb:6NH0|rcsb pdb:6NHD|rcsb pdb:5VUM|rcsb pdb:6NHE|rcsb pdb:6PMV|rcsb pdb:6PMW|rcsb pdb:6PMX|rcsb pdb:5VUN|rcsb pdb:5VUO|rcsb pdb:5VUP|rcsb pdb:6PMY|rcsb pdb:6PMZ|rcsb pdb:6PN0|rcsb pdb:6PN1|rcsb pdb:6PN2|rcsb pdb:6PN3|rcsb pdb:6PN4|rcsb pdb:6PN5|rcsb pdb:6PN6|rcsb pdb:6PN7|rcsb pdb:6PN8|rcsb pdb:6PN9|reactome:R-RNO-1222556|reactome:R-RNO-392154|reactome:R-RNO-5578775|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0009725"(response to hormone)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0010181"(FMN binding)|mint:P29476|dip:DIP-33272N|mint:MINT-3982867(identity)	-	comment:mint	-	figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2006/12/20	2014/10/16	rogid:Ija+RwCUuA4Bn250mkinB6WEFDc10116	rogid:zTwUJbUZCIUNrueIAbDtZFY04i010116	intact-crc:1023C24B9FD12AF4|rigid:SBE35K2+0RnW9U33IzjWjsMhudI	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q08AM6	uniprotkb:P29475	intact:EBI-2107455|uniprotkb:Q13174|uniprotkb:Q6IA12|uniprotkb:Q7L4Y1|uniprotkb:Q9BW96|uniprotkb:Q9H6V6|uniprotkb:B3KPJ5|uniprotkb:B3KSM8|ensembl:ENSP00000261776	intact:EBI-7164065|intact:EBI-28983773|ensembl:ENSP00000320758|uniprotkb:O75713|uniprotkb:E9PH30|intact:MINT-122019	psi-mi:vac14_human(display_long)|uniprotkb:Tax1-binding protein 2(gene name synonym)|uniprotkb:VAC14(gene name)|psi-mi:VAC14(display_short)|uniprotkb:TAX1BP2(gene name synonym)|uniprotkb:TRX(gene name synonym)	psi-mi:nos1_human(display_long)|uniprotkb:NOS1(gene name)|psi-mi:NOS1(display_short)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Lemaire et al. (2006)	pubmed:17161399|imex:IM-11097|mint:MINT-5219443	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7164056|mint:MINT-3999902|imex:IM-11097-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060522.3|ensembl:ENSG00000103043(gene)|ensembl:ENST00000261776(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000306"(extrinsic component of vacuolar membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070772"(PAS complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021841|interpro:IPR026825|mint:Q08AM6|rcsb pdb:7K1Y|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|mint:MINT-3999903(identity)	refseq:XP_011536700.1|ensembl:ENSP00000320758|ensembl:ENST00000338101|ensembl:ENSP00000337459|ensembl:ENST00000618760|ensembl:ENSP00000477999|ensembl:ENSG00000089250(gene)|ensembl:ENST00000317775(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042738"|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|rcsb pdb:5UO1|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR039261|mint:P29475|rcsb pdb:4D1N|rcsb pdb:4UCH|rcsb pdb:4UH5|rcsb pdb:4UH6|rcsb pdb:4V3U|rcsb pdb:5ADF|rcsb pdb:5ADG|rcsb pdb:5ADI|rcsb pdb:5FVU|rcsb pdb:5FVV|rcsb pdb:5FVW|rcsb pdb:5FVX|rcsb pdb:5UO3|rcsb pdb:5UO4|rcsb pdb:5UO5|rcsb pdb:5UO6|rcsb pdb:5UO7|rcsb pdb:5VUV|rcsb pdb:5VUW|rcsb pdb:5VUX|rcsb pdb:5VUY|rcsb pdb:5VUZ|rcsb