#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16157	uniprotkb:Q5VST9-3	intact:EBI-941686|intact:EBI-1153635|uniprotkb:A6NJ23|uniprotkb:E5RFL7|uniprotkb:O43400|uniprotkb:Q13768|uniprotkb:Q59FP2|uniprotkb:Q8N604|uniprotkb:Q99407|uniprotkb:A0PJN8|uniprotkb:Q53ER1|ensembl:ENSP00000339620	intact:EBI-941921|ensembl:ENSP00000284548	psi-mi:ank1_human(display_long)|uniprotkb:ANK1(gene name)|psi-mi:ANK1(display_short)|uniprotkb:ANK(gene name synonym)|uniprotkb:Erythrocyte ankyrin(gene name synonym)|uniprotkb:Ankyrin-R(gene name synonym)	psi-mi:q5vst9-3(display_long)|uniprotkb:unc-89-like(isoform synonym)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1556(gene name synonym)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Armani et al. (2006)	pubmed:16962094|imex:IM-19232	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1152657|imex:IM-19232-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000028.3|refseq:NP_001135918.1|refseq:NP_065208.2|refseq:NP_065209.2|refseq:NP_065210.2|refseq:NP_001135917.1|refseq:NP_065211.2|refseq:NP_065213.2|ensembl:ENSG00000029534(gene)|ensembl:ENST00000347528(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031430"(M band)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051117"(ATPase binding)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745|rcsb pdb:1N11|rcsb pdb:2YQF|rcsb pdb:2YVI|rcsb pdb:3F59|rcsb pdb:3KBT|rcsb pdb:3KBU|rcsb pdb:3UD1|rcsb pdb:3UD2|reactome:R-HSA-445095|reactome:R-HSA-447038|reactome:R-HSA-447041|reactome:R-HSA-447043|reactome:R-HSA-6807878	intact:EBI-941850(obscn_human)|ensembl:ENSG00000154358(gene)|ensembl:ENST00000284548(transcript)	-	-	isoform-comment:Lacks the kinase domain. Initially described as obscurin.	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/23	2014/10/16	rogid:hYRMfoQp3GyJ3f5OSQ6UVvCrQHc9606	rogid:XWbIV8Ok6iGGbPONRiWxnowk7yg9606	intact-crc:2AB5C676EC7883CC|rigid:ZfpnkNzr4U0rM7SMJhZonwRCicQ	false	sufficient binding region:22-131	sufficient binding region:6236-6353	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16157-17	uniprotkb:Q5VST9-3	intact:EBI-941819|ensembl:ENSP00000319123	intact:EBI-941921|ensembl:ENSP00000284548	psi-mi:p16157-17(display_long)|uniprotkb:ank1.5(isoform synonym)|uniprotkb:muscle-specific 1(isoform synonym)|uniprotkb:ANK1(gene name)|psi-mi:ANK1(display_short)|uniprotkb:ANK(gene name synonym)|uniprotkb:Ankyrin-R(gene name synonym)|uniprotkb:Erythrocyte ankyrin(gene name synonym)	psi-mi:q5vst9-3(display_long)|uniprotkb:unc-89-like(isoform synonym)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1556(gene name synonym)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Armani et al. (2006)	pubmed:16962094|imex:IM-19232	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1152678|imex:IM-19232-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-941686(ank1_human)|uniprotkb:P16157-17(isoform-parent)|ensembl:ENSG00000029534(gene)|ensembl:ENST00000314214(transcript)	intact:EBI-941850(obscn_human)|ensembl:ENSG00000154358(gene)|ensembl:ENST00000284548(transcript)	-	isoform-comment:"Produced by alternative promoter usage. Ref.4 (AAC01950) sequence is in conflict in position: 63:T->P."	isoform-comment:Lacks the kinase domain. Initially described as obscurin.	