#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6XVZ2 uniprotkb:P18206 intact:EBI-7255868|intact:MINT-2842473 intact:EBI-716775|uniprotkb:Q16450|uniprotkb:Q5SWX2|uniprotkb:Q7Z3B8|uniprotkb:Q8IXU7|ensembl:ENSP00000211998 psi-mi:q6xvz2_shifl(display_long)|uniprotkb:ipaA(gene name)|psi-mi:ipaA(display_short) psi-mi:vinc_human(display_long)|uniprotkb:Metavinculin(gene name synonym)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short) psi-mi:"MI:0114"(x-ray crystallography) Hamiaux et al. (2006) mint:MINT-5218803|pubmed:16826238|imex:IM-10964 taxid:623(shifl)|taxid:623(Shigella flexneri) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8563178|mint:MINT-2842480|imex:IM-10964-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q6XVZ2|refseq:WP_005059309.1|interpro:IPR040658|interpro:IPR015138(Salmonella invasion protein A)|interpro:IPR023225|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|rcsb pdb:2HSQ|mint:MINT-2842481(identity) refseq:NP_003364.1|refseq:NP_054706.1|ensembl:ENSG00000035403(gene)|ensembl:ENST00000211998(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:P18206|rcsb pdb:1RKC|rcsb pdb:1RKE|rcsb pdb:1SYQ|rcsb pdb:1TR2|rcsb pdb:1YDI|rcsb pdb:2GWW|rcsb pdb:2HSQ|rcsb pdb:2IBF|rcsb pdb:3H2U|rcsb pdb:3H2V|rcsb pdb:3JBK|rcsb pdb:3MYI|rcsb pdb:3RF3|rcsb pdb:3S90|go:"GO:0005198"(structural molecule activity)|rcsb pdb:3TJ5|rcsb pdb:3TJ6|rcsb pdb:3VF0|rcsb pdb:4DJ9|rcsb pdb:4EHP|rcsb pdb:4LN2|rcsb pdb:4LNP|rcsb pdb:4PR9|rcsb pdb:5L0C|rcsb pdb:5L0D|rcsb pdb:5L0F|rcsb pdb:5L0G|rcsb pdb:5L0H|rcsb pdb:5L0I|rcsb pdb:5L0J|rcsb pdb:5O2Q|rcsb pdb:6FUY|rcsb pdb:6UPW|rcsb pdb:7KTT|rcsb pdb:7KTU|rcsb pdb:7KTV|rcsb pdb:7KTW|reactome:R-HSA-114608|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048675"(axon extension)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|ensembl:ENSP00000211998|ensembl:ENST00000372755|ensembl:ENSP00000361841|dip:DIP-35570N|mint:MINT-2842482(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/08/04 2014/10/16 rogid:aC7VgMnktLLeAWbmm0FCl/CuQbQ623 rogid:Cs5ZD4u5mH3IHBeKWMRV4cfS+y49606 intact-crc:996490C4BF7DF60F|rigid:Ox186rtcV4JPmu+ad+AhgFvFrUQ false binding-associated region:560-633(MINT-2842515) binding-associated region:2-258(MINT-2842491) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6XVZ2 uniprotkb:P18206 intact:EBI-7255868|intact:MINT-2842473 intact:EBI-716775|uniprotkb:Q16450|uniprotkb:Q5SWX2|uniprotkb:Q7Z3B8|uniprotkb:Q8IXU7|ensembl:ENSP00000211998 psi-mi:q6xvz2_shifl(display_long)|uniprotkb:ipaA(gene name)|psi-mi:ipaA(display_short) psi-mi:vinc_human(display_long)|uniprotkb:Metavinculin(gene name synonym)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short) psi-mi:"MI:0071"(molecular sieving) Hamiaux et al. (2006) mint:MINT-5218803|pubmed:16826238|imex:IM-10964 taxid:623(shifl)|taxid:623(Shigella flexneri) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8563208|mint:MINT-2842518|imex:IM-10964-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q6XVZ2|refseq:WP_005059309.1|interpro:IPR040658|interpro:IPR015138(Salmonella invasion protein A)|interpro:IPR023225|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|rcsb pdb:2HSQ|mint:MINT-2842519(identity) refseq:NP_003364.1|refseq:NP_054706.1|ensembl:ENSG00000035403(gene)|ensembl:ENST00000211998(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:P18206|rcsb pdb:1RKC|rcsb pdb:1RKE|rcsb pdb:1SYQ|rcsb pdb:1TR2|rcsb