#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q63450	uniprotkb:Q3MUI1	intact:EBI-7007884|ensembl:ENSRNOP00000033456|intact:MINT-3375300|uniprotkb:Q63084	intact:EBI-7007865|intact:MINT-3375291	psi-mi:kcc1a_rat(display_long)|uniprotkb:Camk1(gene name)|psi-mi:Camk1(display_short)|uniprotkb:CaM kinase I(gene name synonym)|uniprotkb:CaM kinase I alpha(gene name synonym)	psi-mi:q3mui1_rat(display_long)|uniprotkb:Numb(gene name)|psi-mi:Numb(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tokumitsu et al. (2006)	pubmed:17022975|imex:IM-11384|mint:MINT-5219174	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7007878|mint:MINT-3375327|imex:IM-11384-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006237065.1|ensembl:ENSRNOG00000021781(gene)|ensembl:ENSRNOT00000029728(transcript)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63450|rcsb pdb:1A06|rcsb pdb:1MXE|rcsb pdb:2L7L|reactome:R-RNO-9619229|refseq:NP_604463.1|rgd:629473|mint:MINT-3375329(identity)	go:"GO:0050769"(positive regulation of neurogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|rgd:620107|refseq:NP_579821.1|interpro:IPR016698(Numb/numb-like)|mint:Q3MUI1|mint:MINT-3375328(identity)	-	function:"Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes like transcriptional regulation, hormone production, translational regulation, regulation of actin filament organization and neurite outgrowth. Involved in calcium-dependent activation of the ERK pathway (By similarity). Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CTFR, MYL9, SYN1/synapsin I and SYNII/synapsin II"|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:7KJ2wmUk+WzmKMUkzS52jSWZ54w10116	rogid:7hSdoX6+FkHEA+ygaxvhDiQiRuE10116	intact-crc:EA84909A7C7686FB|rigid:TORaF9iyo7kz0oociFWR/UHlR9o	false	-	glutathione s tranferase tag:?-?(MINT-3375330)|phosphorylated residue:283-283(MINT-3375338)|mutation disrupting interaction:283-283(MINT-3375343)|mutation disrupting interaction:264-264(MINT-3375340)|binding-associated region:238-304(MINT-3375336)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3MUI1	uniprotkb:P18484	intact:EBI-7007865|intact:MINT-3375291	intact:EBI-539360	psi-mi:q3mui1_rat(display_long)|uniprotkb:Numb(gene name)|psi-mi:Numb(display_short)	psi-mi:ap2a2_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tokumitsu et al. (2006)	pubmed:17022975|imex:IM-11384|mint:MINT-5219174	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7007993|mint:MINT-3375389|imex:IM-11384-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050769"(positive regulation of neurogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|rgd:620107|refseq:NP_579821.1|interpro:IPR016698(Numb/numb-like)|mint:Q3MUI1|mint:MINT-3375935(identity)	rgd:71015|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|rcsb pdb:2VGL|rcsb pdb:2XA7|go:"GO:0008021"(synaptic vesicle)|rcsb pdb:4NEE|rcsb pdb:4UQI|rcsb pdb:6OWT|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|go:"GO:0019900"(kinase binding)|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-6798695|reactome:R-RNO-8856825|go:"GO:0019901"(protein kinase binding)|reactome:R-RNO-8856828|go:"GO:0019904"(protein domain specific binding)|reactome:R-RNO-8866427|reactome:R-RNO-8964038|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|mint:P18484|dip:DIP-29765N|mint:MINT-3375390(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:Phosphorilation of Numb inhibits the interactions.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:7hSdoX6+FkHEA+ygaxvhDiQiRuE10116	rogid:/3UaX0n3j6Lo0w7GMn0uWzL5GI010116	intact-crc:6A192EA2D9D8DA5B|rigid:Q/7uisF+YSDgEaIzXphNFvicglU	false	glutathione s tranferase tag:?-?