#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03485	uniprotkb:P03433	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008735|mint:MINT-3375035|imex:IM-11428-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375036(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433|mint:MINT-3375042(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/10/23	2014/10/16	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	rogid:vmY21RjtALOteYkDRockgEeKLss211044	intact-crc:74B6A0C08594504B|rigid:8p4LxMFRVpt3NK7s5C4yVq47oqY	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q7YQC6	uniprotkb:P03485	intact:EBI-7008712|uniprotkb:Q8WNS9|intact:MINT-3374994	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	psi-mi:hsp71_canlf(display_long)|uniprotkb:HSPA1(gene name)|psi-mi:HSPA1(display_short)|uniprotkb:Hsp70(gene name synonym)	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008703|mint:MINT-3375016|imex:IM-11428-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005813"(centrosome)|refseq:NP_001003067.2|mint:Q7YQC6|dip:DIP-44612N|mint:MINT-3375017(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375018(identity)	-	comment:mint|function:In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|figure legend:F1C|figure legend:F1A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/10/23	2014/10/16	rogid:SC2qYD3/UU6J/xkNVva06CmiuQ09615	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	intact-crc:5B1606601BEA4D4E|rigid:Izkf4zG3qjTqiUjfOIScg8vU6rE	false	-	-	1	1	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03485	uniprotkb:P03428	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008764|mint:MINT-3375060|imex:IM-11428-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375061(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428|mint:MINT-3375067(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/10/23	2014/10/16	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044	intact-crc:AE1645947CDBC97E|rigid:30/CfRjJi03PkwesCqkXsx/qIpw	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P03466	uniprotkb:P03485	intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008778|mint:MINT-3375083|imex:IM-11428-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466|mint:MINT-3375090(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375084(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/10/23	2014/10/16	rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	intact-crc:D071A98351748AA3|rigid:lLe2HygvNkmK9vRoKqXViEYo40A	false	-	-	1	1	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0113"(western blot)
uniprotkb:O18840	uniprotkb:P03485	intact:EBI-7008806|ensembl:ENSCAFP00030024748|ensembl:ENSCAFP00040025226|uniprotkb:Q11209|uniprotkb:Q95164|intact:MINT-3375148|uniprotkb:Q8SPX4	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	psi-mi:actb_canlf(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008830|mint:MINT-3375134|imex:IM-11428-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001182774.2|reactome:R-CFA-9035034|reactome:R-CFA-8856828|ensembl:ENSCAFG00030015381(gene)|ensembl:ENSCAFG00040015695(gene)|ensembl:ENSCAFT00030028371(transcript)|ensembl:ENSCAFT00040028964(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0045202"(synapse)|go:"GO:0048870"(cell motility)|go:"GO:0097433"(dense body)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:O18840|reactome:R-CFA-190873|reactome:R-CFA-196025|reactome:R-CFA-2029482|reactome:R-CFA-3928662|reactome:R-CFA-3928665|reactome:R-CFA-4420097|reactome:R-CFA-446353|reactome:R-CFA-5250924|reactome:R-CFA-5626467|reactome:R-CFA-5663213|reactome:R-CFA-5663220|reactome:R-CFA-5674135|reactome:R-CFA-5689603|reactome:R-CFA-5696394|mint:MINT-3375141(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375135(identity)	-	comment:mint|function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/10/23	2014/10/16	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9615	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	intact-crc:771BA78EDF81F2E6|rigid:VZCRMRVvd2pryyoolvxxufRwrnk	false	-	-	1	1	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6TEQ7	uniprotkb:P03485	intact:EBI-7008850|ensembl:ENSCAFP00030015356|intact:MINT-3375172	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	psi-mi:anxa2_canlf(display_long)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:Annexin-2(gene name synonym)	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008843|mint:MINT-3375158|imex:IM-11428-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSCAFG00030009412(gene)|ensembl:ENSCAFT00030017582(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002020"(protease binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0031982"(vesicle)|go:"GO:0046790"(virion binding)|go:"GO:0070382"(exocytic vesicle)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:Q6TEQ7|reactome:R-CFA-6798695|refseq:NP_001002961.1|dip:DIP-44616N|mint:MINT-3375165(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375159(identity)	-	function:Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/10/23	2014/10/16	rogid:ytTAmuAuytDkTUoMfe5aUezdd049615	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	intact-crc:359A114391774B4C|rigid:EuXo+K1NufjZJuhNTEKEUguk/8g	false	-	-	1	1	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03485	uniprotkb:P03452	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	intact:EBI-2548105|uniprotkb:A4GXH4|uniprotkb:Q20N38|uniprotkb:Q83964|uniprotkb:Q8JUU5	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:hema_i34a1(display_long)|uniprotkb:HA(gene name)|psi-mi:HA(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008792|mint:MINT-3375105|imex:IM-11428-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375106(identity)	go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:1RU7|rcsb pdb:1RVX|rcsb pdb:1RVZ|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-198933|go:"GO:0046761"(viral budding from plasma membrane)|refseq:NP_040980.1|interpro:IPR008980(Viral capsid/haemagglutinin protein)|interpro:IPR013828(Haemagglutinin, HA1 chain, alpha/beta region)|interpro:IPR000149(Haemagglutinin, influenza A/B virus type, HA1 chain)|interpro:IPR001364(Haemagglutinin, influenza A/B virus type, HA1/HA2 chain)|mint:P03452|mint:MINT-3375112(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/10/23	2014/10/16	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	rogid:gouXSFq22QLERoidFm6ju2SwoIE211044	intact-crc:2A2CB0131189C415|rigid:1dkfKvrc/zyGWN4ta4i0KZLj7I0	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P15311	uniprotkb:P03485	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008882|mint:MINT-3375185|imex:IM-11428-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N|mint:MINT-3375192(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375186(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:Human Up_Id for ezrin was used instead of the canine one|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/10/23	2014/10/16	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	intact-crc:AF9AD836E75D055E|rigid:Kz9rLKLZ6wiHq0jstRiIYIo1nig	false	-	-	1	1	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03485	uniprotkb:P11142	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008977|mint:MINT-3375204|imex:IM-11428-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375205(identity)	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N|mint:MINT-3375211(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/10/23	2014/10/16	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	intact-crc:F8F9309031DAF398|rigid:AZd5cnL36n04FZJfFmBrzNDb7W0	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03485	uniprotkb:P11142	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7009006|mint:MINT-3375222|imex:IM-11428-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375223(identity)	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N|mint:MINT-3375229(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:The interaction also occurs in MDBK and MDCK cells.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/10/23	2014/10/16	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	intact-crc:521A18F5133A2D84|rigid:AZd5cnL36n04FZJfFmBrzNDb7W0	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11142	uniprotkb:P03485	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:"MI:0049"(filter binding)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7009031|mint:MINT-3375263|imex:IM-11428-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N|mint:MINT-3375264(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375270(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	intact-crc:8AE6C5BD901649F2|rigid:AZd5cnL36n04FZJfFmBrzNDb7W0	false	glutathione s tranferase tag:?-?(MINT-3375282)	binding-associated region:91-252(MINT-3375276)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11142	uniprotkb:P03485	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Watanabe et al. (2006)	pubmed:17022977|imex:IM-11428|mint:MINT-5219178	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7009091|mint:MINT-3375242|imex:IM-11428-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N|mint:MINT-3375243(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533|mint:MINT-3375249(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/10/23	2014/10/16	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044	intact-crc:C590DF9D51FA8378|rigid:AZd5cnL36n04FZJfFmBrzNDb7W0	false	-	binding-associated region:102-201(MINT-3375260)	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)