#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-983681	uniprotkb:O15409	-	intact:EBI-983612|uniprotkb:A0AUV6|uniprotkb:A4D0U8|uniprotkb:Q6ZND1|uniprotkb:Q75MJ3|uniprotkb:Q8IZE0|uniprotkb:Q8N0W2|uniprotkb:Q8N6B7|uniprotkb:Q8N6B8|uniprotkb:Q8NFQ1|uniprotkb:Q8NFQ2|uniprotkb:Q8NFQ3|uniprotkb:Q8NFQ4|uniprotkb:Q8TD74|ensembl:ENSP00000265436|ensembl:ENSP00000377132|uniprotkb:A6NNW4|uniprotkb:B4DLD9	psi-mi:arre2_element_mouse_il2_promoter(display_short)|psi-mi:EBI-983681(display_long)	psi-mi:foxp2_human(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983671|rcsb pdb:2AS5|imex:IM-19878-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027720(see-also)	ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0098582"(innate vocalization behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:O15409|rcsb pdb:2A07|rcsb pdb:2AS5|go:"GO:0046872"(metal ion binding)|refseq:NP_001166237.1|refseq:NP_001166238.1|refseq:NP_055306.1|refseq:NP_683696.2|refseq:NP_683697.2|refseq:NP_683698.2|dip:DIP-29004N|refseq:XP_016868290.1	-	-	-	figure legend:table S1|3d-resolution:30.0-2.70 A|3d-r-factors:24.5% - 28.6%|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2015/08/13	crc64:21E6FBC49C3BECCA	rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606	intact-crc:C17F9E5A394F0C89	false	sufficient binding region:7-21	sufficient binding region:502-584(IPR001766)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-983681	uniprotkb:Q13469	-	intact:EBI-716258|uniprotkb:B5B2N9|uniprotkb:Q13468|uniprotkb:Q5TFW7|uniprotkb:Q5TFW8|uniprotkb:Q9NPX6|uniprotkb:Q9NQH3|uniprotkb:Q9UJR2|uniprotkb:B5B2P0|uniprotkb:B5B2N8|ensembl:ENSP00000379330|uniprotkb:B5B2P2|uniprotkb:B5B2P3	psi-mi:arre2_element_mouse_il2_promoter(display_short)|psi-mi:EBI-983681(display_long)	psi-mi:nfac2_human(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:NFATC2(gene name)|psi-mi:NFATC2(display_short)|uniprotkb:NFAT1(gene name synonym)|uniprotkb:NFATP(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983671|rcsb pdb:2AS5|imex:IM-19878-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027720(see-also)	refseq:NP_001245221.1|refseq:NP_036472.2|refseq:NP_775114.1|refseq:NP_001245223.1|refseq:NP_001245225.1|refseq:NP_001129493.1|ensembl:ENSG00000101096(gene)|ensembl:ENST00000396009(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042493"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR037059|rcsb pdb:1A02|rcsb pdb:1OWR|rcsb pdb:1P7H|go:"GO:1990904"(ribonucleoprotein complex)|rcsb pdb:1PZU|rcsb pdb:1S9K|rcsb pdb:2AS5|rcsb pdb:2O93|interpro:IPR002909(Cell surface receptor IPT/TIG)|rcsb pdb:3QRF|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-5607763|reactome:R-HSA-8877330|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|dip:DIP-27630N	-	-	-	figure legend:table S1|3d-resolution:30.0-2.70 A|3d-r-factors:24.5% - 28.6%|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2015/08/13	crc64:21E6FBC49C3BECCA	rogid:SNvCfCooUb7MH1xO0prmM4jv+o49606	intact-crc:C17F9E5A394F0C89	false	sufficient binding region:7-21	sufficient binding region:392-678(IPR011539)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-983681	uniprotkb:Q9BZS1	-	intact:EBI-983719|uniprotkb:O60827|uniprotkb:Q14DD8|intact:EBI-28970697|ensembl:ENSP00000365380|uniprotkb:Q4ZH51|uniprotkb:A5HJT1|uniprotkb:B7ZLG0|uniprotkb:B9UN80	psi-mi:arre2_element_mouse_il2_promoter(display_short)|psi-mi:EBI-983681(display_long)	psi-mi:foxp3_human(display_long)|uniprotkb:Scurfin(gene name synonym)|uniprotkb:FOXP3(gene name)|psi-mi:FOXP3(display_short)|uniprotkb:IPEX(gene name synonym)|uniprotkb:JM2(orf name)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983697|imex:IM-19878-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027720(see-also)	ensembl:ENST00000376199|ensembl:ENSP00000365372|ensembl:ENSP00000365380|ensembl:ENST00000518685|ensembl:ENSP00000428952|ensembl:ENST00000557224|ensembl:ENSP00000451208|ensembl:ENSG00000049768(gene)|ensembl:ENST00000376207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QRF|rcsb pdb:4WK8|reactome:R-HSA-8877330|reactome:R-HSA-8939256|dip:DIP-36584N|refseq:NP_001107849.1|refseq:NP_054728.2	-	-	-	figure legend:1C|comment:Cooperative binding observed.