pdb:5VV0|rcsb pdb:5VV1|rcsb pdb:5VV2|rcsb pdb:5VV3|rcsb pdb:5VV4|rcsb pdb:5VV5|rcsb pdb:6AUY|rcsb pdb:6AUZ|rcsb pdb:6AV0|rcsb pdb:6AV1|rcsb pdb:6AV2|rcsb pdb:6AV3|rcsb pdb:6AV4|rcsb pdb:6AV5|rcsb pdb:6CIC|rcsb pdb:6CID|rcsb pdb:6NG1|rcsb pdb:6NG2|rcsb pdb:6NG4|rcsb pdb:6NG5|rcsb pdb:6NG6|rcsb pdb:6NG7|rcsb pdb:6NG8|rcsb pdb:6NGA|rcsb pdb:6NGB|rcsb pdb:6NGC|rcsb pdb:6NGD|rcsb pdb:6NGE|rcsb pdb:6NGF|rcsb pdb:5UO2|rcsb pdb:6NGH|rcsb pdb:6NGI|rcsb pdb:6NHB|rcsb pdb:6NHC|rcsb pdb:6PNA|rcsb pdb:6PNB|rcsb pdb:6PNC|rcsb pdb:6PND|rcsb pdb:6PNE|rcsb pdb:6PNF|rcsb pdb:6PNG|rcsb pdb:6PNH|rcsb pdb:6PO5|rcsb pdb:6PO7|rcsb pdb:6PO8|rcsb pdb:6PO9|rcsb pdb:6POA|rcsb pdb:6POB|rcsb pdb:6POC|rcsb pdb:6POT|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-5578775|refseq:NP_001191143.1|refseq:NP_000611.1|refseq:NP_001191147.1|refseq:NP_001191142.1|refseq:XP_016874834.1|refseq:XP_016874835.1|refseq:XP_016874836.1|dip:DIP-40999N|mint:MINT-3999907(identity)	-	-	comment:mint|function:"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter"|function:"Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction"	figure legend:F2D|figure legend:F2E|kinetics:kd 0,23 micromolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/20	2014/10/16	rogid:S9syIZ/DKHNbOM0Nw9oZP5F+AvA9606	rogid:El1bLhrX0trPS1atMOWTFpDa3XU9606	intact-crc:23907BEE643E49A9|rigid:CMDJJ2mMVSNg4FKaxpRWI+PWupk	false	his tag:?-?(MINT-3999905)	glutathione s tranferase tag:?-?(MINT-3999912)|binding-associated region:1-100(MINT-3999909)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q08AM6	uniprotkb:P29475	intact:EBI-2107455|uniprotkb:Q13174|uniprotkb:Q6IA12|uniprotkb:Q7L4Y1|uniprotkb:Q9BW96|uniprotkb:Q9H6V6|uniprotkb:B3KPJ5|uniprotkb:B3KSM8|ensembl:ENSP00000261776	intact:EBI-7164065|intact:EBI-28983773|ensembl:ENSP00000320758|uniprotkb:O75713|uniprotkb:E9PH30|intact:MINT-122019	psi-mi:vac14_human(display_long)|uniprotkb:Tax1-binding protein 2(gene name synonym)|uniprotkb:VAC14(gene name)|psi-mi:VAC14(display_short)|uniprotkb:TAX1BP2(gene name synonym)|uniprotkb:TRX(gene name synonym)	psi-mi:nos1_human(display_long)|uniprotkb:NOS1(gene name)|psi-mi:NOS1(display_short)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemaire et al. (2006)	pubmed:17161399|imex:IM-11097|mint:MINT-5219443	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7164210|mint:MINT-3999924|imex:IM-11097-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060522.3|ensembl:ENSG00000103043(gene)|ensembl:ENST00000261776(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000306"(extrinsic component of vacuolar membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070772"(PAS complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021841|interpro:IPR026825|mint:Q08AM6|rcsb pdb:7K1Y|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|mint:MINT-3999925(identity)	