#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62746	uniprotkb:Q60875	intact:EBI-8329471|intact:MINT-2982781|uniprotkb:Q9CUV7|uniprotkb:P01121|ensembl:ENSMUSP00000067013	intact:EBI-772191|uniprotkb:E9QNW9|uniprotkb:O09115|uniprotkb:Q3TBI4|uniprotkb:Q3TJ16|uniprotkb:Q8CHE1|uniprotkb:Q923E0|uniprotkb:Q9ESG7|ensembl:ENSMUSP00000029694	psi-mi:rhob_mouse(display_long)|uniprotkb:Rhob(gene name)|psi-mi:Rhob(display_short)|uniprotkb:Arhb(gene name synonym)	psi-mi:arhg2_mouse(display_long)|uniprotkb:Kiaa0651(gene name synonym)|uniprotkb:Lbcl1(gene name synonym)|uniprotkb:Lfc(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 1(gene name synonym)|uniprotkb:LBC'S first cousin(gene name synonym)|uniprotkb:Oncogene LFC(gene name synonym)|uniprotkb:Rhobin(gene name synonym)|uniprotkb:Arhgef2(gene name)|psi-mi:Arhgef2(display_short)	psi-mi:"MI:0428"(imaging technique)	Kamon et al. (2006)	mint:MINT-5218962|pubmed:16917499|imex:IM-11031	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8615132|mint:MINT-2982833|imex:IM-11031-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031509.1|ensembl:ENSMUSG00000054364(gene)|ensembl:ENSMUST00000067384(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010008"(endosome membrane)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62746|reactome:R-MMU-114604|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5627117|reactome:R-MMU-5663220|reactome:R-MMU-9013026|mint:MINT-2982834(identity)	refseq:NP_001185840.1|refseq:NP_001185841.1|refseq:NP_001185842.1|refseq:NP_032513.3|refseq:XP_006501130.1|ensembl:ENSMUSG00000028059(gene)|ensembl:ENSMUST00000029694(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002102"(podosome)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071802"(negative regulation of podosome assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q60875|rcsb pdb:5WI4|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|mint:MINT-2982835(identity)	-	comment:mint|function:Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmdc)|taxid:10090(Mus musculus bone marrow-derived dendritic cells)	-	2006/09/18	2014/10/16	rogid:Ek7MCYtpm3JJ78E6nwU/Q9rWZmQ10090	rogid:Le4PMm1AT/ManVpetNT2wBsUlok10090	intact-crc:DC11FB3724BADE36|rigid:ap0wJ43JxtnbIT1uoPd4NwwLnU4	false	-	-	1	1	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)