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2015/08/13	crc64:21E6FBC49C3BECCA	rogid:ZDAplrVbraZ3/8zn8GPK/CPkGnA9606	intact-crc:4A812E207ABB5E5E	false	-	sufficient binding region:335-419(IPR001766)|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-983681	uniprotkb:Q13469	-	intact:EBI-716258|uniprotkb:B5B2N9|uniprotkb:Q13468|uniprotkb:Q5TFW7|uniprotkb:Q5TFW8|uniprotkb:Q9NPX6|uniprotkb:Q9NQH3|uniprotkb:Q9UJR2|uniprotkb:B5B2P0|uniprotkb:B5B2N8|ensembl:ENSP00000379330|uniprotkb:B5B2P2|uniprotkb:B5B2P3	psi-mi:arre2_element_mouse_il2_promoter(display_short)|psi-mi:EBI-983681(display_long)	psi-mi:nfac2_human(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:NFATC2(gene name)|psi-mi:NFATC2(display_short)|uniprotkb:NFAT1(gene name synonym)|uniprotkb:NFATP(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983697|imex:IM-19878-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027720(see-also)	refseq:NP_001245221.1|refseq:NP_036472.2|refseq:NP_775114.1|refseq:NP_001245223.1|refseq:NP_001245225.1|refseq:NP_001129493.1|ensembl:ENSG00000101096(gene)|ensembl:ENST00000396009(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042493"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR037059|rcsb pdb:1A02|rcsb pdb:1OWR|rcsb pdb:1P7H|go:"GO:1990904"(ribonucleoprotein complex)|rcsb pdb:1PZU|rcsb pdb:1S9K|rcsb pdb:2AS5|rcsb pdb:2O93|interpro:IPR002909(Cell surface receptor IPT/TIG)|rcsb pdb:3QRF|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-5607763|reactome:R-HSA-8877330|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|dip:DIP-27630N	-	-	-	figure legend:1C|comment:Cooperative binding observed.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2015/08/13	crc64:21E6FBC49C3BECCA	rogid:SNvCfCooUb7MH1xO0prmM4jv+o49606	intact-crc:4A812E207ABB5E5E	false	-	sufficient binding region:392-678|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-983681	uniprotkb:O15409	-	intact:EBI-983612|uniprotkb:A0AUV6|uniprotkb:A4D0U8|uniprotkb:Q6ZND1|uniprotkb:Q75MJ3|uniprotkb:Q8IZE0|uniprotkb:Q8N0W2|uniprotkb:Q8N6B7|uniprotkb:Q8N6B8|uniprotkb:Q8NFQ1|uniprotkb:Q8NFQ2|uniprotkb:Q8NFQ3|uniprotkb:Q8NFQ4|uniprotkb:Q8TD74|ensembl:ENSP00000265436|ensembl:ENSP00000377132|uniprotkb:A6NNW4|uniprotkb:B4DLD9	psi-mi:arre2_element_mouse_il2_promoter(display_short)|psi-mi:EBI-983681(display_long)	psi-mi:foxp2_human(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983778|imex:IM-19878-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027720(see-also)	ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0098582"(innate vocalization behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:O15409|rcsb pdb:2A07|rcsb pdb:2AS5|go:"GO:0046872"(metal ion binding)|refseq:NP_001166237.1|refseq:NP_001166238.1|refseq:NP_055306.1|refseq:NP_683696.2|refseq:NP_683697.2|refseq:NP_683698.2|dip:DIP-29004N|refseq:XP_016868290.1	-	-	-	figure legend:S1E|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2015/08/13	crc64:21E6FBC49C3BECCA	rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606	intact-crc:A98FE41B70A9D090	false	-	sufficient binding region:502-584	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-983681	uniprotkb:Q13469	-	intact:EBI-716258|uniprotkb:B5B2N9|uniprotkb:Q13468|uniprotkb:Q5TFW7|uniprotkb:Q5TFW8|uniprotkb:Q9NPX6|uniprotkb:Q9NQH3|uniprotkb:Q9UJR2|uniprotkb:B5B2P0|uniprotkb:B5B2N8|ensembl:ENSP00000379330|uniprotkb:B5B2P2|uniprotkb:B5B2P3	