refseq:XP_011536700.1|ensembl:ENSP00000320758|ensembl:ENST00000338101|ensembl:ENSP00000337459|ensembl:ENST00000618760|ensembl:ENSP00000477999|ensembl:ENSG00000089250(gene)|ensembl:ENST00000317775(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042738"|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|rcsb pdb:5UO1|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR039261|mint:P29475|rcsb pdb:4D1N|rcsb pdb:4UCH|rcsb pdb:4UH5|rcsb pdb:4UH6|rcsb pdb:4V3U|rcsb pdb:5ADF|rcsb pdb:5ADG|rcsb pdb:5ADI|rcsb pdb:5FVU|rcsb pdb:5FVV|rcsb pdb:5FVW|rcsb pdb:5FVX|rcsb pdb:5UO3|rcsb pdb:5UO4|rcsb pdb:5UO5|rcsb pdb:5UO6|rcsb pdb:5UO7|rcsb pdb:5VUV|rcsb pdb:5VUW|rcsb pdb:5VUX|rcsb pdb:5VUY|rcsb pdb:5VUZ|rcsb pdb:5VV0|rcsb pdb:5VV1|rcsb pdb:5VV2|rcsb pdb:5VV3|rcsb pdb:5VV4|rcsb pdb:5VV5|rcsb pdb:6AUY|rcsb pdb:6AUZ|rcsb pdb:6AV0|rcsb pdb:6AV1|rcsb pdb:6AV2|rcsb pdb:6AV3|rcsb pdb:6AV4|rcsb pdb:6AV5|rcsb pdb:6CIC|rcsb pdb:6CID|rcsb pdb:6NG1|rcsb pdb:6NG2|rcsb pdb:6NG4|rcsb pdb:6NG5|rcsb pdb:6NG6|rcsb pdb:6NG7|rcsb pdb:6NG8|rcsb pdb:6NGA|rcsb pdb:6NGB|rcsb pdb:6NGC|rcsb pdb:6NGD|rcsb pdb:6NGE|rcsb pdb:6NGF|rcsb pdb:5UO2|rcsb pdb:6NGH|rcsb pdb:6NGI|rcsb pdb:6NHB|rcsb pdb:6NHC|rcsb pdb:6PNA|rcsb pdb:6PNB|rcsb pdb:6PNC|rcsb pdb:6PND|rcsb pdb:6PNE|rcsb pdb:6PNF|rcsb pdb:6PNG|rcsb pdb:6PNH|rcsb pdb:6PO5|rcsb pdb:6PO7|rcsb pdb:6PO8|rcsb pdb:6PO9|rcsb pdb:6POA|rcsb pdb:6POB|rcsb pdb:6POC|rcsb pdb:6POT|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-5578775|refseq:NP_001191143.1|refseq:NP_000611.1|refseq:NP_001191147.1|refseq:NP_001191142.1|refseq:XP_016874834.1|refseq:XP_016874835.1|refseq:XP_016874836.1|dip:DIP-40999N|mint:MINT-3999929(identity)	-	-	comment:mint|function:"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter"|function:"Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction"	figure legend:F3|figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/20	2014/10/16	rogid:S9syIZ/DKHNbOM0Nw9oZP5F+AvA9606	rogid:El1bLhrX0trPS1atMOWTFpDa3XU9606	intact-crc:CF0A39122FE55E4C|rigid:CMDJJ2mMVSNg4FKaxpRWI+PWupk	false	binding-associated region:335-782(MINT-3999941)|mutation disrupting interaction:773-782(MINT-3999943)|mutation decreasing interaction:778-782(MINT-3999949)|his tag:?-?(MINT-3999926)	binding-associated region:1-100(MINT-3999932)|glutathione s tranferase tag:?-?(MINT-3999930)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q08AM6	uniprotkb:P29475	intact:EBI-2107455|uniprotkb:Q13174|uniprotkb:Q6IA12|uniprotkb:Q7L4Y1|uniprotkb:Q9BW96|uniprotkb:Q9H6V6|uniprotkb:B3KPJ5|uniprotkb:B3KSM8|ensembl:ENSP00000261776	intact:EBI-7164065|intact:EBI-28983773|ensembl:ENSP00000320758|uniprotkb:O75713|uniprotkb:E9PH30|intact:MINT-122019	psi-mi:vac14_human(display_long)|uniprotkb:Tax1-binding protein 2(gene name synonym)|uniprotkb:VAC14(gene name)|psi-mi:VAC14(display_short)|uniprotkb:TAX1BP2(gene name synonym)|uniprotkb:TRX(gene name