#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51907	refseq:XM_001065465	intact:EBI-8579840|ensembl:ENSRNOP00000020272|intact:MINT-2839476|uniprotkb:Q63727|uniprotkb:Q9JJP8|uniprotkb:O88389	intact:EBI-8579829|intact:MINT-7306943	psi-mi:eaa3_rat(display_long)|uniprotkb:Slc1a1(gene name)|psi-mi:Slc1a1(display_short)|uniprotkb:Eaac1(gene name synonym)|uniprotkb:Eaat3(gene name synonym)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 3(gene name synonym)|uniprotkb:Excitatory amino-acid carrier 1(gene name synonym)|uniprotkb:Solute carrier family 1 member 1(gene name synonym)	psi-mi:xm_001065465(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8579834|mint:MINT-2839469|imex:IM-11054-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000014816(gene)|ensembl:ENSRNOT00000020272(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005253"(anion channel activity)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0022008"(neurogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033229"(cysteine transmembrane transporter activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036293"(response to decreased oxygen levels)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042883"(cysteine transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060013"(righting reflex)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060047"(heart contraction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061744"(motor behavior)|go:"GO:0070777"(D-aspartate transport)|go:"GO:0070778"(L-aspartate transmembrane transport)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0070997"(neuron death)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071944"(cell periphery)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090313"(regulation of protein targeting to membrane)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097386"(glial cell projection)|go:"GO:0097440"(apical dendrite)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098877"(neurotransmitter receptor transport to plasma membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0140010"(D-aspartate transmembrane transporter activity)|go:"GO:0150002"(distal dendrite)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1903712"(cysteine transmembrane transport)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990708"(conditioned place preference)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:P51907|reactome:R-RNO-210500|reactome:R-RNO-425393|refseq:NP_037164.3|rgd:3696|mint:MINT-2839471(identity)	mint:MINT-7306945(identity)	-	comment:mint|function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5|comment:"Stoichiometry: 1.0"	comment:mint|no-uniprot-update:|comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2006/08/01	2014/10/16	rogid:3FwolEdHTBF0qgnvi+CUIl02Cg410116	-	intact-crc:B99F296501A019C4	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
refseq:XM_001065465.1	uniprotkb:Q9R0I6	intact:EBI-8579909|intact:MINT-7306954	intact:EBI-8579875|ensembl:ENSRNOP00000009336|intact:MINT-2839635	psi-mi:xm_001065465.1(display_long)	psi-mi:xiap_rat(display_long)|uniprotkb:Api3(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP homolog A(gene name synonym)|uniprotkb:Xiap(gene name)|psi-mi:Xiap(display_short)|uniprotkb:Birc4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8579903|mint:MINT-2839614|imex:IM-11054-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:MINT-2839622(identity)	go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042579|mint:Q9R0I6|reactome:R-RNO-111459|reactome:R-RNO-111463|reactome:R-RNO-111464|reactome:R-RNO-111469|reactome:R-RNO-3769402|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5668541|reactome:R-RNO-5675482|reactome:R-RNO-5676594|reactome:R-RNO-8948747|reactome:R-RNO-8948751|reactome:R-RNO-9627069|ensembl:ENSRNOG00000006967(gene)|ensembl:ENSRNOT00000009336(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|rgd:620692|refseq:NP_071567.1|refseq:XP_006257570.1|refseq:XP_006257571.1|refseq:XP_017457637.1|refseq:XP_017457638.1|refseq:XP_017457639.1|refseq:XP_017457640.1|mint:MINT-2839615(identity)	-	comment:mint|no-uniprot-update:|comment:"Stoichiometry: 1.0"	comment:mint|function:Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B|comment:"Stoichiometry: 1.0"	figure legend:F7A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2006/08/01	2014/10/16	-	rogid:u/YXglI2W9a2koVgNpIRKo+mAqo10116	intact-crc:A86FFBBF587CDE35	false	-	-	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0113"(western blot)