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/23	2014/10/16	rogid:adlvU+yjuP/12mvz1YnqDUKhTgc9606	rogid:XWbIV8Ok6iGGbPONRiWxnowk7yg9606	intact-crc:21E6C5AA11CB8C91|rigid:ysM3j53C/2bauCbLhDf3LMqhP/c	false	sufficient binding region:22-155	sufficient binding region:6236-6353	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16157	uniprotkb:Q5VST9-3	intact:EBI-941686|intact:EBI-1153635|uniprotkb:A6NJ23|uniprotkb:E5RFL7|uniprotkb:O43400|uniprotkb:Q13768|uniprotkb:Q59FP2|uniprotkb:Q8N604|uniprotkb:Q99407|uniprotkb:A0PJN8|uniprotkb:Q53ER1|ensembl:ENSP00000339620	intact:EBI-941921|ensembl:ENSP00000284548	psi-mi:ank1_human(display_long)|uniprotkb:ANK1(gene name)|psi-mi:ANK1(display_short)|uniprotkb:ANK(gene name synonym)|uniprotkb:Erythrocyte ankyrin(gene name synonym)|uniprotkb:Ankyrin-R(gene name synonym)	psi-mi:q5vst9-3(display_long)|uniprotkb:unc-89-like(isoform synonym)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1556(gene name synonym)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Armani et al. (2006)	pubmed:16962094|imex:IM-19232	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1152826|imex:IM-19232-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000028.3|refseq:NP_001135918.1|refseq:NP_065208.2|refseq:NP_065209.2|refseq:NP_065210.2|refseq:NP_001135917.1|refseq:NP_065211.2|refseq:NP_065213.2|ensembl:ENSG00000029534(gene)|ensembl:ENST00000347528(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031430"(M band)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051117"(ATPase binding)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745|rcsb pdb:1N11|rcsb pdb:2YQF|rcsb pdb:2YVI|rcsb pdb:3F59|rcsb pdb:3KBT|rcsb pdb:3KBU|rcsb pdb:3UD1|rcsb pdb:3UD2|reactome:R-HSA-445095|reactome:R-HSA-447038|reactome:R-HSA-447041|reactome:R-HSA-447043|reactome:R-HSA-6807878	intact:EBI-941850(obscn_human)|ensembl:ENSG00000154358(gene)|ensembl:ENST00000284548(transcript)	go:"GO:0030506"(ankyrin binding)	-	isoform-comment:Lacks the kinase domain. Initially described as obscurin.	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:hYRMfoQp3GyJ3f5OSQ6UVvCrQHc9606	rogid:XWbIV8Ok6iGGbPONRiWxnowk7yg9606	intact-crc:94FD9480F0936E46|rigid:ZfpnkNzr4U0rM7SMJhZonwRCicQ	false	sufficient binding region:22-131|glutathione s tranferase tag:?-?	sufficient binding region:6215-6353|35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16157-17	uniprotkb:Q5VST9-3	intact:EBI-941819|ensembl:ENSP00000319123	intact:EBI-941921|ensembl:ENSP00000284548	psi-mi:p16157-17(display_long)|uniprotkb:ank1.5(isoform synonym)|uniprotkb:muscle-specific 1(isoform synonym)|uniprotkb:ANK1(gene name)|psi-mi:ANK1(display_short)|uniprotkb:ANK(gene name synonym)|uniprotkb:Ankyrin-R(gene name synonym)|uniprotkb:Erythrocyte ankyrin(gene name synonym)	psi-mi:q5vst9-3(display_long)|uniprotkb:unc-89-like(isoform synonym)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1556(gene name synonym)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Armani et al. (2006)	pubmed:16962094|imex:IM-19232	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1152856|imex:IM-19232-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-941686(ank1_human)|uniprotkb:P16157-17(isoform-parent)|ensembl:ENSG00000029534(gene)|ensembl:ENST00000314214(transcript)	intact:EBI-941850(obscn_human)|ensembl:ENSG00000154358(gene)|ensembl:ENST00000284548(transcript)	go:"GO:0030506"(ankyrin binding)	isoform-comment:"Produced by alternative promoter usage. Ref.4 (AAC01950) sequence is in conflict in position: 63:T->P."	isoform-comment:Lacks the kinase domain. Initially described as obscurin.	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:adlvU+yjuP/12mvz1YnqDUKhTgc9606	rogid:XWbIV8Ok6iGGbPONRiWxnowk7yg9606	intact-crc:4056E9605196A0AC|rigid:ysM3j53C/2bauCbLhDf3LMqhP/c	false	sufficient binding region:22-155|glutathione s tranferase tag:?