#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q27957	uniprotkb:P10096	intact:EBI-7025612|ensembl:ENSBTAP00000070614|uniprotkb:Q9TRW3|uniprotkb:Q9TRW4|uniprotkb:A2VDP9|intact:MINT-3387832	intact:EBI-7025562|ensembl:ENSBTAP00000037577|uniprotkb:P79130|uniprotkb:Q3ZCB1|intact:MINT-3387840	psi-mi:tppp_bovin(display_long)|uniprotkb:TPPP(gene name)|psi-mi:TPPP(display_short)|uniprotkb:25 kDa brain-specific protein(gene name synonym)|uniprotkb:p25-alpha(gene name synonym)	psi-mi:g3p_bovin(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Oláh et al. (2006)	pubmed:17027006|imex:IM-11225|mint:MINT-5219202	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7025555|mint:MINT-3387853|imex:IM-11225-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000052247(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0015631"(tubulin binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032288"(myelin assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051418"(microtubule nucleation by microtubule organizing center)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0150051"(postsynaptic Golgi apparatus)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR008907(P25-alpha)|interpro:IPR011992(EF-Hand type)|interpro:IPR030792|mint:Q27957|ensembl:ENSBTAT00000078768(transcript)|refseq:NP_776401.1|mint:MINT-3387854(identity)	ensembl:ENSBTAG00000014731(gene)|ensembl:ENSBTAT00000037753(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0099162"(regulation of neurotransmitter loading into synaptic vesicle)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P10096|rcsb pdb:4O59|rcsb pdb:4O63|reactome:R-BTA-70171|reactome:R-BTA-70263|go:"GO:0000226"(microtubule cytoskeleton organization)|refseq:NP_001029206.1|mint:MINT-3387855(identity)	-	comment:mint|function:Promotes in vitro the polymerization of tubulin into double-walled tubules and polymorphic aggregates or bundled stabilized microtubules blocks. When overexpressed, inhibits mitotic spindle assembly and nuclear envelope breakdown, apparently without affecting other cellular events|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F1B|figure legend:F1A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovin-brain)|taxid:9913(Bos taurus brain)	-	2006/11/22	2014/10/16	rogid:FpmQtJ1d/XjPpPzwFjtP80FjH6M9913	rogid:b2z+q7+LvZlblioRlPMfHBcEg6M9913	intact-crc:202D088D1C027D7C|rigid:62WmaeR+6z7VBtda2HAMDA4JGwo	false	-	-	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q27957	uniprotkb:P46406	intact:EBI-7025612|ensembl:ENSBTAP00000070614|uniprotkb:Q9TRW3|uniprotkb:Q9TRW4|uniprotkb:A2VDP9|intact:MINT-3387832	intact:EBI-2750726|uniprotkb:Q4AC92	psi-mi:tppp_bovin(display_long)|uniprotkb:TPPP(gene name)|psi-mi:TPPP(display_short)|uniprotkb:25 kDa brain-specific protein(gene name synonym)|uniprotkb:p25-alpha(gene name synonym)	psi-mi:g3p_rabit(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Oláh et al. (2006)	pubmed:17027006|imex:IM-11225|mint:MINT-5219202	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7025670|mint:MINT-3387919|imex:IM-11225-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000052247(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0015631"(tubulin binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032288"(myelin assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051418"(microtubule nucleation by microtubule organizing center)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0150051"(postsynaptic Golgi apparatus)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR008907(P25-alpha)|interpro:IPR011992(EF-Hand type)|interpro:IPR030792|mint:Q27957|ensembl:ENSBTAT00000078768(transcript)|refseq:NP_776401.1|mint:MINT-3387926(identity)	refseq:NP_001075722.1|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097452"(GAIT complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|rcsb pdb:1J0X|dip:DIP-6005N|mint:P46406|mint:MINT-3387920(identity)	-	comment:mint|function:Promotes in vitro the polymerization of tubulin into double-walled tubules and polymorphic aggregates or bundled stabilized microtubules blocks. When overexpressed, inhibits mitotic spindle assembly and nuclear envelope breakdown, apparently without affecting other cellular events|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/22	