#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19024	uniprotkb:Q9Z1P2	intact:EBI-7051888|ensembl:ENSRNOP00000026691|uniprotkb:Q6LEB7|intact:MINT-3973915	intact:EBI-920286|ensembl:ENSRNOP00000069598	psi-mi:kcna5_rat(display_long)|uniprotkb:Kcna5(gene name)|psi-mi:Kcna5(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv1.5(gene name synonym)|uniprotkb:RCK7(gene name synonym)|uniprotkb:RK4(gene name synonym)	psi-mi:actn1_rat(display_long)|uniprotkb:Actn1(gene name)|psi-mi:Actn1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eldstrom et al. (2006)	pubmed:17054951|imex:IM-10905|mint:MINT-5219254	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7051881|mint:MINT-3973933|imex:IM-10905-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000019719(gene)|go:"GO:0086052"(membrane repolarization during SA node cell action potential)|go:"GO:0086087"(voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization)|go:"GO:0086089"(voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization)|go:"GO:0086090"(voltage-gated potassium channel activity involved in SA node cell action potential repolarization)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098914"(membrane repolarization during atrial cardiac muscle cell action potential)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000288"(positive regulation of myoblast proliferation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004052(Potassium channel, voltage dependent, Kv1.5)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|mint:P19024|reactome:R-RNO-1296072|ensembl:ENSRNOT00000026691(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0014704"(intercalated disc)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0034705"(potassium channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0045121"(membrane raft)|go:"GO:0046691"(intracellular canaliculus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086050"(membrane repolarization during bundle of His cell action potential)|refseq:NP_037104.1|rgd:2953|mint:MINT-3973934(identity)	rgd:70907|refseq:NP_112267.1|ensembl:ENSRNOG00000056756(gene)|ensembl:ENSRNOT00000088795(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005519"(cytoskeletal regulatory protein binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q9Z1P2|reactome:R-RNO-114608|reactome:R-RNO-446388|reactome:R-RNO-9013405|reactome:R-RNO-9013418|reactome:R-RNO-9035034|mint:MINT-3973935(identity)	-	comment:mint|function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient	-	figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2006/12/18	2014/10/16	rogid:Qcb1z+hiv2D2bn7GN5TRJZIwxtE10116	rogid:e8zdF7HOx12sx9WE9oJe6tk9br810116	intact-crc:4F019DCAD2DB88C5|rigid:teEXG2E2RApHjRluUBQngIv4duo	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q62600	uniprotkb:P51638	intact:EBI-7052018|uniprotkb:Q75NE4|uniprotkb:Q62734|uniprotkb:O88672|intact:MINT-202608|uniprotkb:O89041|uniprotkb:Q68GV6	intact:EBI-7051951|ensembl:ENSRNOP00000007601|intact:MINT-145738	psi-mi:nos3_rat(display_long)|uniprotkb:Nos3(gene name)|psi-mi:Nos3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:cav3_rat(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eldstrom et al. (2006)	pubmed:17054951|imex:IM-10905|mint:MINT-5219254	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7051944|mint:MINT-3973973|imex:IM-10905-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q62600|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009750"(response to fructose)|go:"GO:0010038"(response to metal ion)|go:"GO:0010181"(FMN binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0014823"(response to activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030324"(lung development)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034097"(response to cytokine)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0036017"(response to erythropoietin)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060348"(bone development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0071000"(response to magnetism)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1901556"(response to candesartan)|go:"GO:1901558"(response to metformin)|go:"GO:1901652"(response to peptide)|go:"GO:1901654"(response to ketone)|go:"GO:1902074"(response to salt)|go:"GO:1903576"(response to L-arginine)|go:"GO:1904648"(cellular response to rotenone)|go:"GO:1990478"(response to ultrasound)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|reactome:R-RNO-1222556|reactome:R-RNO-1474151|reactome:R-RNO-203615|reactome:R-RNO-203641|reactome:R-RNO-203754|reactome:R-RNO-392154|reactome:R-RNO-5218920|reactome:R-RNO-9009391|rgd:3186|refseq:NP_068610.1|dip:DIP-41833N|mint:MINT-3973978(identity)	ensembl:ENSRNOG00000005798(gene)|ensembl:ENSRNOT00000007601(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51638|reactome:R-RNO-445355|rgd:2281|refseq:NP_062028.1|mint:MINT-3973974(identity)	-	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"	comment:mint|function:May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels	figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2006/12/18	2014/10/16	rogid:GAf5Sj7pV//hAQqxd/xnWwW/C1I10116	rogid:eYZd6IiZ3bI+r1Rq8K3S82iogYU10116	intact-crc:12A592769B78EF0C|rigid:fQGzXCVUiYNU8xwiEv+1iicSY/g	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P19024	uniprotkb:Q99376	intact:EBI-7051888|ensembl:ENSRNOP00000026691|uniprotkb:Q6LEB7|intact:MINT-3973915	intact:EBI-2112551|intact:EBI-21232392|uniprotkb:G3V679|ensembl:ENSRNOP00000002407	psi-mi:kcna5_rat(display_long)|uniprotkb:Kcna5(gene name)|psi-mi:Kcna5(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv1.5(gene name synonym)|uniprotkb:RCK7(gene name synonym)|uniprotkb:RK4(gene name synonym)	psi-mi:tfr1_rat(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Eldstrom et al. (2006)	pubmed:17054951|imex:IM-10905|mint:MINT-5219254	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7052106|mint:MINT-3973948|imex:IM-10905-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000019719(gene)|go:"GO:0086052"(membrane repolarization during SA node cell action potential)|go:"GO:0086087"(voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization)|go:"GO:0086089"(voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization)|go:"GO:0086090"(voltage-gated potassium channel activity involved in SA node cell action potential repolarization)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098914"(membrane repolarization during atrial cardiac muscle cell action potential)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000288"(positive regulation of myoblast proliferation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004052(Potassium channel, voltage dependent, Kv1.5)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|mint:P19024|reactome:R-RNO-1296072|ensembl:ENSRNOT00000026691(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0014704"(intercalated disc)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0034705"(potassium channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0045121"(membrane raft)|go:"GO:0046691"(intracellular canaliculus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086050"(membrane repolarization during bundle of His cell action potential)|refseq:NP_037104.1|rgd:2953|mint:MINT-3973949(identity)	rgd:70488|refseq:NP_073203.1|refseq:XP_006248524.1|refseq:XP_006248525.1|ensembl:ENSRNOG00000001766(gene)|ensembl:ENSRNOT00000002407(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0046688"(response to copper ion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q99376|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-917977|reactome:R-RNO-9696270|reactome:R-RNO-9696273|go:"GO:0016323"(basolateral plasma membrane)|mint:MINT-3973953(identity)	-	comment:mint|function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient	-	figure legend:F5A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/18	2020/08/14	rogid:Qcb1z+hiv2D2bn7GN5TRJZIwxtE10116	rogid:vqeLiefAr+SqCtwOnGUhDJPpcHo10116	intact-crc:39267406F638AE81|rigid:QOYyfZv8M7NVEKDMwQSOkSV069s	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0113"(western blot)