(MINT-3375936)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q3MUI1	uniprotkb:P84092	intact:EBI-7007865|intact:MINT-3375291	intact:EBI-297693|uniprotkb:P53679|uniprotkb:P20172|ensembl:ENSRNOP00000070202	psi-mi:q3mui1_rat(display_long)|uniprotkb:Numb(gene name)|psi-mi:Numb(display_short)	psi-mi:ap2m1_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:Ap2m1(gene name)|psi-mi:Ap2m1(display_short)|uniprotkb:Mu2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tokumitsu et al. (2006)	pubmed:17022975|imex:IM-11384|mint:MINT-5219174	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7007977|mint:MINT-3375355|imex:IM-11384-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050769"(positive regulation of neurogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|rgd:620107|refseq:NP_579821.1|interpro:IPR016698(Numb/numb-like)|mint:Q3MUI1|mint:MINT-3375356(identity)	go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:P84092|rcsb pdb:1BW8|rcsb pdb:1BXX|rcsb pdb:1HES|rcsb pdb:1I31|rcsb pdb:2BP5|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2PR9|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:3H85|rcsb pdb:3ML6|rcsb pdb:4UQI|rcsb pdb:5C7Z|rcsb pdb:5FPI|rcsb pdb:5WRK|go:"GO:0097718"(disordered domain specific binding)|rcsb pdb:5WRL|rcsb pdb:5WRM|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6RH6|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|ensembl:ENSRNOG00000001709(gene)|ensembl:ENSRNOT00000088821(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097494"(regulation of vesicle size)|rgd:620135|refseq:NP_446289.1|dip:DIP-29761N|mint:MINT-3375373(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:Phosphorilation of Numb inhibits the interactions.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:7hSdoX6+FkHEA+ygaxvhDiQiRuE10116	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA10116	intact-crc:D3C8891A5EBC8672|rigid:T2aTW451PLbPiL6sL+lfDod2BvM	false	glutathione s tranferase tag:?-?(MINT-3375357)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q3MUI1	uniprotkb:P62944-2	intact:EBI-7007865|intact:MINT-3375291	intact:EBI-7008032|ensembl:ENSRNOP00000070905|ensembl:ENSRNOP00000073619|intact:MINT-1908569	psi-mi:q3mui1_rat(display_long)|uniprotkb:Numb(gene name)|psi-mi:Numb(display_short)	psi-mi:p62944-2(display_long)|uniprotkb:Ap2b1(gene name)|psi-mi:Ap2b1(display_short)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Clapb1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tokumitsu et al. (2006)	pubmed:17022975|imex:IM-11384|mint:MINT-5219174	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008025|mint:MINT-3375438|imex:IM-11384-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050769"(positive regulation of neurogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|rgd:620107|refseq:NP_579821.1|interpro:IPR016698(Numb/numb-like)|mint:Q3MUI1|mint:MINT-3375945(identity)	ensembl:ENSRNOG00000061543(gene)|ensembl:ENSRNOT00000088198(transcript)|ensembl:ENSRNOT00000090446(transcript)|intact:EBI-7048246(isoform-parent)|mint:MINT-3375446(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	isoform-comment:Brain specific.|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:Phosphorilation of Numb inhibits the interactions.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:7hSdoX6+FkHEA+ygaxvhDiQiRuE10116	rogid:RpFHKbLgdxGqagTUoCCgQ2W+9nw10116	intact-crc:1C6BEE1F30689C4C|rigid:Fe/4z+DMd7UMHZhA5b85vjiCbgQ	false	glutathione s tranferase tag:?-?(MINT-3375946)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q3MUI1	uniprotkb:Q66HM2	intact:EBI-7007865|intact:MINT-3375291	intact:EBI-2255846|ensembl:ENSRNOP00000060992	psi-mi:q3mui1_rat(display_long)|uniprotkb:Numb(gene name)|psi-mi:Numb(display_short)	psi-mi:q66hm2_rat(display_long)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)	psi-mi:"MI:0096"(pull down)	Tokumitsu et al. (2006)	pubmed:17022975|imex:IM-11384|mint:MINT-5219174	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008009|mint:MINT-3375405|imex:IM-11384-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050769"(positive regulation of neurogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|rgd:620107|refseq:NP_579821.1|interpro:IPR016698(Numb/numb-like)|mint:Q3MUI1|mint:MINT-3375406(identity)	rgd:71015|refseq:NP_112270.2|ensembl:ENSRNOG00000019534(gene)|ensembl:ENSRNOT00000064254(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:Q66HM2|mint:MINT-3375413(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:Phosphorilation of Numb inhibits the interactions.