#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03137	uniprotkb:Q03137	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wiesner et al. (2006)	pubmed:16977320|imex:IM-11436|mint:MINT-5219102	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6976479|mint:MINT-3381536|imex:IM-11436-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|mint:MINT-3381542(identity)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|mint:MINT-3381604(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/10	2014/10/16	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	intact-crc:9BF8F4BC113101A6|rigid:YuU7rKxJi7EpK8lUTe/Z9DxvC4g	false	glutathione s tranferase tag:?-?(MINT-3381626)|mutation decreasing interaction:610-610,604-604(MINT-3381543)|binding-associated region:586-986(MINT-3381628)	glutathione s tranferase tag:?-?(MINT-3381613)|binding-associated region:586-986(MINT-3381619)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P54763	uniprotkb:P54763	intact:EBI-537711|uniprotkb:Q9QVY4|uniprotkb:Q62213|uniprotkb:A3KG00|uniprotkb:A3KG01|uniprotkb:A3KG02|uniprotkb:A3KG89|uniprotkb:A3KG90|uniprotkb:Q6GTQ7|uniprotkb:Q6P5F1|ensembl:ENSMUSP00000101471	intact:EBI-537711|uniprotkb:Q9QVY4|uniprotkb:Q62213|uniprotkb:A3KG00|uniprotkb:A3KG01|uniprotkb:A3KG02|uniprotkb:A3KG89|uniprotkb:A3KG90|uniprotkb:Q6GTQ7|uniprotkb:Q6P5F1|ensembl:ENSMUSP00000101471	psi-mi:ephb2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor EPH-3(gene name synonym)|uniprotkb:Neural kinase(gene name synonym)|uniprotkb:Nuk receptor tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-3(gene name synonym)|uniprotkb:Ephb2(gene name)|psi-mi:Ephb2(display_short)|uniprotkb:Epth3(gene name synonym)|uniprotkb:Nuk(gene name synonym)|uniprotkb:Sek3(gene name synonym)	psi-mi:ephb2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor EPH-3(gene name synonym)|uniprotkb:Neural kinase(gene name synonym)|uniprotkb:Nuk receptor tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-3(gene name synonym)|uniprotkb:Ephb2(gene name)|psi-mi:Ephb2(display_short)|uniprotkb:Epth3(gene name synonym)|uniprotkb:Nuk(gene name synonym)|uniprotkb:Sek3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wiesner et al. (2006)	pubmed:16977320|imex:IM-11436|mint:MINT-5219102	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6976556|mint:MINT-3381640|imex:IM-11436-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277682.1|refseq:NP_034272.1|refseq:XP_006538594.1|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0001655"(urogenital system development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016310"(phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0005003"(ephrin receptor activity)|interpro:IPR011009(Protein kinase-like)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR011641(GCC2 and GCC3)|go:"GO:0106028"(neuron projection retraction)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|mint:P54763|rcsb pdb:1JPA|rcsb pdb:1KGY|rcsb pdb:1NUK|interpro:IPR000719(Protein kinase, core)|rcsb pdb:1SHW|rcsb pdb:2HEN|rcsb pdb:3ETP|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|reactome:R-MMU-2682334|interpro:IPR003961(Fibronectin, type III)|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|ensembl:ENSMUSG00000028664(gene)|ensembl:ENSMUST00000105845(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|dip:DIP-34917N|mint:MINT-3381719(identity)	refseq:NP_001277682.1|refseq:NP_034272.1|refseq:XP_006538594.1|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0001655"(urogenital system development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016310"(phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0005003"(ephrin receptor activity)|interpro:IPR011009(Protein kinase-like)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR011641(GCC2 and GCC3)|go:"GO:0106028"(neuron projection retraction)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|mint:P54763|rcsb pdb:1JPA|rcsb pdb:1KGY|rcsb pdb:1NUK|interpro:IPR000719(Protein kinase, core)|rcsb pdb:1SHW|rcsb pdb:2HEN|rcsb pdb:3ETP|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|reactome:R-MMU-2682334|interpro:IPR003961(Fibronectin, type III)|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|ensembl:ENSMUSG00000028664(gene)|ensembl:ENSMUST00000105845(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|dip:DIP-34917N|mint:MINT-3381641(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/10	2015/11/10	rogid:QgDJW2yhMS13Eb5l3DR03T814gI10090	rogid:QgDJW2yhMS13Eb5l3DR03T814gI10090	