2014/10/16	rogid:FpmQtJ1d/XjPpPzwFjtP80FjH6M9913	rogid:KAUZGWUD9KH101k31hsREciDO+49986	intact-crc:17D504391B0D312F|rigid:PaoelualdQ71DCxCCiVOxiyLYGQ	false	-	-	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q27957	uniprotkb:P04406	intact:EBI-7025612|ensembl:ENSBTAP00000070614|uniprotkb:Q9TRW3|uniprotkb:Q9TRW4|uniprotkb:A2VDP9|intact:MINT-3387832	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:tppp_bovin(display_long)|uniprotkb:TPPP(gene name)|psi-mi:TPPP(display_short)|uniprotkb:25 kDa brain-specific protein(gene name synonym)|uniprotkb:p25-alpha(gene name synonym)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Oláh et al. (2006)	pubmed:17027006|imex:IM-11225|mint:MINT-5219202	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7025783|mint:MINT-3387937|imex:IM-11225-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000052247(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0015631"(tubulin binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032288"(myelin assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051418"(microtubule nucleation by microtubule organizing center)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0150051"(postsynaptic Golgi apparatus)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR008907(P25-alpha)|interpro:IPR011992(EF-Hand type)|interpro:IPR030792|mint:Q27957|ensembl:ENSBTAT00000078768(transcript)|refseq:NP_776401.1|mint:MINT-3387943(identity)	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)|mint:MINT-3387938(identity)	-	comment:mint|function:Promotes in vitro the polymerization of tubulin into double-walled tubules and polymorphic aggregates or bundled stabilized microtubules blocks. When overexpressed, inhibits mitotic spindle assembly and nuclear envelope breakdown, apparently without affecting other cellular events|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/11/22	2014/10/16	rogid:FpmQtJ1d/XjPpPzwFjtP80FjH6M9913	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	intact-crc:4F474459CA9C09EB|rigid:p2OUzSK0H2QKPg6zRc8QRO6hg64	false	green fluorescent protein tag:?-?(MINT-3387951)	-	1	1	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:O94811	uniprotkb:P37840	intact:EBI-3927802|ensembl:ENSP00000353785	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:tppp_human(display_long)|uniprotkb:TPPP(gene name)|psi-mi:TPPP(display_short)|uniprotkb:TPPP1(gene name synonym)|uniprotkb:25 kDa brain-specific protein(gene name synonym)|uniprotkb:TPPP/p25(gene name synonym)|uniprotkb:p24(gene name synonym)|uniprotkb:p25-alpha(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Oláh et al. (2006)	pubmed:17027006|imex:IM-11225|mint:MINT-5219202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7025825|mint:MINT-3387974|imex:IM-11225-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171368(gene)|ensembl:ENST00000360578(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0015631"(tubulin binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032288"(myelin assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051418"(microtubule nucleation by microtubule organizing center)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0150051"(postsynaptic Golgi apparatus)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR008907(P25-alpha)|interpro:IPR011992(EF-Hand type)|interpro:IPR030792|mint:O94811|refseq:XP_005248294.2|refseq:NP_008961.1|refseq:XP_016864483.1|mint:MINT-3387981(identity)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N|mint:MINT-3387975(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain)|taxid:9606(Homo sapiens brain)	-	2006/11/22	2014/10/16	rogid:f7JDiVZTcTNdZeHJjWoGIeP3bvg9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:F5154EC10BC9FE39|rigid:0Yb0lmNsRwkwclwkuis9fHekMPE	false	-	-	1	1	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:Q27957	uniprotkb:P10096	intact:EBI-7025612|ensembl:ENSBTAP00000070614|uniprotkb:Q9TRW3|uniprotkb:Q9TRW4|uniprotkb:A2VDP9|intact:MINT-3387832	intact:EBI-7025562|ensembl:ENSBTAP00000037577|uniprotkb:P79130|uniprotkb:Q3ZCB1|intact:MINT-3387840	psi-mi:tppp_bovin(display_long)|uniprotkb:TPPP(gene name)|psi-mi:TPPP(display_short)|uniprotkb:25 kDa brain-specific protein(gene name synonym)|uniprotkb:p25-alpha(gene name synonym)	