#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61743	uniprotkb:O94973	intact:EBI-8603527|ensembl:ENSMUSP00000147439|intact:MINT-2982880|uniprotkb:Q9QX21	intact:EBI-1642835|uniprotkb:O75403|uniprotkb:Q96SI8|uniprotkb:Q53ET1|ensembl:ENSP00000413234	psi-mi:kcj11_mouse(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:ap2a2_human(display_long)|uniprotkb:AP2A2(gene name)|psi-mi:AP2A2(display_short)|uniprotkb:ADTAB(gene name synonym)|uniprotkb:CLAPA2(gene name synonym)|uniprotkb:HYPJ(gene name synonym)|uniprotkb:KIAA0899(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Huntingtin-interacting protein J(gene name synonym)|uniprotkb:Huntingtin yeast partner J(gene name synonym)|uniprotkb:HIP9(gene name synonym)|uniprotkb:Huntingtin-interacting protein 9(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mankouri et al. (2006)	pubmed:16902404|imex:IM-13967|mint:MINT-5218935	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8603519|mint:MINT-2982906|imex:IM-13967-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000096146(gene)|ensembl:ENSMUST00000211674(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q61743|rcsb pdb:5WUA|rcsb pdb:5YKE|rcsb pdb:5YKF|rcsb pdb:5YKG|rcsb pdb:5YW8|rcsb pdb:5YW9|rcsb pdb:5YWA|rcsb pdb:5YWB|rcsb pdb:5YWC|rcsb pdb:6JB1|reactome:R-MMU-1296025|reactome:R-MMU-382556|reactome:R-MMU-422356|reactome:R-MMU-5578775|refseq:NP_034732.1|dip:DIP-42790N|mint:MINT-2982907(identity)	refseq:NP_001229766.1|refseq:NP_036437.1|ensembl:ENST00000448903(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O94973|reactome:R-HSA-167590|ensembl:ENSG00000183020(gene)|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-6798695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|mint:MINT-2982908(identity)	-	comment:mint|function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/18	2014/10/16	rogid:YH8BUXfxLJ46b4AxxBmt1RmrNtM10090	rogid:sda1msOBssgmBiU3ZfSyk3z7/jc9606	intact-crc:C012B794518C0DF6|rigid:OR2/UpxiPTjMKRws1ZZ5gCHBXCc	false	binding-associated region:178-364(MINT-2982919)|glutathione s tranferase tag:?-?(MINT-2982913)	binding-associated region:123-435(MINT-2982926)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61743	uniprotkb:O94973	intact:EBI-8603527|ensembl:ENSMUSP00000147439|intact:MINT-2982880|uniprotkb:Q9QX21	intact:EBI-1642835|uniprotkb:O75403|uniprotkb:Q96SI8|uniprotkb:Q53ET1|ensembl:ENSP00000413234	psi-mi:kcj11_mouse(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:ap2a2_human(display_long)|uniprotkb:AP2A2(gene name)|psi-mi:AP2A2(display_short)|uniprotkb:ADTAB(gene name synonym)|uniprotkb:CLAPA2(gene name synonym)|uniprotkb:HYPJ(gene name synonym)|uniprotkb:KIAA0899(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Huntingtin-interacting protein J(gene name synonym)|uniprotkb:Huntingtin yeast partner J(gene name synonym)|uniprotkb:HIP9(gene name synonym)|uniprotkb:Huntingtin-interacting protein 9(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mankouri et al. (2006)	pubmed:16902404|imex:IM-13967|mint:MINT-5218935	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8603578|mint:MINT-2982929|imex:IM-13967-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000096146(gene)|ensembl:ENSMUST00000211674(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q61743|rcsb pdb:5WUA|rcsb pdb:5YKE|rcsb pdb:5YKF|rcsb pdb:5YKG|rcsb pdb:5YW8|rcsb pdb:5YW9|rcsb pdb:5YWA|rcsb pdb:5YWB|rcsb pdb:5YWC|rcsb pdb:6JB1|reactome:R-MMU-1296025|reactome:R-MMU-382556|reactome:R-MMU-422356|reactome:R-MMU-5578775|refseq:NP_034732.1|dip:DIP-42790N|mint:MINT-2982930(identity)	refseq:NP_001229766.1|refseq:NP_036437.1|ensembl:ENST00000448903(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O94973|reactome:R-HSA-167590|ensembl:ENSG00000183020(gene)|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-6798695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|mint:MINT-2982939(identity)	-	comment:mint|function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/18	2014/10/16	rogid:YH8BUXfxLJ46b4AxxBmt1RmrNtM10090	rogid:sda1msOBssgmBiU3ZfSyk3z7/jc9606	intact-crc:8C4475F722757B57|rigid:OR2/UpxiPTjMKRws1ZZ5gCHBXCc	false	ha tag:?-?(MINT-2982931)	glutathione s tranferase tag:?-?(MINT-2982952)	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)