#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97438	uniprotkb:P18762	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-491143|uniprotkb:Q8BH38|ensembl:ENSMUSP00000062256	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:adrb2_mouse(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:Adrb2(gene name)|psi-mi:Adrb2(display_short)|uniprotkb:Adrb2r(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Sandoz et al. (2006)	pubmed:17110924|imex:IM-11298|mint:MINT-5219335	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7091078|mint:MINT-4050420|imex:IM-11298-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N|mint:MINT-4050421(identity)	go:"GO:0005901"(caveola)|refseq:NP_031446.2|ensembl:ENSMUSG00000045730(gene)|ensembl:ENSMUST00000053640(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001993"(regulation of systemic arterial blood pressure by norepinephrine-epinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003059"(positive regulation of the force of heart contraction by epinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009409"(response to cold)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031649"(heat generation)|go:"GO:0031713"(B2 bradykinin receptor binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P18762|reactome:R-MMU-390696|reactome:R-MMU-418555|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-59568N|mint:MINT-4050422(identity)	-	comment:mint	caution:This sequence has been withdrawn from Uniprot.	figure legend:F6E|comment:in presence of co-overexpressed AKAP150|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/12/27	2014/10/16	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:qkANf2gIbjO7PaPMabhawKJORWI10090	intact-crc:47D6DE3665689BE2|rigid:pURlMVYaBDl+IaFwoF5tjGqxsb0	false	-	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P97438	uniprotkb:D3YVF0	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-7091108|ensembl:ENSMUSP00000114495|uniprotkb:D3Z5C9|intact:MINT-8412175|intact:MINT-4050471	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:akap5_mouse(display_long)|uniprotkb:Akap5(gene name)|psi-mi:Akap5(display_short)|uniprotkb:A-kinase anchor protein 150 kDa(gene name synonym)|uniprotkb:Akap150(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Sandoz et al. (2006)	pubmed:17110924|imex:IM-11298|mint:MINT-5219335	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7091128|mint:MINT-4050458|imex:IM-11298-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N|mint:MINT-4050463(identity)	ensembl:ENSMUSG00000021057(gene)|ensembl:ENSMUST00000154078(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030425"(dendrite)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036394"(amylase secretion)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043624"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045163"(clustering of voltage-gated potassium channels)|go:"GO:0045296"(cadherin binding)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070073"(clustering of voltage-gated calcium channels)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:D3YVF0|reactome:R-MMU-399719|go:"GO:0097110"(scaffold protein binding)|refseq:NP_001094941.1|mint:MINT-4050459(identity)	-	comment:mint	comment:mint	figure legend:F4|figure legend:F1A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/12/27	2014/10/16	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:6rqY3E1HtCUQCj0XqBdXJZiv3BA10090	intact-crc:A74887989789DCF9|rigid:kw/NTv5sWaChtFBXUGd7KlK87CA	false	binding-associated region:298-311(MINT-4050476)	myc tag:?-?(MINT-4050473)	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P97438	uniprotkb:D3YVF0	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-7091108|ensembl:ENSMUSP00000114495|uniprotkb:D3Z5C9|intact:MINT-8412175|intact:MINT-4050471	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:akap5_mouse(display_long)|uniprotkb:Akap5(gene name)|psi-mi:Akap5(display_short)|uniprotkb:A-kinase anchor protein 150 kDa(gene name synonym)|uniprotkb:Akap150(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Sandoz et al. (2006)	pubmed:17110924|imex:IM-11298|mint:MINT-5219335	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7091148|mint:MINT-4050521|imex:IM-11298-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N|mint:MINT-4050526(identity)	ensembl:ENSMUSG00000021057(gene)|ensembl:ENSMUST00000154078(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030425"(dendrite)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036394"(amylase secretion)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043624"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045163"(clustering of voltage-gated potassium channels)|go:"GO:0045296"(cadherin binding)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070073"(clustering of voltage-gated calcium channels)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:D3YVF0|reactome:R-MMU-399719|go:"GO:0097110"(scaffold protein binding)|refseq:NP_001094941.1|mint:MINT-4050522(identity)	-	comment:mint	comment:mint	figure legend:F2A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/12/27	2017/05/18	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:6rqY3E1HtCUQCj0XqBdXJZiv3BA10090	intact-crc:CC523DC12D8EEDFD|rigid:kw/NTv5sWaChtFBXUGd7KlK87CA	