#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q02750	uniprotkb:O15519-1	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-4567563|intact:EBI-7093779|intact:MINT-2589696|intact:EBI-7093972|intact:EBI-7093921|intact:EBI-7093724|intact:EBI-7093827|intact:EBI-8019287|intact:EBI-7158298|intact:EBI-7093876|ensembl:ENSP00000312455|ensembl:ENSP00000399420	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:o15519-1(display_long)|uniprotkb:FLIP-L(isoform synonym)|uniprotkb:CLARP1(isoform synonym)|uniprotkb:MRIT alpha-1(isoform synonym)|uniprotkb:CASH alpha(isoform synonym)|uniprotkb:I-FLICE 1(isoform synonym)|uniprotkb:FLAME-1 gamma(isoform synonym)|uniprotkb:Usurpin alpha(isoform synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Usurpin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakajima et al. (2006)	pubmed:17110930|imex:IM-11199|mint:MINT-5219344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7093716|mint:MINT-3391418|imex:IM-11199-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0|mint:MINT-3391420(identity)	intact:EBI-514941(isoform-parent)|ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|mint:MINT-3391419(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:This interaction increases when MEKK1 is also overexpressed.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/30	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606	intact-crc:EEAC54B418B0D7CE|rigid:ZbgaIZ/ZrsAO1/Y8eQb0BCvRkCg	false	ha tag:?-?(MINT-3391432)	flag tag:?-?(MINT-3391424)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P45985	uniprotkb:O15519-1	intact:EBI-447868|uniprotkb:D3DTS5|uniprotkb:Q5U0B8|uniprotkb:B2R7N7|uniprotkb:B3KYB2|uniprotkb:Q6FHX4|uniprotkb:Q6P9H2|uniprotkb:Q6PIE6|intact:EBI-28973354|ensembl:ENSP00000262445	intact:EBI-4567563|intact:EBI-7093779|intact:MINT-2589696|intact:EBI-7093972|intact:EBI-7093921|intact:EBI-7093724|intact:EBI-7093827|intact:EBI-8019287|intact:EBI-7158298|intact:EBI-7093876|ensembl:ENSP00000312455|ensembl:ENSP00000399420	psi-mi:mp2k4_human(display_long)|uniprotkb:JNK-activating kinase 1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 1(gene name synonym)|uniprotkb:SAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K4(gene name)|psi-mi:MAP2K4(display_short)|uniprotkb:JNKK1(gene name synonym)|uniprotkb:MKK4(gene name synonym)|uniprotkb:PRKMK4(gene name synonym)|uniprotkb:SERK1(gene name synonym)|uniprotkb:MEK4(gene name synonym)|uniprotkb:MAPK/ERK kinase 4(gene name synonym)|uniprotkb:SKK1(gene name synonym)|uniprotkb:SEK1(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 1(gene name synonym)	psi-mi:o15519-1(display_long)|uniprotkb:FLIP-L(isoform synonym)|uniprotkb:CLARP1(isoform synonym)|uniprotkb:MRIT alpha-1(isoform synonym)|uniprotkb:CASH alpha(isoform synonym)|uniprotkb:I-FLICE 1(isoform synonym)|uniprotkb:FLAME-1 gamma(isoform synonym)|uniprotkb:Usurpin alpha(isoform synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Usurpin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakajima et al. (2006)	pubmed:17110930|imex:IM-11199|mint:MINT-5219344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7093807|mint:MINT-3391445|imex:IM-11199-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003001.1|ensembl:ENSP00000262445|ensembl:ENST00000415385|ensembl:ENSP00000410402|refseq:NP_001268364.1|ensembl:ENST00000353533(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009611"(response to wounding)|go:"GO:0030424"(axon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P45985|rcsb pdb:3ALN|rcsb pdb:3ALO|rcsb pdb:3VUT|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-5210891|reactome:R-HSA-5684264|ensembl:ENSG00000065559(gene)|mint:MINT-3391454(identity)	intact:EBI-514941(isoform-parent)|ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|mint:MINT-3391446(identity)	-	comment:"Stoichiometry: 1.0"	-	figure legend:F5B|comment:Only if MEKK1 is also overexpressed.