refseq:XM_001065465.1	uniprotkb:P62898	intact:EBI-8579909|intact:MINT-7306954	intact:EBI-8579936|ensembl:ENSRNOP00000014058|ensembl:ENSRNOP00000041521|uniprotkb:P00009|uniprotkb:Q8C2S2|intact:MINT-1860092	psi-mi:xm_001065465.1(display_long)	psi-mi:cyc_rat(display_long)|uniprotkb:Cycs(gene name)|psi-mi:Cycs(display_short)	psi-mi:"MI:0428"(imaging technique)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8579930|mint:MINT-2839510|imex:IM-11054-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:MINT-7306950(identity)	ensembl:ENSRNOG00000010452(gene)|ensembl:ENSRNOG00000032885(gene)|ensembl:ENSRNOT00000014058(transcript)|ensembl:ENSRNOT00000048429(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|rcsb pdb:5DF5|rcsb pdb:5C9M|rcsb pdb:6N1O|rcsb pdb:7LJX|reactome:R-RNO-111457|reactome:R-RNO-111458|reactome:R-RNO-111459|reactome:R-RNO-2151201|reactome:R-RNO-3299685|reactome:R-RNO-5620971|reactome:R-RNO-5628897|reactome:R-RNO-611105|reactome:R-RNO-9627069|reactome:R-RNO-9707564|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009629"(response to gravity)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P62898|rcsb pdb:5C0Z|go:"GO:0005829"(cytosol)|refseq:XP_003753106.1|rgd:2451|refseq:XP_003751847.1|refseq:NP_036971.1|mint:MINT-2839517(identity)	-	comment:mint|no-uniprot-update:|comment:"Stoichiometry: 1.0"	function:Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2006/08/01	2014/10/16	-	rogid:vpo8RqJEpxq8eWPVl7eJfjlhUb010116	intact-crc:6171BEA4E1724421	false	-	-	1	1	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P53702	uniprotkb:Q60989	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	intact:EBI-517478|uniprotkb:A2BGY6|uniprotkb:O08865|ensembl:ENSMUSP00000026978|ensembl:ENSMUSP00000061074|ensembl:ENSMUSP00000110746|ensembl:ENSMUSP00000110747	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:xiap_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP homolog A(gene name synonym)|uniprotkb:Xiap(gene name)|psi-mi:Xiap(display_short)|uniprotkb:Aipa(gene name synonym)|uniprotkb:Api3(gene name synonym)|uniprotkb:Miha(gene name synonym)|uniprotkb:Birc4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580049|mint:MINT-2839649|imex:IM-11054-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839656(identity)	refseq:NP_033818.2|refseq:NP_001288568.1|refseq:NP_001288570.1|refseq:XP_006541488.1|refseq:XP_006541490.1|refseq:XP_017173848.1|refseq:XP_017173849.1|refseq:XP_017173850.1|refseq:XP_017173851.1|refseq:XP_011249279.1|dip:DIP-33721N|ensembl:ENSMUSG00000025860(gene)|ensembl:ENSMUST00000026978(transcript)|ensembl:ENSMUST00000055483(transcript)|ensembl:ENSMUST00000115094(transcript)|ensembl:ENSMUST00000115095(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042579|mint:Q60989|reactome:R-MMU-111459|reactome:R-MMU-111463|reactome:R-MMU-111464|reactome:R-MMU-111469|reactome:R-MMU-3769402|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-9627069|mint:MINT-2839650(identity)	-	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/01	2014/10/16	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	rogid:nJHDyZvomndsRCl3vfbv33MY/c810090	intact-crc:18444B16676CBF11|rigid:OlhUbRb3hVFNfEN0YT96PNmN40E	false	glutathione s tranferase tag:?-?(MINT-2839675)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51906	uniprotkb:P53702	intact:EBI-8580001|ensembl:ENSMUSP00000025875|uniprotkb:O35875|uniprotkb:O35869|intact:MINT-2839452|uniprotkb:Q6P1F7	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	psi-mi:eaa3_mouse(display_long)|uniprotkb:Slc1a1(gene name)|psi-mi:Slc1a1(display_short)|uniprotkb:Eaac1(gene name synonym)|uniprotkb:Eaat3(gene name synonym)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 3(gene name synonym)|uniprotkb:Excitatory amino-acid carrier 1(gene name synonym)|uniprotkb:Solute carrier family 1 member 1(gene name synonym)	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580029|mint:MINT-2839560|imex:IM-11054-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005253"(anion channel activity)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0022008"(neurogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033229"(cysteine transmembrane transporter activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036293"(response to decreased oxygen levels)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|ensembl:ENSMUSG00000024935(gene)|ensembl:ENSMUST00000025875(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0042802"(identical