#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P55097 uniprotkb:Q8BLE7 intact:EBI-6954854|ensembl:ENSMUSP00000015664|intact:MINT-3089515|uniprotkb:O88718 intact:EBI-6954826|intact:MINT-3089499|uniprotkb:Q920B7 psi-mi:catk_mouse(display_long)|uniprotkb:Ctsk(gene name)|psi-mi:Ctsk(display_short) psi-mi:vglu2_mouse(display_long)|uniprotkb:Slc17a6(gene name)|psi-mi:Slc17a6(display_short)|uniprotkb:Vglut2(gene name synonym)|uniprotkb:Dnpi(gene name synonym)|uniprotkb:Solute carrier family 17 member 6(gene name synonym)|uniprotkb:"Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter"(gene name synonym)|uniprotkb:Differentiation-associated BNPI(gene name synonym) psi-mi:"MI:0428"(imaging technique) Morimoto et al. (2006) pubmed:16957773|imex:IM-11185|mint:MINT-5219042 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-6954819|mint:MINT-3089534|imex:IM-11185-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006501037.1|ensembl:ENSMUSG00000028111(gene)|ensembl:ENSMUST00000015664(transcript)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006955"(immune response)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045453"(bone resorption)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0061037"(negative regulation of cartilage development)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR015644(Peptidase C1A, cathepsin K)|interpro:IPR025660|interpro:IPR038765|interpro:IPR039417|mint:P55097|rcsb pdb:5T6U|rcsb pdb:6BKI|reactome:R-MMU-1442490|reactome:R-MMU-1474228|reactome:R-MMU-1592389|reactome:R-MMU-1679131|reactome:R-MMU-2132295|reactome:R-MMU-8939242|go:"GO:0005737"(cytoplasm)|refseq:NP_031828.2|mint:MINT-3089536(identity) go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015293"(symporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0060076"(excitatory synapse)|go:"GO:0098700"(neurotransmitter loading into synaptic vesicle)|go:"GO:0098793"(presynapse)|go:"GO:1990030"(pericellular basket)|go:"GO:1990384"(hyaloid vascular plexus regression)|reactome:R-MMU-428643|interpro:IPR011701(Major facilitator superfamily MFS-1)|refseq:NP_543129.3|interpro:IPR020846|mint:Q8BLE7|interpro:IPR036259|mint:MINT-3089535(identity) - comment:mint|function:Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation|comment:"Stoichiometry: 1.0" comment:mint|function:Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate|comment:"Stoichiometry: 1.0" figure legend:F2D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-osteoclast)|taxid:10090(Mouse osteoclast) - 2006/09/22 2014/10/16 rogid:EU30E7xNbPn4/qX2pPFd236MrVg10090 rogid:JdWDIXzjrtUwBVMYmbFPELTtVj810090 intact-crc:4E90E7DCCD6278A1|rigid:TeEE3INEQEeuZAxLdsKCPjebPuk false - - 1 1 psi-mi:"MI:0661"(experimental participant identification) psi-mi:"MI:0661"(experimental participant identification) uniprotkb:Q8BLE7 uniprotkb:P68369 intact:EBI-6954826|intact:MINT-3089499|uniprotkb:Q920B7 intact:EBI-400542|uniprotkb:P02551|uniprotkb:P05210|uniprotkb:P05212|uniprotkb:Q3TGF0|uniprotkb:Q3TIW2|uniprotkb:Q3TPJ1|uniprotkb:Q3ULN1|uniprotkb:Q5XJF8|ensembl:ENSMUSP00000094778 psi-mi:vglu2_mouse(display_long)|uniprotkb:Slc17a6(gene name)|psi-mi:Slc17a6(display_short)|uniprotkb:Vglut2(gene name synonym)|uniprotkb:Dnpi(gene name synonym)|uniprotkb:Solute carrier family 17 member 6(gene name synonym)|uniprotkb:"Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter"(gene name synonym)|uniprotkb:Differentiation-associated BNPI(gene name synonym) psi-mi:tba1a_mouse(display_long)|uniprotkb:Tuba1a(gene name)|psi-mi:Tuba1a(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-1(gene name synonym)|uniprotkb:Tuba1(gene name synonym) psi-mi:"MI:0428"(imaging technique) Morimoto et al. (2006) pubmed:16957773|imex:IM-11185|mint:MINT-5219042 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-6954883|mint:MINT-3288776|imex:IM-11185-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015293"(symporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0060076"(excitatory synapse)|go:"GO:0098700"(neurotransmitter loading into synaptic vesicle)|go:"GO:0098793"(presynapse)|go:"GO:1990030"(pericellular basket)|go:"GO:1990384"(hyaloid vascular plexus regression)|reactome:R-MMU-428643|interpro:IPR011701(Major facilitator superfamily MFS-1)|refseq:NP_543129.3|interpro:IPR020846|mint:Q8BLE7|interpro:IPR036259|mint:MINT-3288782(identity) refseq:NP_035783.1|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|ensembl:ENSMUSG00000072235(gene)|ensembl:ENSMUST00000097014(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0055037"(recycling endosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68369|rcsb pdb:6JZD|reactome:R-MMU-190840|reactome:R-MMU-2132295|mint:MINT-3288777(identity) - comment:mint|function:Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2D|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-osteoclast)|taxid:10090(Mouse osteoclast) - 2006/09/22 2014/10/16 rogid:JdWDIXzjrtUwBVMYmbFPELTtVj810090 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY10090 intact-crc:AC79DCD9F32DA297|rigid:IFou+wKvSrZERTe45rf+UrL6cGU false - - 1 1 psi-mi:"MI:0661"(experimental participant identification) psi-mi:"MI:0661"(experimental participant identification)