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/30	2014/10/16	rogid:/ndhkIbnc9oTm68r4DwDUyfXDF89606	rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606	intact-crc:294991EA2ABA849F|rigid:Sf5tjEGJyiOe2iuv18cEptsDfPU	false	ha tag:?-?(MINT-3391460)	flag tag:?-?(MINT-3391452)	1	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15519-1	uniprotkb:O14733	intact:EBI-4567563|intact:EBI-7093779|intact:MINT-2589696|intact:EBI-7093972|intact:EBI-7093921|intact:EBI-7093724|intact:EBI-7093827|intact:EBI-8019287|intact:EBI-7158298|intact:EBI-7093876|ensembl:ENSP00000312455|ensembl:ENSP00000399420	intact:EBI-492605|uniprotkb:O14648|uniprotkb:O14816|uniprotkb:O60452|uniprotkb:O60453|uniprotkb:Q1PG43|uniprotkb:Q8IY10|uniprotkb:B2R9S5|uniprotkb:D6W659|ensembl:ENSP00000381066	psi-mi:o15519-1(display_long)|uniprotkb:FLIP-L(isoform synonym)|uniprotkb:CLARP1(isoform synonym)|uniprotkb:MRIT alpha-1(isoform synonym)|uniprotkb:CASH alpha(isoform synonym)|uniprotkb:I-FLICE 1(isoform synonym)|uniprotkb:FLAME-1 gamma(isoform synonym)|uniprotkb:Usurpin alpha(isoform synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Usurpin(gene name synonym)	psi-mi:mp2k7_human(display_long)|uniprotkb:MAPK/ERK kinase 7(gene name synonym)|uniprotkb:JNK-activating kinase 2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 2(gene name synonym)|uniprotkb:MAP2K7(gene name)|psi-mi:MAP2K7(display_short)|uniprotkb:JNKK2(gene name synonym)|uniprotkb:MKK7(gene name synonym)|uniprotkb:PRKMK7(gene name synonym)|uniprotkb:MEK7(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 4(gene name synonym)|uniprotkb:SKK4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakajima et al. (2006)	pubmed:17110930|imex:IM-11199|mint:MINT-5219344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7093855|mint:MINT-3391468|imex:IM-11199-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-514941(isoform-parent)|ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|mint:MINT-3391477(identity)	refseq:NP_660186.1|ensembl:ENSG00000076984(gene)|ensembl:ENST00000397979(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:O14733|rcsb pdb:2DYL|rcsb pdb:3WZU|rcsb pdb:4UX9|rcsb pdb:5B2K|rcsb pdb:5B2L|rcsb pdb:5B2M|rcsb pdb:5Y8U|rcsb pdb:5Y90|rcsb pdb:5Z1D|rcsb pdb:5Z1E|rcsb pdb:6IB0|rcsb pdb:6IB2|go:"GO:0000187"(obsolete activation of MAPK activity)|rcsb pdb:6QFL|rcsb pdb:6QFR|rcsb pdb:6QFT|rcsb pdb:6QG4|rcsb pdb:6QG7|rcsb pdb:6QHO|rcsb pdb:6QHR|rcsb pdb:6YFZ|rcsb pdb:6YG0|rcsb pdb:6YG1|rcsb pdb:6YG2|rcsb pdb:6YG3|rcsb pdb:6YG4|rcsb pdb:6YG5|rcsb pdb:6YG6|rcsb pdb:6YG7|rcsb pdb:6YZ4|rcsb pdb:7CBX|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-5210891|reactome:R-HSA-450321|refseq:NP_001284484.1|refseq:NP_001284485.1|mint:MINT-3391469(identity)	-	-	comment:"Stoichiometry: 1.0"	figure legend:F6B|figure legend:F6E|figure legend:F5D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/30	2014/10/16	rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606	rogid:fEJqQ+bmZXzL9rSHk/Z01SQJFKM9606	intact-crc:543689CE4A2BF06A|rigid:TE346jlkktESF44YS3sHZ4ANZis	false	flag tag:?-?(MINT-3391478)	ha tag:?-?