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:7hSdoX6+FkHEA+ygaxvhDiQiRuE10116	rogid:FUY6sVuoA7kEnOWKy6KX7J+J3+M10116	intact-crc:B7E6EED244B99AE6|rigid:DHWd/aLmO2f06nWPq1whWIg8boQ	false	glutathione s tranferase tag:?-?(MINT-3375407)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q3MUI1	uniprotkb:Q66HM2	intact:EBI-7007865|intact:MINT-3375291	intact:EBI-2255846|ensembl:ENSRNOP00000060992	psi-mi:q3mui1_rat(display_long)|uniprotkb:Numb(gene name)|psi-mi:Numb(display_short)	psi-mi:q66hm2_rat(display_long)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)	psi-mi:"MI:0096"(pull down)	Tokumitsu et al. (2006)	pubmed:17022975|imex:IM-11384|mint:MINT-5219174	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008074|mint:MINT-3375473|imex:IM-11384-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050769"(positive regulation of neurogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|rgd:620107|refseq:NP_579821.1|interpro:IPR016698(Numb/numb-like)|mint:Q3MUI1|mint:MINT-3375474(identity)	rgd:71015|refseq:NP_112270.2|ensembl:ENSRNOG00000019534(gene)|ensembl:ENSRNOT00000064254(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:Q66HM2|mint:MINT-3375481(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|figure legend:F3C|comment:Phosphorilation of Numb inhibits the interactions.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:7hSdoX6+FkHEA+ygaxvhDiQiRuE10116	rogid:FUY6sVuoA7kEnOWKy6KX7J+J3+M10116	intact-crc:463E689E228D5D4F|rigid:DHWd/aLmO2f06nWPq1whWIg8boQ	false	glutathione s tranferase tag:?-?(MINT-3375475)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3MUI1	uniprotkb:P62944-2	intact:EBI-7007865|intact:MINT-3375291	intact:EBI-7008032|ensembl:ENSRNOP00000070905|ensembl:ENSRNOP00000073619|intact:MINT-1908569	psi-mi:q3mui1_rat(display_long)|uniprotkb:Numb(gene name)|psi-mi:Numb(display_short)	psi-mi:p62944-2(display_long)|uniprotkb:Ap2b1(gene name)|psi-mi:Ap2b1(display_short)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Clapb1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tokumitsu et al. (2006)	pubmed:17022975|imex:IM-11384|mint:MINT-5219174	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008057|mint:MINT-3375454|imex:IM-11384-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050769"(positive regulation of neurogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|rgd:620107|refseq:NP_579821.1|interpro:IPR016698(Numb/numb-like)|mint:Q3MUI1|mint:MINT-3375455(identity)	ensembl:ENSRNOG00000061543(gene)|ensembl:ENSRNOT00000088198(transcript)|ensembl:ENSRNOT00000090446(transcript)|intact:EBI-7048246(isoform-parent)|mint:MINT-3375462(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	isoform-comment:Brain specific.|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F4|figure legend:F3C|comment:Phosphorilation of Numb inhibits the interactions.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:7hSdoX6+FkHEA+ygaxvhDiQiRuE10116	rogid:RpFHKbLgdxGqagTUoCCgQ2W+9nw10116	intact-crc:863CEC1BCC3B8B80|rigid:Fe/4z+DMd7UMHZhA5b85vjiCbgQ	false	glutathione s tranferase tag:?-?(MINT-3375456)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3MUI1	uniprotkb:P68511	intact:EBI-7007865|intact:MINT-3375291	intact:EBI-444647|uniprotkb:P11576|uniprotkb:P70198|ensembl:ENSRNOP00000075701	psi-mi:q3mui1_rat(display_long)|uniprotkb:Numb(gene name)|psi-mi:Numb(display_short)	psi-mi:1433f_rat(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0096"(pull down)	Tokumitsu et al. (2006)	pubmed:17022975|imex:IM-11384|mint:MINT-5219174	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008128|mint:MINT-3375558|imex:IM-11384-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050769"(positive regulation of neurogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|rgd:620107|refseq:NP_579821.1|interpro:IPR016698(Numb/numb-like)|mint:Q3MUI1|mint:MINT-3375565(identity)	rgd:3978|refseq:NP_037184.1|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-5625740|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|ensembl:ENSRNOG00000055471(gene)|ensembl:ENSRNOT00000085735(transcript)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68511|reactome:R-RNO-111447|dip:DIP-299N|mint:MINT-3375559(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:Interaction occurs only if Numb is phosphorylated.