intact-crc:2C8557D72B804F45|rigid:2ocTMtZ8OYda0ySFQc7AB1rs8po	false	binding-associated region:614-898(MINT-3381727)	binding-associated region:614-898(MINT-3381642)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P54763	uniprotkb:P54763	intact:EBI-537711|uniprotkb:Q9QVY4|uniprotkb:Q62213|uniprotkb:A3KG00|uniprotkb:A3KG01|uniprotkb:A3KG02|uniprotkb:A3KG89|uniprotkb:A3KG90|uniprotkb:Q6GTQ7|uniprotkb:Q6P5F1|ensembl:ENSMUSP00000101471	intact:EBI-537711|uniprotkb:Q9QVY4|uniprotkb:Q62213|uniprotkb:A3KG00|uniprotkb:A3KG01|uniprotkb:A3KG02|uniprotkb:A3KG89|uniprotkb:A3KG90|uniprotkb:Q6GTQ7|uniprotkb:Q6P5F1|ensembl:ENSMUSP00000101471	psi-mi:ephb2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor EPH-3(gene name synonym)|uniprotkb:Neural kinase(gene name synonym)|uniprotkb:Nuk receptor tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-3(gene name synonym)|uniprotkb:Ephb2(gene name)|psi-mi:Ephb2(display_short)|uniprotkb:Epth3(gene name synonym)|uniprotkb:Nuk(gene name synonym)|uniprotkb:Sek3(gene name synonym)	psi-mi:ephb2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor EPH-3(gene name synonym)|uniprotkb:Neural kinase(gene name synonym)|uniprotkb:Nuk receptor tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-3(gene name synonym)|uniprotkb:Ephb2(gene name)|psi-mi:Ephb2(display_short)|uniprotkb:Epth3(gene name synonym)|uniprotkb:Nuk(gene name synonym)|uniprotkb:Sek3(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Wiesner et al. (2006)	pubmed:16977320|imex:IM-11436|mint:MINT-5219102	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6976631|mint:MINT-3381737|imex:IM-11436-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277682.1|refseq:NP_034272.1|refseq:XP_006538594.1|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0001655"(urogenital system development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016310"(phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0005003"(ephrin receptor activity)|interpro:IPR011009(Protein kinase-like)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR011641(GCC2 and GCC3)|go:"GO:0106028"(neuron projection retraction)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|mint:P54763|rcsb pdb:1JPA|rcsb pdb:1KGY|rcsb pdb:1NUK|interpro:IPR000719(Protein kinase, core)|rcsb pdb:1SHW|rcsb pdb:2HEN|rcsb pdb:3ETP|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|reactome:R-MMU-2682334|interpro:IPR003961(Fibronectin, type III)|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|ensembl:ENSMUSG00000028664(gene)|ensembl:ENSMUST00000105845(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|dip:DIP-34917N|mint:MINT-3381738(identity)	refseq:NP_001277682.1|refseq:NP_034272.1|refseq:XP_006538594.1|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0001655"(urogenital system development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016310"(phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0005003"(ephrin receptor activity)|interpro:IPR011009(Protein kinase-like)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR011641(GCC2 and GCC3)|go:"GO:0106028"(neuron projection retraction)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|mint:P54763|rcsb pdb:1JPA|rcsb pdb:1KGY|rcsb pdb:1NUK|interpro:IPR000719(Protein kinase, core)|rcsb pdb:1SHW|rcsb pdb:2HEN|rcsb pdb:3ETP|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|reactome:R-MMU-2682334|interpro:IPR003961(Fibronectin, type III)|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|ensembl:ENSMUSG00000028664(gene)|ensembl:ENSMUST00000105845(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|dip:DIP-34917N|mint:MINT-3381745(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/10	2015/11/10	rogid:QgDJW2yhMS13Eb5l3DR03T814gI10090	rogid:QgDJW2yhMS13Eb5l3DR03T814gI10090	intact-crc:8B097FB9D86327F8|rigid:2ocTMtZ8OYda0ySFQc7AB1rs8po	false	binding-associated region:614-898(MINT-3381739)	binding-associated region:614-898(MINT-3381746)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03137	uniprotkb:Q03137	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wiesner et al. (2006)	pubmed:16977320|imex:IM-11436|mint:MINT-5219102	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6976684|mint:MINT-3381480|imex:IM-11436-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|mint:MINT-3381482(identity)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|mint:MINT-3381481(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|figure legend:F1B F1A SF3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/10	2014/10/16	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	