(MINT-3391472)	-	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02750	uniprotkb:O15519-1	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-4567563|intact:EBI-7093779|intact:MINT-2589696|intact:EBI-7093972|intact:EBI-7093921|intact:EBI-7093724|intact:EBI-7093827|intact:EBI-8019287|intact:EBI-7158298|intact:EBI-7093876|ensembl:ENSP00000312455|ensembl:ENSP00000399420	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:o15519-1(display_long)|uniprotkb:FLIP-L(isoform synonym)|uniprotkb:CLARP1(isoform synonym)|uniprotkb:MRIT alpha-1(isoform synonym)|uniprotkb:CASH alpha(isoform synonym)|uniprotkb:I-FLICE 1(isoform synonym)|uniprotkb:FLAME-1 gamma(isoform synonym)|uniprotkb:Usurpin alpha(isoform synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Usurpin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakajima et al. (2006)	pubmed:17110930|imex:IM-11199|mint:MINT-5219344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7093904|mint:MINT-3391491|imex:IM-11199-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0|mint:MINT-3391500(identity)	intact:EBI-514941(isoform-parent)|ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|mint:MINT-3391492(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5E|comment:TNF alpha increases interaction.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/30	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606	intact-crc:DDAE210B8CA33D1D|rigid:ZbgaIZ/ZrsAO1/Y8eQb0BCvRkCg	false	-	flag tag:?-?(MINT-3391515)	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15519-1	uniprotkb:Q02750	intact:EBI-4567563|intact:EBI-7093779|intact:MINT-2589696|intact:EBI-7093972|intact:EBI-7093921|intact:EBI-7093724|intact:EBI-7093827|intact:EBI-8019287|intact:EBI-7158298|intact:EBI-7093876|ensembl:ENSP00000312455|ensembl:ENSP00000399420	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:o15519-1(display_long)|uniprotkb:FLIP-L(isoform synonym)|uniprotkb:CLARP1(isoform synonym)|uniprotkb:MRIT alpha-1(isoform synonym)|uniprotkb:CASH alpha(isoform synonym)|uniprotkb:I-FLICE 1(isoform synonym)|uniprotkb:FLAME-1 gamma(isoform synonym)|uniprotkb:Usurpin alpha(isoform synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Usurpin(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakajima et al. (2006)	pubmed:17110930|imex:IM-11199|mint:MINT-5219344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7093949|mint:MINT-3391521|imex:IM-11199-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-514941(isoform-parent)|ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|mint:MINT-3391522(identity)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0|mint:MINT-3391530(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5F|comment:TNF alpha increases interaction.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/30	2014/10/16	rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:DB65B0E33AD910A2|rigid:ZbgaIZ/ZrsAO1/Y8eQb0BCvRkCg	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14733	uniprotkb:O15519-1	intact:EBI-492605|uniprotkb:O14648|uniprotkb:O14816|uniprotkb:O60452|uniprotkb:O60453|uniprotkb:Q1PG43|uniprotkb:Q8IY10|uniprotkb:B2R9S5|uniprotkb:D6W659|ensembl:ENSP00000381066	intact:EBI-4567563|intact:EBI-7093779|intact:MINT-2589696|intact:EBI-7093972|intact:EBI-7093921|intact:EBI-7093724|intact:EBI-7093827|intact:EBI-8019287|intact:EBI-7158298|intact:EBI-7093876|ensembl:ENSP00000312455|ensembl:ENSP00000399420	psi-mi:mp2k7_human(display_long)|uniprotkb:MAPK/ERK kinase 7(gene name synonym)|uniprotkb:JNK-activating kinase 2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 2(gene name synonym)|uniprotkb:MAP2K7(gene name)|psi-mi:MAP2K7(display_short)|uniprotkb:JNKK2(gene name synonym)|uniprotkb:MKK7(gene name synonym)|uniprotkb:PRKMK7(gene name synonym)|uniprotkb:MEK7(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 4(gene name synonym)|uniprotkb:SKK4(gene name synonym)	psi-mi:o15519-1(display_long)|uniprotkb:FLIP-L(isoform synonym)|uniprotkb:CLARP1(isoform