synonym)	psi-mi:nos1_human(display_long)|uniprotkb:NOS1(gene name)|psi-mi:NOS1(display_short)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemaire et al. (2006)	pubmed:17161399|imex:IM-11097|mint:MINT-5219443	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7164245|mint:MINT-3999953|imex:IM-11097-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060522.3|ensembl:ENSG00000103043(gene)|ensembl:ENST00000261776(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000306"(extrinsic component of vacuolar membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070772"(PAS complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021841|interpro:IPR026825|mint:Q08AM6|rcsb pdb:7K1Y|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|mint:MINT-3999961(identity)	refseq:XP_011536700.1|ensembl:ENSP00000320758|ensembl:ENST00000338101|ensembl:ENSP00000337459|ensembl:ENST00000618760|ensembl:ENSP00000477999|ensembl:ENSG00000089250(gene)|ensembl:ENST00000317775(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042738"|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|rcsb pdb:5UO1|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR039261|mint:P29475|rcsb pdb:4D1N|rcsb pdb:4UCH|rcsb pdb:4UH5|rcsb pdb:4UH6|rcsb pdb:4V3U|rcsb pdb:5ADF|rcsb pdb:5ADG|rcsb pdb:5ADI|rcsb pdb:5FVU|rcsb pdb:5FVV|rcsb pdb:5FVW|rcsb pdb:5FVX|rcsb pdb:5UO3|rcsb pdb:5UO4|rcsb pdb:5UO5|rcsb pdb:5UO6|rcsb pdb:5UO7|rcsb pdb:5VUV|rcsb pdb:5VUW|rcsb pdb:5VUX|rcsb pdb:5VUY|rcsb pdb:5VUZ|rcsb pdb:5VV0|rcsb pdb:5VV1|rcsb pdb:5VV2|rcsb pdb:5VV3|rcsb pdb:5VV4|rcsb pdb:5VV5|rcsb pdb:6AUY|rcsb pdb:6AUZ|rcsb pdb:6AV0|rcsb pdb:6AV1|rcsb pdb:6AV2|rcsb pdb:6AV3|rcsb pdb:6AV4|rcsb pdb:6AV5|rcsb pdb:6CIC|rcsb pdb:6CID|rcsb pdb:6NG1|rcsb pdb:6NG2|rcsb pdb:6NG4|rcsb pdb:6NG5|rcsb pdb:6NG6|rcsb pdb:6NG7|rcsb pdb:6NG8|rcsb pdb:6NGA|rcsb pdb:6NGB|rcsb pdb:6NGC|rcsb pdb:6NGD|rcsb pdb:6NGE|rcsb pdb:6NGF|rcsb pdb:5UO2|rcsb pdb:6NGH|rcsb pdb:6NGI|rcsb pdb:6NHB|rcsb pdb:6NHC|rcsb pdb:6PNA|rcsb pdb:6PNB|rcsb pdb:6PNC|rcsb pdb:6PND|rcsb pdb:6PNE|rcsb pdb:6PNF|rcsb pdb:6PNG|rcsb pdb:6PNH|rcsb pdb:6PO5|rcsb pdb:6PO7|rcsb pdb:6PO8|rcsb pdb:6PO9|rcsb pdb:6POA|rcsb pdb:6POB|rcsb pdb:6POC|rcsb pdb:6POT|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-5578775|refseq:NP_001191143.1|refseq:NP_000611.1|refseq:NP_001191147.1|refseq:NP_001191142.1|refseq:XP_016874834.1|refseq:XP_016874835.1|refseq:XP_016874836.1|dip:DIP-40999N|mint:MINT-3999954(identity)	-	-	comment:mint|function:"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter"|function:"Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction"	figure legend:F4C|figure legend:F4B|figure legend:F4D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/20	2014/10/16	rogid:S9syIZ/DKHNbOM0Nw9oZP5F+AvA9606	rogid:El1bLhrX0trPS1atMOWTFpDa3XU9606	intact-crc:2B7DB3641146DD2C|rigid:CMDJJ2mMVSNg4FKaxpRWI+PWupk	false	glutathione s tranferase tag:?