false	-	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P97438	uniprotkb:D3YVF0	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-7091108|ensembl:ENSMUSP00000114495|uniprotkb:D3Z5C9|intact:MINT-8412175|intact:MINT-4050471	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:akap5_mouse(display_long)|uniprotkb:Akap5(gene name)|psi-mi:Akap5(display_short)|uniprotkb:A-kinase anchor protein 150 kDa(gene name synonym)|uniprotkb:Akap150(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sandoz et al. (2006)	pubmed:17110924|imex:IM-11298|mint:MINT-5219335	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7091170|mint:MINT-4050506|imex:IM-11298-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N|mint:MINT-4050511(identity)	ensembl:ENSMUSG00000021057(gene)|ensembl:ENSMUST00000154078(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030425"(dendrite)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036394"(amylase secretion)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043624"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045163"(clustering of voltage-gated potassium channels)|go:"GO:0045296"(cadherin binding)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070073"(clustering of voltage-gated calcium channels)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:D3YVF0|reactome:R-MMU-399719|go:"GO:0097110"(scaffold protein binding)|refseq:NP_001094941.1|mint:MINT-4050507(identity)	-	comment:mint	comment:mint	figure legend:F1B|figure legend:F6F|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/12/27	2014/10/16	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:6rqY3E1HtCUQCj0XqBdXJZiv3BA10090	intact-crc:A877F4D745A61191|rigid:kw/NTv5sWaChtFBXUGd7KlK87CA	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P97438	uniprotkb:P18762	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-491143|uniprotkb:Q8BH38|ensembl:ENSMUSP00000062256	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:adrb2_mouse(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:Adrb2(gene name)|psi-mi:Adrb2(display_short)|uniprotkb:Adrb2r(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sandoz et al. (2006)	pubmed:17110924|imex:IM-11298|mint:MINT-5219335	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7091193|mint:MINT-4050435|imex:IM-11298-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N|mint:MINT-4050440(identity)	go:"GO:0005901"(caveola)|refseq:NP_031446.2|ensembl:ENSMUSG00000045730(gene)|ensembl:ENSMUST00000053640(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001993"(regulation of systemic arterial blood pressure by norepinephrine-epinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003059"(positive regulation of the force of heart contraction by epinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009409"(response to cold)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031649"(heat generation)|go:"GO:0031713"(B2 bradykinin receptor binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P18762|reactome:R-MMU-390696|reactome:R-MMU-418555|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-59568N|mint:MINT-4050436(identity)	-	comment:mint	caution:This sequence has been withdrawn from Uniprot.	figure legend:F6F|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2006/12/27	2014/10/16	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:qkANf2gIbjO7PaPMabhawKJORWI10090	intact-crc:EBF1CF1E9BE9529E|rigid:pURlMVYaBDl+IaFwoF5tjGqxsb0	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97438	uniprotkb:D3YVF0	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-7091108|ensembl:ENSMUSP00000114495|uniprotkb:D3Z5C9|intact:MINT-8412175|intact:MINT-4050471	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:akap5_mouse(display_long)|uniprotkb:Akap5(gene name)|psi-mi:Akap5(display_short)|uniprotkb:A-kinase anchor protein 150 kDa(gene name synonym)|uniprotkb:Akap150(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sandoz et al. (2006)	pubmed:17110924|imex:IM-11298|mint:MINT-5219335	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7091206|mint:MINT-4050482|imex:IM-11298-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N|mint:MINT-4050489(identity)	ensembl:ENSMUSG00000021057(gene)|ensembl:ENSMUST00000154078(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030425"(dendrite)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036394"(amylase secretion)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043624"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045163"(clustering of voltage-gated potassium channels)|go:"GO:0045296"(cadherin binding)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070073"(clustering of voltage-gated calcium channels)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:D3YVF0|reactome:R-MMU-399719|go:"GO:0097110"(scaffold protein binding)|refseq:NP_001094941.1|mint:MINT-4050483(identity)	-	comment:mint	comment:mint	figure legend:F6F|comment:pag 5865 sx|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2006/12/27	2014/10/16	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:6rqY3E1HtCUQCj0XqBdXJZiv3BA10090	intact-crc:151E2064A8753356|rigid:kw/NTv5sWaChtFBXUGd7KlK87CA	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)