synonym)|uniprotkb:MRIT alpha-1(isoform synonym)|uniprotkb:CASH alpha(isoform synonym)|uniprotkb:I-FLICE 1(isoform synonym)|uniprotkb:FLAME-1 gamma(isoform synonym)|uniprotkb:Usurpin alpha(isoform synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Usurpin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakajima et al. (2006)	pubmed:17110930|imex:IM-11199|mint:MINT-5219344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7093963|mint:MINT-3391541|imex:IM-11199-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660186.1|ensembl:ENSG00000076984(gene)|ensembl:ENST00000397979(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:O14733|rcsb pdb:2DYL|rcsb pdb:3WZU|rcsb pdb:4UX9|rcsb pdb:5B2K|rcsb pdb:5B2L|rcsb pdb:5B2M|rcsb pdb:5Y8U|rcsb pdb:5Y90|rcsb pdb:5Z1D|rcsb pdb:5Z1E|rcsb pdb:6IB0|rcsb pdb:6IB2|go:"GO:0000187"(obsolete activation of MAPK activity)|rcsb pdb:6QFL|rcsb pdb:6QFR|rcsb pdb:6QFT|rcsb pdb:6QG4|rcsb pdb:6QG7|rcsb pdb:6QHO|rcsb pdb:6QHR|rcsb pdb:6YFZ|rcsb pdb:6YG0|rcsb pdb:6YG1|rcsb pdb:6YG2|rcsb pdb:6YG3|rcsb pdb:6YG4|rcsb pdb:6YG5|rcsb pdb:6YG6|rcsb pdb:6YG7|rcsb pdb:6YZ4|rcsb pdb:7CBX|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-5210891|reactome:R-HSA-450321|refseq:NP_001284484.1|refseq:NP_001284485.1|mint:MINT-3391550(identity)	intact:EBI-514941(isoform-parent)|ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|mint:MINT-3391542(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5E|comment:TNF alpha increases interaction.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/30	2014/10/16	rogid:fEJqQ+bmZXzL9rSHk/Z01SQJFKM9606	rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606	intact-crc:DEB6E41661E6F446|rigid:TE346jlkktESF44YS3sHZ4ANZis	false	-	flag tag:?-?(MINT-3391546)	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O14733	uniprotkb:Q13233	intact:EBI-492605|uniprotkb:O14648|uniprotkb:O14816|uniprotkb:O60452|uniprotkb:O60453|uniprotkb:Q1PG43|uniprotkb:Q8IY10|uniprotkb:B2R9S5|uniprotkb:D6W659|ensembl:ENSP00000381066	intact:EBI-49776|ensembl:ENSP00000382423	psi-mi:mp2k7_human(display_long)|uniprotkb:MAPK/ERK kinase 7(gene name synonym)|uniprotkb:JNK-activating kinase 2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 2(gene name synonym)|uniprotkb:MAP2K7(gene name)|psi-mi:MAP2K7(display_short)|uniprotkb:JNKK2(gene name synonym)|uniprotkb:MKK7(gene name synonym)|uniprotkb:PRKMK7(gene name synonym)|uniprotkb:MEK7(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 4(gene name synonym)|uniprotkb:SKK4(gene name synonym)	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakajima et al. (2006)	pubmed:17110930|imex:IM-11199|mint:MINT-5219344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7094009|mint:MINT-3391558|imex:IM-11199-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660186.1|ensembl:ENSG00000076984(gene)|ensembl:ENST00000397979(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:O14733|rcsb pdb:2DYL|rcsb pdb:3WZU|rcsb pdb:4UX9|rcsb pdb:5B2K|rcsb pdb:5B2L|rcsb pdb:5B2M|rcsb pdb:5Y8U|rcsb pdb:5Y90|rcsb pdb:5Z1D|rcsb pdb:5Z1E|rcsb pdb:6IB0|rcsb pdb:6IB2|go:"GO:0000187"(obsolete activation of MAPK activity)|rcsb pdb:6QFL|rcsb pdb:6QFR|rcsb pdb:6QFT|rcsb pdb:6QG4|rcsb pdb:6QG7|rcsb pdb:6QHO|rcsb pdb:6QHR|rcsb pdb:6YFZ|rcsb pdb:6YG0|rcsb pdb:6YG1|rcsb pdb:6YG2|rcsb pdb:6YG3|rcsb pdb:6YG4|rcsb pdb:6YG5|rcsb pdb:6YG6|rcsb pdb:6YG7|rcsb pdb:6YZ4|rcsb pdb:7CBX|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-5210891|reactome:R-HSA-450321|refseq:NP_001284484.1|refseq:NP_001284485.1|mint:MINT-3391559(identity)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-3391565(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5G|figure legend:F6H|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/30	2014/10/16	rogid:fEJqQ+bmZXzL9rSHk/Z01SQJFKM9606	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	intact-crc:002693011411615F|rigid:3ToVgT/HXMFvQ0HoLSrCCEpyQYY	false	ha tag:?