-?(MINT-3999971)|mutation disrupting interaction:777-777(MINT-3999966)|binding-associated region:768-782(MINT-3999968)	binding-associated region:1-100(MINT-3999956)|his tag:?-?(MINT-3999959)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q08AM6	uniprotkb:P29475	intact:EBI-2107455|uniprotkb:Q13174|uniprotkb:Q6IA12|uniprotkb:Q7L4Y1|uniprotkb:Q9BW96|uniprotkb:Q9H6V6|uniprotkb:B3KPJ5|uniprotkb:B3KSM8|ensembl:ENSP00000261776	intact:EBI-7164065|intact:EBI-28983773|ensembl:ENSP00000320758|uniprotkb:O75713|uniprotkb:E9PH30|intact:MINT-122019	psi-mi:vac14_human(display_long)|uniprotkb:Tax1-binding protein 2(gene name synonym)|uniprotkb:VAC14(gene name)|psi-mi:VAC14(display_short)|uniprotkb:TAX1BP2(gene name synonym)|uniprotkb:TRX(gene name synonym)	psi-mi:nos1_human(display_long)|uniprotkb:NOS1(gene name)|psi-mi:NOS1(display_short)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemaire et al. (2006)	pubmed:17161399|imex:IM-11097|mint:MINT-5219443	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7164313|mint:MINT-3999982|imex:IM-11097-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060522.3|ensembl:ENSG00000103043(gene)|ensembl:ENST00000261776(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000306"(extrinsic component of vacuolar membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070772"(PAS complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021841|interpro:IPR026825|mint:Q08AM6|rcsb pdb:7K1Y|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|mint:MINT-3999990(identity)	refseq:XP_011536700.1|ensembl:ENSP00000320758|ensembl:ENST00000338101|ensembl:ENSP00000337459|ensembl:ENST00000618760|ensembl:ENSP00000477999|ensembl:ENSG00000089250(gene)|ensembl:ENST00000317775(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042738"|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|rcsb pdb:5UO1|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR039261|mint:P29475|rcsb pdb:4D1N|rcsb pdb:4UCH|rcsb pdb:4UH5|rcsb pdb:4UH6|rcsb pdb:4V3U|rcsb pdb:5ADF|rcsb pdb:5ADG|rcsb pdb:5ADI|rcsb pdb:5FVU|rcsb pdb:5FVV|rcsb pdb:5FVW|rcsb pdb:5FVX|rcsb pdb:5UO3|rcsb pdb:5UO4|rcsb pdb:5UO5|rcsb pdb:5UO6|rcsb pdb:5UO7|rcsb pdb:5VUV|rcsb pdb:5VUW|rcsb pdb:5VUX|rcsb pdb:5VUY|rcsb pdb:5VUZ|rcsb pdb:5VV0|rcsb pdb:5VV1|rcsb pdb:5VV2|rcsb pdb:5VV3|rcsb pdb:5VV4|rcsb pdb:5VV5|rcsb pdb:6AUY|rcsb pdb:6AUZ|rcsb pdb:6AV0|rcsb pdb:6AV1|rcsb pdb:6AV2|rcsb pdb:6AV3|rcsb pdb:6AV4|rcsb pdb:6AV5|rcsb pdb:6CIC|rcsb pdb:6CID|rcsb pdb:6NG1|rcsb pdb:6NG2|rcsb pdb:6NG4|rcsb pdb:6NG5|rcsb pdb:6NG6|rcsb pdb:6NG7|rcsb pdb:6NG8|rcsb pdb:6NGA|rcsb pdb:6NGB|rcsb pdb:6NGC|rcsb pdb:6NGD|rcsb pdb:6NGE|rcsb pdb:6NGF|rcsb pdb:5UO2|rcsb pdb:6NGH|rcsb pdb:6NGI|rcsb pdb:6NHB|rcsb pdb:6NHC|rcsb pdb:6PNA|rcsb pdb:6PNB|rcsb pdb:6PNC|rcsb pdb:6PND|rcsb pdb:6PNE|rcsb pdb:6PNF|rcsb pdb:6PNG|rcsb pdb:6PNH|rcsb pdb:6PO5|rcsb