#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P54300	uniprotkb:P54302	intact:EBI-1101482	intact:EBI-1101486	psi-mi:luxp_vibha(display_long)|uniprotkb:luxP(gene name)|psi-mi:luxP(display_short)	psi-mi:luxq_vibha(display_long)|uniprotkb:luxQ(gene name)|psi-mi:luxQ(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Neiditch et al. (2006)	imex:IM-12039|pubmed:16990134	taxid:669(vibha)|taxid:669(Vibrio harveyi)	taxid:669(vibha)|taxid:669(Vibrio harveyi)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1101567|wwpdb:2HJ9|imex:IM-12039-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR025997|go:"GO:0042597"(periplasmic space)|rcsb pdb:1JX6|rcsb pdb:1ZHH|rcsb pdb:2HJ9|interpro:IPR028082|rcsb pdb:4YP9|rcsb pdb:4YR7|rcsb pdb:4YRZ	go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR011006(CheY-like)|interpro:IPR015387(LuxQ, periplasmic)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR001789(Signal transduction response regulator, receiver region)|rcsb pdb:1ZHH|rcsb pdb:2HJ9|rcsb pdb:2HJE|interpro:IPR029151|interpro:IPR043056|interpro:IPR036097|interpro:IPR036890	go:"GO:0009372"(quorum sensing)|wwpdb:2HJE(see-also)	-	-	figure legend:3 A-C, Table S1|stimulant:"The complex was found in the presence of autoinducer-2 (AI-2) (3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE- 2,2,6,6A-TETRAOL). AI-2  binding causes a major conformational change  within LuxP, which in turn stabilizes a quaternary  arrangement in which two LuxPQ monomers  are asymmetrically associated."|comment:The LuxQ sequence used has a Gly-Ser at the start not found in the Uniprot sequence at this position.|3d-resolution:2.34 A|3d-r-factors:"Rfree(%) 26.18"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/28	2014/10/16	rogid:u9KiRvM3nlY4XO5V3nXTSB6rTEc669	rogid:4oQhSm0mBS9KsfozvobL9cTQd1Q669	intact-crc:32B917944A5912D0|rigid:oWmuGyKLg5M2/HC8Td9olz8EG04	false	sufficient binding region:27-365	sufficient binding region:248-271,53-238	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54300	uniprotkb:P54302	intact:EBI-1101482	intact:EBI-1101486	psi-mi:luxp_vibha(display_long)|uniprotkb:luxP(gene name)|psi-mi:luxP(display_short)	psi-mi:luxq_vibha(display_long)|uniprotkb:luxQ(gene name)|psi-mi:luxQ(display_short)	psi-mi:"MI:0067"(light scattering)	Neiditch et al. (2006)	imex:IM-12039|pubmed:16990134	taxid:669(vibha)|taxid:669(Vibrio harveyi)	taxid:669(vibha)|taxid:669(Vibrio harveyi)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1101623|imex:IM-12039-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR025997|go:"GO:0042597"(periplasmic space)|rcsb pdb:1JX6|rcsb pdb:1ZHH|rcsb pdb:2HJ9|interpro:IPR028082|rcsb pdb:4YP9|rcsb pdb:4YR7|rcsb pdb:4YRZ	go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR011006(CheY-like)|interpro:IPR015387(LuxQ, periplasmic)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR001789(Signal transduction response regulator, receiver region)|rcsb pdb:1ZHH|rcsb pdb:2HJ9|rcsb pdb:2HJE|interpro:IPR029151|interpro:IPR043056|interpro:IPR036097|interpro:IPR036890	go:"GO:0009372"(quorum sensing)	-	-	stimulant:"The complex was found in the presence of autoinducer-2 (AI-2) (3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE- 2,2,6,6A-TETRAOL). AI-2 binding causes a major conformational change within LuxP, which in turn stabilizes a quaternary arrangement in which two LuxPQ monomers are asymmetrically associated."|comment:The LuxQ sequence used may have a Gly-Ser at the start not found in the Uniprot sequence at this position as the sequence used in the X-ray crystallography experiment does.|comment:It is indicated that deleting the 5 N-terminal residues of LuxP promoted dimerisation of LuxPQ monomers.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/28	2014/10/16	rogid:u9KiRvM3nlY4XO5V3nXTSB6rTEc669	rogid:4oQhSm0mBS9KsfozvobL9cTQd1Q669	intact-crc:55A7C6A4E06202D3|rigid:oWmuGyKLg5M2/HC8Td9olz8EG04	false	sufficient binding region:6-365	sufficient binding region:53-271	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54302	uniprotkb:P54300	intact:EBI-1101486	intact:EBI-1101482	psi-mi:luxq_vibha(display_long)|uniprotkb:luxQ(gene name)|psi-mi:luxQ(display_short)	psi-mi:luxp_vibha(display_long)|uniprotkb:luxP(gene name)|psi-mi:luxP(display_short)	psi-mi:"MI:0067"(light scattering)	Neiditch et al. (2006)	imex:IM-12039|pubmed:16990134	taxid:669(vibha)|taxid:669(Vibrio harveyi)	taxid:669(vibha)|taxid:669(Vibrio harveyi)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1101708|imex:IM-12039-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR011006(CheY-like)|interpro:IPR015387(LuxQ, periplasmic)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR001789(Signal transduction response regulator, receiver region)|rcsb pdb:1ZHH|rcsb pdb:2HJ9|rcsb pdb:2HJE|interpro:IPR029151|interpro:IPR043056|interpro:IPR036097|interpro:IPR036890	interpro:IPR025997|go:"GO:0042597"(periplasmic space)|rcsb pdb:1JX6|rcsb pdb:1ZHH|rcsb pdb:2HJ9|interpro:IPR028082|rcsb pdb:4YP9|rcsb pdb:4YR7|rcsb pdb:4YRZ	go:"GO:0009372"(quorum sensing)	-	-	stimulant:"It is indicated that both LuxPQ monomers and dimers were found in the presence of autoinducer-2 (AI-2) (3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE- 2,2,6,6A-TETRAOL). AI-2 binding causes a major conformational change within LuxP, which in turn stabilizes a quaternary arrangement in which two LuxPQ monomers are asymmetrically associated."|comment:The LuxQ sequence used may have a Gly-Ser at the start not found in the Uniprot sequence at this position as the sequence used in the X-ray crystallography experiment does.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/28	2014/10/16	rogid:4oQhSm0mBS9KsfozvobL9cTQd1Q669	rogid:u9KiRvM3nlY4XO5V3nXTSB6rTEc669	intact-crc:78C62429A7EB7813|rigid:oWmuGyKLg5M2/HC8Td9olz8EG04	false	sufficient binding region:53-271	sufficient binding region:1-365	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)