-?	sufficient binding region:6215-6353|35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16157-17	uniprotkb:Q5VST9-3	intact:EBI-941819|ensembl:ENSP00000319123	intact:EBI-941921|ensembl:ENSP00000284548	psi-mi:p16157-17(display_long)|uniprotkb:ank1.5(isoform synonym)|uniprotkb:muscle-specific 1(isoform synonym)|uniprotkb:ANK1(gene name)|psi-mi:ANK1(display_short)|uniprotkb:ANK(gene name synonym)|uniprotkb:Ankyrin-R(gene name synonym)|uniprotkb:Erythrocyte ankyrin(gene name synonym)	psi-mi:q5vst9-3(display_long)|uniprotkb:unc-89-like(isoform synonym)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1556(gene name synonym)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Armani et al. (2006)	pubmed:16962094|imex:IM-19232	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1152934|imex:IM-19232-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-941686(ank1_human)|uniprotkb:P16157-17(isoform-parent)|ensembl:ENSG00000029534(gene)|ensembl:ENST00000314214(transcript)	intact:EBI-941850(obscn_human)|ensembl:ENSG00000154358(gene)|ensembl:ENST00000284548(transcript)	go:"GO:0030506"(ankyrin binding)	isoform-comment:"Produced by alternative promoter usage. Ref.4 (AAC01950) sequence is in conflict in position: 63:T->P."	isoform-comment:Lacks the kinase domain. Initially described as obscurin.	figure legend:2, 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:adlvU+yjuP/12mvz1YnqDUKhTgc9606	rogid:XWbIV8Ok6iGGbPONRiWxnowk7yg9606	intact-crc:5E7009888763BB0C|rigid:ysM3j53C/2bauCbLhDf3LMqhP/c	false	sufficient binding region:22-155|glutathione s tranferase tag:?-?	35s radiolabel:?-?|sufficient binding region:6226-6260|sufficient binding region:6319-6353	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15273	uniprotkb:Q8WZ42	intact:EBI-954089|ensembl:ENSP00000312624|uniprotkb:Q96L27	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:telt_human(display_long)|uniprotkb:Titin cap protein(gene name synonym)|uniprotkb:TCAP(gene name)|psi-mi:TCAP(display_short)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0096"(pull down)	Armani et al. (2006)	pubmed:16962094|imex:IM-19232	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1153057|imex:IM-19232-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173991(gene)|ensembl:ENST00000309889(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005829"(cytosol)|go:"GO:0007512"(adult heart development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031432"(titin binding)|go:"GO:0031674"(I band)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036122"(BMP binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051373"(FATZ binding)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070080"(titin Z domain binding)|interpro:IPR015667(Telethonin)|interpro:IPR023111|mint:O15273|rcsb pdb:1YA5|rcsb pdb:2F8V|reactome:R-HSA-390522|refseq:NP_003664.1|dip:DIP-35730N	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:2Dfb7mWswRzoRh/YwYCWfzfTEu09606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:92CD23B7A3F7E05B|rigid:dNHVLXyVy6FzdaY6IqREqBfdWhQ	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:6..6-740..740(IPR007110)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16157	uniprotkb:Q5VST9-3	intact:EBI-941686|intact:EBI-1153635|uniprotkb:A6NJ23|uniprotkb:E5RFL7|uniprotkb:O43400|uniprotkb:Q13768|uniprotkb:Q59FP2|uniprotkb:Q8N604|uniprotkb:Q99407|uniprotkb:A0PJN8|uniprotkb:Q53ER1|ensembl:ENSP00000339620	