psi-mi:arre2_element_mouse_il2_promoter(display_short)|psi-mi:EBI-983681(display_long)	psi-mi:nfac2_human(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:NFATC2(gene name)|psi-mi:NFATC2(display_short)|uniprotkb:NFAT1(gene name synonym)|uniprotkb:NFATP(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983778|imex:IM-19878-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027720(see-also)	refseq:NP_001245221.1|refseq:NP_036472.2|refseq:NP_775114.1|refseq:NP_001245223.1|refseq:NP_001245225.1|refseq:NP_001129493.1|ensembl:ENSG00000101096(gene)|ensembl:ENST00000396009(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042493"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR037059|rcsb pdb:1A02|rcsb pdb:1OWR|rcsb pdb:1P7H|go:"GO:1990904"(ribonucleoprotein complex)|rcsb pdb:1PZU|rcsb pdb:1S9K|rcsb pdb:2AS5|rcsb pdb:2O93|interpro:IPR002909(Cell surface receptor IPT/TIG)|rcsb pdb:3QRF|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-5607763|reactome:R-HSA-8877330|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|dip:DIP-27630N	-	-	-	figure legend:S1E|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2015/08/13	crc64:21E6FBC49C3BECCA	rogid:SNvCfCooUb7MH1xO0prmM4jv+o49606	intact-crc:A98FE41B70A9D090	false	-	sufficient binding region:392-678	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-983681	uniprotkb:Q9H334	-	intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6	psi-mi:arre2_element_mouse_il2_promoter(display_short)|psi-mi:EBI-983681(display_long)	psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983839|imex:IM-19878-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027720(see-also)	refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1	-	-	-	figure legend:S1D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2015/08/13	crc64:21E6FBC49C3BECCA	rogid:NREo12e1TLPfsul6Ie0l62NqIa89606	intact-crc:3578879E0D3DD46A	false	-	sufficient binding region:465..465-555..555(IPR001766)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-983681	uniprotkb:Q13469	-	intact:EBI-716258|uniprotkb:B5B2N9|uniprotkb:Q13468|uniprotkb:Q5TFW7|uniprotkb:Q5TFW8|uniprotkb:Q9NPX6|uniprotkb:Q9NQH3|uniprotkb:Q9UJR2|uniprotkb:B5B2P0|uniprotkb:B5B2N8|ensembl:ENSP00000379330|uniprotkb:B5B2P2|uniprotkb:B5B2P3	psi-mi:arre2_element_mouse_il2_promoter(display_short)|psi-mi:EBI-983681(display_long)	psi-mi:nfac2_human(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:NFATC2(gene name)|psi-mi:NFATC2(display_short)|uniprotkb:NFAT1(gene name synonym)|uniprotkb:NFATP(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983839|imex:IM-19878-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027720(see-also)	refseq:NP_001245221.1|refseq:NP_036472.2|refseq:NP_775114.1|refseq:NP_001245223.1|refseq:NP_001245225.1|refseq:NP_001129493.1|ensembl:ENSG00000101096(gene)|ensembl:ENST00000396009(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042493"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR037059|rcsb pdb:1A02|rcsb pdb:1OWR|rcsb pdb:1P7H|go:"GO:1990904"(ribonucleoprotein complex)|rcsb pdb:1PZU|rcsb pdb:1S9K|rcsb pdb:2AS5|rcsb pdb:2O93|interpro:IPR002909(Cell surface receptor IPT/TIG)|rcsb pdb:3QRF|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-5607763|reactome:R-HSA-8877330|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|dip:DIP-27630N	-	-	-	figure legend:S1D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2015/08/13	crc64:21E6FBC49C3BECCA	rogid:SNvCfCooUb7MH1xO0prmM4jv+o49606	intact-crc:3578879E0D3DD46A	false	-	sufficient binding region:392-678	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-983681	uniprotkb:O15409	-	intact:EBI-983612|uniprotkb:A0AUV6|uniprotkb:A4D0U8|uniprotkb:Q6ZND1|uniprotkb:Q75MJ3|uniprotkb:Q8IZE0|uniprotkb:Q8N0W2|uniprotkb:Q8N6B7|uniprotkb:Q8N6B8|uniprotkb:Q8NFQ1|uniprotkb:Q8NFQ2|uniprotkb:Q8NFQ3|uniprotkb:Q8NFQ4|uniprotkb:Q8TD74|ensembl:ENSP00000265436|ensembl:ENSP00000377132|uniprotkb:A6NNW4|uniprotkb:B4DLD9	