protein binding)|go:"GO:0042883"(cysteine transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060013"(righting reflex)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060047"(heart contraction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061744"(motor behavior)|go:"GO:0070777"(D-aspartate transport)|go:"GO:0070778"(L-aspartate transmembrane transport)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0070997"(neuron death)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071944"(cell periphery)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090313"(regulation of protein targeting to membrane)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097386"(glial cell projection)|go:"GO:0097440"(apical dendrite)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098877"(neurotransmitter receptor transport to plasma membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0140010"(D-aspartate transmembrane transporter activity)|go:"GO:0150002"(distal dendrite)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1903712"(cysteine transmembrane transport)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990708"(conditioned place preference)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:P51906|reactome:R-MMU-210500|reactome:R-MMU-425393|refseq:NP_033225.1|mint:MINT-2839571(identity)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839561(identity)	-	comment:mint|function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5|comment:"Stoichiometry: 1.0"	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F6B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/01	2014/10/16	rogid:iWKaN5q9NMKj77R4EqhSMGHOzX410090	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	intact-crc:A2B576AD9546359A|rigid:4ph2QwksQvmb7LvJfVjrJVxGBWo	false	mutation disrupting interaction:1-17(MINT-2839584)	glutathione s tranferase tag:?-?(MINT-2839568)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53702	uniprotkb:Q60989	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	intact:EBI-517478|uniprotkb:A2BGY6|uniprotkb:O08865|ensembl:ENSMUSP00000026978|ensembl:ENSMUSP00000061074|ensembl:ENSMUSP00000110746|ensembl:ENSMUSP00000110747	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:xiap_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP homolog A(gene name synonym)|uniprotkb:Xiap(gene name)|psi-mi:Xiap(display_short)|uniprotkb:Aipa(gene name synonym)|uniprotkb:Api3(gene name synonym)|uniprotkb:Miha(gene name synonym)|uniprotkb:Birc4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580064|mint:MINT-2839798|imex:IM-11054-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839799(identity)	refseq:NP_033818.2|refseq:NP_001288568.1|refseq:NP_001288570.1|refseq:XP_006541488.1|refseq:XP_006541490.1|refseq:XP_017173848.1|refseq:XP_017173849.1|refseq:XP_017173850.1|refseq:XP_017173851.1|refseq:XP_011249279.1|dip:DIP-33721N|ensembl:ENSMUSG00000025860(gene)|ensembl:ENSMUST00000026978(transcript)|ensembl:ENSMUST00000055483(transcript)|ensembl:ENSMUST00000115094(transcript)|ensembl:ENSMUST00000115095(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042579|mint:Q60989|reactome:R-MMU-111459|reactome:R-MMU-111463|reactome:R-MMU-111464|reactome:R-MMU-111469|reactome:R-MMU-3769402|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-9627069|mint:MINT-2839807(identity)	-	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7F|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/01	2014/10/16	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	rogid:nJHDyZvomndsRCl3vfbv33MY/c810090	intact-crc:5CCF893CB29BF67D|rigid:OlhUbRb3hVFNfEN0YT96PNmN40E	false	ha tag:?-?(MINT-2839803)	binding-associated region:124-142(MINT-2839820)|glutathione s tranferase tag:?-?(MINT-2839810)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53702	uniprotkb:P51906	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	intact:EBI-8580001|ensembl:ENSMUSP00000025875|uniprotkb:O35875|uniprotkb:O35869|intact:MINT-2839452|uniprotkb:Q6P1F7	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:eaa3_mouse(display_long)|uniprotkb:Slc1a1(gene name)|psi-mi:Slc1a1(display_short)|uniprotkb:Eaac1(gene name synonym)|uniprotkb:Eaat3(gene name synonym)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 3(gene name synonym)|uniprotkb:Excitatory amino-acid carrier 1(gene name synonym)|uniprotkb:Solute carrier family 1 member 1(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580097|mint:MINT-2839588|imex:IM-11054-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839597(identity)	