psi-mi:g3p_bovin(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Oláh et al. (2006)	pubmed:17027006|imex:IM-11225|mint:MINT-5219202	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7025863|mint:MINT-3387872|imex:IM-11225-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000052247(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0015631"(tubulin binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032288"(myelin assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051418"(microtubule nucleation by microtubule organizing center)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0150051"(postsynaptic Golgi apparatus)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR008907(P25-alpha)|interpro:IPR011992(EF-Hand type)|interpro:IPR030792|mint:Q27957|ensembl:ENSBTAT00000078768(transcript)|refseq:NP_776401.1|mint:MINT-3387879(identity)	ensembl:ENSBTAG00000014731(gene)|ensembl:ENSBTAT00000037753(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0099162"(regulation of neurotransmitter loading into synaptic vesicle)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P10096|rcsb pdb:4O59|rcsb pdb:4O63|reactome:R-BTA-70171|reactome:R-BTA-70263|go:"GO:0000226"(microtubule cytoskeleton organization)|refseq:NP_001029206.1|mint:MINT-3387873(identity)	-	comment:mint|function:Promotes in vitro the polymerization of tubulin into double-walled tubules and polymorphic aggregates or bundled stabilized microtubules blocks. When overexpressed, inhibits mitotic spindle assembly and nuclear envelope breakdown, apparently without affecting other cellular events|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2A|figure legend:F2B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/22	2014/10/16	rogid:FpmQtJ1d/XjPpPzwFjtP80FjH6M9913	rogid:b2z+q7+LvZlblioRlPMfHBcEg6M9913	intact-crc:8F517BB708A0667C|rigid:62WmaeR+6z7VBtda2HAMDA4JGwo	false	-	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:P81948	uniprotkb:Q27957	intact:EBI-6943159|ensembl:ENSBTAP00000065307|uniprotkb:Q17QT1|intact:MINT-3387904|uniprotkb:Q5E986	intact:EBI-7025612|ensembl:ENSBTAP00000070614|uniprotkb:Q9TRW3|uniprotkb:Q9TRW4|uniprotkb:A2VDP9|intact:MINT-3387832	psi-mi:tba4a_bovin(display_long)|uniprotkb:TUBA1(gene name synonym)|uniprotkb:TUBA4A(gene name)|psi-mi:TUBA4A(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)	psi-mi:tppp_bovin(display_long)|uniprotkb:TPPP(gene name)|psi-mi:TPPP(display_short)|uniprotkb:25 kDa brain-specific protein(gene name synonym)|uniprotkb:p25-alpha(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Oláh et al. (2006)	pubmed:17027006|imex:IM-11225|mint:MINT-5219202	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7025876|mint:MINT-3387891|imex:IM-11225-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000030974(gene)|ensembl:ENSBTAT00000085322(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P81948|refseq:NP_001071626.1|mint:MINT-3387892(identity)	ensembl:ENSBTAG00000052247(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0015631"(tubulin binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032288"(myelin assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051418"(microtubule nucleation by microtubule organizing center)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0150051"(postsynaptic Golgi apparatus)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR008907(P25-alpha)|interpro:IPR011992(EF-Hand type)|interpro:IPR030792|mint:Q27957|ensembl:ENSBTAT00000078768(transcript)|refseq:NP_776401.1|mint:MINT-3387898(identity)	-	comment:mint|function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain|comment:"Stoichiometry: 1.0"	comment:mint|function:Promotes in vitro the polymerization of tubulin into double-walled tubules and polymorphic aggregates or bundled stabilized microtubules blocks. When overexpressed, inhibits mitotic spindle assembly and nuclear envelope breakdown, apparently without affecting other cellular events|comment:"Stoichiometry: 1.0"	figure legend:F2A|figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/22	2014/10/16	rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ9913	rogid:FpmQtJ1d/XjPpPzwFjtP80FjH6M9913	intact-crc:EADFAABC0C284CCC|rigid:oaKOg8ODD3IHAy3vQyPF1x5dWn0	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)