intact-crc:4153B6F1CDCED5FD|rigid:YuU7rKxJi7EpK8lUTe/Z9DxvC4g	false	mutation increasing interaction:750-750(MINT-3381491)|mutation decreasing interaction:610-610,604-604(MINT-3381494)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03137	uniprotkb:P54763	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	intact:EBI-537711|uniprotkb:Q9QVY4|uniprotkb:Q62213|uniprotkb:A3KG00|uniprotkb:A3KG01|uniprotkb:A3KG02|uniprotkb:A3KG89|uniprotkb:A3KG90|uniprotkb:Q6GTQ7|uniprotkb:Q6P5F1|ensembl:ENSMUSP00000101471	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:ephb2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor EPH-3(gene name synonym)|uniprotkb:Neural kinase(gene name synonym)|uniprotkb:Nuk receptor tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-3(gene name synonym)|uniprotkb:Ephb2(gene name)|psi-mi:Ephb2(display_short)|uniprotkb:Epth3(gene name synonym)|uniprotkb:Nuk(gene name synonym)|uniprotkb:Sek3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wiesner et al. (2006)	pubmed:16977320|imex:IM-11436|mint:MINT-5219102	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6976729|mint:MINT-3387804|imex:IM-11436-10	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|mint:MINT-3387805(identity)	refseq:NP_001277682.1|refseq:NP_034272.1|refseq:XP_006538594.1|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0001655"(urogenital system development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016310"(phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0005003"(ephrin receptor activity)|interpro:IPR011009(Protein kinase-like)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR011641(GCC2 and GCC3)|go:"GO:0106028"(neuron projection retraction)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|mint:P54763|rcsb pdb:1JPA|rcsb pdb:1KGY|rcsb pdb:1NUK|interpro:IPR000719(Protein kinase, core)|rcsb pdb:1SHW|rcsb pdb:2HEN|rcsb pdb:3ETP|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|reactome:R-MMU-2682334|interpro:IPR003961(Fibronectin, type III)|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|ensembl:ENSMUSG00000028664(gene)|ensembl:ENSMUST00000105845(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|dip:DIP-34917N|mint:MINT-3387817(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:SF3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/10	2015/11/10	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	rogid:QgDJW2yhMS13Eb5l3DR03T814gI10090	intact-crc:6AE16C0E2A1CE33E|rigid:Nc+ix/4DYHwCQd/SzJPyg7MKC+g	false	-	phosphorylated residue:596-596(MINT-3388216)|mutation disrupting interaction:596-596(MINT-3388218)|binding-associated region:588-601(MINT-3388214)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q03137	uniprotkb:Q03145	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	intact:EBI-529701|uniprotkb:Q60633|uniprotkb:Q62212|uniprotkb:Q3UNI2|ensembl:ENSMUSP00000006614	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:epha2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor ECK(gene name synonym)|uniprotkb:Epithelial cell kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-5(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-2(gene name synonym)|uniprotkb:Epha2(gene name)|psi-mi:Epha2(display_short)|uniprotkb:Eck(gene name synonym)|uniprotkb:Sek2(gene name synonym)|uniprotkb:Myk2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wiesner et al. (2006)	pubmed:16977320|imex:IM-11436|mint:MINT-5219102	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6976904|mint:MINT-3388272|imex:IM-11436-8	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|mint:MINT-3388280(identity)	refseq:NP_034269.2|dip:DIP-829N|ensembl:ENSMUSG00000006445(gene)|ensembl:ENSMUST00000006614(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014028"(notochord formation)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019838"(growth factor binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060035"(notochord cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0070160"(tight junction)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1904238"(pericyte cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034263|interpro:IPR036116|mint:Q03145|rcsb pdb:5ZRX|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|mint:MINT-3388273(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:SF3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/10	2014/10/16	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	rogid:PppTcjFTGU5TuCWNmeqK9NVjb5w10090	