pdb:6PO7|rcsb pdb:6PO8|rcsb pdb:6PO9|rcsb pdb:6POA|rcsb pdb:6POB|rcsb pdb:6POC|rcsb pdb:6POT|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-5578775|refseq:NP_001191143.1|refseq:NP_000611.1|refseq:NP_001191147.1|refseq:NP_001191142.1|refseq:XP_016874834.1|refseq:XP_016874835.1|refseq:XP_016874836.1|dip:DIP-40999N|mint:MINT-3999983(identity)	-	-	comment:mint|function:"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter"|function:"Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction"	figure legend:F4C|figure legend:F4B|figure legend:F4D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/20	2014/10/16	rogid:S9syIZ/DKHNbOM0Nw9oZP5F+AvA9606	rogid:El1bLhrX0trPS1atMOWTFpDa3XU9606	intact-crc:E6D9775FE45CAE1B|rigid:CMDJJ2mMVSNg4FKaxpRWI+PWupk	false	binding-associated region:768-777(MINT-3999996)|glutathione s tranferase tag:?-?(MINT-3999993)|mutation disrupting interaction:777-777(MINT-3999991)|mutation decreasing interaction:773-773(MINT-4000009)|mutation disrupting interaction:776-776(MINT-4000003)|mutation disrupting interaction:774-774(MINT-4000006)	binding-associated region:1-100(MINT-3999986)|his tag:?-?(MINT-3999984)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P30994	uniprotkb:P29475	intact:EBI-7164364|uniprotkb:Q9QW44|intact:MINT-4000039	intact:EBI-7164065|intact:EBI-28983773|ensembl:ENSP00000320758|uniprotkb:O75713|uniprotkb:E9PH30|intact:MINT-122019	psi-mi:5ht2b_rat(display_long)|uniprotkb:Htr2b(gene name)|psi-mi:Htr2b(display_short)|uniprotkb:Srl(gene name synonym)|uniprotkb:5-HT-2F(gene name synonym)|uniprotkb:Serotonin receptor 2B(gene name synonym)|uniprotkb:Stomach fundus serotonin receptor(gene name synonym)	psi-mi:nos1_human(display_long)|uniprotkb:NOS1(gene name)|psi-mi:NOS1(display_short)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemaire et al. (2006)	pubmed:17161399|imex:IM-11097|mint:MINT-5219443	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7164357|mint:MINT-4000013|imex:IM-11097-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P30994|go:"GO:1904015"(cellular response to serotonin)|reactome:R-RNO-390666|reactome:R-RNO-416476|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007507"(heart development)|go:"GO:0007610"(behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014827"(intestine smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071418"(cellular response to amine stimulus)|go:"GO:0071502"(cellular response to temperature stimulus)|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|rgd:61801|refseq:NP_058946.1|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000482(5-Hydroxytryptamine 2B receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|mint:MINT-4000014(identity)	