go:"GO:0005253"(anion channel activity)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0022008"(neurogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033229"(cysteine transmembrane transporter activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036293"(response to decreased oxygen levels)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|ensembl:ENSMUSG00000024935(gene)|ensembl:ENSMUST00000025875(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0042802"(identical protein binding)|go:"GO:0042883"(cysteine transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060013"(righting reflex)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060047"(heart contraction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061744"(motor behavior)|go:"GO:0070777"(D-aspartate transport)|go:"GO:0070778"(L-aspartate transmembrane transport)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0070997"(neuron death)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071944"(cell periphery)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090313"(regulation of protein targeting to membrane)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097386"(glial cell projection)|go:"GO:0097440"(apical dendrite)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098877"(neurotransmitter receptor transport to plasma membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0140010"(D-aspartate transmembrane transporter activity)|go:"GO:0150002"(distal dendrite)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1903712"(cysteine transmembrane transport)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990708"(conditioned place preference)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:P51906|reactome:R-MMU-210500|reactome:R-MMU-425393|refseq:NP_033225.1|mint:MINT-2839589(identity)	-	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5|comment:"Stoichiometry: 1.0"	figure legend:F6C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/01	2014/10/16	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	rogid:iWKaN5q9NMKj77R4EqhSMGHOzX410090	intact-crc:76370538C67E35D8|rigid:4ph2QwksQvmb7LvJfVjrJVxGBWo	false	glutathione s tranferase tag:?-?(MINT-2839601)	binding-associated region:1-17(MINT-2839611)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53702	uniprotkb:Q60989	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	intact:EBI-517478|uniprotkb:A2BGY6|uniprotkb:O08865|ensembl:ENSMUSP00000026978|ensembl:ENSMUSP00000061074|ensembl:ENSMUSP00000110746|ensembl:ENSMUSP00000110747	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:xiap_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP homolog A(gene name synonym)|uniprotkb:Xiap(gene name)|psi-mi:Xiap(display_short)|uniprotkb:Aipa(gene name synonym)|uniprotkb:Api3(gene name synonym)|uniprotkb:Miha(gene name synonym)|uniprotkb:Birc4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580149|mint:MINT-2839682|imex:IM-11054-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839688(identity)	refseq:NP_033818.2|refseq:NP_001288568.1|refseq:NP_001288570.1|refseq:XP_006541488.1|refseq:XP_006541490.1|refseq:XP_017173848.1|refseq:XP_017173849.1|refseq:XP_017173850.1|refseq:XP_017173851.1|refseq:XP_011249279.1|dip:DIP-33721N|ensembl:ENSMUSG00000025860(gene)|ensembl:ENSMUST00000026978(transcript)|ensembl:ENSMUST00000055483(transcript)|ensembl:ENSMUST00000115094(transcript)|ensembl:ENSMUST00000115095(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042579|mint:Q60989|reactome:R-MMU-111459|reactome:R-MMU-111463|reactome:R-MMU-111464|reactome:R-MMU-111469|reactome:R-MMU-3769402|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-9627069|mint:MINT-2839683(identity)	-	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7C|figure legend:7E|figure legend:7G|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/01	2014/10/16	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	rogid:nJHDyZvomndsRCl3vfbv33MY/c810090	intact-crc:D21FAA26A68B9546|rigid:OlhUbRb3hVFNfEN0YT96PNmN40E	false	binding-associated region:148-272(MINT-2839705)|ha tag:?-?(MINT-2839692)	flag tag:?-?