intact-crc:D63ECF18DD5958F4|rigid:MpxoavhoGYtWRxzpt5Dxh4zQaCw	false	-	mutation disrupting interaction:589-589(MINT-3388317)|binding-associated region:581-593(MINT-3388274)|phosphorylated residue:589-589(MINT-3388315)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q03137	uniprotkb:P54763	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	intact:EBI-537711|uniprotkb:Q9QVY4|uniprotkb:Q62213|uniprotkb:A3KG00|uniprotkb:A3KG01|uniprotkb:A3KG02|uniprotkb:A3KG89|uniprotkb:A3KG90|uniprotkb:Q6GTQ7|uniprotkb:Q6P5F1|ensembl:ENSMUSP00000101471	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:ephb2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor EPH-3(gene name synonym)|uniprotkb:Neural kinase(gene name synonym)|uniprotkb:Nuk receptor tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-3(gene name synonym)|uniprotkb:Ephb2(gene name)|psi-mi:Ephb2(display_short)|uniprotkb:Epth3(gene name synonym)|uniprotkb:Nuk(gene name synonym)|uniprotkb:Sek3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wiesner et al. (2006)	pubmed:16977320|imex:IM-11436|mint:MINT-5219102	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6976777|mint:MINT-3388251|imex:IM-11436-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|mint:MINT-3388264(identity)	refseq:NP_001277682.1|refseq:NP_034272.1|refseq:XP_006538594.1|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0001655"(urogenital system development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016310"(phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0005003"(ephrin receptor activity)|interpro:IPR011009(Protein kinase-like)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR011641(GCC2 and GCC3)|go:"GO:0106028"(neuron projection retraction)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|mint:P54763|rcsb pdb:1JPA|rcsb pdb:1KGY|rcsb pdb:1NUK|interpro:IPR000719(Protein kinase, core)|rcsb pdb:1SHW|rcsb pdb:2HEN|rcsb pdb:3ETP|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|reactome:R-MMU-2682334|interpro:IPR003961(Fibronectin, type III)|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|ensembl:ENSMUSG00000028664(gene)|ensembl:ENSMUST00000105845(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|dip:DIP-34917N|mint:MINT-3388252(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:SF3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/10	2015/11/10	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	rogid:QgDJW2yhMS13Eb5l3DR03T814gI10090	intact-crc:EE5D8B598C41BBD5|rigid:Nc+ix/4DYHwCQd/SzJPyg7MKC+g	false	-	binding-associated region:593-605(MINT-3388258)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q03137	uniprotkb:P54763	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	intact:EBI-537711|uniprotkb:Q9QVY4|uniprotkb:Q62213|uniprotkb:A3KG00|uniprotkb:A3KG01|uniprotkb:A3KG02|uniprotkb:A3KG89|uniprotkb:A3KG90|uniprotkb:Q6GTQ7|uniprotkb:Q6P5F1|ensembl:ENSMUSP00000101471	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:ephb2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor EPH-3(gene name synonym)|uniprotkb:Neural kinase(gene name synonym)|uniprotkb:Nuk receptor tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-3(gene name synonym)|uniprotkb:Ephb2(gene name)|psi-mi:Ephb2(display_short)|uniprotkb:Epth3(gene name synonym)|uniprotkb:Nuk(gene name synonym)|uniprotkb:Sek3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wiesner et al. (2006)	pubmed:16977320|imex:IM-11436|mint:MINT-5219102	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6976753|mint:MINT-3388222|imex:IM-11436-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|mint:MINT-3388235(identity)	refseq:NP_001277682.1|refseq:NP_034272.1|refseq:XP_006538594.1|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0001655"(urogenital system development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016310"(phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0005003"(ephrin receptor activity)|interpro:IPR011009(Protein kinase-like)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR011641(GCC2 and GCC3)|go:"GO:0106028"(neuron projection retraction)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|mint:P54763|rcsb pdb:1JPA|rcsb pdb:1KGY|rcsb pdb:1NUK|interpro:IPR000719(Protein kinase, core)|rcsb pdb:1SHW|rcsb pdb:2HEN|rcsb pdb:3ETP|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|reactome:R-MMU-2682334|interpro:IPR003961(Fibronectin, type