refseq:XP_011536700.1|ensembl:ENSP00000320758|ensembl:ENST00000338101|ensembl:ENSP00000337459|ensembl:ENST00000618760|ensembl:ENSP00000477999|ensembl:ENSG00000089250(gene)|ensembl:ENST00000317775(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042738"|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|rcsb pdb:5UO1|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR039261|mint:P29475|rcsb pdb:4D1N|rcsb pdb:4UCH|rcsb pdb:4UH5|rcsb pdb:4UH6|rcsb pdb:4V3U|rcsb pdb:5ADF|rcsb pdb:5ADG|rcsb pdb:5ADI|rcsb pdb:5FVU|rcsb pdb:5FVV|rcsb pdb:5FVW|rcsb pdb:5FVX|rcsb pdb:5UO3|rcsb pdb:5UO4|rcsb pdb:5UO5|rcsb pdb:5UO6|rcsb pdb:5UO7|rcsb pdb:5VUV|rcsb pdb:5VUW|rcsb pdb:5VUX|rcsb pdb:5VUY|rcsb pdb:5VUZ|rcsb pdb:5VV0|rcsb pdb:5VV1|rcsb pdb:5VV2|rcsb pdb:5VV3|rcsb pdb:5VV4|rcsb pdb:5VV5|rcsb pdb:6AUY|rcsb pdb:6AUZ|rcsb pdb:6AV0|rcsb pdb:6AV1|rcsb pdb:6AV2|rcsb pdb:6AV3|rcsb pdb:6AV4|rcsb pdb:6AV5|rcsb pdb:6CIC|rcsb pdb:6CID|rcsb pdb:6NG1|rcsb pdb:6NG2|rcsb pdb:6NG4|rcsb pdb:6NG5|rcsb pdb:6NG6|rcsb pdb:6NG7|rcsb pdb:6NG8|rcsb pdb:6NGA|rcsb pdb:6NGB|rcsb pdb:6NGC|rcsb pdb:6NGD|rcsb pdb:6NGE|rcsb pdb:6NGF|rcsb pdb:5UO2|rcsb pdb:6NGH|rcsb pdb:6NGI|rcsb pdb:6NHB|rcsb pdb:6NHC|rcsb pdb:6PNA|rcsb pdb:6PNB|rcsb pdb:6PNC|rcsb pdb:6PND|rcsb pdb:6PNE|rcsb pdb:6PNF|rcsb pdb:6PNG|rcsb pdb:6PNH|rcsb pdb:6PO5|rcsb pdb:6PO7|rcsb pdb:6PO8|rcsb pdb:6PO9|rcsb pdb:6POA|rcsb pdb:6POB|rcsb pdb:6POC|rcsb pdb:6POT|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-5578775|refseq:NP_001191143.1|refseq:NP_000611.1|refseq:NP_001191147.1|refseq:NP_001191142.1|refseq:XP_016874834.1|refseq:XP_016874835.1|refseq:XP_016874836.1|dip:DIP-40999N|mint:MINT-4000028(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system"	comment:mint|function:"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter"|function:"Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction"	figure legend:F4E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/20	2014/10/16	rogid:AlPJoDz+lavvWTZV+QzkBe47c5Y10116	rogid:El1bLhrX0trPS1atMOWTFpDa3XU9606	intact-crc:CC031DC86C1B7655|rigid:ZKnEV3EW2qhg3MTV8L44a0MfVQc	false	binding-associated region:464-479(MINT-4000021)|glutathione s tranferase tag:?-?(MINT-4000024)|mutation decreasing interaction:477-479(MINT-4000019)	his tag:?-?(MINT-4000033)|binding-associated region:1-100(MINT-4000030)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q08AM6	uniprotkb:P29475	intact:EBI-2107455|uniprotkb:Q13174|uniprotkb:Q6IA12|uniprotkb:Q7L4Y1|uniprotkb:Q9BW96|uniprotkb:Q9H6V6|uniprotkb:B3KPJ5|uniprotkb:B3KSM8|ensembl:ENSP00000261776	intact:EBI-7164065|intact:EBI-28983773|ensembl:ENSP00000320758|uniprotkb:O75713|uniprotkb:E9PH30|intact:MINT-122019	psi-mi:vac14_human(display_long)|uniprotkb:Tax1-binding protein 2(gene name synonym)|uniprotkb:VAC14(gene name)|psi-mi:VAC14(display_short)|uniprotkb:TAX1BP2(gene name synonym)|uniprotkb:TRX(gene name synonym)	psi-mi:nos1_human(display_long)|uniprotkb:NOS1(gene name)|psi-mi:NOS1(display_short)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Lemaire