psi-mi:arre2_element_mouse_il2_promoter(display_short)|psi-mi:EBI-983681(display_long)	psi-mi:foxp2_human(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983799|imex:IM-19878-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027720(see-also)	ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0098582"(innate vocalization behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:O15409|rcsb pdb:2A07|rcsb pdb:2AS5|go:"GO:0046872"(metal ion binding)|refseq:NP_001166237.1|refseq:NP_001166238.1|refseq:NP_055306.1|refseq:NP_683696.2|refseq:NP_683697.2|refseq:NP_683698.2|dip:DIP-29004N|refseq:XP_016868290.1	-	-	-	figure legend:S1F|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2015/08/13	crc64:21E6FBC49C3BECCA	rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606	intact-crc:C2F907269F40DC44	false	-	sufficient binding region:502-584	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-983681	uniprotkb:Q13469	-	intact:EBI-716258|uniprotkb:B5B2N9|uniprotkb:Q13468|uniprotkb:Q5TFW7|uniprotkb:Q5TFW8|uniprotkb:Q9NPX6|uniprotkb:Q9NQH3|uniprotkb:Q9UJR2|uniprotkb:B5B2P0|uniprotkb:B5B2N8|ensembl:ENSP00000379330|uniprotkb:B5B2P2|uniprotkb:B5B2P3	psi-mi:arre2_element_mouse_il2_promoter(display_short)|psi-mi:EBI-983681(display_long)	psi-mi:nfac2_human(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:NFATC2(gene name)|psi-mi:NFATC2(display_short)|uniprotkb:NFAT1(gene name synonym)|uniprotkb:NFATP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983799|imex:IM-19878-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027720(see-also)	refseq:NP_001245221.1|refseq:NP_036472.2|refseq:NP_775114.1|refseq:NP_001245223.1|refseq:NP_001245225.1|refseq:NP_001129493.1|ensembl:ENSG00000101096(gene)|ensembl:ENST00000396009(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042493"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR037059|rcsb pdb:1A02|rcsb pdb:1OWR|rcsb pdb:1P7H|go:"GO:1990904"(ribonucleoprotein complex)|rcsb pdb:1PZU|rcsb pdb:1S9K|rcsb pdb:2AS5|rcsb pdb:2O93|interpro:IPR002909(Cell surface receptor IPT/TIG)|rcsb pdb:3QRF|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-5607763|reactome:R-HSA-8877330|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|dip:DIP-27630N	-	-	-	figure legend:S1F|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2015/08/13	crc64:21E6FBC49C3BECCA	rogid:SNvCfCooUb7MH1xO0prmM4jv+o49606	intact-crc:C2F907269F40DC44	false	-	sufficient binding region:392-678	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
ensembl:ENSMUSG00000027720	uniprotkb:Q9BZS1	intact:EBI-10960725	intact:EBI-983719|uniprotkb:O60827|uniprotkb:Q14DD8|intact:EBI-28970697|ensembl:ENSP00000365380|uniprotkb:Q4ZH51|uniprotkb:A5HJT1|uniprotkb:B7ZLG0|uniprotkb:B9UN80	uniprotkb:Il2(gene name)|psi-mi:Il2(display_short)|uniprotkb:Il-2(gene name synonym)|ensembl:il2_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000027720(display_long)	psi-mi:foxp3_human(display_long)|uniprotkb:Scurfin(gene name synonym)|uniprotkb:FOXP3(gene name)|psi-mi:FOXP3(display_short)|uniprotkb:IPEX(gene name synonym)|uniprotkb:JM2(orf name)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10960710|imex:IM-19878-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_032392.1	ensembl:ENST00000376199|ensembl:ENSP00000365372|ensembl:ENSP00000365380|ensembl:ENST00000518685|ensembl:ENSP00000428952|ensembl:ENST00000557224|ensembl:ENSP00000451208|ensembl:ENSG00000049768(gene)|ensembl:ENST00000376207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QRF|rcsb pdb:4WK8|reactome:R-HSA-8877330|reactome:R-HSA-8939256|dip:DIP-36584N|refseq:NP_001107849.1|refseq:NP_054728.2	-	-	-	figure legend:6A|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2006/08/08	2015/08/13	-	rogid:ZDAplrVbraZ3/8zn8GPK/CPkGnA9606	-	false	sufficient binding region:?