-?(MINT-3391577)	binding-associated region:1118-1493(MINT-3391574)|myc tag:?-?(MINT-3391568)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02750	uniprotkb:Q13233	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-49776|ensembl:ENSP00000382423	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakajima et al. (2006)	pubmed:17110930|imex:IM-11199|mint:MINT-5219344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7094050|mint:MINT-3391583|imex:IM-11199-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0|mint:MINT-3391584(identity)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-3391592(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5H|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/30	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	intact-crc:ACCE334320396C2B|rigid:FAP6+ipYRcWdEE3OcYWKdnuAsL4	false	ha tag:?-?(MINT-3391588)	binding-associated region:1118-1493(MINT-3391593)|myc tag:?-?(MINT-3391597)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99683	uniprotkb:O14733	intact:EBI-476263|uniprotkb:Q5THN3|uniprotkb:Q99461|uniprotkb:A6NIA0|uniprotkb:B4DGB2|ensembl:ENSP00000351908	intact:EBI-492605|uniprotkb:O14648|uniprotkb:O14816|uniprotkb:O60452|uniprotkb:O60453|uniprotkb:Q1PG43|uniprotkb:Q8IY10|uniprotkb:B2R9S5|uniprotkb:D6W659|ensembl:ENSP00000381066	psi-mi:m3k5_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:MAP3K5(gene name)|psi-mi:MAP3K5(display_short)|uniprotkb:ASK1(gene name synonym)|uniprotkb:MAPKKK5(gene name synonym)|uniprotkb:MEKK5(gene name synonym)	psi-mi:mp2k7_human(display_long)|uniprotkb:MAPK/ERK kinase 7(gene name synonym)|uniprotkb:JNK-activating kinase 2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 2(gene name synonym)|uniprotkb:MAP2K7(gene name)|psi-mi:MAP2K7(display_short)|uniprotkb:JNKK2(gene name synonym)|uniprotkb:MKK7(gene name synonym)|uniprotkb:PRKMK7(gene name synonym)|uniprotkb:MEK7(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 4(gene name synonym)|uniprotkb:SKK4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakajima et al. (2006)	pubmed:17110930|imex:IM-11199|mint:MINT-5219344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7094073|mint:MINT-3391607|imex:IM-11199-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005914.1|dip:DIP-29516N|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|ensembl:ENSG00000197442(gene)|ensembl:ENST00000359015(transcript)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:Q99683|rcsb pdb:2CLQ|rcsb pdb:3VW6|rcsb pdb:4BF2|rcsb pdb:4BHN|rcsb pdb:4BIB|rcsb pdb:4BIC|rcsb pdb:4BID|rcsb pdb:4BIE|rcsb pdb:5ULM|rcsb pdb:5UOR|rcsb pdb:5UOX|rcsb pdb:5UP3|rcsb pdb:5V19|rcsb pdb:5V24|rcsb pdb:5VIL|rcsb pdb:5VIO|rcsb pdb:6E2M|rcsb pdb:6E2N|rcsb pdb:6E2O|rcsb pdb:6EJL|rcsb pdb:6OYT|rcsb pdb:6OYW|rcsb pdb:6VRE|rcsb pdb:6XIH|reactome:R-HSA-2559580|mint:MINT-3391616(identity)	refseq:NP_660186.1|ensembl:ENSG00000076984(gene)|ensembl:ENST00000397979(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:O14733|rcsb pdb:2DYL|rcsb pdb:3WZU|rcsb pdb:4UX9|rcsb pdb:5B2K|rcsb pdb:5B2L|rcsb pdb:5B2M|rcsb pdb:5Y8U|rcsb pdb:5Y90|rcsb pdb:5Z1D|rcsb pdb:5Z1E|rcsb pdb:6IB0|rcsb pdb:6IB2|go:"GO:0000187"(obsolete activation of MAPK activity)|rcsb pdb:6QFL|rcsb pdb:6QFR|rcsb pdb:6QFT|rcsb pdb:6QG4|rcsb pdb:6QG7|rcsb pdb:6QHO|rcsb pdb:6QHR|rcsb pdb:6YFZ|rcsb pdb:6YG0|rcsb pdb:6YG1|rcsb pdb:6YG2|rcsb pdb:6YG3|rcsb pdb:6YG4|rcsb pdb:6YG5|rcsb pdb:6YG6|rcsb pdb:6YG7|rcsb pdb:6YZ4|rcsb pdb:7CBX|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-5210891|reactome:R-HSA-450321|refseq:NP_001284484.1|refseq:NP_001284485.1|mint:MINT-3391608(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:This interaction decreases if FLIP is also over-expressed.