(MINT-2839699)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53702	uniprotkb:P51906	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	intact:EBI-8580001|ensembl:ENSMUSP00000025875|uniprotkb:O35875|uniprotkb:O35869|intact:MINT-2839452|uniprotkb:Q6P1F7	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:eaa3_mouse(display_long)|uniprotkb:Slc1a1(gene name)|psi-mi:Slc1a1(display_short)|uniprotkb:Eaac1(gene name synonym)|uniprotkb:Eaat3(gene name synonym)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 3(gene name synonym)|uniprotkb:Excitatory amino-acid carrier 1(gene name synonym)|uniprotkb:Solute carrier family 1 member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580126|mint:MINT-2839533|imex:IM-11054-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839534(identity)	go:"GO:0005253"(anion channel activity)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0022008"(neurogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033229"(cysteine transmembrane transporter activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036293"(response to decreased oxygen levels)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|ensembl:ENSMUSG00000024935(gene)|ensembl:ENSMUST00000025875(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0042802"(identical protein binding)|go:"GO:0042883"(cysteine transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060013"(righting reflex)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060047"(heart contraction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061744"(motor behavior)|go:"GO:0070777"(D-aspartate transport)|go:"GO:0070778"(L-aspartate transmembrane transport)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0070997"(neuron death)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071944"(cell periphery)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090313"(regulation of protein targeting to membrane)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097386"(glial cell projection)|go:"GO:0097440"(apical dendrite)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098877"(neurotransmitter receptor transport to plasma membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0140010"(D-aspartate transmembrane transporter activity)|go:"GO:0150002"(distal dendrite)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1903712"(cysteine transmembrane transport)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990708"(conditioned place preference)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:P51906|reactome:R-MMU-210500|reactome:R-MMU-425393|refseq:NP_033225.1|mint:MINT-2839540(identity)	-	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5|comment:"Stoichiometry: 1.0"	figure legend:F6A|figure legend:F6D|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/01	2014/10/16	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	rogid:iWKaN5q9NMKj77R4EqhSMGHOzX410090	intact-crc:436100C2B0D89A9E|rigid:4ph2QwksQvmb7LvJfVjrJVxGBWo	false	binding-associated region:148-272(MINT-2839557)|flag tag:?-?(MINT-2839551)	ha tag:?-?(MINT-2839554)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53702	uniprotkb:Q62210	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	intact:EBI-647504|uniprotkb:O08864|uniprotkb:A6H6S7|ensembl:ENSMUSP00000091422|ensembl:ENSMUSP00000140049	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:birc2_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:Birc2(gene name)|psi-mi:Birc2(display_short)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580173|mint:MINT-2839713|imex:IM-11054-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839714(identity)	refseq:NP_031491.2|refseq:NP_001278432.1|refseq:XP_017168599.1|ensembl:ENSMUSG00000057367(gene)|ensembl:ENSMUST00000074246(transcript)|ensembl:ENSMUST00000190341(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q62210|reactome:R-MMU-111465|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-2839724(identity)	-	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/01	2014/10/16	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	rogid:dYfLagyPs9Ceg7miQnJCJzKHRPk10090	intact-crc:167DA0AE383849C3|rigid:CTcHR4JvGR4yZRl51LkqBt/wC6M	false	ha tag:?-?(MINT-2839721)	flag tag:?-?