III)|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|ensembl:ENSMUSG00000028664(gene)|ensembl:ENSMUST00000105845(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|dip:DIP-34917N|mint:MINT-3388223(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:SF3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/10	2015/11/10	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	rogid:QgDJW2yhMS13Eb5l3DR03T814gI10090	intact-crc:5D74D192F32D6E75|rigid:Nc+ix/4DYHwCQd/SzJPyg7MKC+g	false	-	mutation disrupting interaction:602-602(MINT-3388224)|phosphorylated residue:602-602(MINT-3388227)|binding-associated region:597-608(MINT-3388229)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q03137	uniprotkb:Q03145	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	intact:EBI-529701|uniprotkb:Q60633|uniprotkb:Q62212|uniprotkb:Q3UNI2|ensembl:ENSMUSP00000006614	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:epha2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor ECK(gene name synonym)|uniprotkb:Epithelial cell kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-5(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-2(gene name synonym)|uniprotkb:Epha2(gene name)|psi-mi:Epha2(display_short)|uniprotkb:Eck(gene name synonym)|uniprotkb:Sek2(gene name synonym)|uniprotkb:Myk2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wiesner et al. (2006)	pubmed:16977320|imex:IM-11436|mint:MINT-5219102	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6976961|mint:MINT-3388342|imex:IM-11436-6	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|mint:MINT-3388355(identity)	refseq:NP_034269.2|dip:DIP-829N|ensembl:ENSMUSG00000006445(gene)|ensembl:ENSMUST00000006614(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014028"(notochord formation)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019838"(growth factor binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060035"(notochord cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0070160"(tight junction)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1904238"(pericyte cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034263|interpro:IPR036116|mint:Q03145|rcsb pdb:5ZRX|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|mint:MINT-3388343(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:SF3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/10	2014/10/16	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	rogid:PppTcjFTGU5TuCWNmeqK9NVjb5w10090	intact-crc:898F811C3FE3EB60|rigid:MpxoavhoGYtWRxzpt5Dxh4zQaCw	false	-	binding-associated region:586-598(MINT-3388349)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q03137	uniprotkb:Q03145	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	intact:EBI-529701|uniprotkb:Q60633|uniprotkb:Q62212|uniprotkb:Q3UNI2|ensembl:ENSMUSP00000006614	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:epha2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor ECK(gene name synonym)|uniprotkb:Epithelial cell kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-5(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-2(gene name synonym)|uniprotkb:Epha2(gene name)|psi-mi:Epha2(display_short)|uniprotkb:Eck(gene name synonym)|uniprotkb:Sek2(gene name synonym)|uniprotkb:Myk2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wiesner et al. (2006)	pubmed:16977320|imex:IM-11436|mint:MINT-5219102	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6976936|mint:MINT-3388322|imex:IM-11436-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|mint:MINT-3388335(identity)	refseq:NP_034269.2|dip:DIP-829N|ensembl:ENSMUSG00000006445(gene)|ensembl:ENSMUST00000006614(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014028"(notochord formation)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019838"(growth factor binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060035"(notochord cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0070160"(tight junction)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1904238"(pericyte cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034263|interpro:IPR036116|mint:Q03145|rcsb pdb:5ZRX|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|mint:MINT-3388323(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:SF3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/10	2014/10/16	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	rogid:PppTcjFTGU5TuCWNmeqK9NVjb5w10090	intact-crc:9F5BBF0EBB50E1E2|rigid:MpxoavhoGYtWRxzpt5Dxh4zQaCw	false	-	phosphorylated residue:595-595(MINT-3388327)|binding-associated region:590-602(MINT-3388329)|mutation disrupting interaction:595-595(MINT-3388324)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)