intact:EBI-941921|ensembl:ENSP00000284548	psi-mi:ank1_human(display_long)|uniprotkb:ANK1(gene name)|psi-mi:ANK1(display_short)|uniprotkb:ANK(gene name synonym)|uniprotkb:Erythrocyte ankyrin(gene name synonym)|uniprotkb:Ankyrin-R(gene name synonym)	psi-mi:q5vst9-3(display_long)|uniprotkb:unc-89-like(isoform synonym)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1556(gene name synonym)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Armani et al. (2006)	pubmed:16962094|imex:IM-19232	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1152982|imex:IM-19232-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000028.3|refseq:NP_001135918.1|refseq:NP_065208.2|refseq:NP_065209.2|refseq:NP_065210.2|refseq:NP_001135917.1|refseq:NP_065211.2|refseq:NP_065213.2|ensembl:ENSG00000029534(gene)|ensembl:ENST00000347528(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031430"(M band)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051117"(ATPase binding)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR040745|rcsb pdb:1N11|rcsb pdb:2YQF|rcsb pdb:2YVI|rcsb pdb:3F59|rcsb pdb:3KBT|rcsb pdb:3KBU|rcsb pdb:3UD1|rcsb pdb:3UD2|reactome:R-HSA-445095|reactome:R-HSA-447038|reactome:R-HSA-447041|reactome:R-HSA-447043|reactome:R-HSA-6807878	intact:EBI-941850(obscn_human)|ensembl:ENSG00000154358(gene)|ensembl:ENST00000284548(transcript)	go:"GO:0001725"(stress fiber)	-	isoform-comment:Lacks the kinase domain. Initially described as obscurin.	figure legend:4K, L, M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2006/10/23	2014/10/16	rogid:hYRMfoQp3GyJ3f5OSQ6UVvCrQHc9606	rogid:XWbIV8Ok6iGGbPONRiWxnowk7yg9606	intact-crc:39AB8F7628633FED|rigid:ZfpnkNzr4U0rM7SMJhZonwRCicQ	false	myc tag:?-?	sufficient binding region:6041-6620|green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P16157-17	uniprotkb:Q5VST9-3	intact:EBI-941819|ensembl:ENSP00000319123	intact:EBI-941921|ensembl:ENSP00000284548	psi-mi:p16157-17(display_long)|uniprotkb:ank1.5(isoform synonym)|uniprotkb:muscle-specific 1(isoform synonym)|uniprotkb:ANK1(gene name)|psi-mi:ANK1(display_short)|uniprotkb:ANK(gene name synonym)|uniprotkb:Ankyrin-R(gene name synonym)|uniprotkb:Erythrocyte ankyrin(gene name synonym)	psi-mi:q5vst9-3(display_long)|uniprotkb:unc-89-like(isoform synonym)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1556(gene name synonym)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Armani et al. (2006)	pubmed:16962094|imex:IM-19232	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1153001|imex:IM-19232-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-941686(ank1_human)|uniprotkb:P16157-17(isoform-parent)|ensembl:ENSG00000029534(gene)|ensembl:ENST00000314214(transcript)	intact:EBI-941850(obscn_human)|ensembl:ENSG00000154358(gene)|ensembl:ENST00000284548(transcript)	go:"GO:0001725"(stress fiber)	isoform-comment:"Produced by alternative promoter usage. Ref.4 (AAC01950) sequence is in conflict in position: 63:T->P."	isoform-comment:Lacks the kinase domain. Initially described as obscurin.	figure legend:4E, F, G, 6O, R|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2006/10/23	2014/10/16	rogid:adlvU+yjuP/12mvz1YnqDUKhTgc9606	rogid:XWbIV8Ok6iGGbPONRiWxnowk7yg9606	intact-crc:0399AA8F83020BE1|rigid:ysM3j53C/2bauCbLhDf3LMqhP/c	false	myc tag:?-?	sufficient binding region:6226-6265|green fluorescent protein tag:n-n|sufficient binding region:6319-6358	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)