(MINT-2839729)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53702	uniprotkb:Q60989	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	intact:EBI-517478|uniprotkb:A2BGY6|uniprotkb:O08865|ensembl:ENSMUSP00000026978|ensembl:ENSMUSP00000061074|ensembl:ENSMUSP00000110746|ensembl:ENSMUSP00000110747	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:xiap_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP homolog A(gene name synonym)|uniprotkb:Xiap(gene name)|psi-mi:Xiap(display_short)|uniprotkb:Aipa(gene name synonym)|uniprotkb:Api3(gene name synonym)|uniprotkb:Miha(gene name synonym)|uniprotkb:Birc4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580209|mint:MINT-2839773|imex:IM-11054-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839774(identity)	refseq:NP_033818.2|refseq:NP_001288568.1|refseq:NP_001288570.1|refseq:XP_006541488.1|refseq:XP_006541490.1|refseq:XP_017173848.1|refseq:XP_017173849.1|refseq:XP_017173850.1|refseq:XP_017173851.1|refseq:XP_011249279.1|dip:DIP-33721N|ensembl:ENSMUSG00000025860(gene)|ensembl:ENSMUST00000026978(transcript)|ensembl:ENSMUST00000055483(transcript)|ensembl:ENSMUST00000115094(transcript)|ensembl:ENSMUST00000115095(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042579|mint:Q60989|reactome:R-MMU-111459|reactome:R-MMU-111463|reactome:R-MMU-111464|reactome:R-MMU-111469|reactome:R-MMU-3769402|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-9627069|mint:MINT-2839784(identity)	-	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/01	2014/10/16	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	rogid:nJHDyZvomndsRCl3vfbv33MY/c810090	intact-crc:E076EB93E7ED52C5|rigid:OlhUbRb3hVFNfEN0YT96PNmN40E	false	ha tag:?-?(MINT-2839781)	myc tag:?-?(MINT-2839789)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53702	uniprotkb:O08863	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	intact:EBI-642236|uniprotkb:E9QLX3	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:birc3_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:Birc3(gene name)|psi-mi:Birc3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580191|mint:MINT-2839754|imex:IM-11054-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839763(identity)	refseq:NP_031490.2|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|mint:O08863|dip:DIP-43742N|mint:MINT-2839755(identity)	-	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/01	2014/10/16	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	rogid:rPZRfzbIHpwQop1BRwyZl+TfhUg10090	intact-crc:16E9BAAAB1CD1D3D|rigid:b6uXHFRSTidzxmsiLoptc9Pq1Q0	false	ha tag:?-?(MINT-2839767)	flag tag:?-?(MINT-2839759)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53702	uniprotkb:P51906	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	intact:EBI-8580001|ensembl:ENSMUSP00000025875|uniprotkb:O35875|uniprotkb:O35869|intact:MINT-2839452|uniprotkb:Q6P1F7	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:eaa3_mouse(display_long)|uniprotkb:Slc1a1(gene name)|psi-mi:Slc1a1(display_short)|uniprotkb:Eaac1(gene name synonym)|uniprotkb:Eaat3(gene name synonym)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 3(gene name synonym)|uniprotkb:Excitatory amino-acid carrier 1(gene name synonym)|uniprotkb:Solute carrier family 1 member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580227|mint:MINT-2839825|imex:IM-11054-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839834(identity)	go:"GO:0005253"(anion channel activity)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0022008"(neurogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033229"(cysteine transmembrane transporter activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036293"(response to decreased oxygen levels)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|ensembl:ENSMUSG00000024935(gene)|ensembl:ENSMUST00000025875(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0042802"(identical protein binding)|go:"GO:0042883"(cysteine transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060013"(righting reflex)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060047"(heart contraction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061744"(motor behavior)|go:"GO:0070777"(D-aspartate transport)|go:"GO:0070778"(L-aspartate transmembrane transport)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0070997"(neuron death)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071944"(cell periphery)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090313"(regulation of protein targeting to membrane)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097386"(glial cell projection)|go:"GO:0097440"(apical dendrite)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098877"(neurotransmitter receptor transport to plasma membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0140010"(D-aspartate transmembrane transporter activity)|go:"GO:0150002"(distal dendrite)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1903712"(cysteine transmembrane transport)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990708"(conditioned place preference)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:P51906|reactome:R-MMU-210500|reactome:R-MMU-425393|refseq:NP_033225.1|mint:MINT-2839826(identity)	-	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5|comment:"Stoichiometry: 1.0"	figure legend:F7G|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/01	2014/10/16	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	rogid:iWKaN5q9NMKj77R4EqhSMGHOzX410090	intact-crc:E35426B9571CE13C|rigid:4ph2QwksQvmb7LvJfVjrJVxGBWo	false	ha tag:?