#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19359	uniprotkb:Q03062	intact:EBI-6998821|ensembl:ENSRNOP00000005674|intact:MINT-3376271	intact:EBI-6998882|ensembl:ENSRNOP00000018769|intact:MINT-3376257	psi-mi:ascl1_rat(display_long)|uniprotkb:Ascl1(gene name)|psi-mi:Ascl1(display_short)|uniprotkb:Ash1(gene name synonym)|uniprotkb:Mash-1(gene name synonym)	psi-mi:hes5_rat(display_long)|uniprotkb:Hes5(gene name)|psi-mi:Hes5(display_short)|uniprotkb:Hes-5(gene name synonym)|uniprotkb:Hairy and enhancer of split 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2006)	pubmed:17006542|imex:IM-11118|mint:MINT-5219153	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6998935|mint:MINT-3376285|imex:IM-11118-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000004294(gene)|ensembl:ENSRNOT00000005674(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021529"(spinal cord oligodendrocyte cell differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021779"(oligodendrocyte cell fate commitment)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0048699"(generation of neurons)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR036638|mint:P19359|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|refseq:NP_071779.1|rgd:71010|mint:MINT-3376287(identity)	ensembl:ENSRNOG00000013850(gene)|ensembl:ENSRNOT00000018769(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021781"(glial cell fate commitment)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031641"(regulation of myelination)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072049"(comma-shaped body morphogenesis)|go:"GO:0072050"(S-shaped body morphogenesis)|go:"GO:0072086"(specification of loop of Henle identity)|go:"GO:0072282"(metanephric nephron tubule morphogenesis)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2000978"(negative regulation of forebrain neuron differentiation)|go:"GO:2000981"(negative regulation of inner ear receptor cell differentiation)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:Q03062|go:"GO:0003690"(double-stranded DNA binding)|refseq:NP_077359.1|rgd:621340|mint:MINT-3376286(identity)	-	comment:mint|function:"May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Activates transcription by binding to the E box (5'-CANNTG-3')"|comment:"Stoichiometry: 1.0"	comment:mint|function:Transcriptional repressor of genes that require a bHLH protein for their transcription|comment:"Stoichiometry: 1.0"	figure legend:F6B|figure legend:F6C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-oligodendrocyt)|taxid:10090(Mus musculus)	-	2006/10/23	2014/10/16	rogid:5E8VRJ/gOyARONf+KANa7C5MwIg10116	rogid:v+Njux6PgR8VJpj96lHiksTHhJ410116	intact-crc:59FF0617AAB1332C|rigid:9VmRDeoCNRT87EQvNIhkfDXrRfE	false	-	myc tag:?-?(MINT-3376295)|binding-associated region:29-166(MINT-3376302)	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03062	uniprotkb:O55170	intact:EBI-6998882|ensembl:ENSRNOP00000018769|intact:MINT-3376257	intact:EBI-1185693|ensembl:ENSRNOP00000015283	psi-mi:hes5_rat(display_long)|uniprotkb:Hes5(gene name)|psi-mi:Hes5(display_short)|uniprotkb:Hes-5(gene name synonym)|uniprotkb:Hairy and enhancer of split 5(gene name synonym)	psi-mi:sox10_rat(display_long)|uniprotkb:Sox10(gene name)|psi-mi:Sox10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2006)	pubmed:17006542|imex:IM-11118|mint:MINT-5219153	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6998980|mint:MINT-3376311|imex:IM-11118-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000013850(gene)|ensembl:ENSRNOT00000018769(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021781"(glial cell fate commitment)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031641"(regulation of myelination)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072049"(comma-shaped body morphogenesis)|go:"GO:0072050"(S-shaped body morphogenesis)|go:"GO:0072086"(specification of loop of Henle identity)|go:"GO:0072282"(metanephric nephron tubule morphogenesis)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2000978"(negative regulation of forebrain neuron differentiation)|go:"GO:2000981"(negative regulation of inner ear receptor cell differentiation)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:Q03062|go:"GO:0003690"(double-stranded DNA binding)|refseq:NP_077359.1|rgd:621340|mint:MINT-3376312(identity)	rgd:3735|refseq:NP_062066.1|ensembl:ENSRNOG00000011305(gene)|ensembl:ENSRNOT00000015283(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010626"(negative regulation of Schwann cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0048469"(cell maturation)|go:"GO:0048484"(enteric nervous system development)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|interpro:IPR036910|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048709"(oligodendrocyte differentiation)|mint:O55170|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061138"(morphogenesis of a branching epithelium)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|refseq:XP_017450187.1|mint:MINT-3376322(identity)	-	comment:mint|function:Transcriptional repressor of genes that require a bHLH protein for their transcription|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7A|figure legend:F7B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-oligodendrocyt)|taxid:10090(Mus musculus)	-	2006/10/23	2014/10/16	rogid:v+Njux6PgR8VJpj96lHiksTHhJ410116	rogid:Hd/UiEz1qp9nrNUhB7fQABrM8/810116	intact-crc:1AE7DEF5EC857E0B|rigid:vDcXAxmh86DleqD9oAqC0gyrWp8	false	binding-associated region:29-166(MINT-3376320)|myc tag:?-?(MINT-3376313)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)