-?	myc tag:?-?|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q99JB6	ensembl:ENSMUSG00000027720	intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093	intact:EBI-10960725	psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym)	uniprotkb:Il2(gene name)|psi-mi:Il2(display_short)|uniprotkb:Il-2(gene name synonym)|ensembl:il2_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000027720(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10960715|imex:IM-19878-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N	refseq:NP_032392.1	-	-	-	figure legend:6A-2|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2006/08/08	2015/08/13	rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000026011	uniprotkb:Q9BZS1	intact:EBI-10960795	intact:EBI-983719|uniprotkb:O60827|uniprotkb:Q14DD8|intact:EBI-28970697|ensembl:ENSP00000365380|uniprotkb:Q4ZH51|uniprotkb:A5HJT1|uniprotkb:B7ZLG0|uniprotkb:B9UN80	uniprotkb:Ctla4(gene name)|psi-mi:Ctla4(display_short)|ensembl:ctla4_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000026011(display_long)	psi-mi:foxp3_human(display_long)|uniprotkb:Scurfin(gene name synonym)|uniprotkb:FOXP3(gene name)|psi-mi:FOXP3(display_short)|uniprotkb:IPEX(gene name synonym)|uniprotkb:JM2(orf name)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10960781|imex:IM-19878-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	uniprotkb:Q6GTR6(see-also)|uniprotkb:P09793(see-also)|refseq:NP_033973.2	ensembl:ENST00000376199|ensembl:ENSP00000365372|ensembl:ENSP00000365380|ensembl:ENST00000518685|ensembl:ENSP00000428952|ensembl:ENST00000557224|ensembl:ENSP00000451208|ensembl:ENSG00000049768(gene)|ensembl:ENST00000376207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QRF|rcsb pdb:4WK8|reactome:R-HSA-8877330|reactome:R-HSA-8939256|dip:DIP-36584N|refseq:NP_001107849.1|refseq:NP_054728.2	-	-	-	figure legend:6A-3|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2006/08/08	2015/08/13	-	rogid:ZDAplrVbraZ3/8zn8GPK/CPkGnA9606	-	false	sufficient binding region:?-?	myc tag:?-?|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q99JB6	ensembl:ENSMUSG00000026011	intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093	intact:EBI-10960795	psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym)	uniprotkb:Ctla4(gene name)|psi-mi:Ctla4(display_short)|ensembl:ctla4_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000026011(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10960813|imex:IM-19878-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N	uniprotkb:Q6GTR6(see-also)|uniprotkb:P09793(see-also)|refseq:NP_033973.2	-	-	-	figure legend:6A-4|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2006/08/08	2015/08/13	rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000026770	uniprotkb:Q9BZS1	intact:EBI-5259554	intact:EBI-983719|uniprotkb:O60827|uniprotkb:Q14DD8|intact:EBI-28970697|ensembl:ENSP00000365380|uniprotkb:Q4ZH51|uniprotkb:A5HJT1|uniprotkb:B7ZLG0|uniprotkb:B9UN80	psi-mi:il2ra_mouse_gene(display_short)|psi-mi:ENSMUSG00000026770(display_long)	psi-mi:foxp3_human(display_long)|uniprotkb:Scurfin(gene name synonym)|uniprotkb:FOXP3(gene name)|psi-mi:FOXP3(display_short)|uniprotkb:IPEX(gene name synonym)|uniprotkb:JM2(orf name)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10960819|imex:IM-19878-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000376199|ensembl:ENSP00000365372|ensembl:ENSP00000365380|ensembl:ENST00000518685|ensembl:ENSP00000428952|ensembl:ENST00000557224|ensembl:ENSP00000451208|ensembl:ENSG00000049768(gene)|ensembl:ENST00000376207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QRF|rcsb pdb:4WK8|reactome:R-HSA-8877330|reactome:R-HSA-8939256|dip:DIP-36584N|refseq:NP_001107849.1|refseq:NP_054728.2	-	-	-	figure legend:6A-5|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2006/08/08	2015/08/13	-	rogid:ZDAplrVbraZ3/8zn8GPK/CPkGnA9606	-	false	sufficient binding region:?