#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q64663	uniprotkb:Q96RD7	intact:EBI-7037509|ensembl:ENSRNOP00000001746|intact:MINT-3379474	intact:EBI-7037612|ensembl:ENSP00000227638|uniprotkb:Q543A0|uniprotkb:O75968|uniprotkb:Q6UW26|uniprotkb:Q96L77|uniprotkb:Q96RS5|intact:MINT-3379479|uniprotkb:Q96AM9	psi-mi:p2rx7_rat(display_long)|uniprotkb:P2rx7(gene name)|psi-mi:P2rx7(display_short)|uniprotkb:ATP receptor(gene name synonym)|uniprotkb:Purinergic receptor(gene name synonym)|uniprotkb:P2Z receptor(gene name synonym)	psi-mi:panx1_human(display_long)|uniprotkb:PANX1(gene name)|psi-mi:PANX1(display_short)|uniprotkb:MRS1(gene name synonym)|uniprotkb:UNQ2529/PRO6028(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pelegrin et al. (2006)	pubmed:17036048|imex:IM-11247|mint:MINT-5219214	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7037606|mint:MINT-3379454|imex:IM-11247-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070230"(positive regulation of lymphocyte apoptotic process)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098794"(postsynapse)|go:"GO:0099161"(regulation of presynaptic dense core granule exocytosis)|go:"GO:1904172"(positive regulation of bleb assembly)|go:"GO:1904669"(ATP export)|interpro:IPR001429(P2X purinoreceptor)|interpro:IPR003050(P2X7 purinoceptor)|interpro:IPR027309|ensembl:ENSRNOG00000001296(gene)|ensembl:ENSRNOT00000001746(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001614"(purinergic nucleotide receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001845"(phagolysosome assembly)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004931"(extracellularly ATP-gated cation channel activity)|mint:Q64663|rcsb pdb:6U9V|rcsb pdb:6U9W|reactome:R-RNO-139853|reactome:R-RNO-418346|reactome:R-RNO-844456|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006649"(phospholipid transfer to membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008219"(cell death)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010467"(gene expression)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012501"(programmed cell death)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032059"(bleb)|go:"GO:0032060"(bleb assembly)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0035590"(purinergic nucleotide receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043132"(NAD transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015267"(channel activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016485"(protein processing)|refseq:NP_062129.1|rgd:3241|mint:MINT-3379455(identity)	ensembl:ENSG00000110218(gene)|ensembl:ENST00000227638(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0022840"(leak channel activity)|go:"GO:0032059"(bleb)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048477"(oogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR000990(Innexin)|interpro:IPR039099|mint:Q96RD7|rcsb pdb:6LTN|rcsb pdb:6LTO|rcsb pdb:6M02|rcsb pdb:6M66|rcsb pdb:6M67|rcsb pdb:6M68|rcsb pdb:6V6D|rcsb pdb:6WBF|rcsb pdb:6WBG|rcsb pdb:6WBI|rcsb pdb:6WBK|rcsb pdb:6WBL|rcsb pdb:6WBM|rcsb pdb:6WBN|rcsb pdb:7DWB|reactome:R-HSA-112303|reactome:R-HSA-844456|refseq:NP_056183.2|dip:DIP-43936N|mint:MINT-3379456(identity)	-	comment:mint|function:Receptor for ATP that acts as a ligand gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells|comment:"Stoichiometry: 1.0"	comment:mint|function:Structural component of the gap junctions|comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/11/06	2014/10/16	rogid:uWBbXowantacie9Fq8DgI/2vRm810116	rogid:4RTDyFKsL6d8oA8AsJT285+Yz1M9606	intact-crc:E813B0DCEE362B20|rigid:b8D0lzN6oTwMiLW/7IWVKZ4bhKc	false	tag:?-?(MINT-3379467)	myc tag:?-?(MINT-3379460)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)