#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9WUA5	uniprotkb:Q9WV60	intact:EBI-1040928|uniprotkb:Q8BY80|ensembl:ENSMUSP00000066050|uniprotkb:G5E8E2	intact:EBI-400793|ensembl:ENSMUSP00000023507	psi-mi:epm2a_mouse(display_long)|uniprotkb:Epm2a(gene name)|psi-mi:Epm2a(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:gsk3b_mouse(display_long)|uniprotkb:Gsk3b(gene name)|psi-mi:Gsk3b(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2006)	imex:IM-12037|pubmed:16959610	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1040938|imex:IM-12037-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000055493(gene)|ensembl:ENSMUST00000069106(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006914"(autophagy)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044260"(cellular macromolecule metabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|go:"GO:0007399"(nervous system development)|refseq:NP_034276.2	refseq:NP_062801.1|dip:DIP-32446N|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006983"(ER overload response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034452"(dynactin binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:Q9WV60|rcsb pdb:4NU1|rcsb pdb:5AIR|rcsb pdb:6AE3|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3371453|reactome:R-MMU-399956|reactome:R-MMU-4641262|reactome:R-MMU-5250924|reactome:R-MMU-5610785|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046849"(bone remodeling)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0106027"(neuron projection organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|ensembl:ENSMUSG00000022812(gene)|ensembl:ENSMUST00000023507(transcript)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)	psi-mi:"MI:0469"(intact)	-	-	figure legend:7 E, S3|comment:"The mutation in laforin (cys265ser) did not affect binding, indicating the association does not require laforin phosphatase activity."|comment:The association was not affected by PDGF.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2006/09/20	2014/10/16	rogid:lpytge02SPNx88wHsa5gT28gOiM10090	rogid:FKe0WkOBBYU0vIJLmcFNMJ+KVHA10090	intact-crc:9AB7FA17DB0C9F01|rigid:HrYDDIvPJE+8nsCdbW+i6IR5TwI	false	v5 tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9WUA5	uniprotkb:Q9WV60	intact:EBI-1040928|uniprotkb:Q8BY80|ensembl:ENSMUSP00000066050|uniprotkb:G5E8E2	intact:EBI-400793|ensembl:ENSMUSP00000023507	psi-mi:epm2a_mouse(display_long)|uniprotkb:Epm2a(gene name)|psi-mi:Epm2a(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:gsk3b_mouse(display_long)|uniprotkb:Gsk3b(gene name)|psi-mi:Gsk3b(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2006)	imex:IM-12037|pubmed:16959610	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1040953|imex:IM-12037-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000055493(gene)|ensembl:ENSMUST00000069106(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006914"(autophagy)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044260"(cellular macromolecule metabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|go:"GO:0007399"(nervous system development)|refseq:NP_034276.2	refseq:NP_062801.1|dip:DIP-32446N|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006983"(ER overload response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034452"(dynactin binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:Q9WV60|rcsb pdb:4NU1|rcsb pdb:5AIR|rcsb pdb:6AE3|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3371453|reactome:R-MMU-399956|reactome:R-MMU-4641262|reactome:R-MMU-5250924|reactome:R-MMU-5610785|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046849"(bone remodeling)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0106027"(neuron projection organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|ensembl:ENSMUSG00000022812(gene)|ensembl:ENSMUST00000023507(transcript)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)	psi-mi:"MI:0469"(intact)	-	-	figure legend:7 E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2006/09/20	2014/10/16	rogid:lpytge02SPNx88wHsa5gT28gOiM10090	rogid:FKe0WkOBBYU0vIJLmcFNMJ+KVHA10090	intact-crc:E3C6AD8DE17081F4|rigid:HrYDDIvPJE+8nsCdbW+i6IR5TwI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-1040992	uniprotkb:Q9WUA5	-	intact:EBI-1040928|uniprotkb:Q8BY80|ensembl:ENSMUSP00000066050|uniprotkb:G5E8E2	psi-mi:gsk3b-hu-bsa_protein(display_short)|psi-mi:EBI-1040992(display_long)	psi-mi:epm2a_mouse(display_long)|uniprotkb:Epm2a(gene name)|psi-mi:Epm2a(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Wang et al. (2006)	imex:IM-12037|pubmed:16959610	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1040998|imex:IM-12037-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	uniprotkb:P49841(multiple parent)|uniprotkb:P02769(multiple parent)	ensembl:ENSMUSG00000055493(gene)|ensembl:ENSMUST00000069106(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006914"(autophagy)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0044260"(cellular macromolecule metabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|go:"GO:0007399"(nervous system development)|refseq:NP_034276.2	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"Residue 15 (serine) is phosphorylated."|comment:"The protein reference given by the authors for the human GSK-3beta (NP_002084) has an insertion of 13 residues between residues 303 and 304 of the Uniprotkb sequence (P49841)."	-	figure legend:7 F|resulting-ptm:"The peptide representing human GSK-3beta (with modifications) fused to BSA, is dephosphorylated on ser15. The authors state that this residue corresponds to GSK-3beta Ser9."|antibodies:This dephosphorylation was detected using antibodies specific for phosphorylated GSK-3beta Ser9.|comment:The laforin did not dephosphorylate Bad.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:qxn44CSnrVKkt2+1XLv3KSvXjs49606	rogid:lpytge02SPNx88wHsa5gT28gOiM10090	intact-crc:A7569EE923257FCE|rigid:Kc/w1wJmATgFI3QStPGXGeKA9xQ	false	O-phospho-L-serine:?-?	v5 tag:?-?|mutation disrupting interaction:265-265	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)