|figure legend:SF4G|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/30	2014/10/16	rogid:/txMHg7GSCpK8ij48YDHGARX3es9606	rogid:fEJqQ+bmZXzL9rSHk/Z01SQJFKM9606	intact-crc:A8880A2218947CC6|rigid:Bujqm8xrPxOxwICnM/qIWV7rPVE	false	myc tag:?-?(MINT-3391620)	ha tag:?-?(MINT-3391613)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O14733	uniprotkb:O43318	intact:EBI-492605|uniprotkb:O14648|uniprotkb:O14816|uniprotkb:O60452|uniprotkb:O60453|uniprotkb:Q1PG43|uniprotkb:Q8IY10|uniprotkb:B2R9S5|uniprotkb:D6W659|ensembl:ENSP00000381066	intact:EBI-358684|uniprotkb:O43317|uniprotkb:O43319|uniprotkb:Q9NZ70|uniprotkb:Q9NTR3|uniprotkb:E1P523|uniprotkb:Q5TDN2|uniprotkb:Q5TDN3|uniprotkb:B2RE27|uniprotkb:Q5TDT7|ensembl:ENSP00000358335	psi-mi:mp2k7_human(display_long)|uniprotkb:MAPK/ERK kinase 7(gene name synonym)|uniprotkb:JNK-activating kinase 2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 2(gene name synonym)|uniprotkb:MAP2K7(gene name)|psi-mi:MAP2K7(display_short)|uniprotkb:JNKK2(gene name synonym)|uniprotkb:MKK7(gene name synonym)|uniprotkb:PRKMK7(gene name synonym)|uniprotkb:MEK7(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 4(gene name synonym)|uniprotkb:SKK4(gene name synonym)	psi-mi:m3k7_human(display_long)|uniprotkb:MAP3K7(gene name)|psi-mi:MAP3K7(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakajima et al. (2006)	pubmed:17110930|imex:IM-11199|mint:MINT-5219344	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7094094|mint:MINT-3391633|imex:IM-11199-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660186.1|ensembl:ENSG00000076984(gene)|ensembl:ENST00000397979(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:O14733|rcsb pdb:2DYL|rcsb pdb:3WZU|rcsb pdb:4UX9|rcsb pdb:5B2K|rcsb pdb:5B2L|rcsb pdb:5B2M|rcsb pdb:5Y8U|rcsb pdb:5Y90|rcsb pdb:5Z1D|rcsb pdb:5Z1E|rcsb pdb:6IB0|rcsb pdb:6IB2|go:"GO:0000187"(obsolete activation of MAPK activity)|rcsb pdb:6QFL|rcsb pdb:6QFR|rcsb pdb:6QFT|rcsb pdb:6QG4|rcsb pdb:6QG7|rcsb pdb:6QHO|rcsb pdb:6QHR|rcsb pdb:6YFZ|rcsb pdb:6YG0|rcsb pdb:6YG1|rcsb pdb:6YG2|rcsb pdb:6YG3|rcsb pdb:6YG4|rcsb pdb:6YG5|rcsb pdb:6YG6|rcsb pdb:6YG7|rcsb pdb:6YZ4|rcsb pdb:7CBX|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-5210891|reactome:R-HSA-450321|refseq:NP_001284484.1|refseq:NP_001284485.1|mint:MINT-3391634(identity)	refseq:NP_003179.1|refseq:NP_663304.1|refseq:NP_663305.1|refseq:NP_663306.1|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSG00000135341(gene)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|ensembl:ENST00000369329(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43318|rcsb pdb:2EVA|rcsb pdb:2YIY|rcsb pdb:4GS6|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5V5N|rcsb pdb:7NTH|rcsb pdb:7NTI|reactome:R-HSA-1169091|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-4086398|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27523N|mint:MINT-3391642(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:This interaction decreases if FLIP is also over-expressed.|figure legend:SF4H|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/30	2014/10/16	rogid:fEJqQ+bmZXzL9rSHk/Z01SQJFKM9606	rogid:U/W3xH9XPl6BIdCcfrw1gG/+n7Y9606	intact-crc:7D6563FB431E3683|rigid:YO+u1te5uiNHvqEDttXOzin0QaA	false	ha tag:?-?(MINT-3391638)	myc tag:?-?(MINT-3391645)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)