et al. (2006)	pubmed:17161399|imex:IM-11097|mint:MINT-5219443	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7164539|mint:MINT-3999876|imex:IM-11097-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060522.3|ensembl:ENSG00000103043(gene)|ensembl:ENST00000261776(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000306"(extrinsic component of vacuolar membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070772"(PAS complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021841|interpro:IPR026825|mint:Q08AM6|rcsb pdb:7K1Y|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|mint:MINT-3999884(identity)	refseq:XP_011536700.1|ensembl:ENSP00000320758|ensembl:ENST00000338101|ensembl:ENSP00000337459|ensembl:ENST00000618760|ensembl:ENSP00000477999|ensembl:ENSG00000089250(gene)|ensembl:ENST00000317775(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042738"|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|rcsb pdb:5UO1|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR039261|mint:P29475|rcsb pdb:4D1N|rcsb pdb:4UCH|rcsb pdb:4UH5|rcsb pdb:4UH6|rcsb pdb:4V3U|rcsb pdb:5ADF|rcsb pdb:5ADG|rcsb pdb:5ADI|rcsb pdb:5FVU|rcsb pdb:5FVV|rcsb pdb:5FVW|rcsb pdb:5FVX|rcsb pdb:5UO3|rcsb pdb:5UO4|rcsb pdb:5UO5|rcsb pdb:5UO6|rcsb pdb:5UO7|rcsb pdb:5VUV|rcsb pdb:5VUW|rcsb pdb:5VUX|rcsb pdb:5VUY|rcsb pdb:5VUZ|rcsb pdb:5VV0|rcsb pdb:5VV1|rcsb pdb:5VV2|rcsb pdb:5VV3|rcsb pdb:5VV4|rcsb pdb:5VV5|rcsb pdb:6AUY|rcsb pdb:6AUZ|rcsb pdb:6AV0|rcsb pdb:6AV1|rcsb pdb:6AV2|rcsb pdb:6AV3|rcsb pdb:6AV4|rcsb pdb:6AV5|rcsb pdb:6CIC|rcsb pdb:6CID|rcsb pdb:6NG1|rcsb pdb:6NG2|rcsb pdb:6NG4|rcsb pdb:6NG5|rcsb pdb:6NG6|rcsb pdb:6NG7|rcsb pdb:6NG8|rcsb pdb:6NGA|rcsb pdb:6NGB|rcsb pdb:6NGC|rcsb pdb:6NGD|rcsb pdb:6NGE|rcsb pdb:6NGF|rcsb pdb:5UO2|rcsb pdb:6NGH|rcsb pdb:6NGI|rcsb pdb:6NHB|rcsb pdb:6NHC|rcsb pdb:6PNA|rcsb pdb:6PNB|rcsb pdb:6PNC|rcsb pdb:6PND|rcsb pdb:6PNE|rcsb pdb:6PNF|rcsb pdb:6PNG|rcsb pdb:6PNH|rcsb pdb:6PO5|rcsb pdb:6PO7|rcsb pdb:6PO8|rcsb pdb:6PO9|rcsb pdb:6POA|rcsb pdb:6POB|rcsb pdb:6POC|rcsb pdb:6POT|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-5578775|refseq:NP_001191143.1|refseq:NP_000611.1|refseq:NP_001191147.1|refseq:NP_001191142.1|refseq:XP_016874834.1|refseq:XP_016874835.1|refseq:XP_016874836.1|dip:DIP-40999N|mint:MINT-3999877(identity)	-	-	comment:mint|function:"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter"|function:"Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction"	figure legend:F2C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/20	2014/10/16	rogid:S9syIZ/DKHNbOM0Nw9oZP5F+AvA9606	rogid:El1bLhrX0trPS1atMOWTFpDa3XU9606	intact-crc:4C2CD543E669E54F|rigid:CMDJJ2mMVSNg4FKaxpRWI+PWupk	false	his tag:?-?(MINT-3999885)	binding-associated region:1-100(MINT-3999880)|glutathione s tranferase tag:?-?(MINT-3999878)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)