-?(MINT-2839841)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51906	uniprotkb:P53702	intact:EBI-8580001|ensembl:ENSMUSP00000025875|uniprotkb:O35875|uniprotkb:O35869|intact:MINT-2839452|uniprotkb:Q6P1F7	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	psi-mi:eaa3_mouse(display_long)|uniprotkb:Slc1a1(gene name)|psi-mi:Slc1a1(display_short)|uniprotkb:Eaac1(gene name synonym)|uniprotkb:Eaat3(gene name synonym)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 3(gene name synonym)|uniprotkb:Excitatory amino-acid carrier 1(gene name synonym)|uniprotkb:Solute carrier family 1 member 1(gene name synonym)	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580252|mint:MINT-2839850|imex:IM-11054-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005253"(anion channel activity)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0022008"(neurogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033229"(cysteine transmembrane transporter activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036293"(response to decreased oxygen levels)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|ensembl:ENSMUSG00000024935(gene)|ensembl:ENSMUST00000025875(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0042802"(identical protein binding)|go:"GO:0042883"(cysteine transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060013"(righting reflex)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060047"(heart contraction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061744"(motor behavior)|go:"GO:0070777"(D-aspartate transport)|go:"GO:0070778"(L-aspartate transmembrane transport)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0070997"(neuron death)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071944"(cell periphery)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090313"(regulation of protein targeting to membrane)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097386"(glial cell projection)|go:"GO:0097440"(apical dendrite)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098877"(neurotransmitter receptor transport to plasma membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0140010"(D-aspartate transmembrane transporter activity)|go:"GO:0150002"(distal dendrite)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1903712"(cysteine transmembrane transport)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990708"(conditioned place preference)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:P51906|reactome:R-MMU-210500|reactome:R-MMU-425393|refseq:NP_033225.1|mint:MINT-2839851(identity)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839857(identity)	-	comment:mint|function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5|comment:"Stoichiometry: 1.0"	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:NFA|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/08/01	2014/10/16	rogid:iWKaN5q9NMKj77R4EqhSMGHOzX410090	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	intact-crc:13F282BEADF2794F|rigid:4ph2QwksQvmb7LvJfVjrJVxGBWo	false	binding-associated region:1-34(MINT-2839873)|tag:?-?(MINT-2839871)	tag:?-?(MINT-2839859)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51907	refseq:XM_001065465.1	intact:EBI-8579840|ensembl:ENSRNOP00000020272|intact:MINT-2839476|uniprotkb:Q63727|uniprotkb:Q9JJP8|uniprotkb:O88389	intact:EBI-8579909|intact:MINT-7306954	psi-mi:eaa3_rat(display_long)|uniprotkb:Slc1a1(gene name)|psi-mi:Slc1a1(display_short)|uniprotkb:Eaac1(gene name synonym)|uniprotkb:Eaat3(gene name synonym)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 3(gene name synonym)|uniprotkb:Excitatory amino-acid carrier 1(gene name synonym)|uniprotkb:Solute carrier family 1 member 1(gene name synonym)	psi-mi:xm_001065465.1(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580285|mint:MINT-2841792|imex:IM-11054-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000014816(gene)|ensembl:ENSRNOT00000020272(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005253"(anion channel