pdb:1YDI|rcsb pdb:2GWW|rcsb pdb:2HSQ|rcsb pdb:2IBF|rcsb pdb:3H2U|rcsb pdb:3H2V|rcsb pdb:3JBK|rcsb pdb:3MYI|rcsb pdb:3RF3|rcsb pdb:3S90|go:"GO:0005198"(structural molecule activity)|rcsb pdb:3TJ5|rcsb pdb:3TJ6|rcsb pdb:3VF0|rcsb pdb:4DJ9|rcsb pdb:4EHP|rcsb pdb:4LN2|rcsb pdb:4LNP|rcsb pdb:4PR9|rcsb pdb:5L0C|rcsb pdb:5L0D|rcsb pdb:5L0F|rcsb pdb:5L0G|rcsb pdb:5L0H|rcsb pdb:5L0I|rcsb pdb:5L0J|rcsb pdb:5O2Q|rcsb pdb:6FUY|rcsb pdb:6UPW|rcsb pdb:7KTT|rcsb pdb:7KTU|rcsb pdb:7KTV|rcsb pdb:7KTW|reactome:R-HSA-114608|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048675"(axon extension)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|ensembl:ENSP00000211998|ensembl:ENST00000372755|ensembl:ENSP00000361841|dip:DIP-35570N|mint:MINT-2842526(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3|figure legend:SF1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/08/04 2014/10/16 rogid:aC7VgMnktLLeAWbmm0FCl/CuQbQ623 rogid:Cs5ZD4u5mH3IHBeKWMRV4cfS+y49606 intact-crc:ACE19B9BFBE64F04|rigid:Ox186rtcV4JPmu+ad+AhgFvFrUQ false binding-associated region:560-633(MINT-2842520) binding-associated region:1-250(MINT-2842527) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6XVZ2 uniprotkb:P18206 intact:EBI-7255868|intact:MINT-2842473 intact:EBI-716775|uniprotkb:Q16450|uniprotkb:Q5SWX2|uniprotkb:Q7Z3B8|uniprotkb:Q8IXU7|ensembl:ENSP00000211998 psi-mi:q6xvz2_shifl(display_long)|uniprotkb:ipaA(gene name)|psi-mi:ipaA(display_short) psi-mi:vinc_human(display_long)|uniprotkb:Metavinculin(gene name synonym)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short) psi-mi:"MI:0051"(fluorescence technology) Hamiaux et al. (2006) mint:MINT-5218803|pubmed:16826238|imex:IM-10964 taxid:623(shifl)|taxid:623(Shigella flexneri) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8563239|mint:MINT-2842543|imex:IM-10964-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q6XVZ2|refseq:WP_005059309.1|interpro:IPR040658|interpro:IPR015138(Salmonella invasion protein A)|interpro:IPR023225|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|rcsb pdb:2HSQ|mint:MINT-2842551(identity) refseq:NP_003364.1|refseq:NP_054706.1|ensembl:ENSG00000035403(gene)|ensembl:ENST00000211998(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:P18206|rcsb pdb:1RKC|rcsb pdb:1RKE|rcsb pdb:1SYQ|rcsb pdb:1TR2|rcsb pdb:1YDI|rcsb pdb:2GWW|rcsb pdb:2HSQ|rcsb pdb:2IBF|rcsb pdb:3H2U|rcsb pdb:3H2V|rcsb pdb:3JBK|rcsb pdb:3MYI|rcsb pdb:3RF3|rcsb pdb:3S90|go:"GO:0005198"(structural molecule activity)|rcsb pdb:3TJ5|rcsb pdb:3TJ6|rcsb pdb:3VF0|rcsb pdb:4DJ9|rcsb pdb:4EHP|rcsb pdb:4LN2|rcsb pdb:4LNP|rcsb pdb:4PR9|rcsb pdb:5L0C|rcsb pdb:5L0D|rcsb pdb:5L0F|rcsb pdb:5L0G|rcsb pdb:5L0H|rcsb pdb:5L0I|rcsb pdb:5L0J|rcsb pdb:5O2Q|rcsb pdb:6FUY|rcsb pdb:6UPW|rcsb pdb:7KTT|rcsb pdb:7KTU|rcsb pdb:7KTV|rcsb pdb:7KTW|reactome:R-HSA-114608|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048675"(axon extension)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|ensembl:ENSP00000211998|ensembl:ENST00000372755|ensembl:ENSP00000361841|dip:DIP-35570N|mint:MINT-2842544(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/08/04 2014/10/16 rogid:aC7VgMnktLLeAWbmm0FCl/CuQbQ623 rogid:Cs5ZD4u5mH3IHBeKWMRV4cfS+y49606 intact-crc:27C78721C5675978|rigid:Ox186rtcV4JPmu+ad+AhgFvFrUQ false binding-associated region:560-633(MINT-2842556) binding-associated region:1-250(MINT-2842545) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)