|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:7hSdoX6+FkHEA+ygaxvhDiQiRuE10116	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10116	intact-crc:82085615174EFA97|rigid:9KAkGKmyPaRCGOWJPJob9NS/UI0	false	mutation disrupting interaction:264-264(MINT-3375572)|glutathione s tranferase tag:?-?(MINT-3375566)|mutation disrupting interaction:283-283(MINT-3375576)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3MUI1	uniprotkb:P68511	intact:EBI-7007865|intact:MINT-3375291	intact:EBI-444647|uniprotkb:P11576|uniprotkb:P70198|ensembl:ENSRNOP00000075701	psi-mi:q3mui1_rat(display_long)|uniprotkb:Numb(gene name)|psi-mi:Numb(display_short)	psi-mi:1433f_rat(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0096"(pull down)	Tokumitsu et al. (2006)	pubmed:17022975|imex:IM-11384|mint:MINT-5219174	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008091|mint:MINT-3375499|imex:IM-11384-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050769"(positive regulation of neurogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|rgd:620107|refseq:NP_579821.1|interpro:IPR016698(Numb/numb-like)|mint:Q3MUI1|mint:MINT-3375500(identity)	rgd:3978|refseq:NP_037184.1|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-5625740|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|ensembl:ENSRNOG00000055471(gene)|ensembl:ENSRNOT00000085735(transcript)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68511|reactome:R-RNO-111447|dip:DIP-299N|mint:MINT-3375507(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:Interaction occurs only if Numb is phosphorylated.|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:7hSdoX6+FkHEA+ygaxvhDiQiRuE10116	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10116	intact-crc:8080CF4F861C7B52|rigid:9KAkGKmyPaRCGOWJPJob9NS/UI0	false	glutathione s tranferase tag:?-?(MINT-3375501)|mutation decreasing interaction:264-264(MINT-3375554)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3MUI1	uniprotkb:P68511	intact:EBI-7007865|intact:MINT-3375291	intact:EBI-444647|uniprotkb:P11576|uniprotkb:P70198|ensembl:ENSRNOP00000075701	psi-mi:q3mui1_rat(display_long)|uniprotkb:Numb(gene name)|psi-mi:Numb(display_short)	psi-mi:1433f_rat(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0096"(pull down)	Tokumitsu et al. (2006)	pubmed:17022975|imex:IM-11384|mint:MINT-5219174	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7008165|mint:MINT-8007644|imex:IM-11384-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050769"(positive regulation of neurogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|rgd:620107|refseq:NP_579821.1|interpro:IPR016698(Numb/numb-like)|mint:Q3MUI1|mint:MINT-8007648(identity)|uniprotkb:Q3MUI1(original identifier)	rgd:3978|refseq:NP_037184.1|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-5625740|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|ensembl:ENSRNOG00000055471(gene)|ensembl:ENSRNOT00000085735(transcript)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68511|reactome:R-RNO-111447|dip:DIP-299N|mint:MINT-8007645(identity)|uniprotkb:P68511(original identifier)	-	comment:mint	-	comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2006/10/23	2014/10/16	rogid:7hSdoX6+FkHEA+ygaxvhDiQiRuE10116	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10116	intact-crc:CE5B4782722AE9CF|rigid:9KAkGKmyPaRCGOWJPJob9NS/UI0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)