#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q86PE7	uniprotkb:Q24306	intact:EBI-987197	intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795	psi-mi:q86pe7_drome(display_long)|uniprotkb:IKKepsilon(gene name)|psi-mi:IKKepsilon(display_short)|uniprotkb:ik2(gene name synonym)|uniprotkb:CG2615(orf name)	psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kuranaga et al. (2006)	imex:IM-12036|pubmed:16887178	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-987225|imex:IM-12036-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000902"(cell morphogenesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007015"(actin filament organization)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0008219"(cell death)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035160"(maintenance of epithelial integrity, open tracheal system)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0051286"(cell tip)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061572"(actin filament bundle organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|interpro:IPR041087|interpro:IPR041309|flybase:FBgn0086657	refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751	psi-mi:"MI:0469"(intact)	-	-	comment:When the S2 cells were treated with DmIKK epsilon dsRNA endogenous DIAP1 was not immunoprecipitated by anti DmIKK antibodies. Deletion of the ubl motif results in a decreased interaction.|figure legend:3C|caution:The interaction was not detected by GST pull down as stated by authors.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2006/08/14	2014/10/16	rogid:ghvEPXi10QkqZzEgjXLxjvATI2g7227	rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227	intact-crc:2F69F93992765B48|rigid:Vo3pmbYY4RRW+vLbcbqP4+6QcLw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24306	uniprotkb:Q86PE7	intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795	intact:EBI-987197	psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym)	psi-mi:q86pe7_drome(display_long)|uniprotkb:IKKepsilon(gene name)|psi-mi:IKKepsilon(display_short)|uniprotkb:ik2(gene name synonym)|uniprotkb:CG2615(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuranaga et al. (2006)	imex:IM-12036|pubmed:16887178	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988077|imex:IM-12036-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751	go:"GO:0000902"(cell morphogenesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007015"(actin filament organization)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0008219"(cell death)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035160"(maintenance of epithelial integrity, open tracheal system)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0051286"(cell tip)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061572"(actin filament bundle organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|interpro:IPR041087|interpro:IPR041309|flybase:FBgn0086657	psi-mi:"MI:0469"(intact)	-	-	figure legend:3E|caution:The interaction was not detected by GST pull down as stated by authors.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2006/08/14	2014/10/16	rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227	rogid:ghvEPXi10QkqZzEgjXLxjvATI2g7227	intact-crc:5657F1A22F2B9D51|rigid:Vo3pmbYY4RRW+vLbcbqP4+6QcLw	false	flag tag:?-?	necessary binding region:313..313-378..378|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24306	uniprotkb:Q86PE7	intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795	intact:EBI-987197	psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym)	psi-mi:q86pe7_drome(display_long)|uniprotkb:IKKepsilon(gene name)|psi-mi:IKKepsilon(display_short)|uniprotkb:ik2(gene name synonym)|uniprotkb:CG2615(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Kuranaga et al. (2006)	imex:IM-12036|pubmed:16887178	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988161|imex:IM-12036-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751	go:"GO:0000902"(cell morphogenesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007015"(actin filament organization)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0008219"(cell death)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035160"(maintenance of epithelial integrity, open tracheal system)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0051286"(cell tip)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061572"(actin filament bundle organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|interpro:IPR041087|interpro:IPR041309|flybase:FBgn0086657	go:"GO:0016310"(phosphorylation)	-	-	figure legend:3F|resulting-ptm:"DIAP1 (th) was found to be phosphorylated. Radioactive p32 was used to indicate phsphorylation."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/14	2014/10/16	rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227	rogid:ghvEPXi10QkqZzEgjXLxjvATI2g7227	intact-crc:28CFB6BB2B666B3B|rigid:Vo3pmbYY4RRW+vLbcbqP4+6QcLw	false	his tag:?-?	flag tag:?-?|mutation decreasing interaction:19-19|mutation decreasing interaction:160-160|mutation decreasing interaction:250-250|necessary binding region:313-378	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86PE7	-	intact:EBI-987197	-	psi-mi:q86pe7_drome(display_long)|uniprotkb:IKKepsilon(gene name)|psi-mi:IKKepsilon(display_short)|uniprotkb:ik2(gene name synonym)|uniprotkb:CG2615(orf name)	-	psi-mi:"MI:0424"(protein kinase assay)	Kuranaga et al. (2006)	imex:IM-12036|pubmed:16887178	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988177|imex:IM-12036-5	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	go:"GO:0000902"(cell morphogenesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007015"(actin filament organization)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0008219"(cell death)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035160"(maintenance of epithelial integrity, open tracheal system)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0051286"(cell tip)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061572"(actin filament bundle organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|interpro:IPR041087|interpro:IPR041309|flybase:FBgn0086657	-	go:"GO:0016310"(phosphorylation)	-	-	figure legend:3F|resulting-ptm:IKK epsilon was found to be auto-phosphorylated. Radioactive p32 was used to indicate phsphorylation.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/14	2014/10/16	rogid:ghvEPXi10QkqZzEgjXLxjvATI2g7227	-	intact-crc:5A484A97450F6C1E	false	flag tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-
uniprotkb:Q9UHD2	-	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	-	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Kuranaga et al. (2006)	imex:IM-12036|pubmed:16887178	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988192|imex:IM-12036-6	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	-	go:"GO:0016310"(phosphorylation)	-	-	figure legend:4D|resulting-ptm:The self phosphorylation was studied using radioactive P32|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/14	2014/10/16	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	-	intact-crc:31D1A7B4CDF72556	false	flag tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-
uniprotkb:P98170	uniprotkb:Q9UHD2	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Kuranaga et al. (2006)	imex:IM-12036|pubmed:16887178	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988198|imex:IM-12036-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	go:"GO:0016310"(phosphorylation)	-	-	figure legend:4D|resulting-ptm:The BIRC4 or XIAP was phosphorylated as indicated by radioactive P32.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/14	2014/10/16	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	intact-crc:842D9C8557AFA853|rigid:VnBr/uOaZ5D7XPhMd0Aaa4adewA	false	-	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)