activity)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0022008"(neurogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033229"(cysteine transmembrane transporter activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036293"(response to decreased oxygen levels)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042883"(cysteine transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060013"(righting reflex)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060047"(heart contraction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061744"(motor behavior)|go:"GO:0070777"(D-aspartate transport)|go:"GO:0070778"(L-aspartate transmembrane transport)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0070997"(neuron death)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071944"(cell periphery)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090313"(regulation of protein targeting to membrane)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097386"(glial cell projection)|go:"GO:0097440"(apical dendrite)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098877"(neurotransmitter receptor transport to plasma membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0140010"(D-aspartate transmembrane transporter activity)|go:"GO:0150002"(distal dendrite)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1903712"(cysteine transmembrane transport)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990708"(conditioned place preference)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:P51907|reactome:R-RNO-210500|reactome:R-RNO-425393|refseq:NP_037164.3|rgd:3696|mint:MINT-2841799(identity)	mint:MINT-2841793(identity)	-	comment:mint|function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5|comment:"Stoichiometry: 1.0"	comment:mint|no-uniprot-update:|comment:"Stoichiometry: 1.0"	figure legend:F8A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-motor_neuron)|taxid:10116(Rat motor neuon)	-	2006/08/01	2014/10/16	rogid:3FwolEdHTBF0qgnvi+CUIl02Cg410116	-	intact-crc:FCA54C95C0592ABA	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P53702	uniprotkb:Q60989	intact:EBI-8579982|ensembl:ENSMUSP00000033717|ensembl:ENSMUSP00000107743|intact:MINT-2839666|uniprotkb:Q6P5G5	intact:EBI-517478|uniprotkb:A2BGY6|uniprotkb:O08865|ensembl:ENSMUSP00000026978|ensembl:ENSMUSP00000061074|ensembl:ENSMUSP00000110746|ensembl:ENSMUSP00000110747	psi-mi:cchl_mouse(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:Hccs(gene name)|psi-mi:Hccs(display_short)|uniprotkb:Cchl(gene name synonym)	psi-mi:xiap_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP homolog A(gene name synonym)|uniprotkb:Xiap(gene name)|psi-mi:Xiap(display_short)|uniprotkb:Aipa(gene name synonym)|uniprotkb:Api3(gene name synonym)|uniprotkb:Miha(gene name synonym)|uniprotkb:Birc4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kiryu-Seo et al. (2006)	pubmed:16858406|imex:IM-11054|mint:MINT-5218852	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8580307|mint:MINT-2839907|imex:IM-11054-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031352(gene)|ensembl:ENSMUST00000033717(transcript)|ensembl:ENSMUST00000112115(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53702|refseq:NP_032248.3|refseq:XP_006528768.1|refseq:NP_001317978.1|refseq:NP_001317979.1|mint:MINT-2839914(identity)	refseq:NP_033818.2|refseq:NP_001288568.1|refseq:NP_001288570.1|refseq:XP_006541488.1|refseq:XP_006541490.1|refseq:XP_017173848.1|refseq:XP_017173849.1|refseq:XP_017173850.1|refseq:XP_017173851.1|refseq:XP_011249279.1|dip:DIP-33721N|ensembl:ENSMUSG00000025860(gene)|ensembl:ENSMUST00000026978(transcript)|ensembl:ENSMUST00000055483(transcript)|ensembl:ENSMUST00000115094(transcript)|ensembl:ENSMUST00000115095(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042579|mint:Q60989|reactome:R-MMU-111459|reactome:R-MMU-111463|reactome:R-MMU-111464|reactome:R-MMU-111469|reactome:R-MMU-3769402|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-9627069|mint:MINT-2839908(identity)	-	function:Links covalently the heme group to the apoprotein of cytochrome c|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F8B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-motor_neuron)|taxid:10090(Mouse motor neuron)	-	2006/08/01	2014/10/16	rogid:0aPMgGZvEaCZHq065LzqaPILSLg10090	rogid:nJHDyZvomndsRCl3vfbv33MY/c810090	intact-crc:2D4F0054042E176F|rigid:OlhUbRb3hVFNfEN0YT96PNmN40E	false	-	-	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0113"(western blot)