-?	myc tag:?-?|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q99JB6	ensembl:ENSMUSG00000026770	intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093	intact:EBI-5259554	psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym)	psi-mi:il2ra_mouse_gene(display_short)|psi-mi:ENSMUSG00000026770(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10960831|imex:IM-19878-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N	-	-	-	-	figure legend:6A-6|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2006/08/08	2015/08/13	rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000027720	uniprotkb:Q60591	intact:EBI-10960725	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	uniprotkb:Il2(gene name)|psi-mi:Il2(display_short)|uniprotkb:Il-2(gene name synonym)|ensembl:il2_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000027720(display_long)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10960867|imex:IM-19878-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_032392.1	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	-	-	-	figure legend:6 B/C|causality statement:Q9BZS1 increased binding of  Q60591 to ENSMUSG00000027720|causality statement:"CHEBI:4031  decreases binding of  Q60591 to ENSMUSG00000027720"|antagonist:"Cyclosporin A (CHEBI:4031) -an immunosuppressant, inhibiting the calcineurin induced dephosphorylation of  NFATc, resulting in reduced IL2 production and suppression of  T cell activation."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2006/08/08	2015/08/13	-	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000026011	uniprotkb:Q60591	intact:EBI-10960795	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	uniprotkb:Ctla4(gene name)|psi-mi:Ctla4(display_short)|ensembl:ctla4_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000026011(display_long)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10960901|imex:IM-19878-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	uniprotkb:Q6GTR6(see-also)|uniprotkb:P09793(see-also)|refseq:NP_033973.2	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	-	-	-	figure legend:6 B/C|causality statement:Q9BZS1 increased binding of  Q60591 to ENSMUSG00000026011|antagonist:"Cyclosporin A (CHEBI:4031) -an immunosuppressant, inhibiting the calcineurin induced dephosphorylation of  NFATc, resulting in reduced IL2 production and suppression of  T cell activation."|causality statement:"CHEBI:4031 decreases binding of  Q60591 to ENSMUSG00000026011"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2006/08/08	2015/08/13	-	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000026770	uniprotkb:Q60591	intact:EBI-5259554	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:il2ra_mouse_gene(display_short)|psi-mi:ENSMUSG00000026770(display_long)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wu et al. (2006)	pubmed:16873067|imex:IM-19878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10960911|imex:IM-19878-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	-	-	-	figure legend:6 B/C|causality statement:Q9BZS1 increases binding of  Q60591 to ENSMUSG00000026770|antagonist:"Cyclosporin A (CHEBI:4031) -an immunosuppressant, inhibiting the calcineurin induced dephosphorylation of  NFATc, resulting in reduced IL2 production and suppression of  T cell activation."|causality statement:"CHEBI:4031  decreases binding of   Q60591 to ENSMUSG00000026770"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2006/08/08	2015/08/13	-	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)